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Cat. No.: HY-P12260

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AJICAP reagent 1b

AJICAP reagent 1b is a thiophenyl ester-based site-specific conjugation reagent for antibody modification applications. AJICAP reagent 1b is used in HER2-positive gastric cancer-related research.

For research use only. We do not sell to patients.

CAS No.: 3027489-02-4
Formula: C₁₀₅H₁₄₃N₂₉O₂₆S₄
Molecular Weight:2355.70

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Custom Peptide Synthesis

AJICAP reagent 1b Chemical Structure

CAS No.: 3027489-02-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
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Biological Activity

Description

AJICAP reagent 1b is a thiophenyl ester-based site-specific conjugation reagent for antibody modification applications. AJICAP reagent 1b is used in HER2-positive gastric cancer-related research^[1].

In Vitro

AJICAP reagent 1b (2.5 equivalents; 1 h) enables efficient site-specific conjugation of native antibodies at Lys248, producing homogeneous antibody-thiol intermediates with an average PAR of 2.0 and minimal aggregation^[1].
AJICAP reagent 1b (2.7 equivalents; 1 h) produces site-specific Lys248 ADCs from trastuzumab and rituximab with high DAR values and low aggregation across various drug-linkers^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .

Chemical Information

CAS No. 3027489-02-4
Molecular Weight 2355.70
Formula C₁₀₅H₁₄₃N₂₉O₂₆S₄
Sequence

Ac-Arg-Gly-Asn-Cys-Ala-Tyr-His-Lys(4-oxo-4-((3-oxo-3-(phenylthio)propyl)thio)butanoic acid)-Gly-Gln-Leu-Val-Trp-Cys-Thr-Tyr-His-NH2 (disulfide bridge:Cys4-Cys14)
Sequence Shortening

Ac-RGNCAYH-Lys(4-oxo-4-((3-oxo-3-(phenylthio)propyl)thio)butanoic acid)-GQLVWCTYH-NH2 (disulfide bridge:Cys4-Cys14)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Fujii T, et al. AJICAP Second Generation: Improved Chemical Site-Specific Conjugation Technology for Antibody-Drug Conjugate Production. Bioconjugate chemistry. 2023 Mar 09;34(4):728-38. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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