Search Result

Results for "

delivery of mRNA

" in MedChemExpress (MCE) Product Catalog:

By Targets:	mRNA (5) Amino Acid Derivatives (3) Biochemical Assay Reagents (24) DNA Alkylator/Crosslinker (1) DNA/RNA Synthesis (5) Drug Intermediate (1) Endogenous Metabolite (1) FGFR (1) Fluorescent Dye (32) Isotope-Labeled Compounds (4) Liposome (96) LYTACs (1) SARS-CoV (3) Toll-like Receptor (TLR) (1) Transferrin Receptor (1) Transthyretin (TTR) (1) VEGFR (1)
By Research Areas:	Cancer (37) Cardiovascular Disease (3) Infection (9) Inflammation/Immunology (17) Metabolic Disease (5) Neurological Disease (2)
Oligonucleotides:	Fluorescent Lipids (6) Antigens (1) Pegylated Lipids (13) Liposome (3) mRNA (4) Phospholipids (4) Cationic Lipids (69) Reporter Genes (1) Cap Analogs (5) Cholesterol (1)

165

Inhibitors & Agonists

Screening Libraries

Fluorescent Dyes

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Oligonucleotides

GMP Molecules

Targets Recommended: mRNA

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-138170

ALC-0315 Maximum Cited Publications 39 Publications Verification	Liposome SARS-CoV	Infection
ALC-0315 is an ionisable aminolipid that is responsible for mRNA compaction and aids mRNA cellular delivery and its cytoplasmic release through suspected endosomal destabilization. ALC-0315 can be used to form lipid nanoparticle (LNP) delivery vehicles. Lipid-Nanoparticles have been used in the research of mRNA COVID-19 vaccine .

HY-145405

C12-200 15+ Cited Publications	Liposome	Others
C12-200 is a type of ionizable cationic lipid and helper lipid commonly used for mRNA delivery. In the hemophilia B mouse model, mRNA encoding human erythropoietin (EPO) and coagulation factor IX (FIX) can be successfully delivered and expressed using C12-200. C12-200 is utilized in research related to hemophilia B .

HY-138171

Lipid 5 3 Publications Verification	Liposome	Others
Lipid 5 is an amino lipid that affords efficient mRNA delivery in rodent and primate models. Lipid 5 shows optimal pharmacokinetics and non-toxic side effects .

HY-148842

C14-4	Liposome	Others
C14-4 is an ionizable lipid utilized for the synthesis of lipid nanoparticles (LNPs). C14-4 enhances mRNA delivery, enabling the effective transport of mRNA to primary human T cells, which in turn induces functional protein expression. C14-4 demonstrates high transfection efficiency while maintaining low cytotoxicity .

HY-151507

306Oi10 1 Publications Verification	Liposome	Others
306Oi10 is a branched ionizable lipid that can be used to construct lipid nanoparticles (LNPs) for delivering messenger RNA. The surface ionization of lipid nanoparticles is related to the effectiveness of mRNA delivery. The tail of 306Oi10 has a one-carbon branch, which provides it with stronger surface ionization compared to lipids with linear tails, thereby enhancing its mRNA delivery efficacy. 306Oi10 can be used in research related to mRNA delivery .

HY-167036

DMG-PEG2000-Mal	Biochemical Assay Reagents	Others
DMG-PEG2000-Mal is a pegylated lipid with a molecular weight of 2000. DMG-PEG-Mal serves as a component of lipid nanoparticles for mRNA delivery .

HY-171306

MK16	Liposome	Others
MK16 is a lipid material that can be used to construct blood-brain barrier penetrable lipid nanoparticles for mRNA delivery. MK16 facilitates blood-brain barrier crossing via γ-secretase-mediated and caveolae-mediated transcytosis. MK16 can be used for drug delivery research .

HY-142977

6-Oxohexyl 2-hexyldecanoate, 80% (ELSD)	Drug Intermediate	Others
6-Oxohexyl 2-hexyldecanoate, 80% (ELSD) is an intermediate in the synthesis of ALC-0315. 6-Oxohexyl 2-hexyldecanoate, 80% (ELSD) can be used in research on drug delivery, such as mRNA delivery .

HY-145795

OF-02	Liposome	Others
OF-02 is an ionizable lipid for mRNA delivery and a key component of lipid nanoparticles (LNPs). OF-02 is protonated in the acidic endosomal environment to promote endosomal escape of mRNA and efficiently induce protein expression in target cells. OF-02 relies on the pH-responsive membrane fusion properties to form a complex with mRNA and destroy the endosomal membrane structure to achieve mRNA release in the cytoplasm. OF-02 is mainly used in the development of mRNA vaccines, gene editing, and protein replacement therapy[1][2][3].

HY-153229

Firefly luciferase mRNA-LNP 1 Publications Verification	mRNA Biochemical Assay Reagents	Others
Firefly luciferase mRNA-LNP is a lipid nanoparticle (LNP) containing firefly luciferase mRNA. Firefly luciferase mRNA-LNP exhibits a stable nanostructure, in which LNP plays a key role in effectively protecting and transporting mRNA to cells. Luciferase is a bioluminescent reporter gene for gene regulation and functional studies. Firefly Luciferase mRNA-LNP expresses firefly luciferase protein after entering the cells, which is often used for promoter activity detection or dual fluorescent molecular complementation experiments. Firefly luciferase mRNA-LNP is studied in research for RNA delivery, cell viability, and translation efficiency .

HY-46759

Genevant CL1	Liposome	Infection
Genevant CL1 is an ionizable lipid (pKa = 6.3) suitable for the preparation of lipid nanoparticles (LNPs) for delivering nucleic acid payloads and intramuscular vaccines. Genevant CL1 is a component of lipid nanoparticle delivery systems for mRNA vaccines .

HY-N16040

DMG-pSar25	Liposome	Others
DMG-pSar25 is a double lipid-tailed polysarcosine lipid with 25 sarcosine moieties, serving as a PEG lipid substitute in lipid nanoparticle formulations for mRNA delivery. DMG-pSar25 supports mRNA delivery in lipid nanoparticle formulations .

HY-148049

TT3	Liposome	Others
TT3 is an ionizable lipid-like material and a lipid nanoparticle (LLNs)-based mRNA delivery vector. TT3 exhibits liver and spleen specificity and excellent delivery efficiency .

HY-W590532

306-O12B 1 Publications Verification	Liposome	Others
306-O12B is an ionizable cationic lipid used to prepare lipid nanoparticles (LNPs) for the delivery of mRNA .

HY-153080

Firefly Luciferase mRNA(N1-Me-Pseudo UTP)	Fluorescent Dye mRNA	Others
Firefly Luciferase mRNA (N1-Me-Pseudo UTP) is a modified form of firefly luciferase mRNA, which is N1-methylated pseudo uridine (N1-Me-Pseudo UTP). Firefly Luciferase mRNA (N1-Me-Pseudo UTP) is a commonly used reporter molecule in biomedical and mRNA research and its core function is to rapidly and quantitatively monitor the expression and delivery efficiency of mRNA through the emission of light signals .

HY-147354

TriGalNAc CBz	LYTACs	Cardiovascular Disease
TriGalNAc CBz is a GalNAc derivative and tri-GalNAc is an asialoglycoprotein receptor (ASGPR) ligand. TriGalNAc CBz can be used for mRNA drug delivery as well as lysosomal targeted chimerism (LYTAC) studies .

HY-145793

FTT5 2 Publications Verification	Liposome	Cardiovascular Disease
FTT5 is an ionizable lipid that can be used to prepare lipid nanoparticles for efficient delivery of long-chain mRNA in vivo .

HY-138622

24:0 Lyso PC	Liposome	Others
24:0 Lyso PC is a lysophospholipid (LyP). 24:0 Lyso PC could be used for mRNA drug delivery .

HY-159726

C10-200	Liposome	Others
C10-200 is an ionizable cationic lipid that can be used to generate lipid nanoparticles (LNPs). C10-200 is used in the study of mRNA delivery .

HY-148855

OF-C4-Deg-Lin	Liposome	Others
OF-C4-Deg-Lin is an ionizable lipid with varied linker lengths. OF-C4-Deg-Lin can be used in the generation of lipid nanoparticles (LNPs) for the delivery of siRNA and mRNA .

HY-170704

DSPE-PEG2000-TCO	Liposome	Metabolic Disease Cancer
DSPE-PEG2000-TCO is a click chemistry coupling partner. DSPE-PEG2000-TCO undergoes a reverse electron-demand Diels-Alder click reaction to form a covalent linkage with tetrazine-modified Cetuximab (HY-P9905). DSPE-PEG2000-TCO maintains the stability of lipid nanoparticles (LNPs) and has high mRNA encapsulation efficiency, which supports cellular uptake and mRNA transfection. DSPE-PEG2000-TCO is used to prepare EGFR-targeted and APN-targeted mRNA-loaded LNPs, mediating receptor-dependent endocytosis, mRNA delivery, and intestinal epithelial transcytosis .

HY-153235

COVID-19 Spike Protein mRNA-LNP	mRNA SARS-CoV Liposome	Infection
COVID-19 Spike Protein mRNA-LNP is a lipid nanoparticle (LNP) containing *mRNA* encoding COVID-19 Spike Protein. COVID-19 Spike Protein undertakes the functions of virus binding with host cell receptors, thereby mediating the entry of COVID-19 virus into cells. COVID-19 Spike Protein is an important site of action for host neutralizing antibodies and a key target for vaccine design. COVID-19 Spike Protein mRNA-LNP can be used for RNA delivery, vaccine formulation and design targeting SARS-CoV-2 .

HY-153879

C12-TLRa	Liposome Toll-like Receptor (TLR)	Infection Inflammation/Immunology
C12-TLRa is an ionized adjuvant lipid. C12-TLRa targets TLR7/8 receptors in endosomes. C12-TLRa enhances mRNA delivery as a structural component of LNPs. C12-TLRa enhances innate immune responses. C12-TLRa can be used for the research of SARS-CoV-2 mRNA vaccine .

HY-W441015A

DSPE-m-PEG3400-NHS	Liposome	Others
DSPE-m-PEG3400-NHS is a pegylated phospholipid derivatives which can be used to prepare liposome or lipid nanoparticles for targeted drug delivery system, such as DNA or mRNA vaccine .

HY-W590683

9A1P9	Liposome	Others
9A1P9 is a multi-tail ionizable cationic phospholipid. 9A1P9 induces membrane destabilization. 9A1P9 can be used for mRNA delivery t .

HY-W590681

113-O12B	Liposome	Others
113-O12B is a disulfide bond-containing ionizable cationic lipidoid. 113-O12B can be used in that generation of lipid nanoparticles (LNPs) for the delivery of mRNA .

HY-159700

AA3-DLin	Liposome	Infection
AA3-DLin is an ionizable cationic lipid with a pK_a value of 5.8. AA3-DLin is used to delivery mRNA combined with lipid nanoparticles (LNPs). AA3-DLin LNP COVID-19 vaccines encapsulating SARS CoV-2 spike mRNAs successfully induces strong immunogenicity in a BALB/c mouse model .

HY-172526

4A3-SCC-10	Liposome	Cancer
4A3-SCC-10 is a biodegradable ionizable lipid containing disulfide bonds. 4A3-SCC-10 can be used to prepare lipid nanoparticles (LNPs) for the delivery of mRNA in vitro and in vivo. 4A3-SCC-10 can be used for broad applications such as gene editing, vaccine, and cancer detection .

HY-164190

m7(3'Ma-Biotin)Gppp(2'OMe)ApG ammonium solution (25mM)	DNA/RNA Synthesis	Others
m7(3'Ma-Biotin)Gppp(2'OMe)ApG ammonium is a Biotin-labled cap analogue that can be used for mRNA synthesis. The efficiency of mRNA delivery can be determined by the detection of Biotin by flow cytometry, which can be used to track mRNA in cells and in living animals and to screen delivery lipid ratios.

HY-153231A

eGFP mRNA-LNP (500 ng/μL)	Fluorescent Dye Liposome	Others
eGFP mRNA-LNP (500 ng/μL) is a lipid nanoparticle (LNP) containing eGFP mRNA. eGFP mRNA-LNP carries Enhanced Green Fluorescent Protein (eGFP), which will express green fluorescent protein after entering the cell. eGFP is commonly used as a reporter gene detectable by fluorescence microscopy or flow cytometry (excitation wavelength = 488 nm; emission wavelength = 535/40 bandpass). eGFP mRNA-LNP can be used for RNA delivery, translation efficiency and cell viability .

HY-160554

C12-113	Liposome	Infection Inflammation/Immunology
C12-113 is a lipidoid delivery agent that can be used to transfect siRNA into cells. C12-113 can also be combined with other lipids to form lipid nanoparticles (LNPs) for the delivery of mRNA encoding the spike glycoprotein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in mice .

HY-153372

93-O17S	Liposome	Others
93-O17S is an ionizable lipid. 93-O17S is involved in the construction of LNP. 93-O17S can achieve mRNA delivery to the spleen .

HY-143700

18:0 DAP	Biochemical Assay Reagents	Others
18:0 DAP is a cationic or ionizable lipid with no unsaturated bonds in its hydrocarbon chain. The mRNA encapsulation efficiency of 18:0 DAP is 0%. 18:0 DAP cannot form functional lipid nanoparticles suitable for mRNA delivery .

HY-148363

Heptadecan-9-yl 8-((6-(decyloxy)-6-oxohexyl)(2-hydroxyethyl)amino)octanoate	Liposome	Inflammation/Immunology
Heptadecan-9-yl 8-((6-(decyloxy)-6-oxohexyl)(2-hydroxyethyl)amino)octanoate can be used in lipid nanoparticles (LNP) delivery systems for mRNA vaccine delivery .

HY-138170GL

ALC-0315 (GMP Like)	Liposome SARS-CoV	Infection
ALC-0315 (GMP Like) is ALC-0315 (HY-138170) produced by using GMP like guidelines. GMP Like small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. ALC-0315 is an ionisable aminolipid that is responsible for mRNA compaction and aids mRNA cellular delivery and its cytoplasmic release through suspected endosomal destabilization. ALC-0315 can be used to form lipid nanoparticle (LNP) delivery vehicles. Lipid-Nanoparticles have been used in the research of mRNA COVID-19 vaccine .

HY-151511

A12-Iso5-2DC18	Liposome	Cancer
A12-Iso5-2DC18, an ionizable cationic lipid, is a potent mRNA delivery lipid vehicle .

HY-W440895

DSPE-PEG1000-SH	Biochemical Assay Reagents	Others
DSPE-PEG1000-SH is an amphiphilic poly-PEG that can form lipid bilayers in water. This amphiphilic polymer can form lipid bilayers in aqueous solution and can be used to embed active molecules for drug delivery systems such as mRNA vaccines.

HY-156985

Lipid AX4	Isotope-Labeled Compounds Liposome	Others
Lipid AX4 is an ionizable cationic lipid with the _pK_a of 6.89， and can be used the study for the formation of lipid nanoparticles (LNPs) for the delivery of mRNA in vivo .

HY-156448

80-O14B 1 Publications Verification	Liposome	Cancer
80-O14B is a cationic lipid-like compound. 80-O14B can be used in mRNA delivery studies .

HY-138622S1

24:0 Lyso PC-d4	Isotope-Labeled Compounds	Others
24:0 Lyso PC-d₄4 is the deuterium labeled 24:0 Lyso PC. 24:0 Lyso PC is a lysophospholipid (LyP). 24:0 Lyso PC could be used for mRNA drug delivery .

HY-151512

A12-Iso5-4DC19	Liposome	Inflammation/Immunology Cancer
A12-Iso5-4DC19 is an ionizable cationic lipid. A12-Iso5-4DC19 can facilitate mRNA delivery and be used for the research of RNA vaccines .

HY-176753

Lipid 20b	Liposome	Inflammation/Immunology
Lipid 20b is a thiophene ionizable cationic lipid. Lipid 20 b can be used to generate lipid nanoparticles (LNPs) for the delivery of mRNA in vivo. Lipid 20b can be studied in research for enhancing mRNA vaccine delivery and transfection efficacy .

HY-164189

m7(3'Ma-Cy3)Gppp(2'OMe)ApG ammonium	DNA/RNA Synthesis	Others
m7(3'Ma-Cy3)Gppp(2'OMe)ApG ammonium is a Cy3-labled cap analogue that can be used for mRNA synthesis. The efficiency of mRNA delivery can be determined by the detection of Cy3 by flow cytometry, which can be used to track mRNA in cells and in living animals and to screen delivery lipid ratios.

HY-172018

CP-LC-0729	Liposome	Cancer
CP-LC-0729 is an ionizable cationic amino lipid efficient delivery of different kinds of RNA (mRNA, cRNA and saRNA) .

HY-171896

A28-C6B2	Liposome	Inflammation/Immunology Cancer
A28-C6B2 is an ionizable cationic lipid with a pK_a of 6.43, and can be used to generate lipid nanoparticles (LNPs) for mRNA delivery in vivo. A28-C6B2 can be studied in research for enhancing the selective delivery of mRNA to the spleen, particularly to antigen-presenting cells .

HY-171898

Lipid I97	Liposome	Inflammation/Immunology Cancer
Lipid I97 is an ionizable lipid derived from vitamin B₅ (pK_a = 6.23). Lipid I97 can be used to generate lipid nanoparticles (LNPs) for mRNA delivery in vivo. Lipid I97 can be studied in research for enhancing mRNA transfection efficiency and long-term stability as well as formulation of mRNA vaccines .

HY-186041

E12LA6B6O3	Amino Acid Derivatives	Others
E12LA6B6O3 is an amino lipid that can be used to prepare nanoparticles for drug delivery, such as mRNA .

HY-P3402

HBpep-K	Amino Acid Derivatives	Others
HBpep-K is a peptide that can form co aggregated droplets. HBpep-K can efficiently load and deliver small peptides, proteins, and mRNA. HBpep-K can protect mRNA from RNase degradation. HBpep-K is commonly used for drug delivery .

HY-P3402A

HBpep-K acetate	Amino Acid Derivatives	Others
HBpep-K acetate is a peptide that can form co aggregated droplets. HBpep-K acetate can efficiently load and deliver small peptides, proteins, and mRNA. HBpep-K acetate can protect mRNA from RNase degradation. HBpep-K acetate is commonly used for drug delivery .

HY-153371

50-C2-C9-4tail	Liposome	Others
50-C2-C9-4tail has been used in the generation of lipid nanoparticles (LNPs) for the delivery of siRNA and mRNA in vitro and in vivo.

Cat. No.	Product Name

HY-L251

Ionizable Lipid Compound Library

95 compounds

Ionizable lipids are a class of specialized, functional lipid molecules with pH-sensitive charge characteristics. They are primarily divided into two major categories: ionizable cationic lipids and ionizable anionic lipids, though the term typically specifies ionizable cationic lipids within the biomedical field. Structurally, these lipids consist of an ionizable hydrophilic headgroup, a biodegradable linker, and hydrophobic tails. Their primary application is serving as the key delivery vehicle in lipid nanoparticles (LNPs) to encapsulate negatively charged nucleic acid macromolecules, such as mRNA vaccines, siRNA therapeutics, and CRISPR gene-editing components. In a physiological, neutral environment, they remain electrically neutral to minimize systemic toxicity and prolong circulation time. Upon entering the acidic microenvironment of cellular endosomes, however, they undergo protonation to become positively charged, thereby inducing membrane fusion and enabling the highly efficient intracellular release of the nucleic acid cargo. Consequently, they serve as the technological cornerstone for bringing nucleic acid therapies into clinical application.

To accelerate the translational process of cutting-edge nucleic acid drugs, MCE has meticulously constructed an ionizable lipid compound library containing 95 high-performance molecules, aiming to provide researchers and pharmaceutical professionals with a high-throughput, multi-dimensional lipid screening platform.

Cat. No.	Product Name	Type

HY-138170GL

ALC-0315 (GMP Like)

Fluorescent Dyes

ALC-0315 (GMP Like) is ALC-0315 (HY-138170) produced by using GMP like guidelines. GMP Like small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. ALC-0315 is an ionisable aminolipid that is responsible for mRNA compaction and aids mRNA cellular delivery and its cytoplasmic release through suspected endosomal destabilization. ALC-0315 can be used to form lipid nanoparticle (LNP) delivery vehicles. Lipid-Nanoparticles have been used in the research of mRNA COVID-19 vaccine .

HY-D2565

Cy5.5-PEG2000-DSPE	Fluorescent Dyes
Cy5.5-PEG2000-DSPE is a PEG phospholipid with Cy5.5 (HY-D0924) dye used in protein/nucelic acid labeling and fluorescence microscopy. Cy5.5-PEG2000-DSPE can self-assemble in aqueous solution to form micelles/lipid bilayer and used to prepare liposomes or nanoparticles for nutrients delivery such as mRNA or DNA vaccine.

HY-D2593

Cy7.5-PEG2000-DSPE	Fluorescent Dyes
Cy7.5-PEG2000-DSPE is a PEG phospholipid with CY7.5 (HY-D0926) dye used in protein/nucelic acid labeling and fluorescence microscopy. Cy7.5-PEG2000-DSPE can self-assemble in aqueous solution to form micelles/lipid bilayer and used to prepare liposomes or nanoparticles for nutrients delivery such as mRNA or DNA vaccine (Ex/Em=770/820 nm).

HY-D2610

ICG PEG2000 DSPE	Fluorescent Dyes
ICG PEG2000 DSPE is a PEG phospholipid with Indocyanine green (ICG) (HY-D0711) dye used in protein/nucelic acid labeling and fluorescence microscopy. ICG PEG2000 DSPE can self-assemble in aqueous solution to form micelles/lipid bilayer and used to prepare liposomes or nanoparticles for nutrients delivery such as mRNA or DNA vaccine (Ex/Em=785/813 nm).

HY-D2887B

RB-PEG-DSPE (MW 1000) Rhodamine B-PEG-DSPE (MW 1000)	Fluorescent Dyes
RB-PEG-DSPE (MW 1000) (Rhodamine B-PEG-DSPE (MW 1000)) is a PEG phospholipid labeled Rhodamine B (HY-Y0016). RB-PEG-DSPE (MW 1000) can be used to prepare liposomes or nanoparticles for nutrients delivery such as mRNA or DNA vaccine (Ex/Em = 546/610 nm) .

HY-D2526

Cy3 IRGD-PEG-DSPE	Fluorescent Dyes
Cy3 IRGD-PEG-DSPE is a PEG phospholipid with Cy3 (HY-D0822) dye used in protein/nucelic acid labeling and fluorescence microscopy. Cy3 IRGD-PEG-DSPE can self-assemble in aqueous solution to form micelles/lipid bilayer and used to prepare liposomes or nanoparticles for nutrients delivery such as mRNA or DNA vaccine.

HY-D2887H

RB-PEG10000-DSPE Rhodamine B-PEG10000-DSPE	Fluorescent Dyes
RB-PEG10000-DSPE (Rhodamine B-PEG10000-DSPE) is a PEG phospholipid labeled Rhodamine B (HY-Y0016). RB-PEG10000-DSPE can be used to prepare liposomes or nanoparticles for nutrients delivery such as mRNA or DNA vaccine (Ex/Em=546/610 nm) .

HY-D2887C

RB-PEG2000-DSPE Rhodamine B-PEG2000-DSPE	Fluorescent Dyes
RB-PEG2000-DSPE (Rhodamine B-PEG2000-DSPE) is a PEG phospholipid labeled Rhodamine B (HY-Y0016). RB-PEG2000-DSPE can be used to prepare liposomes or nanoparticles for nutrients delivery such as mRNA or DNA vaccine (Ex/Em=546/610 nm) .

HY-D2887D

RB-PEG3400-DSPE Rhodamine B-PEG3400-DSPE	Fluorescent Dyes
RB-PEG3400-DSPE (Rhodamine B-PEG3400-DSPE) is a PEG phospholipid labeled Rhodamine B (HY-Y0016). RB-PEG3400-DSPE can be used to prepare liposomes or nanoparticles for nutrients delivery such as mRNA or DNA vaccine (Ex/Em=546/610 nm) .

HY-D2887A

RB-PEG600-DSPE Rhodamine B-PEG600-DSPE	Fluorescent Dyes
RB-PEG600-DSPE (Rhodamine B-PEG600-DSPE) is a PEG phospholipid labeled Rhodamine B (HY-Y0016). RB-PEG600-DSPE can be used to prepare liposomes or nanoparticles for nutrients delivery such as mRNA or DNA vaccine (Ex/Em=546/610 nm) .

HY-D2609

ICG PEG1000 DSPE	Fluorescent Dyes
ICG PEG1000 DSPE is a PEG phospholipid with Indocyanine green (ICG) (HY-D0711) dye used in protein/nucelic acid labeling and fluorescence microscopy. ICG PEG1000 DSPE can self-assemble in aqueous solution to form micelles/lipid bilayer and used to prepare liposomes or nanoparticles for nutrients delivery such as mRNA or DNA vaccine (Ex/Em=785/813 nm).

HY-D2611

ICG PEG3400 DSPE	Fluorescent Dyes
ICG PEG3400 DSPE is a PEG phospholipid with Indocyanine green (ICG) (HY-D0711) dye used in protein/nucelic acid labeling and fluorescence microscopy. ICG PEG3400 DSPE can self-assemble in aqueous solution to form micelles/lipid bilayer and used to prepare liposomes or nanoparticles for nutrients delivery such as mRNA or DNA vaccine (Ex/Em=785/813 nm).

HY-D2613

ICG PEG10000 DSPE	Fluorescent Dyes
ICG PEG10000 DSPE is a PEG phospholipid with Indocyanine green (ICG) (HY-D0711) dye used in protein/nucelic acid labeling and fluorescence microscopy. ICG PEG10000 DSPE can self-assemble in aqueous solution to form micelles/lipid bilayer and used to prepare liposomes or nanoparticles for nutrients delivery such as mRNA or DNA vaccine (Ex/Em=785/813 nm).

HY-D2517

Cy3-PEG5000-DSPE	Fluorescent Dyes
Cy3-PEG5000-DSPE is a PEG phospholipid with Cy3 (HY-D0822) dye used in protein/nucelic acid labeling. Cy3-PEG5000-DSPE can self-assemble in aqueous solution to form micelles/lipid bilayer and used to prepare liposomes or nanoparticles for nutrients delivery such as mRNA or DNA vaccine.

HY-D2544

Cy5-PEG5000-DSPE	Fluorescent Dyes
Cy5-PEG5000-DSPE is a PEG phospholipid with Cy5 (HY-D0821) dye used in protein/nucelic acid labeling and fluorescence microscopy. Cy5-PEG5000-DSPE can self-assemble in aqueous solution to form micelles/lipid bilayer and used to prepare liposomes or nanoparticles for nutrients delivery such as mRNA or DNA vaccine.

HY-D2542

Cy5-PEG2000-DSPE	Fluorescent Dyes
Cy5-PEG2000-DSPE is a PEG phospholipid with Cy5 (HY-D0821) dye used in protein/nucelic acid labeling and fluorescence microscopy. Cy5-PEG2000-DSPE can self-assemble in aqueous solution to form micelles/lipid bilayer and used to prepare liposomes or nanoparticles for nutrients delivery such as mRNA or DNA vaccine.

HY-D2516

Cy3-PEG3400-DSPE	Fluorescent Dyes
Cy3-PEG3400-DSPE is a PEG phospholipid with Cy3 (HY-D0822) dye used in protein/nucelic acid labeling and fluorescence microscopy. Cy3-PEG3400-DSPE can self-assemble in aqueous solution to form micelles/lipid bilayer and used to prepare liposomes or nanoparticles for nutrients delivery such as mRNA or DNA vaccine.

HY-D2595

Cy7.5-PEG5000-DSPE	Fluorescent Dyes
Cy7.5-PEG5000-DSPE is a PEG phospholipid with CY7.5 (HY-D0926) dye used in protein/nucelic acid labeling and fluorescence microscopy. Cy7.5-PEG5000-DSPE can self-assemble in aqueous solution to form micelles/lipid bilayer and used to prepare liposomes or nanoparticles for nutrients delivery such as mRNA or DNA vaccine (Ex/Em=770/820 nm).

HY-D2592

Cy7.5-PEG1000-DSPE	Fluorescent Dyes
Cy7.5-PEG1000-DSPE is a PEG phospholipid with CY7.5 (HY-D0926) dye used in protein/nucelic acid labeling and fluorescence microscopy. Cy7.5-PEG1000-DSPE can self-assemble in aqueous solution to form micelles/lipid bilayer and used to prepare liposomes or nanoparticles for nutrients delivery such as mRNA or DNA vaccine (Ex/Em=770/820 nm).

HY-D2887

RB-PEG400-DSPE Rhodamine B-PEG400-DSPE	Fluorescent Dyes
RB-PEG400-DSPE (Rhodamine B-PEG400-DSPE) is a PEG phospholipid labeled Rhodamine B (HY-Y0016). RB-PEG400-DSPE can be used to prepare liposomes or nanoparticles for nutrients delivery such as mRNA or DNA vaccine (Ex/Em=546/610 nm) .

HY-D2887E

RB-PEG5000-DSPE Rhodamine B-PEG5000-DSPE	Fluorescent Dyes
RB-PEG5000-DSPE (Rhodamine B-PEG5000-DSPE) is a PEG phospholipid labeled Rhodamine B (HY-Y0016). RB-PEG5000-DSPE can be used to prepare liposomes or nanoparticles for nutrients delivery such as mRNA or DNA vaccine (Ex/Em=546/610 nm) .

HY-D2612

ICG PEG5000 DSPE	Fluorescent Dyes
ICG PEG5000 DSPE is a PEG phospholipid with Indocyanine green (ICG) (HY-D0711) dye used in protein/nucelic acid labeling and fluorescence microscopy. ICG PEG5000 DSPE can self-assemble in aqueous solution to form micelles/lipid bilayer and used to prepare liposomes or nanoparticles for nutrients delivery such as mRNA or DNA vaccine (Ex/Em=785/813 nm).

HY-D2541

Cy5-PEG1000-DSPE	Fluorescent Dyes
Cy5-PEG1000-DSPE is a PEG phospholipid with Cy5 (HY-D0821) dye used in protein/nucelic acid labeling and fluorescence microscopy. Cy5-PEG1000-DSPE can self-assemble in aqueous solution to form micelles/lipid bilayer and used to prepare liposomes or nanoparticles for nutrients delivery such as mRNA or DNA vaccine.

HY-D2543

Cy5-PEG3400-DSPE	Fluorescent Dyes
Cy5-PEG3400-DSPE is a PEG phospholipid with Cy5 (HY-D0821) dye used in protein/nucelic acid labeling and fluorescence microscopy. Cy5-PEG3400-DSPE can self-assemble in aqueous solution to form micelles/lipid bilayer and used to prepare liposomes or nanoparticles for nutrients delivery such as mRNA or DNA vaccine.

HY-D2545

Cy5-PEG10000-DSPE	Fluorescent Dyes
Cy5-PEG10000-DSPE is a PEG phospholipid with Cy5 (HY-D0821) dye used in protein/nucelic acid labeling and fluorescence microscopy. Cy5-PEG10000-DSPE can self-assemble in aqueous solution to form micelles/lipid bilayer and used to prepare liposomes or nanoparticles for nutrients delivery such as mRNA or DNA vaccine.

HY-D2567

Cy5.5-PEG5000-DSPE	Fluorescent Dyes
Cy5.5-PEG5000-DSPE is a PEG phospholipid with Cy5.5 (HY-D0924) dye used in protein/nucelic acid labeling and fluorescence microscopy. Cy5.5-PEG5000-DSPE can self-assemble in aqueous solution to form micelles/lipid bilayer and used to prepare liposomes or nanoparticles for nutrients delivery such as mRNA or DNA vaccine.

HY-D2566

Cy5.5-PEG3400-DSPE	Fluorescent Dyes
Cy5.5-PEG3400-DSPE is a PEG phospholipid with Cy5.5 (HY-D0924) dye used in protein/nucelic acid labeling and fluorescence microscopy. Cy5.5-PEG3400-DSPE can self-assemble in aqueous solution to form micelles/lipid bilayer and used to prepare liposomes or nanoparticles for nutrients delivery such as mRNA or DNA vaccine.

HY-D2564

Cy5.5-PEG1000-DSPE	Fluorescent Dyes
Cy5.5-PEG1000-DSPE is a PEG phospholipid with Cy5.5 (HY-D0924) dye used in protein/nucelic acid labeling and fluorescence microscopy. Cy5.5-PEG1000-DSPE can self-assemble in aqueous solution to form micelles/lipid bilayer and used to prepare liposomes or nanoparticles for nutrients delivery such as mRNA or DNA vaccine.

HY-D2568

Cy5.5-PEG10000-DSPE	Fluorescent Dyes
Cy5.5-PEG10000-DSPE is a PEG phospholipid with Cy5.5 (HY-D0924) dye used in protein/nucelic acid labeling and fluorescence microscopy. Cy5.5-PEG10000-DSPE can self-assemble in aqueous solution to form micelles/lipid bilayer and used to prepare liposomes or nanoparticles for nutrients delivery such as mRNA or DNA vaccine.

HY-D2596

Cy7.5-PEG10000-DSPE	Fluorescent Dyes
Cy7.5-PEG10000-DSPE is a PEG phospholipid with CY7.5 (HY-D0926) dye used in protein/nucelic acid labeling and fluorescence microscopy. Cy7.5-PEG10000-DSPE can self-assemble in aqueous solution to form micelles/lipid bilayer and used to prepare liposomes or nanoparticles for nutrients delivery such as mRNA or DNA vaccine (Ex/Em=770/820 nm).

HY-D2594

Cy7.5-PEG3400-DSPE	Fluorescent Dyes
Cy7.5-PEG3400-DSPE is a PEG phospholipid with CY7.5 (HY-D0926) dye used in protein/nucelic acid labeling and fluorescence microscopy. Cy7.5-PEG3400-DSPE can self-assemble in aqueous solution to form micelles/lipid bilayer and used to prepare liposomes or nanoparticles for nutrients delivery such as mRNA or DNA vaccine (Ex/Em=770/820 nm).

Cat. No.	Product Name	Type

HY-138170

ALC-0315 Maximum Cited Publications 39 Publications Verification	Biochemical Assay Reagents
ALC-0315 is an ionisable aminolipid that is responsible for mRNA compaction and aids mRNA cellular delivery and its cytoplasmic release through suspected endosomal destabilization. ALC-0315 can be used to form lipid nanoparticle (LNP) delivery vehicles. Lipid-Nanoparticles have been used in the research of mRNA COVID-19 vaccine .

HY-145405

C12-200 15+ Cited Publications	Biochemical Assay Reagents
C12-200 is a type of ionizable cationic lipid and helper lipid commonly used for mRNA delivery. In the hemophilia B mouse model, mRNA encoding human erythropoietin (EPO) and coagulation factor IX (FIX) can be successfully delivered and expressed using C12-200. C12-200 is utilized in research related to hemophilia B .

HY-138171

Lipid 5 3 Publications Verification	Biochemical Assay Reagents
Lipid 5 is an amino lipid that affords efficient mRNA delivery in rodent and primate models. Lipid 5 shows optimal pharmacokinetics and non-toxic side effects .

HY-148842

C14-4	Biochemical Assay Reagents
C14-4 is an ionizable lipid utilized for the synthesis of lipid nanoparticles (LNPs). C14-4 enhances mRNA delivery, enabling the effective transport of mRNA to primary human T cells, which in turn induces functional protein expression. C14-4 demonstrates high transfection efficiency while maintaining low cytotoxicity .

HY-W583868

1-Palmitoyl-2-oleoyl-sn-glycero-3-PE

1,2-POPE; 16:0-18:1 PE

Biochemical Assay Reagents

1-Palmitoyl-2-oleoyl-sn-glycero-3-PE (1,2-POPE; 16:0-18:1 PE) is a phosphatidylethanolamine (PE) lipid. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE can induce lipid bilayer to form a hexagonal phase (HII) structure in an acidic environment and promote membrane fusion. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE can enhance the endosomal escape ability of lipid nanoparticles (LNPs) and improve the cellular delivery efficiency of nucleic acid drugs such as mRNA. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE can be used for LNP carrier targeting of gene therapy and mRNA vaccines .

HY-151507

306Oi10

1 Publications Verification

Biochemical Assay Reagents

306Oi10 is a branched ionizable lipid that can be used to construct lipid nanoparticles (LNPs) for delivering messenger RNA. The surface ionization of lipid nanoparticles is related to the effectiveness of mRNA delivery. The tail of 306Oi10 has a one-carbon branch, which provides it with stronger surface ionization compared to lipids with linear tails, thereby enhancing its mRNA delivery efficacy. 306Oi10 can be used in research related to mRNA delivery .

HY-167036

DMG-PEG2000-Mal	Biochemical Assay Reagents
DMG-PEG2000-Mal is a pegylated lipid with a molecular weight of 2000. DMG-PEG-Mal serves as a component of lipid nanoparticles for mRNA delivery .

HY-142977

6-Oxohexyl 2-hexyldecanoate, 80% (ELSD)	Biochemical Assay Reagents
6-Oxohexyl 2-hexyldecanoate, 80% (ELSD) is an intermediate in the synthesis of ALC-0315. 6-Oxohexyl 2-hexyldecanoate, 80% (ELSD) can be used in research on drug delivery, such as mRNA delivery .

HY-W440896

DSPE-PEG2000-SH

Biochemical Assay Reagents

DSPE-PEG2000-SH is an amphiphilic thiol-functionalized DSPE-PEG molecule. DSPE-PEG2000-SH inserts into extracellular vesicle (EV) bilayer membranes via hydrophobic interactions, displaying surface thiol groups to form EV-SH crosslinkers.DSPE-PEG2000-SH enables crosslinking of EV-SH with 8-arm PEG-norbornene via thiol-ene photochemistry to construct hydrogels, with hydrogel mechanical properties tunable via PEG segment molecular weight variation.DSPE-PEG2000-SH can be used to encapsulate agents for drug delivery system, such as mRNA vaccine .

HY-172723

DSPE-PEG2000-T7

Biochemical Assay Reagents

DSPE-PEG2000-T7 is a PEGylated compound composed of DSPE and peptideT7. T7 (HAIYPRH) specifically binds to TfR. DSPE-PEG2000-T7 can be used to prepare T7-modified liposomes, where liposomes modified with both T7 and DA7R peptides can effectively co-deliver Doxorubicin (HY-15142A) and Vincristine (HY-N0488A) to gliomas. DSPE-PEG2000-T7 can also be used to prepare nanomodulators that mediate the co-delivery of tyrosine hydroxylase mRNA and interferon gene stimulator antagonists for synergistic intervention in Parkinson's disease .

HY-145795

OF-02

Biochemical Assay Reagents

OF-02 is an ionizable lipid for mRNA delivery and a key component of lipid nanoparticles (LNPs). OF-02 is protonated in the acidic endosomal environment to promote endosomal escape of mRNA and efficiently induce protein expression in target cells. OF-02 relies on the pH-responsive membrane fusion properties to form a complex with mRNA and destroy the endosomal membrane structure to achieve mRNA release in the cytoplasm. OF-02 is mainly used in the development of mRNA vaccines, gene editing, and protein replacement therapy[1][2][3].

HY-153229

Firefly luciferase mRNA-LNP

1 Publications Verification

Biochemical Assay Reagents

Firefly luciferase mRNA-LNP is a lipid nanoparticle (LNP) containing firefly luciferase mRNA. Firefly luciferase mRNA-LNP exhibits a stable nanostructure, in which LNP plays a key role in effectively protecting and transporting mRNA to cells. Luciferase is a bioluminescent reporter gene for gene regulation and functional studies. Firefly Luciferase mRNA-LNP expresses firefly luciferase protein after entering the cells, which is often used for promoter activity detection or dual fluorescent molecular complementation experiments. Firefly luciferase mRNA-LNP is studied in research for RNA delivery, cell viability, and translation efficiency .

HY-46759

Genevant CL1	Biochemical Assay Reagents
Genevant CL1 is an ionizable lipid (pKa = 6.3) suitable for the preparation of lipid nanoparticles (LNPs) for delivering nucleic acid payloads and intramuscular vaccines. Genevant CL1 is a component of lipid nanoparticle delivery systems for mRNA vaccines .

HY-148049

TT3	Biochemical Assay Reagents
TT3 is an ionizable lipid-like material and a lipid nanoparticle (LLNs)-based mRNA delivery vector. TT3 exhibits liver and spleen specificity and excellent delivery efficiency .

HY-W590532

306-O12B 1 Publications Verification	Biochemical Assay Reagents
306-O12B is an ionizable cationic lipid used to prepare lipid nanoparticles (LNPs) for the delivery of mRNA .

HY-150229

306-N16B

Biochemical Assay Reagents

306-N16B is a selective lung-targeted lipid nanoparticle that reversibly targets lung endothelial cells and specific immune cells through selective adsorption of a protein corona mediated by differences in tail structure (such as fibrinogen β/γ chain). 306-N16B binds to specific plasma proteins in the blood to form a protein corona, which guides the particles to be enriched in the lungs, releases mRNA and promotes target cell gene expression, exerts efficient lung cell transfection activity, and can precisely regulate gene delivery of different cell types in the lungs (such as endothelial cells and macrophages). 306-N16B can be used in gene therapy technologies for hereditary lung diseases including pulmonary lymphangioleiomyomatosis (LAM), restoring tumor suppressor function by delivering Tsc2 mRNA, and can also be used for lung-specific mRNA vaccines and gene editing therapies .

HY-145793

FTT5 2 Publications Verification	Biochemical Assay Reagents
FTT5 is an ionizable lipid that can be used to prepare lipid nanoparticles for efficient delivery of long-chain mRNA in vivo .

HY-138622

24:0 Lyso PC	Biochemical Assay Reagents
24:0 Lyso PC is a lysophospholipid (LyP). 24:0 Lyso PC could be used for mRNA drug delivery .

HY-148855

OF-C4-Deg-Lin	Biochemical Assay Reagents
OF-C4-Deg-Lin is an ionizable lipid with varied linker lengths. OF-C4-Deg-Lin can be used in the generation of lipid nanoparticles (LNPs) for the delivery of siRNA and mRNA .

HY-153235

COVID-19 Spike Protein mRNA-LNP

Biochemical Assay Reagents

COVID-19 Spike Protein mRNA-LNP is a lipid nanoparticle (LNP) containing mRNA encoding COVID-19 Spike Protein. COVID-19 Spike Protein undertakes the functions of virus binding with host cell receptors, thereby mediating the entry of COVID-19 virus into cells. COVID-19 Spike Protein is an important site of action for host neutralizing antibodies and a key target for vaccine design. COVID-19 Spike Protein mRNA-LNP can be used for RNA delivery, vaccine formulation and design targeting SARS-CoV-2 .

HY-W441015A

DSPE-m-PEG3400-NHS	Biochemical Assay Reagents
DSPE-m-PEG3400-NHS is a pegylated phospholipid derivatives which can be used to prepare liposome or lipid nanoparticles for targeted drug delivery system, such as DNA or mRNA vaccine .

HY-153231A

eGFP mRNA-LNP (500 ng/μL)

Biochemical Assay Reagents

eGFP mRNA-LNP (500 ng/μL) is a lipid nanoparticle (LNP) containing eGFP mRNA. eGFP mRNA-LNP carries Enhanced Green Fluorescent Protein (eGFP), which will express green fluorescent protein after entering the cell. eGFP is commonly used as a reporter gene detectable by fluorescence microscopy or flow cytometry (excitation wavelength = 488 nm; emission wavelength = 535/40 bandpass). eGFP mRNA-LNP can be used for RNA delivery, translation efficiency and cell viability .

HY-153372

93-O17S	Biochemical Assay Reagents
93-O17S is an ionizable lipid. 93-O17S is involved in the construction of LNP. 93-O17S can achieve mRNA delivery to the spleen .

HY-143700

18:0 DAP	Biochemical Assay Reagents
18:0 DAP is a cationic or ionizable lipid with no unsaturated bonds in its hydrocarbon chain. The mRNA encapsulation efficiency of 18:0 DAP is 0%. 18:0 DAP cannot form functional lipid nanoparticles suitable for mRNA delivery .

HY-148363

Heptadecan-9-yl 8-((6-(decyloxy)-6-oxohexyl)(2-hydroxyethyl)amino)octanoate	Biochemical Assay Reagents
Heptadecan-9-yl 8-((6-(decyloxy)-6-oxohexyl)(2-hydroxyethyl)amino)octanoate can be used in lipid nanoparticles (LNP) delivery systems for mRNA vaccine delivery .

HY-138170GL

ALC-0315 (GMP Like)

Biochemical Assay Reagents

HY-151511

A12-Iso5-2DC18	Biochemical Assay Reagents
A12-Iso5-2DC18, an ionizable cationic lipid, is a potent mRNA delivery lipid vehicle .

HY-W440895

DSPE-PEG1000-SH	Biochemical Assay Reagents
DSPE-PEG1000-SH is an amphiphilic poly-PEG that can form lipid bilayers in water. This amphiphilic polymer can form lipid bilayers in aqueous solution and can be used to embed active molecules for drug delivery systems such as mRNA vaccines.

HY-W440910

DSPE-PEG5000-Cy3	Biochemical Assay Reagents
DSPE-PEG5000-Cy3 is a phospholipid PEG polymer with Cy3 dye used in labeling and fluorescence microscopy. The polymer can self-assemble in aqueous solution to form micelles/lipid bilayer and used to prepare liposomes or nanoparticles for nutrients delivery such as mRNA or DNA vaccine.

HY-156448

80-O14B 1 Publications Verification	Biochemical Assay Reagents
80-O14B is a cationic lipid-like compound. 80-O14B can be used in mRNA delivery studies .

HY-151512

A12-Iso5-4DC19	Biochemical Assay Reagents
A12-Iso5-4DC19 is an ionizable cationic lipid. A12-Iso5-4DC19 can facilitate mRNA delivery and be used for the research of RNA vaccines .

HY-W440912

DSPE-PEG3400-Cy5	Biochemical Assay Reagents
DSPE-PEG3400-Cy5 is a PEG phospholipid with Cy5 dye used in protein/nucelic acid labeling and fluorescence microscopy. The polymer can self-assemble in aqueous solution to form micelles/lipid bilayer and used to prepare liposomes or nanoparticles for nutrients delivery such as mRNA or DNA vaccine.

HY-153371

50-C2-C9-4tail	Biochemical Assay Reagents
50-C2-C9-4tail has been used in the generation of lipid nanoparticles (LNPs) for the delivery of siRNA and mRNA in vitro and in vivo.

HY-46759A

Genevant CL1 monohydrochloride	Biochemical Assay Reagents
Genevant CL1 monohydrochloride is an ionizable lipid (pKa = 6.3) suitable for the preparation of lipid nanoparticles (LNPs) for delivering nucleic acid payloads and intramuscular vaccines. Genevant CL1 monohydrochloride is a component of lipid nanoparticle delivery systems for mRNA vaccines .

HY-W440899

DSPE-PEG1000-SPDP	Biochemical Assay Reagents
DSPE-PEG1000-SPDP is a thiol reactive PEG lipid. The polymer is amphiphilic and spontaneously forms lipid bilayer in water. It can be used to encapsulate nutrients or therapeutics for targeted drug delivery, for example mRNA or DNA vaccine, liposomal doxorubicin for anti tumor.

HY-145798

N1,N3,N5-Tris(4-dodecylhexadecyl)benzene-1,3,5-tricarboxamide	Biochemical Assay Reagents
N1,N3,N5-Tris(4-dodecylhexadecyl)benzene-1,3,5-tricarboxamide is an analogue of TT3 (HY-148049). TT3 is an ionizable lipid-like materials for mRNA delivery .

HY-W440909

DSPE-PEG3400-Cy3	Biochemical Assay Reagents
DSPE-PEG3400-Cy3 is a phospholipid PEG polymer with Cy3 dye used in labeling and fluorescence microscopy. The polymer can self-assemble in aqueous solution to form micelles/lipid bilayer and used to prepare liposomes or nanoparticles for nutrients delivery such as mRNA or DNA vaccine.

HY-W441003

DSPE-PEG2000-IA	Biochemical Assay Reagents
DSPE-PEG2000-IA is a thiol reactive phospholipid polyPEG. The iodoacetyll group is reactive with thiol to produce a thioether linkage. The polymer can self-assemble in water to form lipid bilayer and can be used to encapsulate drugs in targeted delivery application, such as liposomal doxorubicin as an anti cancer drug or mRNA vaccine.

HY-W440907

DSPE-PEG5000-Vinylsulfone	Biochemical Assay Reagents
DSPE-PEG5000-Vinylsulfone is a viniyl sulfone PEG lipid which can be used for bioconjugation with cysteine or other thiol molecule through thiol-ene reaction. The polymer is a self-assembling reagetn which forms lipid bilayer in water and can be used as drug carrier to delivery therapeutic agents, such as mRNA or DNA vaccine.

HY-W440905

DSPE-PEG2000-Vinylsulfone	Biochemical Assay Reagents
DSPE-PEG2000-Vinylsulfone is a viniyl sulfone PEG lipid which can be used for bioconjugation with cysteine or other thiol molecule through thiol-ene reaction. The polymer is a self-assembling reagetn which forms lipid bilayer in water and can be used as drug carrier to delivery therapeutic agents, such as mRNA or DNA vaccine.

HY-W440904

DSPE-PEG1000-Vinylsulfone	Biochemical Assay Reagents
DSPE-PEG1000-Vinylsulfone is a viniyl sulfone PEG lipid which can be used for bioconjugation with cysteine or other thiol molecule through thiol-ene reaction. The polymer is a self-assembling reagetn which forms lipid bilayer in water and can be used as drug carrier to delivery therapeutic agents, such as mRNA or DNA vaccine.

HY-W440988D

DOPE-mPEG750	Biochemical Assay Reagents
DOPE-mPEG750 is a PEGylated phospholipid containing DOPE. DOPE-mPEG750 combines the membrane fusion capabilities of DOPE with the stealth properties of PEG, playing a crucial role in mRNA vaccines, long-circulating liposomes, and drug delivery systems.

HY-W440988E

DOPE-mPEG10000	Biochemical Assay Reagents
DOPE-mPEG10000 is a PEGylated phospholipid containing DOPE. DOPE-mPEG10000 combines the membrane fusion capabilities of DOPE with the stealth properties of PEG, playing a crucial role in mRNA vaccines, long-circulating liposomes, and drug delivery systems.

HY-W440988H

DOPE-mPEG20000	Biochemical Assay Reagents
DOPE-mPEG20000 is a PEGylated phospholipid containing DOPE. DOPE-mPEG20000 combines the membrane fusion capabilities of DOPE with the stealth properties of PEG, playing a crucial role in mRNA vaccines, long-circulating liposomes, and drug delivery systems.

HY-W440988I

DOPE-mPEG30000	Biochemical Assay Reagents
DOPE-mPEG30000 is a PEGylated phospholipid containing DOPE. DOPE-mPEG30000 combines the membrane fusion capabilities of DOPE with the stealth properties of PEG, playing a crucial role in mRNA vaccines, long-circulating liposomes, and drug delivery systems.

HY-W440988A

DOPE-mPEG350	Biochemical Assay Reagents
DOPE-mPEG350 is a PEGylated phospholipid containing DOPE. DOPE-mPEG350 combines the membrane fusion capabilities of DOPE with the stealth properties of PEG, playing a crucial role in mRNA vaccines, long-circulating liposomes, and drug delivery systems.

HY-W440988B

DOPE-mPEG500	Biochemical Assay Reagents
DOPE-mPEG500 is a PEGylated phospholipid containing DOPE. DOPE-mPEG500 combines the membrane fusion capabilities of DOPE with the stealth properties of PEG, playing a crucial role in mRNA vaccines, long-circulating liposomes, and drug delivery systems.

HY-W440988C

DOPE-mPEG550	Biochemical Assay Reagents
DOPE-mPEG550 is a PEGylated phospholipid containing DOPE. DOPE-mPEG550 combines the membrane fusion capabilities of DOPE with the stealth properties of PEG, playing a crucial role in mRNA vaccines, long-circulating liposomes, and drug delivery systems.

HY-W440906

DSPE-PEG3400-Vinylsulfone	Biochemical Assay Reagents
DSPE-PEG3400-Vinylsulfone is a viniyl sulfone PEG lipid which can be used for bioconjugation with cysteine or other thiol molecule through thiol-ene reaction. The polymer is a self-assembling reagetn which forms lipid bilayer in water and can be used as drug carrier to delivery therapeutic agents, such as mRNA or DNA vaccine.

Cat. No.	Product Name	Target	Research Area

HY-P4084A

KLA seq acetate	Peptides	Others
KLA seq acetate is a cell membrane-penetrating α-helical amphipathic model peptide. KLA seq acetate conjugates peptide nucleic acids (PNAs) for delivery to mammalian cells. KLA seq acetate covalently links targeted mRNA and fluorescein to form a delivery system that has low re-export and is less resistant to serum effects .

HY-P3402

HBpep-K	Amino Acid Derivatives	Others
HBpep-K is a peptide that can form co aggregated droplets. HBpep-K can efficiently load and deliver small peptides, proteins, and mRNA. HBpep-K can protect mRNA from RNase degradation. HBpep-K is commonly used for drug delivery .

HY-P3402A

HBpep-K acetate	Amino Acid Derivatives	Others
HBpep-K acetate is a peptide that can form co aggregated droplets. HBpep-K acetate can efficiently load and deliver small peptides, proteins, and mRNA. HBpep-K acetate can protect mRNA from RNase degradation. HBpep-K acetate is commonly used for drug delivery .

HY-P11453

R9H6	Biochemical Assay Reagents	Cancer
R9H6 is a peptide containing nine arginine peptides and six histidine peptides. The LP(R9H6)m nanocomplex containing R9H6 exhibits high efficiency in mRNA delivery. R9H6 can be used in the research of anaplastic thyroid cancer .

HY-P11698

Guanidino-G-Clamp-PNA	DNA Alkylator/Crosslinker Transthyretin (TTR)	Cancer
Guanidino-G-Clamp-PNA is a highly efficient sequence-specific RNA binder and gene silencer. Guanidino-G-Clamp-PNA precisely targets such targets as miR-155 or transthyretin (TTR) mRNA through base pairing: the former regulates tumor-related signaling pathways by reducing microRNA activity, while the latter inhibits the translation of harmful proteins via steric hindrance. Guanidino-G-Clamp-PNA effectively stabilizes DNA/RNA duplexes, induces cancer cell apoptosis, and suppresses tumor growth. In addition, Guanidino-G-Clamp-PNA can be conjugated with targeting ligands to improve tissue-specific delivery and reduce in vivo adverse reactions, and it can also enhance the splicing regulation efficacy of other oligonucleotide platforms (such as PMO) when integrated into them. Guanidino-G-Clamp-PNA is applicable to the research of various diseases including diffuse large B-cell lymphoma and hereditary transthyretin-related amyloidosis .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N16040

DMG-pSar25	Structural Classification Lipid	Liposome
DMG-pSar25 is a double lipid-tailed polysarcosine lipid with 25 sarcosine moieties, serving as a PEG lipid substitute in lipid nanoparticle formulations for mRNA delivery. DMG-pSar25 supports mRNA delivery in lipid nanoparticle formulations .

Cat. No.	Product Name	Chemical Structure

HY-138622S1

24:0 Lyso PC-d4
24:0 Lyso PC-d₄4 is the deuterium labeled 24:0 Lyso PC. 24:0 Lyso PC is a lysophospholipid (LyP). 24:0 Lyso PC could be used for mRNA drug delivery .

HY-138622S

24:0 Lyso PC-13C6
24:0 Lyso PC- ¹³C₆ is the ¹³C labeled 24:0 Lyso PC. 24:0 Lyso PC is a lysophospholipid (LyP). 24:0 Lyso PC could be used for mRNA drug delivery .

HY-W583868S

1-Palmitoyl-2-oleoyl-sn-glycero-3-PE-d62

1-Palmitoyl-2-oleoyl-sn-glycero-3-PE-d₆₂ (1,2-POPE-d₆₂) is the deuterium labeled 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE (1,2-POPE; 16:0-18:1 PE) is a phosphatidylethanolamine (PE) lipid. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE can induce lipid bilayer to form a hexagonal phase (HII) structure in an acidic environment and promote membrane fusion. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE can enhance the endosomal escape ability of lipid nanoparticles (LNPs) and improve the cellular delivery efficiency of nucleic acid drugs such as mRNA. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE can be used for LNP carrier targeting of gene therapy and mRNA vaccines .

Cat. No.	Product Name		Classification

HY-138170

ALC-0315 Maximum Cited Publications 39 Publications Verification		Cationic Lipids
ALC-0315 is an ionisable aminolipid that is responsible for mRNA compaction and aids mRNA cellular delivery and its cytoplasmic release through suspected endosomal destabilization. ALC-0315 can be used to form lipid nanoparticle (LNP) delivery vehicles. Lipid-Nanoparticles have been used in the research of mRNA COVID-19 vaccine .

HY-145405

C12-200 15+ Cited Publications		Cationic Lipids
C12-200 is a type of ionizable cationic lipid and helper lipid commonly used for mRNA delivery. In the hemophilia B mouse model, mRNA encoding human erythropoietin (EPO) and coagulation factor IX (FIX) can be successfully delivered and expressed using C12-200. C12-200 is utilized in research related to hemophilia B .

HY-138171

Lipid 5 3 Publications Verification		Cationic Lipids
Lipid 5 is an amino lipid that affords efficient mRNA delivery in rodent and primate models. Lipid 5 shows optimal pharmacokinetics and non-toxic side effects .

HY-148842

C14-4		Cationic Lipids Cationic Lipids
C14-4 is an ionizable lipid utilized for the synthesis of lipid nanoparticles (LNPs). C14-4 enhances mRNA delivery, enabling the effective transport of mRNA to primary human T cells, which in turn induces functional protein expression. C14-4 demonstrates high transfection efficiency while maintaining low cytotoxicity .

HY-W583868

1-Palmitoyl-2-oleoyl-sn-glycero-3-PE 1,2-POPE; 16:0-18:1 PE		Phospholipids
1-Palmitoyl-2-oleoyl-sn-glycero-3-PE (1,2-POPE; 16:0-18:1 PE) is a phosphatidylethanolamine (PE) lipid. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE can induce lipid bilayer to form a hexagonal phase (HII) structure in an acidic environment and promote membrane fusion. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE can enhance the endosomal escape ability of lipid nanoparticles (LNPs) and improve the cellular delivery efficiency of nucleic acid drugs such as mRNA. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE can be used for LNP carrier targeting of gene therapy and mRNA vaccines .

HY-151507

306Oi10 1 Publications Verification		Cationic Lipids
306Oi10 is a branched ionizable lipid that can be used to construct lipid nanoparticles (LNPs) for delivering messenger RNA. The surface ionization of lipid nanoparticles is related to the effectiveness of mRNA delivery. The tail of 306Oi10 has a one-carbon branch, which provides it with stronger surface ionization compared to lipids with linear tails, thereby enhancing its mRNA delivery efficacy. 306Oi10 can be used in research related to mRNA delivery .

HY-167036

DMG-PEG2000-Mal		Pegylated Lipids
DMG-PEG2000-Mal is a pegylated lipid with a molecular weight of 2000. DMG-PEG-Mal serves as a component of lipid nanoparticles for mRNA delivery .

HY-171306

MK16		Cationic Lipids
MK16 is a lipid material that can be used to construct blood-brain barrier penetrable lipid nanoparticles for mRNA delivery. MK16 facilitates blood-brain barrier crossing via γ-secretase-mediated and caveolae-mediated transcytosis. MK16 can be used for drug delivery research .

HY-142977

6-Oxohexyl 2-hexyldecanoate, 80% (ELSD)		Phospholipids
6-Oxohexyl 2-hexyldecanoate, 80% (ELSD) is an intermediate in the synthesis of ALC-0315. 6-Oxohexyl 2-hexyldecanoate, 80% (ELSD) can be used in research on drug delivery, such as mRNA delivery .

HY-W440896

DSPE-PEG2000-SH		Pegylated Lipids
DSPE-PEG2000-SH is an amphiphilic thiol-functionalized DSPE-PEG molecule. DSPE-PEG2000-SH inserts into extracellular vesicle (EV) bilayer membranes via hydrophobic interactions, displaying surface thiol groups to form EV-SH crosslinkers.DSPE-PEG2000-SH enables crosslinking of EV-SH with 8-arm PEG-norbornene via thiol-ene photochemistry to construct hydrogels, with hydrogel mechanical properties tunable via PEG segment molecular weight variation.DSPE-PEG2000-SH can be used to encapsulate agents for drug delivery system, such as mRNA vaccine .

HY-172723

DSPE-PEG2000-T7		Pegylated Lipids
DSPE-PEG2000-T7 is a PEGylated compound composed of DSPE and peptideT7. T7 (HAIYPRH) specifically binds to TfR. DSPE-PEG2000-T7 can be used to prepare T7-modified liposomes, where liposomes modified with both T7 and DA7R peptides can effectively co-deliver Doxorubicin (HY-15142A) and Vincristine (HY-N0488A) to gliomas. DSPE-PEG2000-T7 can also be used to prepare nanomodulators that mediate the co-delivery of tyrosine hydroxylase mRNA and interferon gene stimulator antagonists for synergistic intervention in Parkinson's disease .

HY-145795

OF-02		Cationic Lipids
OF-02 is an ionizable lipid for mRNA delivery and a key component of lipid nanoparticles (LNPs). OF-02 is protonated in the acidic endosomal environment to promote endosomal escape of mRNA and efficiently induce protein expression in target cells. OF-02 relies on the pH-responsive membrane fusion properties to form a complex with mRNA and destroy the endosomal membrane structure to achieve mRNA release in the cytoplasm. OF-02 is mainly used in the development of mRNA vaccines, gene editing, and protein replacement therapy[1][2][3].

HY-153229

Firefly luciferase mRNA-LNP 1 Publications Verification		mRNA Liposome
Firefly luciferase mRNA-LNP is a lipid nanoparticle (LNP) containing firefly luciferase mRNA. Firefly luciferase mRNA-LNP exhibits a stable nanostructure, in which LNP plays a key role in effectively protecting and transporting mRNA to cells. Luciferase is a bioluminescent reporter gene for gene regulation and functional studies. Firefly Luciferase mRNA-LNP expresses firefly luciferase protein after entering the cells, which is often used for promoter activity detection or dual fluorescent molecular complementation experiments. Firefly luciferase mRNA-LNP is studied in research for RNA delivery, cell viability, and translation efficiency .

HY-46759

Genevant CL1		Cationic Lipids
Genevant CL1 is an ionizable lipid (pKa = 6.3) suitable for the preparation of lipid nanoparticles (LNPs) for delivering nucleic acid payloads and intramuscular vaccines. Genevant CL1 is a component of lipid nanoparticle delivery systems for mRNA vaccines .

HY-174497

eGFP mRNA		mRNA Reporter Genes
eGFP mRNA expresses green fluorescent protein derived from the jellyfish Aequorea victoria. eGFP is a commonly used direct-detection reporter gene in mammalian cell culture, which produces bright green fluorescence. This product is synthesized without modified nucleosides, with a Cap1 version cap analog at the 5' end and a 100nt PolyA tail at the 3' end. It can be used as a positive reference for IVT (in vitro transcription) or LNP delivery systems.

HY-148049

TT3		Cationic Lipids
TT3 is an ionizable lipid-like material and a lipid nanoparticle (LLNs)-based mRNA delivery vector. TT3 exhibits liver and spleen specificity and excellent delivery efficiency .

HY-W590532

306-O12B 1 Publications Verification		Cationic Lipids
306-O12B is an ionizable cationic lipid used to prepare lipid nanoparticles (LNPs) for the delivery of mRNA .

HY-153080

Firefly Luciferase mRNA(N1-Me-Pseudo UTP)		mRNA
Firefly Luciferase mRNA (N1-Me-Pseudo UTP) is a modified form of firefly luciferase mRNA, which is N1-methylated pseudo uridine (N1-Me-Pseudo UTP). Firefly Luciferase mRNA (N1-Me-Pseudo UTP) is a commonly used reporter molecule in biomedical and mRNA research and its core function is to rapidly and quantitatively monitor the expression and delivery efficiency of mRNA through the emission of light signals .

HY-150229

306-N16B		Cationic Lipids
306-N16B is a selective lung-targeted lipid nanoparticle that reversibly targets lung endothelial cells and specific immune cells through selective adsorption of a protein corona mediated by differences in tail structure (such as fibrinogen β/γ chain). 306-N16B binds to specific plasma proteins in the blood to form a protein corona, which guides the particles to be enriched in the lungs, releases mRNA and promotes target cell gene expression, exerts efficient lung cell transfection activity, and can precisely regulate gene delivery of different cell types in the lungs (such as endothelial cells and macrophages). 306-N16B can be used in gene therapy technologies for hereditary lung diseases including pulmonary lymphangioleiomyomatosis (LAM), restoring tumor suppressor function by delivering Tsc2 mRNA, and can also be used for lung-specific mRNA vaccines and gene editing therapies .

HY-145793

FTT5 2 Publications Verification		Cationic Lipids
FTT5 is an ionizable lipid that can be used to prepare lipid nanoparticles for efficient delivery of long-chain mRNA in vivo .

HY-138622

24:0 Lyso PC		Phospholipids
24:0 Lyso PC is a lysophospholipid (LyP). 24:0 Lyso PC could be used for mRNA drug delivery .

HY-159726

C10-200		Cationic Lipids
C10-200 is an ionizable cationic lipid that can be used to generate lipid nanoparticles (LNPs). C10-200 is used in the study of mRNA delivery .

HY-148855

OF-C4-Deg-Lin		Cationic Lipids
OF-C4-Deg-Lin is an ionizable lipid with varied linker lengths. OF-C4-Deg-Lin can be used in the generation of lipid nanoparticles (LNPs) for the delivery of siRNA and mRNA .

HY-153235

COVID-19 Spike Protein mRNA-LNP		mRNA Liposome Antigens
COVID-19 Spike Protein mRNA-LNP is a lipid nanoparticle (LNP) containing *mRNA* encoding COVID-19 Spike Protein. COVID-19 Spike Protein undertakes the functions of virus binding with host cell receptors, thereby mediating the entry of COVID-19 virus into cells. COVID-19 Spike Protein is an important site of action for host neutralizing antibodies and a key target for vaccine design. COVID-19 Spike Protein mRNA-LNP can be used for RNA delivery, vaccine formulation and design targeting SARS-CoV-2 .

HY-153879

C12-TLRa		Cationic Lipids
C12-TLRa is an ionized adjuvant lipid. C12-TLRa targets TLR7/8 receptors in endosomes. C12-TLRa enhances mRNA delivery as a structural component of LNPs. C12-TLRa enhances innate immune responses. C12-TLRa can be used for the research of SARS-CoV-2 mRNA vaccine .

HY-151509

A2-Iso5-2DC18		Cationic Lipids
A2-Iso5-2DC18 is a dihydroimidazole-linked lipid, served as potent mRNA delivery vehicle. A2-Iso5-2DC18 can be used for antitumor research, including B16F10 melanoma. .

HY-W441015A

DSPE-m-PEG3400-NHS		Pegylated Lipids
DSPE-m-PEG3400-NHS is a pegylated phospholipid derivatives which can be used to prepare liposome or lipid nanoparticles for targeted drug delivery system, such as DNA or mRNA vaccine .

HY-W590683

9A1P9		Cationic Lipids
9A1P9 is a multi-tail ionizable cationic phospholipid. 9A1P9 induces membrane destabilization. 9A1P9 can be used for mRNA delivery t .

HY-W590681

113-O12B		Cationic Lipids
113-O12B is a disulfide bond-containing ionizable cationic lipidoid. 113-O12B can be used in that generation of lipid nanoparticles (LNPs) for the delivery of mRNA .

HY-159700

AA3-DLin		Cationic Lipids
AA3-DLin is an ionizable cationic lipid with a pK_a value of 5.8. AA3-DLin is used to delivery mRNA combined with lipid nanoparticles (LNPs). AA3-DLin LNP COVID-19 vaccines encapsulating SARS CoV-2 spike mRNAs successfully induces strong immunogenicity in a BALB/c mouse model .

HY-164190

m7(3'Ma-Biotin)Gppp(2'OMe)ApG ammonium solution (25mM)		Cap Analogs
m7(3'Ma-Biotin)Gppp(2'OMe)ApG ammonium is a Biotin-labled cap analogue that can be used for mRNA synthesis. The efficiency of mRNA delivery can be determined by the detection of Biotin by flow cytometry, which can be used to track mRNA in cells and in living animals and to screen delivery lipid ratios.

HY-153231A

eGFP mRNA-LNP (500 ng/μL)		Liposome
eGFP mRNA-LNP (500 ng/μL) is a lipid nanoparticle (LNP) containing eGFP mRNA. eGFP mRNA-LNP carries Enhanced Green Fluorescent Protein (eGFP), which will express green fluorescent protein after entering the cell. eGFP is commonly used as a reporter gene detectable by fluorescence microscopy or flow cytometry (excitation wavelength = 488 nm; emission wavelength = 535/40 bandpass). eGFP mRNA-LNP can be used for RNA delivery, translation efficiency and cell viability .

HY-160554

C12-113		Cationic Lipids
C12-113 is a lipidoid delivery agent that can be used to transfect siRNA into cells. C12-113 can also be combined with other lipids to form lipid nanoparticles (LNPs) for the delivery of mRNA encoding the spike glycoprotein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in mice .

HY-153372

93-O17S		Cationic Lipids
93-O17S is an ionizable lipid. 93-O17S is involved in the construction of LNP. 93-O17S can achieve mRNA delivery to the spleen .

HY-W583869

1-Stearoyl-2-oleoyl-sn-glycerol-3-phosphoethanolamine 1-Stearoyl-2-Oleoyl-sn-glycero-3-PE; 18:0-18:1 PE; PE(18:0/18:1)		Phospholipids
1-Stearoyl-2-oleoyl-sn-glycerol-3-phosphoethanolamine is a phospholipids that contains stearic acid and oleic acid at the sn-1 and sn-2 positions, respectively. It has been used in the generation of lipid nanoparticles (LNPs) for in vitro delivery of mRNA or nuclear-targeted plasmid DNA.

HY-143700

18:0 DAP		Cationic Lipids
18:0 DAP is a cationic or ionizable lipid with no unsaturated bonds in its hydrocarbon chain. The mRNA encapsulation efficiency of 18:0 DAP is 0%. 18:0 DAP cannot form functional lipid nanoparticles suitable for mRNA delivery .

HY-148363

Heptadecan-9-yl 8-((6-(decyloxy)-6-oxohexyl)(2-hydroxyethyl)amino)octanoate		Cationic Lipids
Heptadecan-9-yl 8-((6-(decyloxy)-6-oxohexyl)(2-hydroxyethyl)amino)octanoate can be used in lipid nanoparticles (LNP) delivery systems for mRNA vaccine delivery .

HY-151511

A12-Iso5-2DC18		Cationic Lipids
A12-Iso5-2DC18, an ionizable cationic lipid, is a potent mRNA delivery lipid vehicle .

HY-W440895

DSPE-PEG1000-SH		Pegylated Lipids
DSPE-PEG1000-SH is an amphiphilic poly-PEG that can form lipid bilayers in water. This amphiphilic polymer can form lipid bilayers in aqueous solution and can be used to embed active molecules for drug delivery systems such as mRNA vaccines.

HY-W440910

DSPE-PEG5000-Cy3		Pegylated Lipids Fluorescent Lipids
DSPE-PEG5000-Cy3 is a phospholipid PEG polymer with Cy3 dye used in labeling and fluorescence microscopy. The polymer can self-assemble in aqueous solution to form micelles/lipid bilayer and used to prepare liposomes or nanoparticles for nutrients delivery such as mRNA or DNA vaccine.

HY-159709

VL-422		Cationic Lipids
VL-422 is an ionizable cationic lipid. VL-422 delivers CRISPR complementary single-guide RNA (sgRNA) and Cas9 mRNA to enable in vitro and in vivo gene editing. LNPs containing VL-422 loaded with Cas9 mRNA and sgRNA targeting the ANGPTL3 gene induce the deletion of premature stop codons within the ANGPTL3 gene in the liver of cynomolgus monkeys. Loss-of-function of ANGPTL3 leads to decreased levels of LDL, HDL and cholesterol in plasma. The VL-422 delivery system can be used for the research of gene editing strategies targeting lipid metabolism diseases .

HY-177531

S-Ac7-DOg		Cationic Lipids
S-Ac7-DOG is a cationic lipid with biodegradability, low immunogenicity and high nucleic acid transfection capacity, which is commonly used to construct lipid nanoparticles for nucleic acid molecule delivery. S-Ac7-DOG can bind to mRNA, microRNA and self-amplifying RNA through electrostatic interaction. Lipid nanoparticles formed by S-Ac7-DOG enter cells via an energy-dependent endocytic pathway, release nucleic acid cargos, induce antigen-specific CD8 ⁺ T cell responses, promote the generation of precursor memory T cells, and regulate neuroinflammatory pathways. S-Ac7-DOG can be used in the research of retinal diseases, neuroinflammation and cancer .

HY-156985

Lipid AX4		Cationic Lipids
Lipid AX4 is an ionizable cationic lipid with the _pK_a of 6.89， and can be used the study for the formation of lipid nanoparticles (LNPs) for the delivery of mRNA in vivo .

HY-156448

80-O14B 1 Publications Verification		Cationic Lipids
80-O14B is a cationic lipid-like compound. 80-O14B can be used in mRNA delivery studies .

HY-151512

A12-Iso5-4DC19		Cationic Lipids
A12-Iso5-4DC19 is an ionizable cationic lipid. A12-Iso5-4DC19 can facilitate mRNA delivery and be used for the research of RNA vaccines .

HY-W440912

DSPE-PEG3400-Cy5		Pegylated Lipids Fluorescent Lipids
DSPE-PEG3400-Cy5 is a PEG phospholipid with Cy5 dye used in protein/nucelic acid labeling and fluorescence microscopy. The polymer can self-assemble in aqueous solution to form micelles/lipid bilayer and used to prepare liposomes or nanoparticles for nutrients delivery such as mRNA or DNA vaccine.

HY-176753

Lipid 20b		Cationic Lipids
Lipid 20b is a thiophene ionizable cationic lipid. Lipid 20 b can be used to generate lipid nanoparticles (LNPs) for the delivery of mRNA in vivo. Lipid 20b can be studied in research for enhancing mRNA vaccine delivery and transfection efficacy .

HY-164189

m7(3'Ma-Cy3)Gppp(2'OMe)ApG ammonium		Cap Analogs
m7(3'Ma-Cy3)Gppp(2'OMe)ApG ammonium is a Cy3-labled cap analogue that can be used for mRNA synthesis. The efficiency of mRNA delivery can be determined by the detection of Cy3 by flow cytometry, which can be used to track mRNA in cells and in living animals and to screen delivery lipid ratios.

HY-172018

CP-LC-0729		Cationic Lipids
CP-LC-0729 is an ionizable cationic amino lipid efficient delivery of different kinds of RNA (mRNA, cRNA and saRNA) .

HY-171896

A28-C6B2		Cationic Lipids
A28-C6B2 is an ionizable cationic lipid with a pK_a of 6.43, and can be used to generate lipid nanoparticles (LNPs) for mRNA delivery in vivo. A28-C6B2 can be studied in research for enhancing the selective delivery of mRNA to the spleen, particularly to antigen-presenting cells .

Targets Recommended: mRNA

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-138170GL

ALC-0315 (GMP Like)	Liposome SARS-CoV	Infection
ALC-0315 (GMP Like) is ALC-0315 (HY-138170) produced by using GMP like guidelines. GMP Like small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. ALC-0315 is an ionisable aminolipid that is responsible for mRNA compaction and aids mRNA cellular delivery and its cytoplasmic release through suspected endosomal destabilization. ALC-0315 can be used to form lipid nanoparticle (LNP) delivery vehicles. Lipid-Nanoparticles have been used in the research of mRNA COVID-19 vaccine .

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