724429-20-3
Chemical Structure
M12
- CAS No.: 724429-20-3
- Formula:C14H10Cl2FNO2
- Molecular Weight:314.14
InChIKey: JYYWPDDLKJAJHY-UHFFFAOYSA-N
SMILES: O=C(C1=C(Cl)N=C(Cl)C(F)=C1)OC2=CC(C)=CC(C)=C2
Biological Activity: M12 is a DCAF11-dependent molecular glue degrader activated by glutathionylation, which induces CRL4DCAF11-mediated degradation of DDX18. M12 is a precursor compound that requires metabolic activation: it is conjugated with glutathione (GSH) under the catalysis of glutathione S-transferase (GST) to form GSH-M12, which interacts with DCAF11 and promotes the recruitment of DDX18. M12 is applicable for studies on targeted protein degradation and DCAF11-dependent molecular glue mechanisms[1].
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M12 | M12 is a DCAF11-dependent molecular glue degrader activated by glutathionylation, which induces CRL4DCAF11-mediated degradation of DDX18. M12 is a precursor compound that requires metabolic activation: it is conjugated with glutathione (GSH) under the catalysis of glutathione S-transferase (GST) to form GSH-M12, which interacts with DCAF11 and promotes the recruitment of DDX18. M12 is applicable for studies on targeted protein degradation and DCAF11-dependent molecular glue mechanisms. | |||||||||||||||||||||
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