1914-99-4
Chemical Structure
Chlorophosphonazo III
- CAS No.: 1914-99-4
- Formula:C22H16Cl2N4O14P2S2
- Molecular Weight:757.36
IUPAC Name: 3,6-bis((E)-(4-chloro-2-phosphonophenyl)diazenyl)-4,5-dihydroxynaphthalene-2,7-disulfonic acid
InChIKey: LMBABJNSZGKTBA-NBHCHVEOSA-N
SMILES: O=P(O)(C1=CC(Cl)=CC=C1/N=N/C2=C(C3=C(C=C2S(=O)(O)=O)C=C(S(=O)(O)=O)C(/N=N/C4=CC=C(C=C4P(O)(O)=O)Cl)=C3O)O)O
Biological Activity: Chlorophosphonazo III is a cell membrane-permeable contrast agent and spectrophotometric reagent. Chlorophosphonazo III forms stable 1:1 complexes with intracellular calcium, magnesium, uranium, titanium, zirconium, thorium, scandium, equivalent actinides and protactinium. Chlorophosphonazo III generates photoacoustic signals correlated with Ca2+ concentrations, which is applicable for imaging 3D tumor cell cultures and tumor spheroids. Chlorophosphonazo III exhibits no cytotoxicity, can be used for spectrophotometric detection of target ions, and the absorbance of its complexes remains stable for up to one week within the pH range of 2.2 to 7.0[1][2].
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Chlorophosphonazo III | Chlorophosphonazo III is a cell membrane-permeable contrast agent and spectrophotometric reagent. Chlorophosphonazo III forms stable 1:1 complexes with intracellular calcium, magnesium, uranium, titanium, zirconium, thorium, scandium, equivalent actinides and protactinium. Chlorophosphonazo III generates photoacoustic signals correlated with Ca2+ concentrations, which is applicable for imaging 3D tumor cell cultures and tumor spheroids. Chlorophosphonazo III exhibits no cytotoxicity, can be used for spectrophotometric detection of target ions, and the absorbance of its complexes remains stable for up to one week within the pH range of 2.2 to 7.0. | |||||||||||||||||||||
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- [1]. Liu WW, et al. Functional photoacoustic calcium imaging using chlorophosphonazo III in a 3D tumor cell culture. Biomed Opt Express. 2021;12(2):1154-1166. Published 2021 Feb 1. [Content Brief]
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[2]. Ferguson J W, et al. Simultaneous spectrophotometric determination of calcium and magnesium with chlorophosphonazo III. Analytical Chemistry, 1964, 36(4): 796-799.
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