country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Art. -Nr.: HY-P12260

Copy Link Print Information

AJICAP reagent 1b

AJICAP reagent 1b is a thiophenyl ester-based site-specific conjugation reagent for antibody modification applications. AJICAP reagent 1b is used in HER2-positive gastric cancer-related research.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 3027489-02-4
Formel: C₁₀₅H₁₄₃N₂₉O₂₆S₄
Molecular Weight:2355.70

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Kundenspezifische Peptidsynthese

AJICAP reagent 1b Chemical Structure

CAS. Nr.: 3027489-02-4

Größe

Preis

Verfügbarkeit

Menge

Amount: USD 0.00

* Bitte wählen Sie Menge, bevor Sie Artikel hinzufügen.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

AJICAP reagent 1b is a thiophenyl ester-based site-specific conjugation reagent for antibody modification applications. AJICAP reagent 1b is used in HER2-positive gastric cancer-related research^[1].

In Vitro

AJICAP reagent 1b (2.5 equivalents; 1 h) enables efficient site-specific conjugation of native antibodies at Lys248, producing homogeneous antibody-thiol intermediates with an average PAR of 2.0 and minimal aggregation^[1].
AJICAP reagent 1b (2.7 equivalents; 1 h) produces site-specific Lys248 ADCs from trastuzumab and rituximab with high DAR values and low aggregation across various drug-linkers^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .

Chemical Information

CAS. Nr. 3027489-02-4
Molecular Weight 2355.70
Formel C₁₀₅H₁₄₃N₂₉O₂₆S₄
Sequence

Ac-Arg-Gly-Asn-Cys-Ala-Tyr-His-Lys(4-oxo-4-((3-oxo-3-(phenylthio)propyl)thio)butanoic acid)-Gly-Gln-Leu-Val-Trp-Cys-Thr-Tyr-His-NH2 (disulfide bridge:Cys4-Cys14)
Sequence Shortening

Ac-RGNCAYH-Lys(4-oxo-4-((3-oxo-3-(phenylthio)propyl)thio)butanoic acid)-GQLVWCTYH-NH2 (disulfide bridge:Cys4-Cys14)
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Fujii T, et al. AJICAP Second Generation: Improved Chemical Site-Specific Conjugation Technology for Antibody-Drug Conjugate Production. Bioconjugate chemistry. 2023 Mar 09;34(4):728-38. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

Angebot einholen Auf Lager

Other size

Angebot einholen