244-76-8
Chemical Structure
α-Carboline
Synonym(s): alpha-Carboline
- CAS No.: 244-76-8
- Formula:C11H8N2
- Molecular Weight:168.19
IUPAC Name: 9H-pyrido[2,3-b]indole
InChIKey: BPMFPOGUJAAYHL-UHFFFAOYSA-N
SMILES: C12=C(NC3=CC=CC=C32)N=CC=C1
Biological Activity: α-Carboline (alpha-Carboline) is an important core scaffold of drug molecules. α-Carboline and its functionalized derivatives possess a broad range of biological activities, mainly including significant tumor cytotoxicity, protein kinase inhibitory activity, central nervous system regulatory capacity, and the strong mutagenicity of some modified products. α-Carboline can be used in research on various cancers[1][2][3][4].
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α-Carboline | 99.73% | α-Carboline (alpha-Carboline) is an important core scaffold of drug molecules. α-Carboline and its functionalized derivatives possess a broad range of biological activities, mainly including significant tumor cytotoxicity, protein kinase inhibitory activity, central nervous system regulatory capacity, and the strong mutagenicity of some modified products. α-Carboline can be used in research on various cancers. | ||||||||||||||||||||
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Alpha-Carboline-15N2 | Alpha-Carboline-15N2 is the 15N2-labeled α-Carboline (HY-W094994). α-Carboline (alpha-Carboline) is an important core scaffold of drug molecules. α-Carboline and its functionalized derivatives possess a broad range of biological activities, mainly including significant tumor cytotoxicity, protein kinase inhibitory activity, central nervous system regulatory capacity, and the strong mutagenicity of some modified products. α-Carboline can be used in research on various cancers. | |||||||||||||||||||||
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References
- [1]. Ghafourzadeh M, et al. Anti-leishmanial and immunomodulatory effects of harmaline against Leishmania tropica through molecular docking, gene expression profiling and oxidative stress modulation. Scientific Reports. 2026 Sep 3.
- [2]. Sarı C, et al. Toward the design of new α-carboline derivatives against anaplastic lymphoma kinase (ALK): a comprehensive in silico approach. ChemistrySelect. 2025;10(44):e00850.
- [3]. Xu Z, et al. An insight into the in vivo antitumor therapeutic potential of indole-(fused) pyri(mi)dine hybrids. Future Med Chem. 2025;17(10):1155-73.
- [4]. Li D, et al. Comprehensive review of α-carboline alkaloids: Natural products, updated synthesis, and biological activities. Frontiers in chemistry. 2022;10:988327. [Content Brief]
