6 Results for "

hepatic microsomal enzymes

" in MedChemExpress (MCE) Product Catalog:
Products (6)

6 Results for "hepatic microsomal enzymes" in MCE Product Catalog:

Cat. No.: HY-B1341
CAS No.: 68-23-5
Synonyms: Enidrel; SC-4642; NSC 15432
Norethynodrel (Enidrel; SC-4642) is an orally active progestogen analog that reduces estrogen-like effects and enhances progestogen-like responses in endometrial stromal cells. Norethynodrel also promotes cell maturation and predecidual cell formation by inducing organelle hyperplasia and glycogen accumulation. Norethynodrel competitively inhibits drug-metabolizing enzymes in rat liver microsomes, thereby prolonging Pentobarbital sleep time, while exhibiting multiple effects including reduced body weight gain, attenuated heart rate elevation and ovulation inhibition. In mouse models, Norethynodrel significantly increases the incidence of mammary adenocarcinoma, cervical cancer and pituitary tumors. Norethynodrel can be used for mechanism research on related diseases such as mammary adenocarcinoma, cervical cancer, ovarian tubular adenoma and pituitary adenoma .
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Cat. No.: HY-P11358
CAS No.: 159718-10-2
IRW is an orally active tripeptide produced from egg white with angiotensin converting enzyme (ACE) inhibitory properties. IRW can prevent high-fat diet (HFD)-induced Non-alcoholic fatty liver disease (NAFLD) by modulating hepatic lipid metabolism and increasing mitochondrial content. IRW decreases hepatic triglyceride content and lipid droplet size. IRW increases the hepatic mitochondrial complexes and citrate synthase activity, phosphorylation of 5’-AMP-activated protein kinase and microsomal triglyceride transfer protein abundance. IRW increases phosphorylated acetyl CoA carboxylase and mitochondrial complexes, IRW can be used for the research of inflammation .
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Cat. No.: HY-76737
CAS No.: 7005-72-3
Synonyms: 4-CDE
Target:  

Estrogen Receptor/ERR

Research Areas:  

Endocrinology

4-Chlorodiphenyl ether (4-CDE) is an estrogen-mimicking active compound. 4-Chlorodiphenyl ether maintains the survival of endometriotic cysts and exhibits estrogenic activity associated with the growth of endometriotic implants. 4-Chlorodiphenyl ether can be used in research related to endometriosis .
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Cat. No.: HY-W040305
CAS No.: 99-30-9
2,6-Dichloro-4-nitroaniline is an orally active Herbicide, Fungicide and uncoupler. 2,6-Dichloro-4-nitroaniline uncouples oxidative phosphorylation and inhibits electron transport. 2,6-Dichloro-4-nitroaniline induces biphenyl hydroxylase activity in rat liver. 2,6-Dichloro-4-nitroaniline increases the relative liver weight of rats via hepatomegaly without altering their body weight .
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Cat. No.: HY-E72096
Target:  

Cytochrome P450

Research Areas:  

Others

Human CYP2B6, Reductase+b5 refers to a near-physiological recombinant microsomal system co-expressed in insect cells, consisting of human cytochrome P450 2B6, NADPH-P450 oxidoreductase (CPR) and cytochrome b5. Human CYP2B6 is a human cytochrome P450 subtype belonging to the CYP2 family, and also serves as a minor but highly polymorphic hepatic metabolic enzyme that metabolizes various prodrugs or xenobiotics .
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Cat. No.: HY-W096907
CAS No.: 213-46-7
Research Areas:  

Cancer

Picene is a polycyclic aromatic hydrocarbon of environmental relevance. Picene can be widely distributed in the environment as the result of incomplete combustion of organic matter. Picene is found to be inactive as complete carcinogen, while it acts in a high dose as a weak tumor initiator .
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