603-45-2
Chemical Structure
Rosolic acid
- CAS No.: 603-45-2
- Formula:C19H14O3
- Molecular Weight:290.31
IUPAC Name: 4-(bis(4-hydroxyphenyl)methylene)cyclohexa-2,5-dien-1-one
InChIKey: FYEHYMARPSSOBO-UHFFFAOYSA-N
SMILES: C1=C(C=CC(=C1)O)C(=C2C=CC(=O)C=C2)C3=CC=C(C=C3)O
Biological Activity: Rosolic acid is a Michael acceptor molecule isolated from the rhizomes of Plantago asiatica L. Rosolic acid inhibits Keap1, promotes Nrf2 nuclear translocation, and upregulates HO-1 and NQO-1. Rosolic acid reduces ER stress markers PERK, ATF-6, GRP78, and CHOP, as well as oxidative stress, ROS production, inflammation, and apoptosis. Rosolic acid upregulates SOD, CAT, and GPx activities, induces angiogenesis and insulin secretion, and restores endothelial function and pancreatic beta cell protection under ER stress. Rosolic acid can be used in research on diabetes and endothelial dysfunction[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Rosolic acid | Rosolic acid is a Michael acceptor molecule isolated from the rhizomes of Plantago asiatica L. Rosolic acid inhibits Keap1, promotes Nrf2 nuclear translocation, and upregulates HO-1 and NQO-1. Rosolic acid reduces ER stress markers PERK, ATF-6, GRP78, and CHOP, as well as oxidative stress, ROS production, inflammation, and apoptosis. Rosolic acid upregulates SOD, CAT, and GPx activities, induces angiogenesis and insulin secretion, and restores endothelial function and pancreatic beta cell protection under ER stress. Rosolic acid can be used in research on diabetes and endothelial dysfunction. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. Amin KN, et al. Effect of Rosolic acid on endothelial dysfunction under ER stress in pancreatic microenvironment. Free radical research. 2021 Jun;55(6):698-713. [Content Brief]
- [2]. Amin KN, et al. Therapeutic Effect of Rosolic Acid against Endothelial Dysfunction in Diabetic Wistar Rats. Current medicinal chemistry. 2026;33(1):232-249.
- [3]. Foresti R, et al. Differential activation of heme oxygenase-1 by chalcones and rosolic acid in endothelial cells. The Journal of pharmacology and experimental therapeutics. 2005 Feb;312(2):686-93.
