20127-63-3
Chemical Structure
1-Formyl-beta-carboline
- CAS No.: 20127-63-3
- Formula:C12H8N2O
- Molecular Weight:196.21
IUPAC Name: 9H-pyrido[3,4-b]indole-1-carbaldehyde
InChIKey: CHQBGSRZQLMDEX-UHFFFAOYSA-N
SMILES: C1=CC=C2C(=C1)C3=C(C(=NC=C3)C=O)N2
Biological Activity: 1-Formyl-beta-carboline is an alkaloid with inhibitory activity against Newcastle disease virus (NDV). 1-Formyl-beta-carboline can effectively inhibit different genotypes of NDV with IC50 values within 10 μM, and its inhibition rate is more than 90% at a concentration of 20 μM. 1-Formyl-beta-carboline mainly exerts its effects by inhibiting the adsorption and entry processes in the NDV life cycle. 1-Formyl-beta-carboline has been identified as a novel HN inhibitor that can directly interact with the NDV HN protein and affect the adsorption of NDV. 1-Formyl-beta-carboline also inhibits the entry of NDV by inhibiting the PI3K/Akt signaling pathway rather than the ERK pathway[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
1-Formyl-beta-carboline | 99.27% | 1-Formyl-beta-carboline is an alkaloid with inhibitory activity against Newcastle disease virus (NDV). 1-Formyl-beta-carboline can effectively inhibit different genotypes of NDV with IC50 values within 10 μM, and its inhibition rate is more than 90% at a concentration of 20 μM. 1-Formyl-beta-carboline mainly exerts its effects by inhibiting the adsorption and entry processes in the NDV life cycle. 1-Formyl-beta-carboline has been identified as a novel HN inhibitor that can directly interact with the NDV HN protein and affect the adsorption of NDV. 1-Formyl-beta-carboline also inhibits the entry of NDV by inhibiting the PI3K/Akt signaling pathway rather than the ERK pathway. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
-
Similarity Score 0.83
HY-101392AHarmane hydrochloride -
Similarity Score 0.82
HY-101392Harmane -
Similarity Score 0.82
HY-W777360Harman-13C2,15N -
Similarity Score 0.77
HY-W700834Harman-d3 -
Similarity Score 0.73
HY-W106860R9H-Carbazole-3-carbaldehyde (Standard) -
Similarity Score 0.72
HY-W008566Norharmane -
Similarity Score 0.72
HY-W1975333-Hydroxymethyl-β-carboline -
Similarity Score 0.71
HY-107811Harmol -
Similarity Score 0.70
HY-W094994α-Carboline -
Explore the MedChemAI to find more analogs
