949792-00-1
Chemical Structure
HDAC8-IN-13
- No. CAS: 949792-00-1
- Formula:C10H10N2O3S
- Molecular Weight:238.26
IUPAC Name: N-hydroxy-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]thiazepine-7-carboxamide
InChIKey: IHRMVRSHVCKOFW-UHFFFAOYSA-N
SMILES: O=C(C1=CC=C(SCCC(N2)=O)C2=C1)NO
Biological Activity: HDAC8-IN-13 is a novel histone deacetylase 8 (HDAC8) inhibitor with antiparasitic activity. HDAC8-IN-13 can effectively inhibit the acetyl-L-lysine deacetylase activity of schistosomes, affecting the parasite's infectivity. HDAC8-IN-13 can induce apoptosis and cause the death of schistosome cells. Through a specific structural basis design, HDAC8-IN-13 exhibits reduced affinity for human HDACs, thereby enhancing its selectivity[1].
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HDAC8-IN-13 | HDAC8-IN-13 is a novel histone deacetylase 8 (HDAC8) inhibitor with antiparasitic activity. HDAC8-IN-13 can effectively inhibit the acetyl-L-lysine deacetylase activity of schistosomes, affecting the parasite's infectivity. HDAC8-IN-13 can induce apoptosis and cause the death of schistosome cells. Through a specific structural basis design, HDAC8-IN-13 exhibits reduced affinity for human HDACs, thereby enhancing its selectivity. | |||||||||||||||||||||
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