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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
42 Results for "
epithelial barrier
" in MedChemExpress (MCE) Product Catalog:
Products (42)
42 Results for "epithelial barrier" in MCE Product Catalog:
4
Category:
Plants Endogenous metabolite Indole Alkaloids Alkaloids Human Gut Microbiota Metabolites Microorganisms Cruciferae Other Diseases Isatis tinctoria L. Disease Research Fields
Target:
2
Research Areas:
Tegoprazan (CJ-12420), a potassium-competitive acid blocker, is a reversible, orally active and highly selective inhibitor of gastric H +/K +-ATPase. Tegoprazan inhibits gastric acid secretion and motility against porcine, canine and human H +/K +-ATPase with IC50 values ranging from 0.29-0.52 μM in vitro. Tegoprazan significantly improves colitis and enhances the intestinal epithelial barrier function in mice. Tegoprazan is promising for research of Inflammatory bowel, gastric acid-related, motilityimpaired diseases .
2
Category:
Stilbenes Polygonaceae Rheum officinale Baill. Phenols Polyphenols Plants Disease Research Fields Cancer
Target:
1
1 Cited Publications
Cat. No.: HY-112624I
CAS No.: 9004-54-0
Synonyms: Dextran 3; Dextran D3; Dextran T3(MW 2400-3600)
1
1 Cited Publications
Cat. No.: HY-N0819
CAS No.: 89412-79-3
1
Category:
Flavonols Flavonoids Myrtaceae Phenols Polyphenols Plants Disease Research Fields Syzygium aromaticum Cancer
Target:
1
Research Areas:
Chlorothalonil is a broad-spectrum foliar fungicide with oral activity. Chlorothalonil can be used to combat fungal diseases in vegetable and crop leaves. Chlorothalonil can alter the microbial community in the soil. Chlorothalonil inhibits spermatogenesis. Chlorothalonil can cause intestinal epithelial barrier dysfunction and fetal toxicity .
1
1 Cited Publications
Cat. No.: HY-P1108A
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Research Areas:
1
1 Cited Publications
Cat. No.: HY-P1108
CAS No.: 681260-70-8
Target:
Research Areas:
Cat. No.: HY-W040203
CAS No.: 82494-09-5
Cat. No.: HY-W007376R
CAS No.: 487-89-8
Synonyms: 3-Formylindole (Standard)
Cat. No.: HY-170522
CAS No.: 2924181-80-4
Synonyms: ISM012-042
Target:
Research Areas:
Garutadustat (ISM012-042) is an orally active, selective inhibitor of PHD1 and PHD2, with IC50 values of 1.9 nM and 2.5 nM, respectively. Garutadustat stabilizes HIF1α protein in intestinal epithelial cells, thereby activating gene transcription programs associated with mucus production, tight junction formation, anti-inflammatory mediator generation and wound healing, which fundamentally promotes mucosal barrier repair and regulates intestinal immunity. Garutadustat can be used for the research of inflammatory bowel disease .
Cat. No.: HY-174976
CAS No.: 3076057-63-8
Target:
Research Areas:
FHND5032 is an orally active miR-124 inducer. FHND5032 significantly upregulates miR-124 expression in macrophages. FHND5032 disrupts inflammatory signaling, promotes macrophage reprogramming, and restores the epithelial barrier function by inhibiting the PIK3R2/PI3K/Akt axis. FHND5032 alleviates colitis and reduces inflammatory burden in ulcerative colitis mice. FHND5032 can be used for the study of ulcerative colitis .
Cat. No.: HY-N4031
CAS No.: 82375-29-9
Cat. No.: HY-W042337
CAS No.: 2581-34-2
Target:
Research Areas:
3-Methyl-4-nitrophenol, an environmental contaminant, is a well-known constituent of diesel exhaust particles and degradation products of insecticide fenitrothion. 3-Methyl-4-nitrophenol can induce nasal epithelial cell apoptosis and increase the permeability of the nasal epithelial barrier. 3-Methyl-4-nitrophenol is also toxic to the female reproductive system.
Cat. No.: HY-132818
CAS No.: 1416973-63-1
Synonyms: P-1037
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Research Areas:
Idrevloride, an epithelial sodium channel (ENaC) inhibitor (WO2016133967), can be used for the research of skin disorders .
Cat. No.: HY-P5755
Research Areas:
PARP-1-IN-2 (compound 11g) is a potent PARP1 inhibitor, with an IC50 of 149 nM, and ADME prediction indicates it has high blood-brain barrier permeability. PARP1-IN-2 shows significantly potent anti-proliferative activity against Human lung adenocarcinoma epithelial cell line A549. PARP1-IN-2 can induce A549 cells apoptosis .
Cat. No.: HY-Y1890B
CAS No.: 61791-12-6
Category:
Stilbenes Polygonaceae Rheum officinale Baill. Phenols Plants Disease Research Fields Cancer
Target:
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
