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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
7 Results for "
chemical derivatization
" in MedChemExpress (MCE) Product Catalog:
Products (7)
7 Results for "chemical derivatization" in MCE Product Catalog:
1
1 Cited Publications
Cat. No.: HY-D1730
CAS No.: 1374019-99-4
Target:
Research Areas:
AF488 NHS ester is an amine specific fluorescence probe (Em=525 nm). AF488 NHS ester reacts with sulfhydryl groups and amines in aqueous and biological samples then change their chemical structure and fluorescence properties after derivatization .
1
1 Cited Publications
Cat. No.: HY-D1730A
Cat. No.: HY-W020027
CAS No.: 79-39-0
Synonyms: 2-Methylacrylamide
Target:
Research Areas:
Methacrylamide (2-Methylacrylamide) is a vinyl monomer and gelatin derivatization reagent that enables chemical crosslinking of Gelatins (HY-Y1365) via free radical polymerization, facilitating the formation of chemically stable hydrogels and the synthesis of pyridine-containing polymers. Methacrylamide is used in research related to biomaterials and polymer synthesis .
Cat. No.: HY-N9607
CAS No.: 168074-97-3
Target:
Cat. No.: HY-W020027R
CAS No.: 79-39-0
Synonyms: 2-Methylacrylamide (Standard)
Research Areas:
Methacrylamide (2-Methylacrylamide) (Standard) is the analytical standard of Methacrylamide (2-Methylacrylamide) (HY-W020027). This product is intended for research and analytical applications. Methacrylamide is a vinyl monomer and gelatin derivatization reagent that enables chemical crosslinking of Gelatins (HY-Y1365) via free radical polymerization, facilitating the formation of chemically stable hydrogels and the synthesis of pyridine-containing polymers. Methacrylamide is used in research related to biomaterials and polymer synthesis .
Cat. No.: HY-N18264
CAS No.: 184424-55-3
Target:
Cat. No.: HY-L945
74 compounds
Sulfonyl fluoride (-SO₂F) overcomes the poor target selectivity of traditional covalent warheads that rely heavily on cysteine. With high stability and tunable electrophilicity under physiological conditions, it targets multiple nucleophilic residues including Lys, Tyr, Ser and His, offering expanded druggable space, lower off-target risks and prolonged efficacy. It is widely used in covalent inhibitors, molecular glues, PROTACs and chemical probes.
MCE has built a highly diverse sulfonyl fluoride fragment library with 1,162 structurally diverse, drug-like fragments. Designed for balanced reactivity, stability and compatibility, these molecules feature tunable electrophilicity, simple scaffolds and high derivatization potential. Combined with SuFEx click chemistry, the library enables efficient modular modification and rapid structure optimization.
Ideal for targeting non-cysteine residues, this library improves covalent screening and probe development efficiency, serving as a precise tool for early-stage covalent drug discovery and chemical biology research.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
