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dGuo

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-W018158
    DHICA

    5,6-Dihydroxyindole-2-carboxylic acid

    		 Endogenous Metabolite GPR35 Arrestin DNA/RNA Synthesis Drug Intermediate SOD Cancer
    DHICA (5,6-Dihydroxyindole-2-carboxylic acid) is an eumelanin building block, GPR35 agonist and melanin synthesis intermediate. DHICA activates GPR35, triggering dynamic mass redistribution and β-arrestin translocation. DHICA interacts with DNA and interferes with Fpg activity . DHICA promotes the generation of single-strand breaks in plasmid DNA. DHICA increases the activity and expression levels of SOD and Catalase. DHICA is applicable to research related to skin cancer and colon cancer .
    DHICA
  • HY-106934A
    Peldesine dihydrochloride
    1 Publications Verification

    BCX 34 dihydrochloride

    		 Nucleoside Antimetabolite/Analog HIV Infection Inflammation/Immunology Cancer
    Peldesine (BCX 34) dihydrochloride is a potent, competitive, reversible and orally active purine nucleoside phosphorylase (PNP) inhibitor with IC50s of 36 nM, 5 nM, and 32 nM for human, rat, and mouse red blood cell (RBC) PNP, respectively. Peldesine dihydrochloride is also a T-cell proliferation inhibitor with an IC50 of 800 nM. Peldesine dihydrochloride has the potential for cutaneous T-cell lymphoma, psoriasis and HIV infection research .
    Peldesine dihydrochloride
  • HY-106934
    Peldesine

    BCX 34

    		 Nucleoside Antimetabolite/Analog HIV Infection Inflammation/Immunology Cancer
    Peldesine (BCX 34) is a potent, competitive, reversible and orally active purine nucleoside phosphorylase (PNP) inhibitor with IC50s of 36 nM, 5 nM, and 32 nM for human, rat, and mouse red blood cell (RBC) PNP, respectively. Peldesine is also a T-cell proliferation inhibitor with an IC50 of 800 nM. Peldesine has the potential for cutaneous T-cell lymphoma, psoriasis and HIV infection research .
    Peldesine
  • HY-106934AR
    Peldesine dihydrochloride (Standard)

    BCX 34 dihydrochloride (Standard)

    		 Nucleoside Antimetabolite/Analog HIV Reference Standards Infection Inflammation/Immunology Cancer
    Peldesine (dihydrochloride) (Standard) is the analytical standard of Peldesine (dihydrochloride). This product is intended for research and analytical applications. Peldesine (BCX 34) dihydrochloride is a potent, competitive, reversible and orally active purine nucleoside phosphorylase (PNP) inhibitor with IC50s of 36 nM, 5 nM, and 32 nM for human, rat, and mouse red blood cell (RBC) PNP, respectively. Peldesine dihydrochloride is also a T-cell proliferation inhibitor with an IC50 of 800 nM. Peldesine dihydrochloride has the potential for cutaneous T-cell lymphoma, psoriasis and HIV infection research .
    Peldesine dihydrochloride (Standard)

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