684234-55-7
684234-55-7
Chemical Structure
PARP-1-IN-2
- CAS No.: 684234-55-7
- Formula:C22H15Cl2N3O2
- Molecular Weight:424.28
IUPAC Name: 2-(2-chloro-5-hydroxyphenyl)acetic acid
InChIKey: ASIIOGZHCMSESG-UHFFFAOYSA-N
SMILES: O=C(NC1=CC=CC(Cl)=C1)CN(N=C(C2=CC=C(Cl)C=C2)C3=C4C=CC=C3)C4=O
Biological Activity: PARP-1-IN-2 (compound 11g) is a potent PARP1 inhibitor, with an IC50 of 149 nM, and ADME prediction indicates it has high blood-brain barrier permeability. PARP1-IN-2 shows significantly potent anti-proliferative activity against Human lung adenocarcinoma epithelial cell line A549. PARP1-IN-2 can induce A549 cells apoptosis[1].
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PARP-1-IN-2 | 99.48% | PARP-1-IN-2 (compound 11g) is a potent PARP1 inhibitor, with an IC50 of 149 nM, and ADME prediction indicates it has high blood-brain barrier permeability. PARP1-IN-2 shows significantly potent anti-proliferative activity against Human lung adenocarcinoma epithelial cell line A549. PARP1-IN-2 can induce A549 cells apoptosis. | ||||||||||||||||||||
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References
Keywords
