2824131-20-4
2824131-20-4
Chemical Structure
HDAC8-IN-2
- CAS No.: 2824131-20-4
- Formula:C21H16N2O5
- Molecular Weight:376.36
IUPAC Name: N-(5-(hydroxycarbamoyl)-2-methoxyphenyl)dibenzo[b,d]furan-4-carboxamide
InChIKey: RFROQVRGDKTHLN-UHFFFAOYSA-N
SMILES: COC1=C(C=C(C=C1)C(NO)=O)NC(C2=C3OC4=C(C3=CC=C2)C=CC=C4)=O
Biological Activity: HDAC8-IN-2 (compound 5o) is a potent HDAC8 inhibitor, with IC50 values of 0.27 and 0.32 μM for smHDAC8 (Schistosoma mansoni histone deacetylase 8) and hHDAC8, respectively. HDAC8-IN-2 shows significant killing of the schistosome larvae. HDAC8-IN-2 markedly impairs egg laying of adult worm pairs[1].
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HDAC8-IN-2 | HDAC8-IN-2 (compound 5o) is a potent HDAC8 inhibitor, with IC50 values of 0.27 and 0.32 μM for smHDAC8 (Schistosoma mansoni histone deacetylase 8) and hHDAC8, respectively. HDAC8-IN-2 shows significant killing of the schistosome larvae. HDAC8-IN-2 markedly impairs egg laying of adult worm pairs. | |||||||||||||||||||||
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