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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
10 Results for "
endothelial protection
" in MedChemExpress (MCE) Product Catalog:
Products (10)
10 Results for "endothelial protection" in MCE Product Catalog:
11
11 Publications Verification
Cat. No.: HY-P1929
CAS No.: 128270-60-0
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11
11 Publications Verification
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Research Areas:
4
4 Cited Publications
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AA147 is a endoplasmic reticulum (ER) proteostasis regulator. AA147 promotes protection against oxidative damage in neuronal cells and prevents endothelial barrier dysfunction by activating ATF6 arm (selectively) of the unfolded protein response (UPR) and the NRF2 oxidative stress response. AA147 can rebalances XBP1s expression in vivo, and also induces survival motor neuron (SMN) expression and spinal motorneuron (MN) protection .
3
3 Cited Publications
Synonyms: S1P1 agonist 3
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SAR247799 (S1P1 agonist 3) is an oral activity, selective G-protein-biased sphingosine-1 phosphate receptor-1 (S1P1 ) agonist, with EC50s rang from 12.6 to 493 nM in S1P1-overexpressing cells and HUVECs. SAR247799 can be used for the research of endothelial protection, including type-2 diabetes, metabolic syndrome .
3
3 Cited Publications
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LFHP-1c is an PGAM5 inhibitor with neuroprotective activity in brain ischemic stroke. LFHP-1c protects blood-brain barrier integrity from ischemia-induced injury. LFHP-1c binds to endothelial PGAM5 to inhibit the activity of PGAM5 phosphatase and the interaction of PGAM5 with NRF2. LFHP-1c exhibits in vitro and in vivo protection .
1
1 Cited Publications
Cat. No.: HY-W009749
CAS No.: 56-88-2
Category:
Cardiovascular Disease Human Gut Microbiota Metabolites Microorganisms Disease markers Endocrine diseases Amino acids Nervous System Disorder Endogenous metabolite Disease Research Fields
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1
1 Cited Publications
Cat. No.: HY-W009749C
CAS No.: 61125-50-6
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Cat. No.: HY-W104821
CAS No.: 603-45-2
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Keap1-Nrf2 Quinone Reductase PERK ATF6 Reactive Oxygen Species (ROS) Apoptosis SOD Glutathione Peroxidase
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Rosolic acid is a Michael acceptor molecule isolated from the rhizomes of Plantago asiatica L. Rosolic acid inhibits Keap1, promotes Nrf2 nuclear translocation, and upregulates HO-1 and NQO-1. Rosolic acid reduces ER stress markers PERK, ATF-6, GRP78, and CHOP, as well as oxidative stress, ROS production, inflammation, and apoptosis. Rosolic acid upregulates SOD, CAT, and GPx activities, induces angiogenesis and insulin secretion, and restores endothelial function and pancreatic beta cell protection under ER stress. Rosolic acid can be used in research on diabetes and endothelial dysfunction .
Cat. No.: HY-W009749R
CAS No.: 56-88-2
Cat. No.: HY-W009749CR
CAS No.: 61125-50-6
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
