5 Results for "

glutathionylation

" in MedChemExpress (MCE) Product Catalog:
Products (5)

5 Results for "glutathionylation" in MCE Product Catalog:

Cat. No.: HY-185057
CAS No.: 41656-56-8
Synonyms: S-Lactylglutathione; (R)-S-Lactoylglutathione
S-D-Lactoylglutathione (S-Lactylglutathione; (R)-S-Lactoylglutathione) is a multifunctional metabolic intermediate of the glyoxalase system. S-D-Lactoylglutathione activates K + efflux in bacteria by displacing inhibitory glutathione from KefGB channels, thereby acidifying the cytoplasm. In eukaryotic cells, S-D-Lactoylglutathione mediates S-glutathionylation as a substrate of glyoxalase 2. S-D-Lactoylglutathione serves as a sensitive metabolic biomarker for neodymium nitrate neurotoxicity; when used in combination with MSCs-exo, it upregulates glutathione levels, downregulates lactate dehydrogenase and Glo2 levels, and inhibits cellular inflammatory responses and pyroptosis. S-D-Lactoylglutathione can be used in research related to prostate cancer, breast cancer, non-small cell lung cancer, sepsis-associated encephalopathy, and neurotoxicity .
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Cat. No.: HY-D0844F
Synonyms: N,N-Biotinyl glutathione disulfide TFA; Biotin-GSSG TFA
Target:  

Inhibitory Antibodies

Research Areas:  

Others

Biotin-glutathione oxidized TFA ((N,N-Biotinyl glutathione disulfide TFA; Biotin-GSSG TFA) is an inducer of protein S-glutathionylation and a detection probe for S-glutathionylated proteins. Biotin-glutathione oxidized TFA forms protein-glutathione disulfide adducts, mimics components of oxidative stress, and drives protein S-glutathionylation. Biotin-glutathione oxidized TFA enables the labeling, detection, localization and purification of proteins susceptible to S-glutathionylation .
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Cat. No.: HY-189123
CAS No.: 724429-20-3
Research Areas:  

Others

M12 is a DCAF11-dependent molecular glue degrader activated by glutathionylation, which induces CRL4 DCAF11-mediated degradation of DDX18. M12 is a precursor compound that requires metabolic activation: it is conjugated with glutathione (GSH) under the catalysis of glutathione S-transferase (GST) to form GSH-M12, which interacts with DCAF11 and promotes the recruitment of DDX18. M12 is applicable for studies on targeted protein degradation and DCAF11-dependent molecular glue mechanisms .
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Cat. No.: HY-P12260
CAS No.: 3027489-02-4
Research Areas:  

Cancer

AJICAP reagent 1b is a thiophenyl ester-based site-specific conjugation reagent for antibody modification applications. AJICAP reagent 1b is used in HER2-positive gastric cancer-related research .
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Cat. No.: HY-P12261
Research Areas:  

Cancer

AJICAP reagent 6b is an Fc-affinity peptide reagent that site-specifically modifies Lys288 of native antibodies via thiophenyl ester chemistry. AJICAP reagent 6b enables site-specific conjugation of native antibodies at Lys288 with high conversion yield and reduced aggregation. AJICAP reagent 6b can be used for the research of cancer .
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