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Results for "

exchange

" in MedChemExpress (MCE) Product Catalog:

By Targets:	SOS1 (7) Acyltransferase (1) Adenylate Cyclase (1) Aminopeptidase (1) Angiotensin Receptor (3) Anion Exchangers (2) Antibiotic (6) Apoptosis (10) Arf Family GTPase (1) Autophagy (9) Bacterial (10) Bcl-2 Family (1) Biochemical Assay Reagents (45) c-Fms (4) Calcium Channel (9) Calmodulin (3) Carbonic Anhydrase (1) CDK (1) CFTR (1) Chloride Channel (5) CMV (1) Connexin (1) COX (9) DNA Methyltransferase (5) DNA/RNA Synthesis (5) DOCK (2) Dopamine Receptor (1) Drug Derivative (6) Drug Intermediate (2) Drug Metabolite (1) Elastase (1) Endogenous Metabolite (5) Endothelin Receptor (1) Enterovirus (2) Environmental Pollutants (7) ERK (6) Eukaryotic Initiation Factor (eIF) (2) Exosomes (3) Ferroptosis (2) Fluorescent Dye (1) Fungal (3) GLUT (2) Hapten (1) HCV (1) HDAC (1) Herbicide (1) HIV (3) Interleukin Related (1) Isotope-Labeled Compounds (8) JAK (1) LPL Receptor (1) MDM-2/p53 (1) MEK (1) Mitogen- and Stress-Activated Protein Kinase (MSK) (1) Molecular Glues (1) Na+/Ca2+ Exchanger (24) Na+/H+ Exchanger (NHE) (40) Neuropeptide Y Receptor (2) NKCC (1) NO Synthase (6) NOD-like Receptor (NLR) (3) P2X Receptor (1) p38 MAPK (2) Parasite (3) PGE synthase (5) Phosphodiesterase (PDE) (2) PKA (3) PKC (1) PKG (1) Potassium Channel (10) Prostaglandin Receptor (5) PTHR (1) Pyroptosis (3) RAD51 (2) Ras (38) Reactive Oxygen Species (ROS) (7) Reference Standards (23) SHP2 (1) Sirtuin (1) SOD (1) Sodium Channel (11) STAT (1) TNF Receptor (1) Toll-like Receptor (TLR) (3) TRP Channel (4) Tyrosinase (1) VDAC (2) Wnt (6) β-catenin (3)
By Research Areas:	Cancer (69) Cardiovascular Disease (61) Endocrinology (5) Infection (15) Inflammation/Immunology (27) Metabolic Disease (32) Neurological Disease (31)
Click Chemistry:	Azide (1) Alkynes (4)

247

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

MCE Kits

Natural
Products

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Targets Recommended: SOS1

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-D0086

DIDS sodium salt 20+ Cited Publications MDL101114ZA	VDAC RAD51	Cancer
DIDS sodium salt (MDL101114ZA) is a dual inhibitor of ABCA1 and VDAC1. DIDS also inhibits RAD51, inhibiting RAD51-mediated homologous pairing and strand exchange reactions. DIDS inhibits anion exchange and binding to red blood cell membranes, inhibits the activation of caspase-3 and -9, and can be used in cancer research .

HY-101044

PPADS tetrasodium 5+ Cited Publications	P2X Receptor Na+/Ca2+ Exchanger	Neurological Disease
PPADS tetrasodiuma is a non-selective P2X receptor antagonist. PPADS tetrasodiuma blocks recombinant P2X1, -2, -3, -5 with IC₅₀s ranging from 1 to 2.6 μM. PPADS tetrasodiuma blocks native P2Y2-like (IC₅₀~0.9 mM) and recombinant P2Y4 (IC₅₀~15 mM) receptors. PPADS tetrasodiuma is an inhibitor of the reverse mode of the Na/Ca ²⁺ exchanger in guinea pig airway smooth muscle .

HY-19693

Cariporide 10+ Cited Publications HOE-642 Free Base	Na+/H+ Exchanger (NHE)	Cardiovascular Disease Inflammation/Immunology Cancer
Cariporide (HOE-642) is a selective Na ⁺/H ⁺ exchange inhibitor.

HY-15754

CGP37157 5+ Cited Publications	Na+/Ca2+ Exchanger	Neurological Disease Cancer
CGP37157 is a potent, selective inhibitor of Na ⁺/Ca ²⁺ exchanger, inhibiting the Na ⁺-induced Ca ²⁺-release from guinea-pig heart mitochondria, with an IC₅₀ of 0.8 μM.

HY-15515

SEA0400 15+ Cited Publications	Na+/Ca2+ Exchanger	Cardiovascular Disease
SEA0400 is a novel and selective inhibitor of the Na ⁺-Ca ²⁺ exchanger (NCX), inhibiting Na ⁺-dependent Ca ²⁺ uptake in cultured neurons, astrocytes, and microglia with IC₅₀s of from 5 to 33 nM.

HY-117656

ESI-05 4 Publications Verification NSC 116966	Acyltransferase	Neurological Disease Metabolic Disease
ESI-05 is a specific exchange proteins directly activated by cAMP 2 (EPAC2) inhibitor. ESI-05 inhibits cAMP-mediated EPAC2 GEF activity with an IC₅₀ of 0.43 μM. ESI-05 can be used for the research of diabetes, insulin secretion and neurological disorders .

HY-W076836

4-Aminobenzaldehyde p-aminobenzaldehyde	Biochemical Assay Reagents	Others
4-Aminobenzaldehyde (p-aminobenzaldehyde) is a useful synthetic reagent and monomer that can be used to synthesize monoazo dyes and photocurable ion exchange resins. 4-Aminobenzaldehyde is also a corrosion inhibitor of metals .

HY-19273

Rimeporide 4 Publications Verification EMD-87580	Na+/H+ Exchanger (NHE)	Metabolic Disease
Rimeporide (EMD-87580) is a potent and selective inhibitor of the Na ⁺/H ⁺ exchanger (NHE-1).

HY-153128

DOCK2-IN-1	DOCK Drug Derivative	Inflammation/Immunology
DOCK2-IN-1 (Compound 3) is an analog of CPYPP (HY-110100) and a DOCK2 inhibitor (IC₅₀ = 19.1 μM). DOCK2-IN-1 binds to the DHR-2 domain of DOCK2 and inhibits its mediated Rac guanine nucleotide exchange factor activity. DOCK2-IN-1 blocks chemokine receptor- and antigen receptor-mediated activation of Rac in lymphocytes. DOCK2-IN-1 significantly inhibits chemotaxis and T cell activation. DOCK2-IN-1 can be used in the research of transplant rejection and organ-specific autoimmune diseases .

HY-B0684

Iopamidol 3 Publications Verification B-15000; SQ-13396	Biochemical Assay Reagents	Cancer
Iopamidol is a nonionic, X-Ray iodinated contrast agent (CA) for a wide variety of diagnostic applications. Iopamidol contains amide and hydroxyl functionalities that can be exploited for the generation of the chemical exchange saturation transfer (CEST) contrast .

HY-112939

Colestilan MCI-196; Colestimide	Biochemical Assay Reagents	Metabolic Disease
Colestilan (MCI-196) is a non-absorbed, non-calcium-based phosphate binder and is also a non-metallic, anion exchange resin. Colestilan is orally active and can be used for hypercholesterolaemia research .

HY-119572

Sodium zirconium cyclosilicate	Biochemical Assay Reagents	Inflammation/Immunology
Sodium zirconium cyclosilicate is an orally administered, non-absorbed, novel, inorganic microporous zirconium silicate compound, is a highly selective cation exchanger that selectively removes excess K ⁺ in vivo. Sodium zirconium cyclosilicate can be used in research of chronic kidney disease (CKD) .

HY-Y0286

Ammonium carbonate, 99% Hartshorn salt, 99%	Environmental Pollutants Biochemical Assay Reagents	Others
Ammonium carbonate (Ammonium carbonate), 99% is a solid amino compound that functions as a buffer, pH regulator, pore-forming agent, and electrocatalytic oxidation substrate. Ammonium carbonate, 99% is a GRAS-grade direct food additive with no restricted daily intake specified by FAO/WHO, and it shows no acute skin toxicity, clinical signs of toxicity, or effects on body weight in rats. Ammonium carbonate, 99% undergoes electrocatalytic oxidation in alkaline solutions with a Pt/C catalyst (carbonate adsorption interferes with activity). Ammonium carbonate, 99% can serve as a fuel for low-temperature polymer fuel cells and anion exchange membrane fuel cells (with performance superior to pure ammonia), and can also form pores in the carrier-free Pt cathode catalyst layer after low-temperature decomposition, thereby enhancing catalyst activity under low-humidity conditions and the performance of proton exchange membrane fuel cells .

HY-P3205

Lysyl endopeptidase, Achromobacter sp 1 Publications Verification Lys-C	Biochemical Assay Reagents	Others
Lysyl endopeptidase, Achromobacter sp (Lys-C) catalyzes carboxyl oxygen exchange reaction. Lysyl endopeptidase has higher substrate binding affinities and higher catalytic rates at the acidic pHs than at the alkaline pHs .

HY-121693

DIDS MDL101114ZA free base	VDAC RAD51	Cancer
DIDS is a dual inhibitor of ABCA1 and VDAC1. DIDS also inhibits RAD51, inhibiting RAD51-mediated homologous pairing and strand exchange reactions. DIDS inhibits anion exchange and binding to red blood cell membranes, inhibits the activation of caspase-3 and -9, and can be used in cancer research .

HY-146243

TH-Z835	Ras Apoptosis	Cancer
TH-Z835 is a mutant selective KRAS (G12D) inhibitor with an IC₅₀ of 1.6 μM. TH-Z835 inhibits both mantGMPPNP/GPPNP exchange and GPPNP/mantGMPPNP exchange .

HY-W046325

DEAE-Cellulose Diethylaminoethyl cellulose	Biochemical Assay Reagents	Others
DEAE-Cellulose (Diethylaminoethyl cellulose), a common biopolymer derivative. DEAE-Cellulose is a weakly basic cellulose anion exchanger .

HY-117958

HJC0197 1 Publications Verification	Ras	Cardiovascular Disease Metabolic Disease Cancer
HJC0197 is a potent Epac1 (exchange protein directly activated by cAMP 1) and Epac2 (IC₅₀=5.9 μM for Epac2) antagonist. HJC0197 selectively blocks cAMP-induced Epac activation. HJC0197 inhibits Epac1-mediated Rap1-GDP exchange activity at 25 μM in the presence of equal concentration of cAMP .

HY-136182A

YM-244769	Na+/Ca2+ Exchanger	Cardiovascular Disease Neurological Disease
YM-244769 is a potent, selective and orally active Na ⁺/Ca ²⁺ exchanger (NCX) inhibitor. YM-244769 preferentially inhibits NCX3 and suppresses the unidirectional outward NCX current (Ca ²⁺ entry mode), with IC₅₀s of 18 nM and 50 nM, respectively. YM-244769 efficiently protects against hypoxia/reoxygenation-induced SH-SY5Y neuronal cell damage. YM-244769 can also increase urine volume and urinary excretion of electrolytes in mice .

HY-106150B

Eniporide hydrochloride 1 Publications Verification EMD-96785 hydrochloride	Na+/H+ Exchanger (NHE)	Cardiovascular Disease
Eniporide hydrochloride (EMD-96785 hydrochloride) is a potent Na ⁺/H ⁺ exchange inhibitor.

HY-E70095

T4 UvsY Protein	Others	Others
T4 UvsY Protein is an accessory protein for in vitro catalysis of strand exchange. T4 UvsY Protein enhances strand exchange by UvsX protein by interacting specifically with UvsX protein. UvsY protein enhances the rate of single-stranded-DNA-dependent ATP hydrolysis by UvsX protein .

HY-W009062

MePhos	Biochemical Assay Reagents	Others
MePhos is an o-BPP ligand. The combination of MePhos and silver carbonate serves as a catalyst for H/D exchange reactions .

HY-128678

ORM-10103	Na+/Ca2+ Exchanger	Cardiovascular Disease
ORM-10103 is a specific inhibitor of the *Na+/Ca2+ exchanger* (NCX), which decreases the NCX current with estimated IC₅₀**s of 55 and 67 nM at -80 and at 20 mV, respectively .

HY-W015987

9-Fluorenylmethyl carbamate Fmoc-NH2	Biochemical Assay Reagents	Others
9-Fluorenylmethyl carbamate (Fmoc-NH2) is an amide compound with an Fmoc protecting group, which can be used as a photobase initiator to prepare organosilane-based proton exchange membranes .

HY-154912

PAT1inh-B01	Chloride Channel	Inflammation/Immunology
PAT1inh-B01 is a selective SLC26A6 inhibitor. PAT1inh-B01 inhibits PAT1 (a Cl ^-/HCO3 ^- exchanger)-mediated anion exchange (IC₅₀: 350 nM). PAT1inh-B01 blocks fluid absorption in small intestine. PAT1inh-B01 can be used for research of small intestinal hyposecretory disorders .

HY-139337

SMCy5.5	Fluorescent Dye	Others
SMCy5.5 is a SMCy dye (ex. 638 nm; em. 705 nm). The high brightness of SMCy5.5 allows for effective tracking and imaging of lipid droplet exchange between adipocytes. SMCy5.5 can be used for lipid droplet labeling studies .

HY-A0236

Aprindine	Sodium Channel Potassium Channel Calcium Channel Calmodulin	Cardiovascular Disease
Aprindine is an Ib-class anti-arrhythmic agent. Aprindine mainly exerts its effect by blocking sodium channels (I_Na), thereby reducing the excitability and conduction velocity of cardiac muscle cells. Aprindine significantly inhibits delayed potassium currents, which helps to prolong the atrial effective refractory period (AERP) and inhibit the occurrence of atrial fibrillation. Aprindine can also regulate intracellular calcium ion concentration by inhibiting Na ⁺/Ca ²⁺ exchange current (INCX), thereby further stabilizing cardiac electrical activity. Aprindine can be used for the study of atrial fibrillation (AF) and ventricular arrhythmias .

HY-139313

NHE3-IN-2	Na+/H+ Exchanger (NHE)	Metabolic Disease
NHE3-IN-2 is a *Na ⁺/H ⁺ exchanger-3 (NHE3)* inhibitor ( patent WO2001079186A1, example 6-Chlor-4-phenyl-2-chinazolinyl-guanidin) .

HY-100298

Caldaret MCC-135	Na+/Ca2+ Exchanger	Cardiovascular Disease
Caldaret is an intracellular Ca ²⁺ handling modulator that acts through reverse mode Na ⁺/Ca ²⁺ exchanger inhibition.

HY-168735

SLC26A4-IN-1	Chloride Channel	Others
SLC26A4-IN-1 (compound 1a) is a pendrin/SLC26A4 inhibitor. pendrin is a Cl ^-/HCO₃ ^- exchanger .

HY-154912A

PAT1inh-B01 hydrochloride	Chloride Channel	Inflammation/Immunology
PAT1inh-B01 hydrocholide is a selective SLC26A6 inhibitor. PAT1inh-B01 hydrocholide inhibits PAT1 (a Cl ^-/HCO3 ^- exchanger)-mediated anion exchange (IC₅₀: 350 nM). PAT1inh-B01 hydrocholide blocks fluid absorption in small intestine. PAT1inh-B01 hydrocholide can be used for research of small intestinal hyposecretory disorders .

HY-138665

HHS-0701	Prostaglandin Receptor	Endocrinology
HHS-0701, a sulfur-triazole exchange (SuTEx) ligand, is a potent tyrosine-reactive prostaglandin reductase 2 (PTGR2) inhibitor. HHS-0701 blocks PTGR2 metabolism of the lipid substrate 15-Keto-PGE2 .

HY-136182

YM-244769 dihydrochloride	Na+/Ca2+ Exchanger	Cardiovascular Disease Neurological Disease
YM-244769 dihydrochloride is a potent, selective and orally active Na ⁺/Ca ²⁺ exchanger (NCX) inhibitor. YM-244769 dihydrochloride preferentially inhibits NCX3 and suppresses the unidirectional outward NCX current (Ca ²⁺ entry mode), with IC₅₀s of 18 nM and 50 nM, respectively. YM-244769 dihydrochloride efficiently protects against hypoxia/reoxygenation-induced SH-SY5Y neuronal cell damage. YM-244769 dihydrochloride can also increase urine volume and urinary excretion of electrolytes in mice .

HY-118778

KR-32568	Na+/H+ Exchanger (NHE)	Cardiovascular Disease
KR-32568 is a *sodium/hydrogen exchanger-1 (NHE-1)* inhibitor with an IC₅₀ of 230 nM. KR-32568 has cardioprotective effects .

HY-A0236A

Aprindine hydrochloride	Sodium Channel Potassium Channel Calcium Channel Calmodulin	Cardiovascular Disease
Aprindine hydrochloride is an Ib-class anti-arrhythmic agent. Aprindine hydrochloride mainly exerts its effect by blocking sodium channels (I_Na), thereby reducing the excitability and conduction velocity of cardiac muscle cells. Aprindine hydrochloride significantly inhibits delayed potassium currents, which helps to prolong the atrial effective refractory period (AERP) and inhibit the occurrence of atrial fibrillation. Aprindine hydrochloride can also regulate intracellular calcium ion concentration by inhibiting Na ⁺/Ca ²⁺ exchange current (INCX), thereby further stabilizing cardiac electrical activity. Aprindine hydrochloride can be used for the study of atrial fibrillation (AF) and ventricular arrhythmias .

HY-173517

NHE-1-IN-2	Na+/H+ Exchanger (NHE)	Neurological Disease
NHE-1-IN-2 (compound 7g) is a potent NHE-1 inhibitor with an IC₅₀ of 0.78 μM. NHE-1-IN-2 alleviates left ventricular systolic dysfunction in mice model of heart failure .

HY-109560

Pentetate zinc trisodium Zn-DTPA trisodium	Biochemical Assay Reagents	Others
Pentetate zinc trisodium (Zn-DTPA trisodium) forms stable chelates with metal ions by exchanging zinc for a metal of greater binding capacity .

HY-100325

NHE3-IN-1	Na+/H+ Exchanger (NHE)	Neurological Disease
NHE3-IN-1 is a *sodium/proton exchanger* type 3 (NHE-3)** inhibitor extracted from patent WO 2011019784 A1.

HY-19273R

Rimeporide (Standard) EMD-87580 (Standard)	Na+/H+ Exchanger (NHE) Reference Standards	Metabolic Disease
Rimeporide (Standard) is the analytical standard of Rimeporide. This product is intended for research and analytical applications. Rimeporide (EMD-87580) is a potent and selective inhibitor of the Na+/H+ exchanger (NHE-1).

HY-107659

YM-244769 hydrochloride	Na+/Ca2+ Exchanger	Cardiovascular Disease Neurological Disease
YM-244769 hydrochloride is a potent, selective and orally active Na ⁺/Ca ²⁺ exchanger (NCX) inhibitor. YM-244769 hydrochloride preferentially inhibits NCX3 and suppresses the unidirectional outward NCX current (Ca ²⁺ entry mode), with IC₅₀s of 18 nM and 50 nM, respectively. YM-244769 hydrochloride efficiently protects against hypoxia/reoxygenation-induced SH-SY5Y neuronal cell damage. YM-244769 hydrochloride can also increase urine volume and urinary excretion of electrolytes in mice .

HY-141490

Beta-D-Glucopyranosyl nitromethane	Drug Derivative	Others
Beta-D-Glucopyranosyl nitromethane, as a salt of a strongly basic anion exchanger in the OH cycle, is a glycosyl derivative of nitromethane .

HY-P4856

pTH-Related Protein (1-40) (human, mouse, rat)	PTHR PKC	Endocrinology
pTH-Related Protein (1-40) (human, mouse, rat) stimulates calcium uptake in rat intestinal cells through PTHR1 receptor and PKCα/β signaling pathways. pTH-Related Protein (1-40) up-regulates parathyroid hormone 1 receptor (PTHR1) protein, four transcellular calcium transporters, potential vanillin member 6 (TRPV6), calcium-binding protein-D9K (CaBP-D9k), sodium-calcium Exchanger 1 (NCX1) and plasma membrane calcium ATPase 1 (PMCA1) .

HY-157236

*AEX Anion-exchange* resin 1**	Biochemical Assay Reagents	Others
AEX Anion-exchange resin 1 is a strong anion exchange chromatography resin, based on monodisperse polystyrene/divinylbenzene (PS-DVB), with a particle size of 50 μm and an ionic ligand of –CH₂N ⁺ (CH₃)₃. AEX Anion-exchange resin 1 can be used for the separation and purification of biological macromolecules such as proteins, antibodies, and viral vaccines.

HY-177125

Repunapanor	Na+/H+ Exchanger (NHE)	Neurological Disease
Repunapanor (compound 123) is a potent *Na+/H+ exchanger* 3 (NHE-3)** inhibitor .

HY-105402

T 162559	Na+/H+ Exchanger (NHE)	Cardiovascular Disease
T 162559 is a potent and selective inhibitor of the Na+/H+ exchanger isoform NHE1 with IC₅₀ values of 0.96 nM. T 162559 does not affect Na+/HCO3- cotransport and Na+/Ca2+ exchange. T 162559 can be used for the research of cardiovascular disease .

HY-120816

WU-07047	Calcium Channel	Cardiovascular Disease
WU-07047, a simplified analog of YM-254890 (HY-111557), is a selective Gαq/11 inhibitor. WU-07047 can inhibit nucleotide exchange .

HY-117064

NY-0173	Ras	Others
NY-0173 is an antagonist of Exchange proteins directly activated by cAMP (EPAC), with IC₅₀s of 3.5 μM (EPAC2)and 4.0 μM (EPAC1) respectively. NY-0173 can be used to elucidate the biological functions of EPAC .

HY-W739372A

Polysodium 4-styrenesulfonate (MW 70000)	Biochemical Assay Reagents	Others
Poly(sodium 4-styrenesulfonate) (MW 70000) is an ion exchange exchange polyelectrolyte .

HY-N10156

1,3,5-Trihydroxy-4-prenylxanthone	Na+/H+ Exchanger (NHE) Phosphodiesterase (PDE) NO Synthase	Inflammation/Immunology
1,3,5-Trihydroxy-4-prenylxanthone is a *Na ⁺/H ⁺ exchange* system inhibitor with a minimum inhibitory concentration of 10 μg/mL . 1,3,5-Trihydroxy-4-prenylxanthone is a phosphodiesterase type 5 (PDE5) inhibitor with an IC₅₀** value of 3.0 μM . 1,3,5-Trihydroxy-4-prenylxanthone inhibits Lipopolysaccharide (LPS) (HY-D1056)-induced NO production in RAW264.7 macrophages, and has anti-inflammatory activities .

HY-107959

Colestipol hydrochloride	Biochemical Assay Reagents
Colestipol hydrochloride, a hypocholesterolemic bile acid‐binding anion‐exchange polymer, is used in the study of hypercholesterolaemia .

Cat. No.	Product Name	Type

HY-D0086

DIDS sodium salt 20+ Cited Publications MDL101114ZA	Fluorescent Dye
DIDS sodium salt (MDL101114ZA) is a dual inhibitor of ABCA1 and VDAC1. DIDS also inhibits RAD51, inhibiting RAD51-mediated homologous pairing and strand exchange reactions. DIDS inhibits anion exchange and binding to red blood cell membranes, inhibits the activation of caspase-3 and -9, and can be used in cancer research .

HY-139337

SMCy5.5	Fluorescent Dye
SMCy5.5 is a SMCy dye (ex. 638 nm; em. 705 nm). The high brightness of SMCy5.5 allows for effective tracking and imaging of lipid droplet exchange between adipocytes. SMCy5.5 can be used for lipid droplet labeling studies .

Cat. No.	Product Name	Type

HY-12495A

ISRIB

25+ Cited Publications

Biochemical Assay Reagents

ISRIB is a brain-penetrant inhibitor of integrated stress response (ISR). Persistent activation of the ISR has been linked to the development of several neurological disorders as ISR represses translation through inhibiting eIF2B. ISRIB inhibits the ISR by promoting the nucleotide exchange activity of eIF2B and recovering the translation, and thus can be used for neurological disorders research .

HY-112624L

Dextran T10 (MW 10,000) Dextran 10; Dextran D10; Dextran T10(MW 8000-12000)	Biochemical Assay Reagents
Dextran T10 (MW 10,000) (Dextran 10) is a dehydrated glucose polymer with an average molecular weight of 10,000. Dextran T10 (MW 10,000) is composed of repeated glucose units, and it has abundant hydroxyl (-OH) groups, which can be used as a natural "magnetic marker" for chemical exchange saturation transfer (CEST) MRI imaging .

HY-W134327A

DEAE-dextran (MW 500000)

Diethylaminoethyl dextran (MW 500000)

Biochemical Assay Reagents

DEAE-Dextran (MW 500000) is a complex carbohydrate polymer consisting of glucose molecules linked by glycosidic bonds and modified with diethylaminoethyl (DEAE) groups. DEAE-Dextran is a cationic molecule that can be used as a transfection reagent to deliver nucleic acids such as DNA or RNA into cells. Its positive charge interacts with negatively charged cell membranes, facilitating the uptake of nucleic acids. DEAE-Dextran can also be used as an ion-exchange chromatography resin, allowing the separation and purification of biomolecules based on their charge.

HY-W076836

4-Aminobenzaldehyde p-aminobenzaldehyde	Biochemical Assay Reagents
4-Aminobenzaldehyde (p-aminobenzaldehyde) is a useful synthetic reagent and monomer that can be used to synthesize monoazo dyes and photocurable ion exchange resins. 4-Aminobenzaldehyde is also a corrosion inhibitor of metals .

HY-D0877

TAPS

Biochemical Assay Reagents

TAPS is an aminosulfonate-based lysozyme stabilizer and connexin channel inhibitor. TAPS maintains the native structure of lysozyme in aqueous solution at pH 7.0 and significantly protects it from heat-induced denaturation. TAPS directly inhibits the activity of heteromeric connexin 32/connexin 26 channels (Cx32/Cx26) via its protonated form, and this inhibitory effect is dependent on the presence of connexin 26. TAPS reduces connexin channel-mediated solute exchange in a recombinant liposome system, resulting in a decreased degree of liposome density shift in transport-specific separation assays. TAPS is a critical compound for investigating the structure and function of connexin channels .

HY-Y0286

Ammonium carbonate, 99%

Hartshorn salt, 99%

Biochemical Assay Reagents

Ammonium carbonate (Ammonium carbonate), 99% is a solid amino compound that functions as a buffer, pH regulator, pore-forming agent, and electrocatalytic oxidation substrate. Ammonium carbonate, 99% is a GRAS-grade direct food additive with no restricted daily intake specified by FAO/WHO, and it shows no acute skin toxicity, clinical signs of toxicity, or effects on body weight in rats. Ammonium carbonate, 99% undergoes electrocatalytic oxidation in alkaline solutions with a Pt/C catalyst (carbonate adsorption interferes with activity). Ammonium carbonate, 99% can serve as a fuel for low-temperature polymer fuel cells and anion exchange membrane fuel cells (with performance superior to pure ammonia), and can also form pores in the carrier-free Pt cathode catalyst layer after low-temperature decomposition, thereby enhancing catalyst activity under low-humidity conditions and the performance of proton exchange membrane fuel cells .

HY-W046325

DEAE-Cellulose Diethylaminoethyl cellulose	Biochemical Assay Reagents
DEAE-Cellulose (Diethylaminoethyl cellulose), a common biopolymer derivative. DEAE-Cellulose is a weakly basic cellulose anion exchanger .

HY-D0172

Tetrabutylammonium bromide

AP 6G; Actiron 43-65; Aliquat 100

Biochemical Assay Reagents

Tetrabutylammonium bromide is an organic ammonium compound, which is often used in catalytic reactions and separation and purification processes. It has a significant catalytic effect in some organic synthesis reactions, and can be used as a surfactant, stabilizer and antibacterial agent, etc. In addition, in some laboratory studies, this compound has also been used as an ion exchanger, solvent extractant, etc.

HY-40145

1-Boc-3-iodoazetidine	Biochemical Assay Reagents
1-Boc-3-iodoazetidine acts as a bifunctional additive for lithium-oxygen (Li-O₂) batteries and can be used to enhance the performance of Li-O₂ batteries. 1-Boc-3-iodoazetidine is applied in the synthesis of C3-functionalized azetidines and C2-functionalized azetidines via a lithium/iodine exchange or β-elimination/lithiation reaction sequence .

HY-W009062

MePhos	Biochemical Assay Reagents
MePhos is an o-BPP ligand. The combination of MePhos and silver carbonate serves as a catalyst for H/D exchange reactions .

HY-75070

(+)-1-(1-Naphthyl)ethylamine

Biochemical Assay Reagents

(+)-1-(1-Naphthyl)ethylamine ((+)-1-(1-NEA)) is a chiral modifier used to introduce enantioselectivity in catalytic hydrogenation reactions. 1-NEA can undergo H-D exchange with D2 in solution to form N?D bonds. That is, 1-NEA can complete Pt surface adsorption and protonation through amine N atoms, indicating that NEA molecules have the potential to impart enantioselectivity to Pt hydrogenation catalysts .

HY-69055

7-Bromoisoquinoline	Biochemical Assay Reagents
7-Bromoisoquinoline is a brominated isoquinoline and synthetic precursor that constructs the isoquinoline functional group at the C17 position of target molecules. 7-Bromoisoquinoline serves as a key synthetic intermediate for the synthesis of cortistatin A-derived anti-angiogenic steroidal analogs (e.g., 7-tributylstannyl isoquinoline). 7-Bromoisoquinoline .

HY-106150

Eniporide

EMD-96785

Biochemical Assay Reagents

Eniporide (EMD 96785) is a Na(+)/H(+) exchange (NHE) inhibitor. Eniporide specifically inhibits the NHE-1 isoform. Eniporide improves cardiac performance inhibition associated with myocardial ischemia/reperfusion in animals, and limits infarct size in experimental models. Eniporide regulates cardiac performance and high-energy phosphate content in clinically relevant pig models of CPB and cardiac arrest .

HY-W739372A

Polysodium 4-styrenesulfonate (MW 70000)	Biochemical Assay Reagents
Poly(sodium 4-styrenesulfonate) (MW 70000) is an ion exchange exchange polyelectrolyte .

HY-157915

HFPB Tetrakis[3,5-bis(1,1,1,3,3,3-hexafluoro-2-methoxy-2-propyl)phenyl]borate, sodium salt, trihydrate	Biochemical Assay Reagents
HFPB (Compound 2) is a type of cation exchanger with high lipophilicity and acid resistivity, which can be used in membrane electrode research .

HY-W739372B

Polysodium 4-styrenesulfonate (MW 1000000)	Biochemical Assay Reagents
Poly(sodium 4-styrenesulfonate) (MW 1000000) is an ion exchange exchange polyelectrolyte .

HY-172387A

CM Cross-linked dextran C 50	Biochemical Assay Reagents
CM Cross-linked dextran C 50 is a weak cation exchanger.

HY-172387

CM Cross-linked dextran C 25	Biochemical Assay Reagents
CM Cross-linked dextran C 25 is a weak cation exchanger.

HY-156045A

Cross-linked dextran G 10	Biochemical Assay Reagents
Cross-linked dextran G 10 is a weak cation exchanger and a hydrophilic gel that can be used as a gel filter filler (Sphere protein separation range: >700 Da; Polysaccharide separation range: >700 Da) .

HY-172388

QAE Cross-linked dextran A 50	Biochemical Assay Reagents
QAE Cross-linked dextran A 50 is a strong anion exchanger.

HY-172388A

QAE Cross-linked dextran A 25	Biochemical Assay Reagents
QAE Cross-linked dextran A 25 is a strong anion exchanger.

HY-141483

DEAE Cross-linked dextran A 50	Biochemical Assay Reagents
DEAE Cross-linked dextran A 50 is a weak anion exchanger.

Cat. No.	Product Name	Target	Research Area

HY-156002

LUNA18 Paluratide	Ras ERK	Cancer
LUNA18 is an orally-available cyclic peptide KRAS and ERK inhibitor. LUNA18 phosphorylates ERK and AKT and decreases cell proliferation in RAS-mutated cancer cells. LUNA18 exhibits RAS signal inhibition and potent anti-cancer activities through inhibiting interaction between RAS and guanine nucleotide exchange factors (GEFs) in a mouse xenograft model. LUNA18 shows significant cellular efficacy against cell lines with KRAS genetic alterations, such as colon cancer, stomach cancer, non-small cell lung cancer and pancreaticcancer .

HY-P5985

mSIRK 2 Publications Verification	ERK	Others
mSIRK (G-Protein βγ Binding Peptide) is an cell-permeable activator of ERK1/2, with EC₅₀ of 2.5-5 μM. mSIRK disrupts the interaction between α and βγ subunits and promotes α subunit dissociation without stimulating nucleotide exchange .

HY-P1723

Spexin 2 Publications Verification Neuropeptide Q	Neuropeptide Y Receptor Apoptosis Ferroptosis Autophagy	Cardiovascular Disease Neurological Disease
Spexin (Neuropeptide Q) is a selective agonist of galanin receptors GAL2 and GAL3, and is a conserved peptide that functions as a neurotransmitter/neuromodulator and endocrine factor. Spexin can function through both central and peripheral actions. Spexin upregulates Beclin 1 to inhibit ferroptosis induced by excessive autophagy, reduces the uptake of long-chain fatty acids by adipocytes, and regulates energy metabolism by increasing lipid oxidation (e.g., reducing the respiratory exchange ratio in rodents). Spexin improves cardiac function in the Doxorubicin hydrochloride (HY-15142)-induced cardiotoxicity model, protects mitochondrial membrane potential, and reduces iron accumulation and lipid peroxidation. Spexin can be used to study obesity and its related metabolic disorders, cardiovascular diseases (e.g., cardioprotection), and side effects of tumor chemotherapy .

HY-P1769

Angiotensin II (5-8), human	Angiotensin Receptor	Metabolic Disease Endocrinology
Angiotensin II (5-8), human is an endogenous C-terminal fragment of the peptide vasoconstrictor angiotensin II . Angiotensin II binds the AT II type 1 (AT1) receptor, stimulating GPCRs in vascular smooth muscle cells and increasing intracellular Ca ²⁺ levels. Angiotensin II also acts at the Na ⁺/H ⁺ exchanger in the proximal tubules of the kidney .

HY-W015987

9-Fluorenylmethyl carbamate Fmoc-NH2	Biochemical Assay Reagents	Others
9-Fluorenylmethyl carbamate (Fmoc-NH2) is an amide compound with an Fmoc protecting group, which can be used as a photobase initiator to prepare organosilane-based proton exchange membranes .

HY-P1382A

Rac1 Inhibitor W56 TFA	Ras	Cancer
Rac1 Inhibitor W56 TFA is a peptide containing residues 45-60 of Rac1. Rac1 Inhibitor W56 TFA inhibits Rac1 interaction with guanine nucleotide exchange factors TrioN, GEF-H1, and Tiam .

HY-P4856

pTH-Related Protein (1-40) (human, mouse, rat)	PTHR PKC	Endocrinology
pTH-Related Protein (1-40) (human, mouse, rat) stimulates calcium uptake in rat intestinal cells through PTHR1 receptor and PKCα/β signaling pathways. pTH-Related Protein (1-40) up-regulates parathyroid hormone 1 receptor (PTHR1) protein, four transcellular calcium transporters, potential vanillin member 6 (TRPV6), calcium-binding protein-D9K (CaBP-D9k), sodium-calcium Exchanger 1 (NCX1) and plasma membrane calcium ATPase 1 (PMCA1) .

HY-P1792

Angiotensin II (1-4), human	Angiotensin Receptor	Metabolic Disease Endocrinology
Angiotensin II (1-4), human is an endogenous peptide produced from AT I by angiotensin-converting-enzyme (ACE). Angiotensin II binds the AT II type 1 (AT1) receptor, stimulating GPCRs in vascular smooth muscle cells and increasing intracellular Ca ²⁺ levels. Angiotensin II also acts at the Na ⁺/H ⁺ exchanger in the proximal tubules of the kidney .

HY-P1382

Rac1 Inhibitor W56	Ras	Cancer
Rac1 Inhibitor W56 is a peptide containing residues 45-60 of Rac1. Rac1 Inhibitor W56 inhibits Rac1 interaction with guanine nucleotide exchange factors TrioN, GEF-H1, and Tiam .

HY-P1723A

Spexin TFA Neuropeptide Q TFA	Neuropeptide Y Receptor Apoptosis Ferroptosis Autophagy	Cardiovascular Disease Metabolic Disease
Spexin (Neuropeptide Q) TFA is a selective agonist of galanin receptors GAL2 and GAL3, and is a conserved peptide that functions as a neurotransmitter/neuromodulator and endocrine factor. Spexin TFA can function through both central and peripheral actions. Spexin TFA upregulates Beclin 1 to inhibit ferroptosis induced by excessive autophagy, reduces the uptake of long-chain fatty acids by adipocytes, and regulates energy metabolism by increasing lipid oxidation (e.g., reducing the respiratory exchange ratio in rodents). Spexin TFA improves cardiac function in the Doxorubicin hydrochloride (HY-15142)-induced cardiotoxicity model, protects mitochondrial membrane potential, and reduces iron accumulation and lipid peroxidation. Spexin TFA can be used to study obesity and its related metabolic disorders, cardiovascular diseases (e.g., cardioprotection), and side effects of tumor chemotherapy .

HY-P10811

Na+-Ca2+ Exchanger XIP	Na+/Ca2+ Exchanger	Neurological Disease
Na ⁺-Ca ²⁺ Exchanger inhibitory peptide (XIP) is a Na ⁺-Ca ²⁺ exchanger inhibitor with a K_i of 200 nM. Na ⁺-Ca ²⁺ Exchanger inhibitory peptide inhibits the Na ⁺-dependent Ca ²⁺ uptake and the Na ⁺-dependent Ca ²⁺ efflux of sarcolemmal vesicles in a noncompetitive manner .

HY-P10685

T-22 [Tyr5,12,Lys7]-Polyphemusin II	HIV CMV	Infection
T-22 (polyphemusin II with [Tyr5,12,Lys7]) is a new synthetic peptide that fights HIV, with an EC₅₀ of 0.008 μg/mL and a CC₅₀ of 54 μg/mL. T22 promotes plant height, photosynthesis, total chlorophyll content, and gas exchange in tomatoes, and it can resist CMV .

HY-P1792A

Angiotensin II (1-4), human TFA	Angiotensin Receptor	Metabolic Disease Endocrinology
Angiotensin II (1-4), human (TFA) is an endogenous peptide produced from AT I by angiotensin-converting-enzyme (ACE). Angiotensin II binds the AT II type 1 (AT1) receptor, stimulating GPCRs in vascular smooth muscle cells and increasing intracellular Ca ²⁺ levels. Angiotensin II also acts at the Na ⁺/H ⁺ exchanger in the proximal tubules of the kidney .

HY-P1383A

Rac1 Inhibitor F56, control peptide TFA	Ras	Others
Rac1 Inhibitor F56, control peptide TFA is a peptide containing residues 45-60 of Rac1. Rac1 Inhibitor F56, control peptide TFA contains a Trp ⁵⁶ to Phe ⁵⁶ mutation. Rac1 Inhibitor F56, control peptide TFA has no effect on Rac1 interaction with its guanine nucleotide exchange factors (GEFs) .

HY-P1383

Rac1 Inhibitor F56, control peptide	Peptides	Others
Rac1 Inhibitor F56, control peptide is a peptide containing residues 45-60 of Rac1. Rac1 Inhibitor F56, control peptide contains a Trp ⁵⁶ to Phe ⁵⁶ mutation. Rac1 Inhibitor F56, control peptide has no effect on Rac1 interaction with its guanine nucleotide exchange factors (GEFs) .

Cat. No.	Product Name

HY-K0257

CM Agarose 6FF
MCE CM Agarose 6FF is a weak cation exchanger formed by covalently coupling carboxymethyl (CM) groups to agarose microspheres. It is suitable for both laboratory research and large-scale industrial purification processes.

HY-K0258

SP Agarose 6FF
MCE SP Agarose 6FF is a strong cation exchanger formed by covalently coupling sulfopropyl (SP) groups to agarose microspheres. It is suitable for both laboratory research and large-scale industrial purification processes.

HY-K0259

DEAE Agarose 6FF
MCE DEAE Agarose 6FF is a weak cation exchanger formed by covalently coupling diethylaminoethyl (DEAE) groups to agarose microspheres. It is suitable for both laboratory research and large-scale industrial purification processes.

HY-K0260

Q Agarose 6FF
MCE Q Agarose 6FF is a strong cation exchanger formed by covalently coupling quarternary ammonium (Q) groups to agarose. It is suitable for both laboratory research and large-scale industrial purification processes.

HY-K0261

SP Agarose HP
MCE SP Agarose HP is a high-resolution strong cation exchanger formed by covalently coupling sulfopropyl (SP) groups to agarose. This medium offers high binding capacity, high specificity, and excellent ligand stability, making it suitable for both laboratory-scale and large-scale industrial purification applications.

HY-K0262

DEAE Agarose HP
MCE DEAE Agarose HP is a high-resolution weak anion exchanger formed by covalently coupling diethylaminoethyl (DEAE) groups to agarose. This medium offers high binding capacity, high specificity, and excellent ligand stability, making it suitable for both laboratory-scale and large-scale industrial purification applications.

HY-K0263

Q Agarose HP
MCE Q Agarose HP is a high-resolution strong anion exchanger formed by covalently coupling quaternary ammonium (Q) groups to agarose. This medium offers high binding capacity, high specificity, and excellent ligand stability, making it suitable for both laboratory-scale and large-scale industrial purification applications.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-100381

Nigericin sodium salt Maximum Cited Publications 221 Publications Verification	Infection Microorganisms Classification of Application Fields Antibiotics Disease Research Disease Research Fields Other Antibiotics Source Classification Cancer	Potassium Channel NOD-like Receptor (NLR) Bacterial Antibiotic Pyroptosis Wnt β-catenin
Nigericin sodium salt is an antibiotic derived from Streptomyces hygroscopicus that act as a K ⁺/H ⁺ ionophore, promoting K ⁺/H ⁺ exchange across mitochondrial membranes. Nigericin sodium salt is a NLRP3 activator. Nigericin sodium salt shows promising anti-cancer activities through decreasing intracellular pH (pHi), and inactivation of Wnt/β-catenin signals. Nigericin sodium salt induces pyroptosis through caspase 1/GSDMD in TNBC .

HY-N0150

Monensin sodium 35+ Cited Publications Monensin A sodium	Structural Classification Microorganisms Classification of Application Fields Antibiotics Antibacterial Disease Research Disease Research Fields Other Antibiotics Plant agriculture research Source Classification Cancer	Exosomes Bacterial Antibiotic Na+/H+ Exchanger (NHE) Parasite Apoptosis Fungal Wnt
Monensin (Monensin A) sodium, an orally active antibiotic, is an ionophore that mediates Na ⁺/H ⁺ exchange. Monensin sodium is a potent Wnt signaling inhibitor. Monensin sodium causes a marked enlargement of the multivesicular bodies (MVBs) and regulates exosome secretion. Monensin sodium can be used for bacterial, fungal, and parasitic infections research, and shows anticancer effects .

HY-N13022

Humic acid 1 Publications Verification	Structural Classification Natural Products Plants Source Classification	Environmental Pollutants Bacterial SOD
Humic acid is an important component of organic matter in soil and water, and serves as a plant regulator. Humic acid has multiple reactive activities such as surface adsorption, ion exchange, and complexation. Humic acid can enhance pyrene degradation by Mycobacterium NJS-1. Humic acid can inhibit the activity of superoxide dismutase and scavenge hydroxyl radicals. Humic acid is also toxic to CEM cells .

HY-W017113

2-Mercaptobenzothiazole 1 Publications Verification	Structural Classification Natural Products Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Environmental Pollutants Endogenous Metabolite
2-Mercaptobenzothiazole is an activator of the aryl hydrocarbon receptor (AhR) , inhibiting thyroid hormone synthesis and dopamine beta-hydroxylase activity . 2-Mercaptobenzothiazole promotes bladder cancer cell invasion by altering the conformation of the AhR ligand binding domain (LBD), activating AhR transcription, and upregulating the mRNA and protein expression of target genes CYP1A1 and CYP1B1 . 2-Mercaptobenzothiazole inhibits thyroid peroxidase (TPO) with an IC₅₀ value of 11.5 μM, induces histological changes such as follicular cell hypertrophy in Xenopus laevis tadpoles, delaying metamorphosis . 2-Mercaptobenzothiazole increases chromosomal aberrations and sister chromatid exchanges (SCEs) in Chinese hamster ovary (CHO) cells, and enhances carcinogenicity in F344/N rats . 2-Mercaptobenzothiazole inhibits norepinephrine synthesis in mice and completely blocks the conversion of exogenous dopamine to norepinephrine in rat cardiomyocytes .

HY-N4302

Monensin 35+ Cited Publications Monensin A	Infection Structural Classification Natural Products Microorganisms Classification of Application Fields Disease Research Fields Source Classification	Exosomes Bacterial Apoptosis Antibiotic Parasite Na+/H+ Exchanger (NHE) Fungal Wnt
Monensin (Monensin A), an orally active antibiotic, is an ionophore that mediates Na ⁺/H ⁺ exchange. Monensin is a potent Wnt signaling inhibitor. Monensin causes a marked enlargement of the multivesicular bodies (MVBs) and regulates exosome secretion. Monensin can be used for bacterial, fungal, and parasitic infections research, and shows anticancer effects .

HY-N0724

Mesaconitine 2 Publications Verification	Alkaloids Structural Classification Classification of Application Fields Ranunculaceae Other Diseases Aconitum carmichaeli Debx. Plants Isoquinoline Alkaloids Disease Research Fields Source Classification	TNF Receptor
Mesaconitine is a nitric oxide synthase activator. Mesaconitine drives extracellular Na ⁺ and Ca ²⁺ influx into endothelial cells, increases intracellular Na ⁺ and Ca ²⁺ concentrations, and triggers nitric oxide release. Mesaconitine is applicable for pain-related research .

HY-N0150R

Monensin sodium (Standard) Monensin A sodium (Standard)	Structural Classification Microorganisms Antibiotics Antibacterial Disease Research Other Antibiotics Plant agriculture research Source Classification	Reference Standards Exosomes Bacterial Antibiotic Na+/H+ Exchanger (NHE) Parasite Apoptosis Fungal Wnt
Monensin (sodium) (Standard) is the analytical standard of Monensin (sodium). This product is intended for research and analytical applications. Monensin (Monensin A) sodium, an orally active antibiotic, is an ionophore that mediates Na+/H+ exchange. Monensin sodium is a potent Wnt signaling inhibitor. Monensin sodium causes a marked enlargement of the multivesicular bodies (MVBs) and regulates exosome secretion. Monensin sodium can be used for bacterial, fungal, and parasitic infections research, and shows anticancer effects .

HY-W004078

4-Hydroxybenzylamine	Monophenols other families Classification of Application Fields Phenols Metabolic Disease Plants Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
4-Hydroxybenzylamine is a natural biogenic amine. 4-Hydroxybenzylamine can be produced through the breakdown metabolism of glucosinolates, with glutamine serving as the non-classical ammonia donor. 4-Hydroxybenzylamine can be utilized for the study of plant amine biosynthesis .

HY-N3918

γ-Fagarine	Infection Alkaloids other families Classification of Application Fields Quinoline Alkaloids Plants Disease Research Fields Source Classification	HCV
γ-Fagarine is a furoquinoline alkaloid naturally occurring in Rutae Herba. γ-Fagarine has strong anti-HCV activities with IC₅₀ of 20.4 μg/mL and is also a sister chromatid exchanges (SCEs) inducer .

HY-N10156

1,3,5-Trihydroxy-4-prenylxanthone	Flavonoids Leguminosae Plants Other Flavonoids Source Classification Erythrina variegata Linn.	Na+/H+ Exchanger (NHE) Phosphodiesterase (PDE) NO Synthase
1,3,5-Trihydroxy-4-prenylxanthone is a *Na ⁺/H ⁺ exchange* system inhibitor with a minimum inhibitory concentration of 10 μg/mL . 1,3,5-Trihydroxy-4-prenylxanthone is a phosphodiesterase type 5 (PDE5) inhibitor with an IC₅₀** value of 3.0 μM . 1,3,5-Trihydroxy-4-prenylxanthone inhibits Lipopolysaccharide (LPS) (HY-D1056)-induced NO production in RAW264.7 macrophages, and has anti-inflammatory activities .

HY-100381R

Nigericin sodium salt (Standard)	Structural Classification Microorganisms Antibiotics Disease Research Other Antibiotics Source Classification	Reference Standards Potassium Channel NOD-like Receptor (NLR) Bacterial Antibiotic Pyroptosis Wnt β-catenin
Nigericin (sodium salt) (Standard) is the analytical standard of Nigericin (sodium salt). This product is intended for research and analytical applications. Nigericin sodium salt is an antibiotic derived from Streptomyces hygroscopicus that act as a K ⁺/H ⁺ ionophore, promoting K ⁺/H ⁺ exchange across mitochondrial membranes. Nigericin sodium salt is a NLRP3 activator. Nigericin sodium salt shows promising anti-cancer activities through decreasing intracellular pH (pHi), and inactivation of Wnt/β-catenin signals. Nigericin sodium salt induces pyroptosis through caspase 1/GSDMD in TNBC .

Cat. No.	Product Name	Chemical Structure

HY-B0464S1

Hydralazine-d5 hydrochloride

Hydralazine-d₅ (hydrochloride) is deuterium-labeled Hydralazine (hydrochloride) (HY-B0464). Hydralazine hydrochloride is an orally active, blood-brain barrier-permeable DNA methyltransferase inhibitor with vasodilatory, arterial smooth muscle relaxant and hypotensive activities. Hydralazine hydrochloride reactivates silenced tumor suppressor genes via mediating DNA demethylation, while exerting neuroprotective and anti-inflammatory properties. Hydralazine hydrochloride inhibits NOS-2 (iNOS) and COX-2, and reduces the production of NO and PGE_E2; meanwhile, Hydralazine hydrochloride scavenges reactive oxygen species and inhibits macrophage activation. Hydralazine hydrochloride alleviates motor dysfunction, neuropathic inflammatory pain, and formalin-induced somatic and emotional pain responses. In addition, Hydralazine hydrochloride directly induces DNA strand breaks and sister chromatid exchange, exhibiting certain mutagenic characteristics. Hydralazine hydrochloride has been widely used in studies on hypertension, various cancers (such as cervical cancer, leukemia), spinal cord injury and the mechanisms of inflammatory pain .

HY-B0464S

Hydralazine-d4 hydrochloride

Hydralazine-d4 hydrochloride is the deuterium labeled Hydralazine hydrochloride. Hydralazine hydrochloride is an orally active, blood-brain barrier-permeable DNA methyltransferase inhibitor with vasodilatory, arterial smooth muscle relaxant and hypotensive activities. Hydralazine hydrochloride reactivates silenced tumor suppressor genes via mediating DNA demethylation, while exerting neuroprotective and anti-inflammatory properties. Hydralazine hydrochloride inhibits NOS-2 (iNOS) and COX-2, and reduces the production of NO and PGE_E2; meanwhile, Hydralazine hydrochloride scavenges reactive oxygen species and inhibits macrophage activation. Hydralazine hydrochloride alleviates motor dysfunction, neuropathic inflammatory pain, and formalin-induced somatic and emotional pain responses. In addition, Hydralazine hydrochloride directly induces DNA strand breaks and sister chromatid exchange, exhibiting certain mutagenic characteristics. Hydralazine hydrochloride has been widely used in studies on hypertension, various cancers (such as cervical cancer, leukemia), spinal cord injury and the mechanisms of inflammatory pain .

HY-W705589

Rimeporide-15N3 hydrochloride
Rimeporide- ¹⁵N₃ (hydrochloride) (EMD-87580- ¹⁵N₃ (hydrochloride)) is ¹⁵N labeled Rimeporide hydrochloride. Rimeporide hydrochloride (EMD-87580 hydrochloride) is a potent and selective inhibitor of the Na ⁺/H ⁺ exchanger (NHE-1).

HY-B0684S

Iopamidol-d8
Iopamidol-d₈ (B-15000-d₈) is the deuterium labeled Iopamidol. Iopamidol is a nonionic, X-Ray iodinated contrast agent (CA) for a wide variety of diagnostic applications. Iopamidol contains amide and hydroxyl functionalities that can be exploited for the generation of the chemical exchange saturation transfer (CEST) contrast .

HY-W710915

Aprindine hydrochloride-d10

Aprindine hydrochloride-d₁₀ is the deuterium labeled Aprindine hydrochloride (HY-A0236A). Aprindine hydrochloride is a class I-b anti-arrhythmic agent and a hERG channel blocker with an IC₅₀ of 0.23 μM. Aprindine hydrochloride has inhibitory effects on Na+/Ca2+ exchanger currents, which is partly responsible for their antiarrhythmic and cardioprotective effects. Aprindine hydrochloride is widely used for trial and ventricular tachyarrhythmias research research.

HY-B0684S1

Iopamidol-d3
Iopamidol-d₃ (B-15000-d₃; SQ-13396-d₃) is the deuterium labeled Iopamidol (HY-B0684). Iopamidol is a nonionic, X-Ray iodinated contrast agent (CA) for a wide variety of diagnostic applications. Iopamidol contains amide and hydroxyl functionalities that can be exploited for the generation of the chemical exchange saturation transfer (CEST) contrast .

HY-W042301S

Xipamide-d6
Xipamide-d₆ is the deuterium labeled Xipamide. Xipamide is a sulfonamide-based diuretic. Xipamide is an antihypertensive agent able to selectively inhibit the anion exchanger (AE) .

HY-W724290

Tetrabutylammonium-d36 bromide

Tetrabutylammonium-d₃₆ bromide (AP 6G-d₃₆ bromide) is the deuterium labeled Tetrabutylammonium bromide (HY-D0172). Tetrabutylammonium bromide is an organic ammonium compound, which is often used in catalytic reactions and separation and purification processes. It has a significant catalytic effect in some organic synthesis reactions, and can be used as a surfactant, stabilizer and antibacterial agent, etc. In addition, in some laboratory studies, this compound has also been used as an ion exchanger, solvent extractant, etc.

Host:	Rabbit (5)
Reactivity:	Human (4) Rat (1) Mouse (1) Escherichia coli (1) GuineaPig (1)
Application:	IHC-P (3) ICC/IF (4) IP (3) IHC-F (1) WB (5) FC (2)
Isotype:	IgG (5)
Conjugation:	Non-conjugated (5)
Clonality:	polyclonal (1) Monoclonal (3) Recombinant (2)
Modification:	Unmodified (4)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P81984

	PREB Antibody (YA1729) Prolactin regulatory element-binding protein; Mammalian guanine nucleotide exchange factor mSec12	WB, IHC-P, ICC/IF, IP	Human
	PREB Antibody (YA1729) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PREB.

HY-P81984A

	PREB Antibody (YA1729)(PBS only) Prolactin regulatory element-binding protein; Mammalian guanine nucleotide exchange factor mSec12	WB, IHC-P, ICC/IF, IP	Human
	PREB Antibody (YA1729) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PREB.

HY-P86281

	PSS2 Antibody (YA5973) PTDSS2; PSS2; Phosphatidylserine synthase 2 ; PSS-2; PtdSer synthase 2; Serine-exchange enzyme II;	WB, FC, IP	Human
	PSS2 Antibody (YA5973) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PSS2.

HY-P87059

	RecA Antibody (YA6752) DNA strand exchange and recombination protein with protease and nuclease activity antibody; lexB antibody; Protein recA antibody; recH antibody; Recombinase A antibody;	WB, ICC/IF	Escherichia coli
	RecA Antibody (YA6752) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to RecA.

HY-P810517

	NCX1 Antibody Na+/Ca2+exchanger 1, CNC, DKFZp779F0871, MGC119581, FLJ37694, FLJ43417, Na+/Ca2+ exchange protein 1, Na+/Ca2+ exchanger, NCX 1, NCX, SLC8A1, SLC8A1 protein, Sodium Calcium exchanger, Sodium/calcium exchanger 1, Solute carrier family 8 member 1, NAC1_HUMAN.	WB, IHC-F, IHC-P, ICC/IF, FC	Human, Mouse, Rat, GuineaPig
	NCX1 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to NCX1.

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Cat. No.	Product Name		Classification

HY-134813

MRTX1133 45+ Cited Publications		Alkynes
MRTX1133 is a noncovalent, potent, and selective alkyne-based KRAS G12D inhibitor. MRTX1133 optimally fills the switch II pocket and extends three substituents to favorably interact with the protein, resulting in an estimated K_D against KRAS G12D of 0.2 pM. MRTX1133 prevents SOS1-catalyzed nucleotide exchange and/or formation of the KRAS G12D/GTP/RAF1 complex, thereby inhibiting mutant KRAS-dependent signal transduction. MRTX1133 selectively inhibits KRAS G12D mutant, but not KRAS wild-type, tumor cells. MRTX1133 has single digit nanomolar activity in cellular assays and marked in vivo efficacy in tumor models harboring KRAS G12D mutations .

HY-139337

SMCy5.5		Alkynes
SMCy5.5 is a SMCy dye (ex. 638 nm; em. 705 nm). The high brightness of SMCy5.5 allows for effective tracking and imaging of lipid droplet exchange between adipocytes. SMCy5.5 can be used for lipid droplet labeling studies .

HY-162446

pan-KRAS-IN-13		Alkynes
pan-KRAS-IN-13 (compound 2) is a potent inhibitor of KRAS, with IC₅₀s of 2.75 nM and 2.89 nM for G12D and G12V, respectively

HY-134318B

8-Azido-ADP disodium		Azide
8-Azido-ADP (disodium) is a covalent-binding inhibitor of mitochondrial adenine nucleotide translocation. 8-Azido-ADP (disodium) causes irreversible inhibition of adenine nucleotide exchange in a light-dependent reaction. 8-Azido-ADP (disodium) inhibits the normal state 4 → 3 transitions of mitochondrial respiration induced by ADP . 8-Azido-ADP (disodium) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-180920

KRAS G12D-IN-36		Alkynes
KRAS G12D-IN-36 (Compound 53a) is a highly selective and orally active KRAS-G12D inhibitor with an IC₅₀ of 1.63 nM. KRAS G12D-IN-36 effectively inhibits p-ERK with an IC₅₀ of 8.4 nM. KRAS G12D-IN-36 shows potent anti-proliferative activity against AsPC-1 cells. KRAS G12D-IN-36 can be used for research on pancreatic cancer .

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