684234-55-7
684234-55-7
Chemical Structure
PARP-1-IN-2
- CAS No.: 684234-55-7
- Formula:C22H15Cl2N3O2
- Molecular Weight:424.28
IUPAC Name: 2-(2-chloro-5-hydroxyphenyl)acetic acid
InChIKey: ASIIOGZHCMSESG-UHFFFAOYSA-N
SMILES: O=C(NC1=CC=CC(Cl)=C1)CN(N=C(C2=CC=C(Cl)C=C2)C3=C4C=CC=C3)C4=O
Biological Activity: PARP-1-IN-2 (compound 11g) is a potent PARP1 inhibitor, with an IC50 of 149 nM, and ADME prediction indicates it has high blood-brain barrier permeability. PARP1-IN-2 shows significantly potent anti-proliferative activity against Human lung adenocarcinoma epithelial cell line A549. PARP1-IN-2 can induce A549 cells apoptosis[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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PARP-1-IN-2 | 99.48% | PARP-1-IN-2 (compound 11g) is a potent PARP1 inhibitor, with an IC50 of 149 nM, and ADME prediction indicates it has high blood-brain barrier permeability. PARP1-IN-2 shows significantly potent anti-proliferative activity against Human lung adenocarcinoma epithelial cell line A549. PARP1-IN-2 can induce A549 cells apoptosis. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.88
HY-153590PARP-1-IN-4 -
Similarity Score 0.85
HY-164713PARP1-IN-31 -
Similarity Score 0.74
HY-147030PARP1-IN-8 -
Similarity Score 0.58
HY-156585CNS-11 -
Similarity Score 0.57
HY-157250BHD -
Similarity Score 0.54
HY-15499K-832 -
Similarity Score 0.54
HY-100933MY-5445 -
Similarity Score 0.53
HY-163900Galectin-8N-IN-2 -
Similarity Score 0.53
HY-148000sEH inhibitor-6 -
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