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hepatocarcinomas

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Antibody (1) ADC Payload (1) Apoptosis (6) Aryl Hydrocarbon Receptor (1) Bacterial (2) Bcl-2 Family (1) Biochemical Assay Reagents (2) Caspase (3) Cytochrome P450 (1) DNA/RNA Synthesis (1) Drug Derivative (1) Drug Intermediate (2) Fungal (1) Glutathione S-transferase (1) HIV (3) HIV Protease (3) Interleukin Related (1) Keap1-Nrf2 (1) MMP (3) NF-κB (1) PARP (1) PD-1/PD-L1 (1) Phosphatase (1) PI3K (1) Reactive Oxygen Species (ROS) (1) Reference Standards (1) SARS-CoV (3) SHP1 (1) SOD (1) TGF-β Receptor (1) Topoisomerase (1) Transmembrane Glycoprotein (1) VD/VDR (1)
By Research Areas:	Cancer (18) Infection (5) Inflammation/Immunology (4) Metabolic Disease (3)

By Targets:

ADC Antibody (1)

ADC Payload (1)

Apoptosis (6)

Aryl Hydrocarbon Receptor (1)

Bacterial (2)

Bcl-2 Family (1)

Biochemical Assay Reagents (2)

Caspase (3)

Cytochrome P450 (1)

DNA/RNA Synthesis (1)

Drug Derivative (1)

Drug Intermediate (2)

Fungal (1)

Glutathione S-transferase (1)

HIV (3)

HIV Protease (3)

Interleukin Related (1)

Keap1-Nrf2 (1)

MMP (3)

NF-κB (1)

PARP (1)

PD-1/PD-L1 (1)

Phosphatase (1)

PI3K (1)

Reactive Oxygen Species (ROS) (1)

Reference Standards (1)

SARS-CoV (3)

SHP1 (1)

SOD (1)

TGF-β Receptor (1)

Topoisomerase (1)

Transmembrane Glycoprotein (1)

VD/VDR (1)

By Research Areas:

Cancer (18)

Infection (5)

Inflammation/Immunology (4)

Metabolic Disease (3)

Inhibitors & Agonists

Biochemical Assay Reagents

Inhibitory Antibodies

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W250111

Carboxymethyl chitosan	Biochemical Assay Reagents Apoptosis Reactive Oxygen Species (ROS) Bcl-2 Family Caspase	Cancer
Carboxymethyl chitosan is a derivative of chitosan. Carboxymethyl chitosan inhibits Apoptosis and ROS. Carboxymethyl chitosan increases the expression of Bcl-2 and reduces the expression of Bax, cytochrome c and caspase-3. Carboxymethyl chitosan inhibits the migration of various cells. Carboxymethyl chitosan exerts antitumor effects on Lewis tumors and hepatocarcinoma .

HY-B0689

Indinavir Maximum Cited Publications 8 Publications Verification MK-639 free base; L-735524 free base	HIV HIV Protease Apoptosis MMP SARS-CoV	Inflammation/Immunology Cancer
Indinavir (MK-639 free base) is an orally active and selective HIV-1 protease inhibitor with a K_i of 0.54 nM for PR. Indinavir exhibits anticancer activity by inhibiting the activation of MMPs-2 hydrolysis, anti-angiogenesis and inducing apoptosis. Indinavir is also a SARS-CoV 3CL ^pro inhibitor .

HY-B0689A

Indinavir sulfate Maximum Cited Publications 8 Publications Verification MK-639; L735524	HIV HIV Protease SARS-CoV Apoptosis MMP	Infection Cancer
Indinavir sulfate (MK-639) is an orally active and selective HIV-1 protease inhibitor with a K_i of 0.54 nM for PR. Indinavir sulfate exhibits anticancer activity by inhibiting the activation of MMPs-2 hydrolysis, anti-angiogenesis and inducing apoptosis. Indinavir sulfate is also a SARS-CoV 3CL ^pro inhibitor .

HY-N2547

Steviolbioside 1 Publications Verification	Drug Intermediate Bacterial	Infection Metabolic Disease Inflammation/Immunology Cancer
Steviolbioside is a sweetener and also an important pharmaceutical intermediate. Steviolbioside can inhibit the proliferation of various tumor cells. Steviolbioside has an MIC of 3.8 µg/mL for Mycobacterium tuberculosis. Steviolbioside also has antidiabetic activity. Steviolbioside can be used in the research of tuberculosis, diabetes and tumors such as breast cancer .

HY-W075903

Hexaamminecobalt(III) chloride Cobalt hexammine trichloride; Hexaamminecobalt trichloride	Biochemical Assay Reagents SOD Glutathione S-transferase	Metabolic Disease Cancer
Hexaamminecobalt (III) chloride is an orally active cobalt coordination compound. Hexaamminecobalt (III) chloride restores the activities of liver antioxidant enzymes (SOD, Catalase) and detoxification enzyme GST. Hexaamminecobalt (III) chloride restores GSH content and reduces DAG. Hexaamminecobalt (III) chloride impairs renal function. Hexaamminecobalt (III) chloride exerts anti-carcinogenic effects in Diethylnitrosamine (HY-N7434)-induced hepatocarcinoma .

HY-131113

N-Nitrosodibutylamine 1 Publications Verification N-Nitroso-di-n-butylamine	Caspase Apoptosis	Cancer
N-Nitrosodibutylamine (N-Nitroso-di-n-butylamine) is a nitrosamine enriched in the drinking water. N-Nitrosodibutylamine regulates caspase pathway. N-Nitrosodibutylamine induces Apoptosis. N-Nitrosodibutylamine induces hepatocarcinoma and oxidative DNA damage .

HY-154825

20-Hydroxyvitamin D3 20(OH)D3; 20S-Hydroxyvitamin D3	VD/VDR Aryl Hydrocarbon Receptor NF-κB Cytochrome P450	Inflammation/Immunology Cancer
20-Hydroxyvitamin D3 (20(OH)D3), a product of vitamin D3 hydroxylation, is a noncalcemic immunomodulator. 20-Hydroxyvitamin D3 binds to vitamin D receptor (VDR), activates VDR and aryl hydrocarbon receptor (AhR) signaling, stimulates CYP24A1 expression, and drives VDR nuclear translocation. 20-Hydroxyvitamin D3 inhibits NF-κB activity via IκBα upregulation. 20-Hydroxyvitamin D3 acts as a substrate for CYP27B1 and rat CYP24A1, undergoing hydroxylation to form dihydroxy-derivatives. 20-Hydroxyvitamin D3 inhibits cell proliferation, colony formation, migration, and tumor growth, and induces cell differentiation in cancer cells. 20-Hydroxyvitamin D3 can be used for the research of inflammatory and autoimmune diseases, melanoma, breast carcinomas, and hepatocarcinoma .

HY-131055

Mytoxin B	ADC Payload PI3K Apoptosis	Cancer
Mytoxin B is an ADC cytotoxin. Mytoxin B is a satratoxin-type trichothecene macrolide and is similar to the effect of LY294002 (HY-10108). Mytoxin B induces cell apoptosis via PI3K/Akt pathway .

HY-N6802

Tigloylgomisin H	Keap1-Nrf2	Cancer
Tigloylgomisin H is a lignan isolated from the fruits of S. chinensis, can induce quinone reductase (QR) activity in Hepa1c1c7 mouse hepatocarcinoma cells. Tigloylgomisin H functions as a monofunctional inducer that specifically upregulates phase II detoxification enzyme NQO1 through the NF-E2-related factor 2 (Nrf2)-ARE pathway, thus represents a potential liver cancer prevention agent .

HY-N2547R

Steviolbioside (Standard)	Reference Standards Drug Intermediate Bacterial	Infection Metabolic Disease Inflammation/Immunology Cancer
Steviolbioside (Standard) is the analytical standard of Steviolbioside (HY-N2547). This product is intended for research and analytical applications. Steviolbioside is a sweetener and also an important pharmaceutical intermediate. Steviolbioside can inhibit the proliferation of various tumor cells. Steviolbioside has an MIC of 3.8 µg/mL for Mycobacterium tuberculosis. Steviolbioside also has antidiabetic activity. Steviolbioside can be used in the research of tuberculosis, diabetes and tumors such as breast cancer .

HY-N1833

3'-Geranyl-3-prenyl-2',4',5,7-tetrahydroxyflavone	Others	Cancer
3'-Geranyl-3-prenyl-2',4',5,7-tetrahydroxyflavone displays cytotoxicity of 1.32, 3.92 and 5.22 μm against the human cervical carcinoma HeLa, human breast carcinoma MCF-7, and human hepatocarcinoma Hep3B cells .

HY-156029

IA1-8H2	Phosphatase	Cancer
IA1-8H2 is a non-covalent, non-competitive inhibitor of PHPT1 (IC₅₀: 3.4 μM). IA1-8H2 can be used for research of lung cancer, hepatocarcinoma, and renal cancer .

HY-B0689B

Indinavir sulfate ethanolate MK-639 ethanolate; L735524 ethanolate	Apoptosis MMP HIV HIV Protease SARS-CoV	Infection Cancer
Indinavir sulfate ethanolate (MK-639 ethanolate) is an orally active and selective HIV-1 protease inhibitor with a K_i of 0.54 nM for PR. Indinavir sulfate ethanolate exhibits anticancer activity by inhibiting the activation of MMPs-2 hydrolysis, anti-angiogenesis and inducing apoptosis. Indinavir sulfate ethanolate is also a SARS-CoV 3CL ^pro inhibitor .

HY-N17973

(-)-Folicanthine	Others	Cancer
(-)-Folicanthine is a dimeric tryptamine-related alkaloid found in the fruits of Chimonanthus praecox. (-)-Folicanthine shows cytotoxic against cancer cells. (-)-Folicanthine can be used for the research of cancer, such as gastric carcinoma and hepatocarcinoma .

HY-P991863

GM103 antibody	ADC Antibody TGF-β Receptor	Cancer
GM103 Antibody is a humanized IgG1 antibody against AMHRII. GM103 Antibody can generate antibody drug conjugate (ADC) (GM103) with a potent auristatin derivative. GM103 Antibody can be used for the study of ovarian cancer and hepatocarcinoma .

HY-P992434

OSE-279	PD-1/PD-L1 SHP1 Interleukin Related	Cancer
OSE-279 is a high-affinity humanized monoclonal bivalent antibody targeting PD-1, the recommended isotype control is HY-P99003. OSE-279 blocks PD-1 ligand binding, inhibits PDL1-induced SHP1 phosphorylation, restores T cell activation, and promotes reactivation of primary T cell effector functions. OSE-279 binds hFcRn receptor, predicts long half-life, induces CD4 and CD8 T cell proliferation, and promotes interleukin 2 and interferon gamma secretion. OSE-279 can be used for the research of advanced malignancies, colon cancer, hepatocarcinoma, mesothelioma .

HY-P992372

huAA98	Drug Derivative Transmembrane Glycoprotein	Cancer
huAA98 is a humanized monoclonal antibody and also a CD146 inhibitor. huAA98 binds to human CD146, regulates its activity and inhibits cancer-related angiogenesis, as well as tube formation, motility, proliferation and migration of endothelial cells. huAA98 inhibits angiogenesis in the chick chorioallantoic membrane assay and reduces microvessel density in human tumor xenograft models. huAA98 shows immunoreactivity only to neovascular vessels within tumors and inhibits the growth of tumor xenograft models. huAA98 can be used in studies related to cancer-related angiogenesis, liver cancer, leiomyosarcoma and pancreatic cancer .

HY-N17442

Echinoside A	Topoisomerase Caspase PARP Fungal DNA/RNA Synthesis	Infection Cancer
Echinoside A is a saponin. Echinoside A can be isolated from sea cucumber. Echinoside A inhibits the catalytic activity of Top2α, reduces the noncovalent binding of Top2α to DNA. Echinoside A activates Caspase-3 and induces PARP cleavage. Echinoside A induces Apoptosis. Echinoside A has anticancer activity against prostate cancer, hepatocellular carcinoma, and S-180 sarcoma. Echinoside A exhibits antifungal activity against a variety of fungi, with a minimum growth inhibitory concentration range of 3.12 to 50.0 μg/mL, including potent activity against Aspergillus and Penicillium species .

Cat. No.	Product Name	Type

HY-W250111

Carboxymethyl chitosan	Biochemical Assay Reagents
Carboxymethyl chitosan is a derivative of chitosan. Carboxymethyl chitosan inhibits Apoptosis and ROS. Carboxymethyl chitosan increases the expression of Bcl-2 and reduces the expression of Bax, cytochrome c and caspase-3. Carboxymethyl chitosan inhibits the migration of various cells. Carboxymethyl chitosan exerts antitumor effects on Lewis tumors and hepatocarcinoma .

HY-W075903

Hexaamminecobalt(III) chloride Cobalt hexammine trichloride; Hexaamminecobalt trichloride	Biochemical Assay Reagents
Hexaamminecobalt (III) chloride is an orally active cobalt coordination compound. Hexaamminecobalt (III) chloride restores the activities of liver antioxidant enzymes (SOD, Catalase) and detoxification enzyme GST. Hexaamminecobalt (III) chloride restores GSH content and reduces DAG. Hexaamminecobalt (III) chloride impairs renal function. Hexaamminecobalt (III) chloride exerts anti-carcinogenic effects in Diethylnitrosamine (HY-N7434)-induced hepatocarcinoma .

Hexaamminecobalt(III) chloride

Cobalt hexammine trichloride; Hexaamminecobalt trichloride

Biochemical Assay Reagents

Hexaamminecobalt (III) chloride is an orally active cobalt coordination compound. Hexaamminecobalt (III) chloride restores the activities of liver antioxidant enzymes (SOD, Catalase) and detoxification enzyme GST. Hexaamminecobalt (III) chloride restores GSH content and reduces DAG. Hexaamminecobalt (III) chloride impairs renal function. Hexaamminecobalt (III) chloride exerts anti-carcinogenic effects in Diethylnitrosamine (HY-N7434)-induced hepatocarcinoma .

Cat. No.	Product Name	Target	Research Area	Image

HY-P991863

GM103 antibody	ADC Antibody TGF-β Receptor	Cancer
GM103 Antibody is a humanized IgG1 antibody against AMHRII. GM103 Antibody can generate antibody drug conjugate (ADC) (GM103) with a potent auristatin derivative. GM103 Antibody can be used for the study of ovarian cancer and hepatocarcinoma .

HY-P992434

OSE-279	PD-1/PD-L1 SHP1 Interleukin Related	Cancer
OSE-279 is a high-affinity humanized monoclonal bivalent antibody targeting PD-1, the recommended isotype control is HY-P99003. OSE-279 blocks PD-1 ligand binding, inhibits PDL1-induced SHP1 phosphorylation, restores T cell activation, and promotes reactivation of primary T cell effector functions. OSE-279 binds hFcRn receptor, predicts long half-life, induces CD4 and CD8 T cell proliferation, and promotes interleukin 2 and interferon gamma secretion. OSE-279 can be used for the research of advanced malignancies, colon cancer, hepatocarcinoma, mesothelioma .

HY-P992372

huAA98	Drug Derivative Transmembrane Glycoprotein	Cancer
huAA98 is a humanized monoclonal antibody and also a CD146 inhibitor. huAA98 binds to human CD146, regulates its activity and inhibits cancer-related angiogenesis, as well as tube formation, motility, proliferation and migration of endothelial cells. huAA98 inhibits angiogenesis in the chick chorioallantoic membrane assay and reduces microvessel density in human tumor xenograft models. huAA98 shows immunoreactivity only to neovascular vessels within tumors and inhibits the growth of tumor xenograft models. huAA98 can be used in studies related to cancer-related angiogenesis, liver cancer, leiomyosarcoma and pancreatic cancer .

Steviolbioside 1 Publications Verification	Trifolium hybridum L. Classification of Application Fields Terpenoids Diterpenoids Plants Compositae Disease Research Fields Sweeteners Source Classification Cancer Food Research	Drug Intermediate Bacterial
Steviolbioside is a sweetener and also an important pharmaceutical intermediate. Steviolbioside can inhibit the proliferation of various tumor cells. Steviolbioside has an MIC of 3.8 µg/mL for Mycobacterium tuberculosis. Steviolbioside also has antidiabetic activity. Steviolbioside can be used in the research of tuberculosis, diabetes and tumors such as breast cancer .

Tigloylgomisin H	Classification of Application Fields Lignans Phenylpropanoids Plants Schisandraceae Schisandra chinensis (Turcz.) Baill. Disease Research Fields Source Classification Cancer	Keap1-Nrf2
Tigloylgomisin H is a lignan isolated from the fruits of S. chinensis, can induce quinone reductase (QR) activity in Hepa1c1c7 mouse hepatocarcinoma cells. Tigloylgomisin H functions as a monofunctional inducer that specifically upregulates phase II detoxification enzyme NQO1 through the NF-E2-related factor 2 (Nrf2)-ARE pathway, thus represents a potential liver cancer prevention agent .

Steviolbioside (Standard)	Structural Classification Trifolium hybridum L. Terpenoids Diterpenoids Plants Compositae Source Classification	Reference Standards Drug Intermediate Bacterial
Steviolbioside (Standard) is the analytical standard of Steviolbioside (HY-N2547). This product is intended for research and analytical applications. Steviolbioside is a sweetener and also an important pharmaceutical intermediate. Steviolbioside can inhibit the proliferation of various tumor cells. Steviolbioside has an MIC of 3.8 µg/mL for Mycobacterium tuberculosis. Steviolbioside also has antidiabetic activity. Steviolbioside can be used in the research of tuberculosis, diabetes and tumors such as breast cancer .

3'-Geranyl-3-prenyl-2',4',5,7-tetrahydroxyflavone	Flavonoids Classification of Application Fields Flavones Phenols Polyphenols Plants Moraceae Disease Research Fields Morus alba Linn. Source Classification Cancer	Others
3'-Geranyl-3-prenyl-2',4',5,7-tetrahydroxyflavone displays cytotoxicity of 1.32, 3.92 and 5.22 μm against the human cervical carcinoma HeLa, human breast carcinoma MCF-7, and human hepatocarcinoma Hep3B cells .

(-)-Folicanthine	Structural Classification Alkaloids Other Alkaloids Calycanthacerae Plants Chimonanthus praecox (L.)Link Source Classification	Others
(-)-Folicanthine is a dimeric tryptamine-related alkaloid found in the fruits of Chimonanthus praecox. (-)-Folicanthine shows cytotoxic against cancer cells. (-)-Folicanthine can be used for the research of cancer, such as gastric carcinoma and hepatocarcinoma .

Echinoside A	Triterpenes Structural Classification Polysaccharides Animals Terpenoids Saccharides Source Classification	Topoisomerase Caspase PARP Fungal DNA/RNA Synthesis
Echinoside A is a saponin. Echinoside A can be isolated from sea cucumber. Echinoside A inhibits the catalytic activity of Top2α, reduces the noncovalent binding of Top2α to DNA. Echinoside A activates Caspase-3 and induces PARP cleavage. Echinoside A induces Apoptosis. Echinoside A has anticancer activity against prostate cancer, hepatocellular carcinoma, and S-180 sarcoma. Echinoside A exhibits antifungal activity against a variety of fungi, with a minimum growth inhibitory concentration range of 3.12 to 50.0 μg/mL, including potent activity against Aspergillus and Penicillium species .

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hepatocarcinomas

Inhibitors & Agonists

Biochemical Assay Reagents

Inhibitory Antibodies

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