Hexaamminecobalt(III) chloride
Based on 1 Customer Validation
Hexaamminecobalt (III) chloride is an orally active cobalt coordination compound. Hexaamminecobalt (III) chloride restores the activities of liver antioxidant enzymes (SOD, Catalase) and detoxification enzyme GST. Hexaamminecobalt (III) chloride restores GSH content and reduces DAG. Hexaamminecobalt (III) chloride impairs renal function. Hexaamminecobalt (III) chloride exerts anti-carcinogenic effects in Diethylnitrosamine (HY-N7434)-induced hepatocarcinoma.
For research use only. We do not sell to patients.
- Purity: 99.50%
- CAS No.: 10534-89-1
- Formula: Cl3CoH18N6
- Molecular Weight:267.48
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Hexaamminecobalt (III) chloride (100 ppm; p.o. via drinking water; 14 weeks) exerts anticarcinogenic effects against Diethylnitrosamine (HY-N7434)-induced hepatocarcinogenesis in BALB/c mice[2].
Hexaamminecobalt (III) chloride (10-20 mg/kg body weight; i.p.; 3 consecutive days) reduces cell viability of preneoplastic liver lesions in mice[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male albino BALB/c mice (average body weight 20-25 g,); DENA-induced hepatocarcinogenesis model[2]
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Dosage:100 ppm in drinking water
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Administration:Oral administration via drinking water, 14 weeks
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Result:Showed significant recovery in body weight gain.
Significantly reduced the relative liver weight.
Reversed the abnormal activities of serum and liver tumor marker enzymes (GGT, LDH).
Reduced lipid peroxidation (decreased MDA levels) and restored the levels/activities of antioxidant parameters (GSH, SOD, CAT) and detoxifying enzyme GST in the liver.
Chemical Information
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CAS No. 10534-89-1
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Appearance Solid
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Molecular Weight 267.48
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Formula Cl3CoH18N6
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Color Brown to orange
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SMILES
ClClCl.[Co].N.N.N.N.N.N
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Synonyms
Cobalt hexammine trichloride; Hexaamminecobalt trichloride
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
H2O : ≥ 50 mg/mL (186.93 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (419 KB)
- English - EN (419 KB)
- Français - FR (419 KB)
- Deutsch - DE (419 KB)
- Norwegian - NO (419 KB)
- Español - ES (419 KB)
- Swedish - SV (419 KB)
- Italian - IT (419 KB)
- Korean - KR (419 KB)
- Portuguese - PT (419 KB)
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Handling Instructions (2659 KB)
References
[1]. Naura AS, et al. Toxic effects of hexaammine cobalt(III) chloride on liver and kidney in mice: Implication of oxidative stress. Drug Chem Toxicol. 2009;32(3):293-9. [Content Brief]
[2]. Naura AS, et al. Anticarcinogenic effects of hexaamminecobalt(III) chloride in mice initiated with diethylnitrosamine. Biol Trace Elem Res. 2007 Nov;119(2):147-65. [Content Brief]
[3]. Naura AS, et al. Studies on mode of action of hexaammine Co(III) chloride against diethylnitrosamine-induced hepatocarcinogenesis in mice. J Biochem Mol Toxicol. 2009 May-Jun;23(3):193-201. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 3.7386 mL | 18.6930 mL | 37.3860 mL | 93.4649 mL |
| 5 mM | 0.7477 mL | 3.7386 mL | 7.4772 mL | 18.6930 mL | |
| 10 mM | 0.3739 mL | 1.8693 mL | 3.7386 mL | 9.3465 mL | |
| 15 mM | 0.2492 mL | 1.2462 mL | 2.4924 mL | 6.2310 mL | |
| 20 mM | 0.1869 mL | 0.9346 mL | 1.8693 mL | 4.6732 mL | |
| 25 mM | 0.1495 mL | 0.7477 mL | 1.4954 mL | 3.7386 mL | |
| 30 mM | 0.1246 mL | 0.6231 mL | 1.2462 mL | 3.1155 mL | |
| 40 mM | 0.0935 mL | 0.4673 mL | 0.9346 mL | 2.3366 mL | |
| 50 mM | 0.0748 mL | 0.3739 mL | 0.7477 mL | 1.8693 mL | |
| 60 mM | 0.0623 mL | 0.3115 mL | 0.6231 mL | 1.5577 mL | |
| 80 mM | 0.0467 mL | 0.2337 mL | 0.4673 mL | 1.1683 mL | |
| 100 mM | 0.0374 mL | 0.1869 mL | 0.3739 mL | 0.9346 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Hexaamminecobalt(III) chloride Related Classifications
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