2824131-20-4

HDAC8-IN-2 Chemical Structure
2824131-20-4

Chemical Structure

HDAC8-IN-2

  • CAS No.: 2824131-20-4
  • Formula:C21H16N2O5
  • Molecular Weight:376.36

IUPAC Name: N-(5-(hydroxycarbamoyl)-2-methoxyphenyl)dibenzo[b,d]furan-4-carboxamide

InChIKey: RFROQVRGDKTHLN-UHFFFAOYSA-N

SMILES: COC1=C(C=C(C=C1)C(NO)=O)NC(C2=C3OC4=C(C3=CC=C2)C=CC=C4)=O

Biological Activity: HDAC8-IN-2 (compound 5o) is a potent HDAC8 inhibitor, with IC50 values of 0.27 and 0.32 μM for smHDAC8 (Schistosoma mansoni histone deacetylase 8) and hHDAC8, respectively. HDAC8-IN-2 shows significant killing of the schistosome larvae. HDAC8-IN-2 markedly impairs egg laying of adult worm pairs[1].

Cat. No. Product Name Purity Description Pricing
HY-144098 		HDAC8-IN-2 HDAC8-IN-2 (compound 5o) is a potent HDAC8 inhibitor, with IC50 values of 0.27 and 0.32 μM for smHDAC8 (Schistosoma mansoni histone deacetylase 8) and hHDAC8, respectively. HDAC8-IN-2 shows significant killing of the schistosome larvae. HDAC8-IN-2 markedly impairs egg laying of adult worm pairs.
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