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11 Results for "
histone deacetylase 8
" in MedChemExpress (MCE) Product Catalog:
Products (11)
11 Results for "histone deacetylase 8" in MCE Product Catalog:
Cat. No.: HY-P83249A
Synonyms: HDAC8; HDACL1; CDA07; histone deacetylase 8; HD8
Target:
Research Areas:
4-Dibenzofurancarboxylic acid is one of the synthesis materials of polycyclic aromatic hydrocarbons (PAHs) and Schistosoma mansoni histone deacetylase 8 (smHDAC8) inhibitors .
Cat. No.: HY-144098
CAS No.: 2824131-20-4
HDAC8-IN-2 (compound 5o) is a potent HDAC8 inhibitor, with IC50 values of 0.27 and 0.32 μM for smHDAC8 (Schistosoma mansoni histone deacetylase 8) and hHDAC8, respectively. HDAC8-IN-2 shows significant killing of the schistosome larvae. HDAC8-IN-2 markedly impairs egg laying of adult worm pairs .
Cat. No.: HY-P702858
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: HDAC8; RPD3; Prev. HDACL1; histone deacetylase-Like 1; Prev. MRXS6; Wilson-Turner X-Linked Mental Retardation Syndrome; Prev. WTS; histone deacetylase; Protein Decrotonylase HDAC8; CDA07; Protein deacetylase HDAC8; CDLS5; KDAC8; histone deacetylase 8; HD8
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P75144
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: HDAC8; RPD3; Prev. HDACL1; histone deacetylase-Like 1; Prev. MRXS6; Wilson-Turner X-Linked Mental Retardation Syndrome; Prev. WTS; histone deacetylase; Protein Decrotonylase HDAC8; CDA07; Protein deacetylase HDAC8; CDLS5; KDAC8; histone deacetylase 8; HD8
Species:
Mouse
Source:
Sf9 insect cells
Cat. No.: HY-117093
CAS No.: 423731-10-6
H8-A5 is a novel human histone deacetylase 8 (HDAC8) inhibitor. A highly specific ZBG-based pharmacophore model was developed by incorporating a custom zinc-binding group (ZBG) feature. Pharmacophore-based virtual screening identified three novel HDAC8 inhibitors with low micromolar IC50 values (1.8-1.9 μM). Further studies showed that H8-A5 was more selective for HDAC8 than HDAC1/4 and exhibited antiproliferative activity in MDA-MB-231 cancer cells. Molecular docking and molecular dynamics studies showed that H8-A5 could bind to HDAC8, providing a good starting point for the development of HDAC8 inhibitors for cancer treatment.
Cat. No.: HY-111027
CAS No.: 949792-00-1
HDAC8-IN-13 is a novel histone deacetylase 8 (HDAC8) inhibitor with antiparasitic activity. HDAC8-IN-13 can effectively inhibit the acetyl-L-lysine deacetylase activity of schistosomes, affecting the parasite's infectivity. HDAC8-IN-13 can induce apoptosis and cause the death of schistosome cells. Through a specific structural basis design, HDAC8-IN-13 exhibits reduced affinity for human HDACs, thereby enhancing its selectivity .
Cat. No.: HY-182035
CAS No.: 2464465-06-1
HDAC8-IN-16 is a selective histone deacetylase 8 (HDAC8) inhibitor with an IC50 of 0.16 μM. HDAC8-IN-16 induces cell apoptosis, triggers G2/M phase cell cycle arrest, and moderately inhibits cancer cell proliferation. HDAC8-IN-16 is applicable to relevant research on colorectal cancer .
Cat. No.: HY-187382
HDAC8-IN-17 is a histone deacetylase 8 inhibitor with human IC50 values of 0.08 μM, 0.44 μM, and 1.9 μM, and high selectivity over HDAC1, HDAC2, HDAC3, and HDAC6. HDAC8-IN-17 exhibits slow-binding, reversible uncompetitive inhibition via allosteric binding to the enzyme-substrate complex. HDAC8-IN-17 induces selective hyperacetylation of SMC3. HDAC8-IN-17 can be used for the research of cancer .
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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
