2 Results for "

hepatic microsomal triglyceride transfer protein

" in MedChemExpress (MCE) Product Catalog:
Products (2)

2 Results for "hepatic microsomal triglyceride transfer protein" in MCE Product Catalog:

7
Lomitapide mesylate
Lomitapide mesylate
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7 Cited Publications
Cat. No.: HY-14668
CAS No.: 202914-84-9
Purity:  99.57%
Synonyms: AEGR-733 mesylate; BMS-201038 mesylate
Target:  

Microsomal Triglyceride Transfer Protein (MTP) mTOR LDLR Autophagy Apoptosis

Research Areas:  

Cardiovascular Disease Neurological Disease Metabolic Disease Cancer

Lomitapide (AEGR-733; BMS-201038) mesylate is an orally active microsomal triglyceride transfer protein (MTP) inhibitor and a selective mTORC1 inhibitor with lipid-lowering activity and BBB permeability. Lomitapide mesylate significantly reduces plasma LDL levels by blocking the assembly and secretion of very-low-density lipoprotein (VLDL). Lomitapide mesylate inhibits mTORC1 in an ATP-dependent manner, thereby inducing AMPK-independent autophagic cell death and suppressing cancer cell growth and apoptosis. Lomitapide mesylate also enhances tumor infiltration of CD8 + T cells. In addition, Lomitapide mesylate inhibits HDAC, improves endothelial function, effectively alleviates vascular inflammation and oxidative stress, and exerts neuroprotective effects in a cerebral ischemia/reperfusion injury model. Lomitapide mesylate can be used in research on related diseases such as colorectal cancer, breast cancer, melanoma, ischemic stroke, and familial hypercholesterolemia .
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IRW
IRW
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Cat. No.: HY-P11358
CAS No.: 159718-10-2
Target:  

Angiotensin-converting Enzyme (ACE) Acetyl-CoA Carboxylase Mitochondrial Metabolism

Research Areas:  

Inflammation/Immunology

IRW is an orally active tripeptide produced from egg white with angiotensin converting enzyme (ACE) inhibitory properties. IRW can prevent high-fat diet (HFD)-induced Non-alcoholic fatty liver disease (NAFLD) by modulating hepatic lipid metabolism and increasing mitochondrial content. IRW decreases hepatic triglyceride content and lipid droplet size. IRW increases the hepatic mitochondrial complexes and citrate synthase activity, phosphorylation of 5’-AMP-activated protein kinase and microsomal triglyceride transfer protein abundance. IRW increases phosphorylated acetyl CoA carboxylase and mitochondrial complexes, IRW can be used for the research of inflammation .
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