Search Result

Results for "

complex III

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (1) AMPK (1) Amyloid-β (1) Antibiotic (3) Apoptosis (4) Arenavirus (1) ATP Synthase (1) Autophagy (4) Bacterial (4) Biochemical Assay Reagents (19) Calcium Channel (1) Caspase (1) CDK (2) CRFR (2) Cytochrome P450 (1) Drug Intermediate (2) Drug Isomer (1) Endogenous Metabolite (3) Environmental Pollutants (2) Factor Xa (3) Fluorescent Dye (2) Fungal (10) GABA Receptor (2) Insecticide (2) Integrin (1) Mitochondrial Metabolism (17) Mixed Lineage Kinase (2) MOFs (3) Na+/K+ ATPase (2) Oxidative Phosphorylation (1) Parasite (4) PD-1/PD-L1 (1) Phosphatase (1) PI3K (2) Potassium Channel (1) Radionuclide-Drug Conjugates (RDCs) (1) Reactive Oxygen Species (ROS) (5) Reference Standards (4) RIP kinase (2) SARS-CoV (1) Sirtuin (1) SOD (1) Thrombin (3) Topoisomerase (1) Transmembrane Glycoprotein (1) TrxR (1)
By Research Areas:	Cancer (16) Cardiovascular Disease (12) Endocrinology (4) Infection (26) Inflammation/Immunology (3) Metabolic Disease (6) Neurological Disease (4)

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Bacterial (4)

Biochemical Assay Reagents (19)

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Caspase (1)

CDK (2)

CRFR (2)

Cytochrome P450 (1)

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Drug Isomer (1)

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MOFs (3)

Na+/K+ ATPase (2)

Oxidative Phosphorylation (1)

Parasite (4)

PD-1/PD-L1 (1)

Phosphatase (1)

PI3K (2)

Potassium Channel (1)

Radionuclide-Drug Conjugates (RDCs) (1)

Reactive Oxygen Species (ROS) (5)

Reference Standards (4)

RIP kinase (2)

SARS-CoV (1)

Sirtuin (1)

SOD (1)

Thrombin (3)

Topoisomerase (1)

Transmembrane Glycoprotein (1)

TrxR (1)

By Research Areas:

Cancer (16)

Cardiovascular Disease (12)

Endocrinology (4)

Infection (26)

Inflammation/Immunology (3)

Metabolic Disease (6)

Neurological Disease (4)

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N6716

Filipin complex 45+ Cited Publications	Fungal Antibiotic	Infection
Filipin complex is a potent polyene macrolide antifungal antibiotic. Filipin complex inserts into membranes and sequester cholesterol into complexes and inhibits PRRSV entry. The Filipin complex consists of about 75.8% Filipin III (HY-N6718), 10.8% Filipin IV, 9.1% Filipin II, and 1.2% Filipin I (Ex/Em = 380/430 nm) .

HY-110282

S3QEL-2	Oxidative Phosphorylation Mitochondrial Metabolism	Metabolic Disease
S3QEL-2, a suppressor of superoxide production from mitochondrial complex III, potently and selectively suppresses site IIIQo superoxide production (IC₅₀=1.7 μM). S3QEL-2 does not affect oxidative phosphorylation, and normal electron flux. S3QEL-2 inhibits HIF-1α accumulation .

HY-101180

C2 Ceramide 2 Publications Verification Ceramide 2	Phosphatase Mitochondrial Metabolism Apoptosis Autophagy	Metabolic Disease Endocrinology
C2 Ceramide (Ceramide 2) is the main lipid of the stratum corneum and a protein phosphatase 1 (PP1) activator. C2 Ceramide activates PP2A and ceramide-activated protein phosphatase (CAPP). C2 Ceramide induces cells differentiation, autophagy and apoptosis, inhibits mitochondrial respiratory chain complex III. C2 Ceramide is also a skin conditioning agent that protects the epidermal barrier from water loss .

HY-12795

Vps34-IN-1 10+ Cited Publications	PI3K Autophagy	Cancer
Vps34-IN-1 is a potent and selective inhibitor of class III Vps34 PI3K. Vps34-IN-1 inhibits phosphorylation of PtdIns by recombinant insect cell expressed Vps34-Vps15 complex with an IC₅₀ of ~25 nM. Vps34-IN-1 can suppress SGK3 activation by reducing PtdIns(3)P levels via lowering phosphorylation of T-loop and hydrophobic motifs. Vps34-IN-1 modulates autophagy .

HY-112177

Myxothiazol	Fungal Mitochondrial Metabolism Antibiotic	Infection
Myxothiazol, an antifungal antibiotic, is a mitochondrial electron transport chain **complex III (bc1 complex)** inhibitor. Myxothiazol inhibits the growth of many yeasts and fungi at concentrations between 0.01 and 3 μg/ml .

HY-Y1101B

4-Methylmorpholine N-oxide N-Methylmorpholine N-Oxide; MMNO; 4-Methylmorpholine 4-oxide	Biochemical Assay Reagents	Others
4-Methylmorpholine N-oxide (N-Methylmorpholine N-Oxide; MMNO; 4-Methylmorpholine 4-oxide) is an amine oxide ligand and ozonation reagent. 4-Methylmorpholine N-oxide forms coordination complexes with lanthanum (III) nitrate and yttrium (III) nitrate via its nitroso oxygen atom. The metal-ligand bonds are dominated by electrostatic interactions with a small covalent component. 4-Methylmorpholine N-oxide is applicable in ozonation reactions for the synthesis of methyl 9-oxononanoate .

HY-132989

Mal-Deferoxamine	Biochemical Assay Reagents Bacterial	Cardiovascular Disease Infection Inflammation/Immunology
Mal-Deferoxamine is a maleimide-functionalized trihydroxamate siderophore derivative that can be isolated from Streptomyces pilosus. Mal-Deferoxamine possesses highly specific Fe (III) chelating ability, and the stability of complexes formed between it and non-Fe (III) metal ions is significantly lower. Mal-Deferoxamine exhibits growth inhibitory effects against Gram-positive bacteria, but shows no obvious inhibitory activity against Gram-negative bacteria (MIC>50 μM). Mal-Deferoxamine is mainly suitable for scientific research in hematology and related fields .

HY-N2787

8-Prenylnaringenin 1 Publications Verification	PI3K Akt AMPK Sirtuin Reactive Oxygen Species (ROS) SOD	Cardiovascular Disease Neurological Disease Metabolic Disease Endocrinology Cancer
8-Prenylnaringenin is an orally active prenyl flavonoid. 8-Prenylnaringenin can be isolated from the hop spike Humulus lupulus. 8-Prenylnaringenin activates the PI3K/Akt pathway and the AMPK pathway, upregulates OXPHOS complexes (II, III, and V) and Sirt1, and reduces ROS production and SOD activity. 8-Prenylnaringenin improves muscle atrophy and obesity and inhibits angiogenesis. 8-Prenylnaringenin exhibits anticancer activity against glioblastoma and colon cancer. 8-Prenylnaringenin also has LH/FSH regulatory activity. 8-prenylnaringenin may be used in bone health research .

HY-130055

HQNO 2 Publications Verification	Mitochondrial Metabolism	Infection
HQNO, secreted by P. aeruginosa, is a potent electron transport chain inhibitor with a K_d of 64 nM for complex III . HQNO is a potent inhibitor of mitochondrial NDH-2 in many species .

HY-164569

NH2 DOTA-GA	Radionuclide-Drug Conjugates (RDCs)	Cancer
NH2 DOTA-GA is a DOTA-based metal chelator that can be used to prepare radionuclide drug conjugates (RDCs) whose carboxylic acid groups can complex metal ions, for example, NH2 DOTA-GA complexes Gd(III) ions.

HY-W007596

Tris(2-phenylpyridinato-C2,N)iridium(III) Ir(ppy)3; Tris[2-(pyridin-2-yl)phenyl]iridium	Biochemical Assay Reagents	Others
Tris(2-phenylpyridinato-C2,N)iridium(III) (Ir(ppy)3) is an iridium(III) containing organometallic complex, which is used as a phosphorescent light-emitting material. Tris(2-phenylpyridinato-C2,N)iridium(III) exhibits high luminous efficiency and good thermal stability, that can be used in organic optoelectronics, especially in improving the luminescence efficiency and stability of organic light-emitting diodes (OLEDs) .

HY-D0202

Arsenazo III	Fluorescent Dye	Others
Arsenazo III is an azo derivative of chromotropic acid, a metal chrome dye, a chelating agent, and a cation complexing agent. Arsenazo III forms stable 1:1 complexes with Ca ²⁺, Mg ²⁺, Sr ²⁺, Ba ²⁺, K ⁺, and Na ⁺, and its binding affinity for Ca ²⁺ depends on pH, alkali metal cation concentration, and buffer parameters. Arsenazo III serves as a colorimetric indicator for micromolar ionized Ca ²⁺ in cells .

HY-W250149

Chlorophosphonazo III	Biochemical Assay Reagents	Cancer
Chlorophosphonazo III is a cell membrane-permeable contrast agent and spectrophotometric reagent. Chlorophosphonazo III forms stable 1:1 complexes with intracellular calcium, magnesium, uranium, titanium, zirconium, thorium, scandium, equivalent actinides and protactinium. Chlorophosphonazo III generates photoacoustic signals correlated with Ca ²⁺ concentrations, which is applicable for imaging 3D tumor cell cultures and tumor spheroids. Chlorophosphonazo III exhibits no cytotoxicity, can be used for spectrophotometric detection of target ions, and the absorbance of its complexes remains stable for up to one week within the pH range of 2.2 to 7.0 .

HY-W012161

Alanylphenylalanine L-Alanyl-L-phenylalanine; H-Ala-Phe-OH	Endogenous Metabolite Drug Intermediate	Others
Alanylphenylalanine (L-Alanyl-L-phenylalanine) is a dipeptide. Alanylphenylalanine forms a mononuclear Au (III) complex through bidentate coordination via its carboxyl oxygen atom and deprotonated amide nitrogen atom .

HY-119687

Bifenazate	Environmental Pollutants GABA Receptor Reactive Oxygen Species (ROS) Mitochondrial Metabolism Insecticide Na+/K+ ATPase	Infection Cardiovascular Disease
Bifenazate is a carbazate acaricide that control 100% of mites at a concentration of 25 ppm . Bifenazate is a positive allosteric modulator of GABA receptor . Bifenazate is the inhibitor for the mitochondrial electron transport chain complex III .

HY-N10661

Ipomoeassin F Ipom-F	SARS-CoV	Infection Cancer
Ipomoeassin F is a potent and selective endoplasmic reticulum (ER) protein-translocation inhibitor by targeting the pore-forming subunit of the Sec61 complex (Sec61α) at the ER membrane. Ipomoeassin F selectively inhibits the ER membrane translocation of SARS-CoV-2 proteins. Ipomoeassin F block the ER translocation of secretory proteins and type I transmembrane proteins (TMPs), but not type III TMPs .

HY-125776

Kresoxim-methyl BAS 490 F	Environmental Pollutants Mitochondrial Metabolism Fungal	Infection
Kresoxim-methyl (BAS 490 F), a Strobilurin-based fungicide, inhibits the respiration at the **complex III (cytochrome bc1 complex)*. Kresoxim-methyl binds to complex* III from yeast with an apparent K_d of 0.07 μM proving a high affinity for this enzyme .

HY-P1858A

Urocortin III, mouse TFA	CRFR	Cardiovascular Disease Neurological Disease Endocrinology
Urocortin III, mouse TFA is a corticotropin-releasing factor (CRF)-related peptide. Urocortin III preferentially binds and activates CRF-R2 . Urocortin III (Ucn3) is a known component of the behavioral stress response system. Urocortin III and CRF-R2 in the medial amygdala regulate complex social dynamics .

HY-P1858

Urocortin III, mouse	CRFR	Cardiovascular Disease Neurological Disease Endocrinology
Urocortin III, mouse is a corticotropin-releasing factor (CRF)-related peptide. Urocortin III preferentially binds and activates CRF-R2 . Urocortin III (Ucn3) is a known component of the behavioral stress response system. Urocortin III and CRF-R2 in the medial amygdala regulate complex social dynamics .

HY-115853

Pyclen	Biochemical Assay Reagents	Others
Pyclen forms kinetically and thermodynamically stable nine-coordinate Ln (III) complexes, as well as Mn (II)-based MRI contrast agents. Pyclen-Based Mn(II) Complexes can be used for liver-specific MRI .

HY-D0179

Cyclam	Biochemical Assay Reagents	Infection Cardiovascular Disease
Cyclam is a metal chelator that forms metal complexes with a variety of metal ions. Cyclam metal complexes exhibits anti-HIV (such as AMD3100), nitric oxide (NO) releasing and scavenging (such as Zn(II)-Cyclam and Ru(II)-Cyclam), and SOD mimetic (such as Mn(III)-Cyclam and Zn(II)-Cyclam) activities .

HY-DY1017

*Filipin complex* (solution)**	Antibiotic Fungal	Infection
Filipin complex (solution) is a potent polyene macrolide antifungal antibiotic. Filipin complex inserts into membranes and sequester cholesterol into complexes and inhibits PRRSV entry. The Filipin complex consists of about 75.8% Filipin III (HY-N6718) , 10.8% Filipin IV, 9.1% Filipin II, and 1.2% Filipin I (Ex/Em = 380/430 nm) . Solvent and concentration: DMSO: 5 mg/mL

HY-W127790

Bathophenanthrolinedisulfonic acid disodium	Biochemical Assay Reagents	Others
Bathophenanthrolinedisulfonic acid disodium salt (BPS) is a colorimetric reagent for iron detection, with a wavelength of 535 nm for iron complex. It can be used for iron determination in aqueous solution systems without the need for extraction solvents. BPS can serve as a precursor to prepare Europium(III) tris(dibenzoylmethanate) bis(bathophenanthrolinedisulfonate) complex and ruthenium(II) tris(bathophenanthrolinedisulfonate), or participate in the catalytic oxidation of 2-hexanol by forming water-soluble complexes with palladium .

HY-P6351

c(avb6)-DOTA TFA	Integrin	Cancer
c(avb6)-DOTA TFA is a conjugate of the αvβ6 integrin selective peptide ring modified with DOTA chelator. The Lu(III) complex of c(avb6)-DOTA TFA has a comparable affinity for αvβ6 integrin (IC₅₀=0.8 nM) and can be used as a tumor diagnostic .

HY-146145

Metyltetraprole	Fungal Mitochondrial Metabolism	Infection
Metyltetraprole is a promising fungicide with EC₅₀ values of both 0.002 ppm against sensitive wild-type and G143A mutant of Zymoseptoria tritici. Metyltetraprole is effective against QoI (quinone outside inhibitor) resistant strains. Metyltetraprole inhibits the respiratory chain via **complex III** .

HY-107966A

Heparin calcium (MW 3600-5000) Nadroparin calcium (MW 3600-5000)	Thrombin Factor Xa Autophagy Bacterial	Cardiovascular Disease Cancer
Heparin (Nadroparin) calcium (MW 3600-5000) is an anticoagulant which binds reversibly to antithrombin III (ATIII) to form a heparin-antithrombin III complex. The complex binds to and irreversibly inactivates thrombin and other activated clotting factors IX, X, XI, and XII and prevents the transformation of fibrinogen to fibrin .

HY-125857B

Cytochrome C (Saccharomyces cerevisiae)	Biochemical Assay Reagents Apoptosis Caspase	Metabolic Disease
Cytochrome C (Saccharomyces cerevisiae) is a type C cytochrome located in the intermembrane space of the mitochondria. As an electron carrier, Cytochrome C (Saccharomyces cerevisiae) transfers electrons between complex III (cytochrome c reductase) and complex IV (cytochrome c oxidase, CIV) of the respiratory chain. Cytochrome C (Saccharomyces cerevisiae) can play a crucial role in triggering apoptosis by being released from the mitochondria into the cytosol .

HY-117897

CK-2-68 1 Publications Verification	Parasite	Infection
CK-2-68 is an inhibitor for complex III in protozoan mitochondrial respiratory chain, by targeting the alternative NADH dehydrogenase (NDH2) of the malarial parasite Plasmodium. CK-2-68 exhibits antimalaria efficacy, that inhibits Plasmodium falciparum infected erythrocytes with an IC₅₀ of 40 nM .

HY-162066

DNDI-6174	Parasite	Infection
DNDI-6174 is an orally active Leishmania cytochrome b (Qi site of cytochrome bc1 complex/complex III) inhibitor. DNDI-6174 binds to the Qi site of Leishmania cytochrome b, inhibits cytochrome bc1 complex activity in the parasite's electron transport chain across promastigote and axenic amastigote stages. DNDI-6174 reduces parasite burden in rodent models, inhibits growth of various Leishmania species, drug-resistant clinical isolates, and Trypanosoma cruzi, with marginal activity against Trypanosoma brucei. DNDI-6174 can be used for the research of visceral leishmaniasis, cutaneous leishmaniasis .

HY-112847B

(E/Z)-Sulfosuccinimidyl oleate sodium (E/Z)-Sulfo-N-succinimidyl oleate sodium	Transmembrane Glycoprotein Mitochondrial Metabolism Drug Isomer	Inflammation/Immunology
(E/Z)-Sulfosuccinimidyl oleate sodium is the racemate of (E)-Sulfosuccinimidyl oleate sodium and (Z)-Sulfosuccinimidyl oleate sodium. Sulfosuccinimidyl oleate sodium (Sulfo-N-succinimidyl oleate sodium) is a long-chain fatty acid that inhibits fatty acid transport into cells. Sulfosuccinimidyl oleate sodium is a potent and irreversible inhibitor of the mitochondrial respiratory chain. Sulfosuccinimidyl oleate sodium binds to the CD36 receptor on the surface of microglial cells. Sulfosuccinimidyl oleate sodium exhibits anti-inflammatory effects .

HY-16336

Motexafin gadolinium PCI 0120; Gadolinium texaphyrin; Gd-Tex	Reactive Oxygen Species (ROS)	Cancer
Motexafin gadolinium (PCI 0120) is a potent antitumor agent. Motexafin gadolinium is a specific texaphyrin in complex with gadolinium(III). Motexafin gadolinium increases intracellular ROS production. Motexafin gadolinium enhances sensitivity of tumor cells to ionizing radiation .

HY-148365

NecroIr1	Mixed Lineage Kinase RIP kinase CDK	Cancer
NecroIr1 is an iridium(III) complex, serves as necroptosis inducers in Cisplatin (HY-17394)-resistant lung cancer cells (A549R). NecroIr1 selectively accumulates in mitochondria, leading to oxidative stress and loss of mitochondrial membrane potential (MMP). NecroIr1 activates receptor-interacting serine-threonine kinase 3 (RIPK3) and Mixed Lineage Kinase (MLKL), and regulates CDK4 expression .

HY-148366

NecroIr2	Mixed Lineage Kinase RIP kinase CDK	Cancer
NecroIr2 is an iridium(III) complex, serves as necroptosis inducers in Cisplatin (HY-17394)-resistant lung cancer cells (A549R). NecroIr2 selectively accumulates in mitochondria, leading to oxidative stress and loss of mitochondrial membrane potential (MMP). NecroIr2 activates receptor-interacting serine-threonine kinase 3 (RIPK3) and mixed lineage kinase domain-like pseudokinase (MLKL), and regulates CDK4 expression .

HY-Y1312

2-Phenylimidazole PhI; 2PZ	Biochemical Assay Reagents	Others
2-Phenylimidazole (PhI) is a corrosion inhibitor for brass and can be used to prepare complexes with ruthenium (III) .

HY-W012232

2,6-Diphenylpyridine	Biochemical Assay Reagents Drug Intermediate	Others
2,6-Diphenylpyridine is a proton acceptor (log(P) = 5) and a tridentate [C^N^C] dianionic ligand. 2,6-Diphenylpyridine efficiently transfers protons through a direct pathway at the interface of two immiscible electrolyte solutions. 2,6-Diphenylpyridine as a tridentate ligand and can form mononuclear and binuclear complexes with gold(III). 2,6-Diphenylpyridin is applicable to research in electrochemical ion transfer kinetics and organometallic chemistry .

HY-115945

Complex III-IN-1	Mitochondrial Metabolism Fungal	Infection
Complex III-IN-1 (Compd 4c-2) is a **complex III** inhibitor. Complex III-IN-1 shows antifungal activity with an EC₅₀ of 18.53 mg/L against sclerotinia sclerotiorum .

HY-115946

Complex III-IN-2	Mitochondrial Metabolism Fungal	Infection
Complex III-IN-2 (Compd 4d-2) is a **complex III** inhibitor. Complex III-IN-2 shows antifungal activity with an EC₅₀ of 29.98 mg/L and 29.31 mg/L against sclerotinia sclerotiorum and R. solani, respectively .

HY-107966

Heparin calcium (MW 15000-19000) Nadroparin calcium (MW 15000-19000)	Thrombin Factor Xa Autophagy Bacterial	Cardiovascular Disease Cancer
Heparin calcium (MW 15000-19000) is an anticoagulant which binds reversibly to antithrombin III (ATIII) to form a heparin-antithrombin III complex. The complex binds to and irreversibly inactivates thrombin and other activated clotting factors IX, X, XI, and XII and prevents the transformation of fibrinogen to fibrin .

HY-W009022

Diantipyrylmethane	Biochemical Assay Reagents	Others
Diantipyrylmethane is a chromogenic reagent commonly used for the determination of the contents of metals such as Au (III), Ti (IV), Ir, Fe (III), molybdenum, neodymium, U (IV), iridium, platinum and rhenium via spectrophotometry and extraction photometry. Diantipyrylmethane can also form a fluorescent complex with Er (III) ions, which is applied to the determination of erbium .

HY-174393

Gamhepathiopine	Parasite Mitochondrial Metabolism	Infection
Gamhepathiopine is a thienopyrimidinone compound. Gamhepathiopine exerts antimalarial effects by targeting the Q_o site of Plasmodium falciparum cytochrome b and inhibiting the activity of **complex III** in the electron transport chain .

HY-123562

GNF7686	Cytochrome P450	Others
GNF7686 is a cytochrome b inhibitor. GNF7686 exhibits inhibitory activity against complex III in the extracts of L. donovani and T. cruzi .

HY-130055R

HQNO (Standard)	Reference Standards Mitochondrial Metabolism	Infection
HQNO (Standard) is the analytical standard of HQNO. This product is intended for research and analytical applications. HQNO, secreted by P. aeruginosa, is a potent electron transport chain inhibitor with a Kd of 64 nM for complex III[1]. HQNO is a potent inhibitor of mitochondrial NDH-2 in many species[2].

HY-125776R

Kresoxim-methyl (Standard) BAS 490 F (Standard)	Reference Standards Fungal Mitochondrial Metabolism	Infection
Kresoxim-methyl (Standard) is the analytical standard of Kresoxim-methyl. This product is intended for research and analytical applications. Kresoxim-methyl (BAS 490 F), a Strobilurin-based fungicide, inhibits the respiration at the complex III (cytochrome bc1 complex). Kresoxim-methyl binds to complex III from yeast with an apparent Kd of 0.07 μM proving a high affinity for this enzyme .

HY-W112277

5,10,15,20-Tetrakis(4-methoxyphenyl)-21H,23H-porphine iron(III) chloride	Endogenous Metabolite Biochemical Assay Reagents	Others
5,10,15,20-Tetrakis(4-methoxyphenyl)-21H,23H-porphine iron(III) chloride is a type of metalloporphyrin complex that features iron(III) at its core.

HY-115853A

Pyclen dihydrochloride	Biochemical Assay Reagents	Others
Pyclen dihydrochloride forms kinetically and thermodynamically stable nine-coordinate Ln (III) complexes, as well as Mn (II)-based MRI contrast agents. Pyclen-Based Mn(II) Complexes can be used for liver-specific MRI .

HY-148340

24RBPyBC	Biochemical Assay Reagents	Others
24RBPyBC is a dinucleating macrocyclic ligand, it contains phenolate pyridine, bipyridine, and amino groups form dinuclear Fe(II) and Fe(III) complexes .

HY-W725476

Bifenazate-d5	Reactive Oxygen Species (ROS)	Infection
Bifenazate-d₅ is the deuterium labeled Bifenazate (HY-119687). Bifenazate is a carbazate acaricide that control 100% of mites at a concentration of 25 ppm . Bifenazate is a positive allosteric modulator of GABA receptor . Bifenazate is the inhibitor for the mitochondrial electron transport chain complex III .

HY-119687R

Bifenazate (Standard)	Reference Standards GABA Receptor Mitochondrial Metabolism Na+/K+ ATPase Reactive Oxygen Species (ROS) Insecticide	Infection Cardiovascular Disease
Bifenazate (Standard) is the analytical standard of Bifenazate. This product is intended for research and analytical applications. Bifenazate is a carbazate acaricide that control 100% of mites at a concentration of 25 ppm . Bifenazate is a positive allosteric modulator of GABA receptor . Bifenazate is the inhibitor for the mitochondrial electron transport chain complex III .

HY-162463

Ir-UA	PD-1/PD-L1	Cancer
Ir-UA is an usnic acid-derived iridium(III) complex that enhances PD-L1 expression and converts "cold tumors" into "hot tumors." Ir-UA stimulates PD-L1 expression by explicitly regulating the PD-L1 transcription factor .

HY-172115

BGC4	TrxR Apoptosis	Cancer
BGC4 is a biphenyl-based gold(III) complex. BGC4 inhibits human recombinant thioredoxin reductase (TrxR) with an IC₅₀ of 10.7 μM, exhibits cytotoxicity (IC₅₀ for MDA-MB-231 is 5.4 μM), and induces apoptosis. BGC4 exhibits antitumor efficacy in mouse models .

Cat. No.	Product Name	Type

HY-N6716

Filipin complex 45+ Cited Publications	Fluorescent Dye
Filipin complex is a potent polyene macrolide antifungal antibiotic. Filipin complex inserts into membranes and sequester cholesterol into complexes and inhibits PRRSV entry. The Filipin complex consists of about 75.8% Filipin III (HY-N6718), 10.8% Filipin IV, 9.1% Filipin II, and 1.2% Filipin I (Ex/Em = 380/430 nm) .

HY-D0202

Arsenazo III

Fluorescent Dye

Arsenazo III is an azo derivative of chromotropic acid, a metal chrome dye, a chelating agent, and a cation complexing agent. Arsenazo III forms stable 1:1 complexes with Ca ²⁺, Mg ²⁺, Sr ²⁺, Ba ²⁺, K ⁺, and Na ⁺, and its binding affinity for Ca ²⁺ depends on pH, alkali metal cation concentration, and buffer parameters. Arsenazo III serves as a colorimetric indicator for micromolar ionized Ca ²⁺ in cells .

HY-DY1017

*Filipin complex* (solution)**	Fluorescent Dye
Filipin complex (solution) is a potent polyene macrolide antifungal antibiotic. Filipin complex inserts into membranes and sequester cholesterol into complexes and inhibits PRRSV entry. The Filipin complex consists of about 75.8% Filipin III (HY-N6718) , 10.8% Filipin IV, 9.1% Filipin II, and 1.2% Filipin I (Ex/Em = 380/430 nm) . Solvent and concentration: DMSO: 5 mg/mL

HY-W075731

(Ir[dF(F)ppy]2(dCF3))PF6	Fluorescent Dye
(Ir[dF (F) ppy]₂ (dCF₃)) PF₆ is a cyclometalated iridium (III) complex that is used in visible light-mediated photocatalytic organic transformations .

HY-W034053

Ir[p-F(Me)ppy]2(dtbbpy)PF6	Fluorescent Dye
Ir[p-F (Me) ppy]₂ (dtbbpy) PF₆ is a cyclometalated iridium (III) complex. Ir[p-F (Me) ppy]₂ (dtbbpy) PF₆ absorbs visible light (460 nm) to form a long-lived charge-separated excited state. Ir[p-F (Me) ppy]₂ (dtbbpy) PF₆ is applicable to visible light-mediated photocatalytic organic transformation reactions .

Cat. No.	Product Name	Type

HY-W250149

Chlorophosphonazo III

Biochemical Assay Reagents

Chlorophosphonazo III is a cell membrane-permeable contrast agent and spectrophotometric reagent. Chlorophosphonazo III forms stable 1:1 complexes with intracellular calcium, magnesium, uranium, titanium, zirconium, thorium, scandium, equivalent actinides and protactinium. Chlorophosphonazo III generates photoacoustic signals correlated with Ca ²⁺ concentrations, which is applicable for imaging 3D tumor cell cultures and tumor spheroids. Chlorophosphonazo III exhibits no cytotoxicity, can be used for spectrophotometric detection of target ions, and the absorbance of its complexes remains stable for up to one week within the pH range of 2.2 to 7.0 .

HY-W127790

Bathophenanthrolinedisulfonic acid disodium

Biochemical Assay Reagents

Bathophenanthrolinedisulfonic acid disodium salt (BPS) is a colorimetric reagent for iron detection, with a wavelength of 535 nm for iron complex. It can be used for iron determination in aqueous solution systems without the need for extraction solvents. BPS can serve as a precursor to prepare Europium(III) tris(dibenzoylmethanate) bis(bathophenanthrolinedisulfonate) complex and ruthenium(II) tris(bathophenanthrolinedisulfonate), or participate in the catalytic oxidation of 2-hexanol by forming water-soluble complexes with palladium .

HY-107966A

Heparin calcium (MW 3600-5000) Nadroparin calcium (MW 3600-5000)	Biochemical Assay Reagents
Heparin (Nadroparin) calcium (MW 3600-5000) is an anticoagulant which binds reversibly to antithrombin III (ATIII) to form a heparin-antithrombin III complex. The complex binds to and irreversibly inactivates thrombin and other activated clotting factors IX, X, XI, and XII and prevents the transformation of fibrinogen to fibrin .

HY-125857B

Cytochrome C (Saccharomyces cerevisiae)

Biochemical Assay Reagents

Cytochrome C (Saccharomyces cerevisiae) is a type C cytochrome located in the intermembrane space of the mitochondria. As an electron carrier, Cytochrome C (Saccharomyces cerevisiae) transfers electrons between complex III (cytochrome c reductase) and complex IV (cytochrome c oxidase, CIV) of the respiratory chain. Cytochrome C (Saccharomyces cerevisiae) can play a crucial role in triggering apoptosis by being released from the mitochondria into the cytosol .

HY-107966

Heparin calcium (MW 15000-19000) Nadroparin calcium (MW 15000-19000)	Biochemical Assay Reagents
Heparin calcium (MW 15000-19000) is an anticoagulant which binds reversibly to antithrombin III (ATIII) to form a heparin-antithrombin III complex. The complex binds to and irreversibly inactivates thrombin and other activated clotting factors IX, X, XI, and XII and prevents the transformation of fibrinogen to fibrin .

HY-W009022

Diantipyrylmethane	Biochemical Assay Reagents
Diantipyrylmethane is a chromogenic reagent commonly used for the determination of the contents of metals such as Au (III), Ti (IV), Ir, Fe (III), molybdenum, neodymium, U (IV), iridium, platinum and rhenium via spectrophotometry and extraction photometry. Diantipyrylmethane can also form a fluorescent complex with Er (III) ions, which is applied to the determination of erbium .

Cat. No.	Product Name	Target	Research Area

HY-P1858A

Urocortin III, mouse TFA	CRFR	Cardiovascular Disease Neurological Disease Endocrinology
Urocortin III, mouse TFA is a corticotropin-releasing factor (CRF)-related peptide. Urocortin III preferentially binds and activates CRF-R2 . Urocortin III (Ucn3) is a known component of the behavioral stress response system. Urocortin III and CRF-R2 in the medial amygdala regulate complex social dynamics .

HY-P1858

Urocortin III, mouse	CRFR	Cardiovascular Disease Neurological Disease Endocrinology
Urocortin III, mouse is a corticotropin-releasing factor (CRF)-related peptide. Urocortin III preferentially binds and activates CRF-R2 . Urocortin III (Ucn3) is a known component of the behavioral stress response system. Urocortin III and CRF-R2 in the medial amygdala regulate complex social dynamics .

HY-P6351

c(avb6)-DOTA TFA	Integrin	Cancer
c(avb6)-DOTA TFA is a conjugate of the αvβ6 integrin selective peptide ring modified with DOTA chelator. The Lu(III) complex of c(avb6)-DOTA TFA has a comparable affinity for αvβ6 integrin (IC₅₀=0.8 nM) and can be used as a tumor diagnostic .

HY-P11790

EPEA tag peptide C-Tag peptide	Biochemical Assay Reagents	Infection
EPEA tag peptide (C-Tag peptide) is an epitope tag peptide. EPEA tag peptide enables elution of the SpaP ^EPEA complex. EPEA tag peptide is applicable to research related to bacterial type III secretion systems .

Cat. No.	Product Name	Target	Research Area	Image

HY-P992155

Arevirumab Arevirumab-3	Arenavirus	Infection
Arevirumab (Arevirumab-3) is a pan-lineage neutralizing human monoclonal antibody cocktail (8.9F, 12.1F, 37.D). Arevirumab protects cynomolgus monkeys from severe Lassa fever caused by lineage II and III LASV isolates. Arevirumab is applicable to research related to Lassa fever .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N6716

Filipin complex 45+ Cited Publications	Structural Classification Microorganisms Antifungal Classification of Application Fields Antibiotics Other Diseases Antiviral Disease Research Disease Research Fields Other Antibiotics Source Classification	Fungal Antibiotic
Filipin complex is a potent polyene macrolide antifungal antibiotic. Filipin complex inserts into membranes and sequester cholesterol into complexes and inhibits PRRSV entry. The Filipin complex consists of about 75.8% Filipin III (HY-N6718), 10.8% Filipin IV, 9.1% Filipin II, and 1.2% Filipin I (Ex/Em = 380/430 nm) .

HY-112177

Myxothiazol	Infection Microorganisms Antifungal Classification of Application Fields Antibiotics Disease Research Disease Research Fields Other Antibiotics Source Classification	Fungal Mitochondrial Metabolism Antibiotic
Myxothiazol, an antifungal antibiotic, is a mitochondrial electron transport chain **complex III (bc1 complex)** inhibitor. Myxothiazol inhibits the growth of many yeasts and fungi at concentrations between 0.01 and 3 μg/ml .

HY-N2787

8-Prenylnaringenin 1 Publications Verification	Structural Classification Flavonoids Classification of Application Fields Humulus lupulus L. Flavonones Phenols Polyphenols Plants Moraceae Disease Research Fields Source Classification Cancer	PI3K Akt AMPK Sirtuin Reactive Oxygen Species (ROS) SOD
8-Prenylnaringenin is an orally active prenyl flavonoid. 8-Prenylnaringenin can be isolated from the hop spike Humulus lupulus. 8-Prenylnaringenin activates the PI3K/Akt pathway and the AMPK pathway, upregulates OXPHOS complexes (II, III, and V) and Sirt1, and reduces ROS production and SOD activity. 8-Prenylnaringenin improves muscle atrophy and obesity and inhibits angiogenesis. 8-Prenylnaringenin exhibits anticancer activity against glioblastoma and colon cancer. 8-Prenylnaringenin also has LH/FSH regulatory activity. 8-prenylnaringenin may be used in bone health research .

HY-130055

HQNO 2 Publications Verification	Infection Natural Products Microorganisms Classification of Application Fields Disease Research Fields Source Classification	Mitochondrial Metabolism
HQNO, secreted by P. aeruginosa, is a potent electron transport chain inhibitor with a K_d of 64 nM for complex III . HQNO is a potent inhibitor of mitochondrial NDH-2 in many species .

HY-W012161

Alanylphenylalanine L-Alanyl-L-phenylalanine; H-Ala-Phe-OH	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite Drug Intermediate
Alanylphenylalanine (L-Alanyl-L-phenylalanine) is a dipeptide. Alanylphenylalanine forms a mononuclear Au (III) complex through bidentate coordination via its carboxyl oxygen atom and deprotonated amide nitrogen atom .

HY-N10661

Ipomoeassin F Ipom-F	Natural Products Ipomoea squamosa Choisy Plants Convolvulaceae	SARS-CoV
Ipomoeassin F is a potent and selective endoplasmic reticulum (ER) protein-translocation inhibitor by targeting the pore-forming subunit of the Sec61 complex (Sec61α) at the ER membrane. Ipomoeassin F selectively inhibits the ER membrane translocation of SARS-CoV-2 proteins. Ipomoeassin F block the ER translocation of secretory proteins and type I transmembrane proteins (TMPs), but not type III TMPs .

HY-130055R

HQNO (Standard)	Natural Products Microorganisms Source Classification	Reference Standards Mitochondrial Metabolism
HQNO (Standard) is the analytical standard of HQNO. This product is intended for research and analytical applications. HQNO, secreted by P. aeruginosa, is a potent electron transport chain inhibitor with a Kd of 64 nM for complex III[1]. HQNO is a potent inhibitor of mitochondrial NDH-2 in many species[2].

HY-165145

Carbazomycin C	Alkaloids Microorganisms Pyrrole Alkaloids Source Classification	Others
Carbazomycin C (compound III) is a minor component of the carbazomycin complex with antibacterial activity, and its structure has been determined by spectroscopic and chemical methods to be 4-hydroxy-3,6-dimethyl-1,2-dimethylcarbazole.

HY-W012161R

Alanylphenylalanine (Standard) L-Alanyl-L-phenylalanine (Standard); H-Ala-Phe-OH (Standard)	Structural Classification Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Endogenous Metabolite Reference Standards
Alanylphenylalanine (Standard) is the analytical standard of Alanylphenylalanine (HY-W012161). This product is intended for research and analytical applications. Alanylphenylalanine is a potential antitumor agent that targets DNA via metal coordination. The complex of Alanylphenylalanine and Au (III) can bind to DNA and inhibit tumor cell proliferation .

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HY-P71088

	UQCRH Protein, Human (GST) Cytochrome b-c1 complex subunit 6; mitochondrial; complex III subunit 6; complex III subunit VIII; Cytochrome c1 non-heme 11 kDa protein; Mitochondrial hinge protein; Ubiquinol-cytochrome c reductase complex 11 kDa protein	Human	E. coli
	UQCRH is an important component of the mitochondrial electron transport chain and contributes to oxidative phosphorylation within the ubiquinol-cytochrome c oxidoreductase complex. It operates in the respiratory chain, transferring electrons from NADH and succinate to molecular oxygen, establishing an electrochemical gradient for ATP synthesis. UQCRH Protein, Human (GST) is the recombinant human-derived UQCRH protein, expressed by E. coli , with N-GST labeled tag.

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HY-W725476

Bifenazate-d5
Bifenazate-d₅ is the deuterium labeled Bifenazate (HY-119687). Bifenazate is a carbazate acaricide that control 100% of mites at a concentration of 25 ppm . Bifenazate is a positive allosteric modulator of GABA receptor . Bifenazate is the inhibitor for the mitochondrial electron transport chain complex III .

Host:	Rabbit (4)
Reactivity:	Human (4) Rat (4) Mouse (2)
Application:	IHC-P (4) ICC/IF (2) IP (4) IHC-F (2) WB (4)
Isotype:	IgG (4)
Conjugation:	Non-conjugated (4)
Clonality:	Monoclonal (2) Recombinant (2)
Modification:	Unmodified (2)

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HY-P82120

	Complex III Subunit 5 Antibody (YA1865) petC; PGR1; RIP1; RIS1; RISP; UQCR5; UQCRFS1	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Mouse, Rat
	Complex III Subunit 5 Antibody (YA1865) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Complex III Subunit 5.

HY-P82613

	Complex III Subunit 7 Antibody (YA2358) QPC; QCR7; QP-C; UQBC; UQBP; UQPC; UQCR6; MC3DN3	WB, IHC-P, IP	Human, Rat
	Complex III Subunit 7 Antibody (YA2358) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Complex III Subunit 7.

HY-P82120A

	Complex III Subunit 5 Antibody (YA1865)(PBS only) petC; PGR1; RIP1; RIS1; RISP; UQCR5; UQCRFS1	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Mouse, Rat
	Complex III Subunit 5 Antibody (YA1865) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Complex III Subunit 5.

HY-P82613A

	Complex III Subunit 7 Antibody (YA2358)(PBS only) QPC; QCR7; QP-C; UQBC; UQBP; UQPC; UQCR6; MC3DN3	WB, IHC-P, IP	Human, Rat
	Complex III Subunit 7 Antibody (YA2358) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Complex III Subunit 7.

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complex III

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