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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
13 Results for "
histone demethylation
" in MedChemExpress (MCE) Product Catalog:
Products (13)
13 Results for "histone demethylation" in MCE Product Catalog:
Cat. No.: HY-173135
CAS No.: 3102423-10-6
Target:
Research Areas:
PROTAC KDM4 degrader-1 is a KDM4 PROTAC degrader that degrades KDM4A-C with DC50 values of 37.53, 39.93, and 49.41 nM, respectively, while sparing KDM4D. PROTAC KDM4 degrader-1 induces cell cycle arrest, apoptosis and antiproliferative activity in esophageal cancer cells. PROTAC KDM4 degrader-1 can be used for the research of esophageal cancer .
Cat. No.: HY-L203
351 compounds
Methylation is an epigenetic modification mechanism that involves adding methyl groups to molecules such as DNA and histones, which can alter gene expression without changing the DNA sequence. This process is catalyzed by enzymes such as DNA methyltransferases (DNMTs) and histone methyltransferases (HMTs), and can be reversed by demethylases. The balance of methylation and demethylation is crucial for maintaining cellular function and genomic stability. Abnormal regulation of methylation may lead to a variety of diseases, including cancer, neurological disorders, and developmental abnormalities. A deep understanding of the molecular mechanisms of methylation metabolism is essential for developing therapeutic strategies for diseases associated with methylation dysregulation.
MCE contains 351 compounds targeting methylation/demethylation enzymes, which is of significant value for studying the pathways of methylation metabolism and exploring their mechanisms of action in diseases.
Cat. No.: HY-P71548
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: JMJD1C; TR-Interacting Protein 8; Prev. TRIP8; DKFZp761F0118; KDM3C; FLJ14374; Jumonji Domain-Containing Protein 1C; TRIP-8; KIAA1380; Putative JmjC Domain-Containing histone demethylation Protein 2C; Probable JmjC Domain-Containing histone demethylation
Species:
Human
Source:
E. coli
Cat. No.: HY-P86931
Synonyms: 5qNCA antibody; C5orf7 antibody; JHDM2B antibody; JmjC domain containing histone demethylation protein 2B antibody; JmjC domain-containing histone demethylation protein 2B antibody; jmjd1b antibody; Jumonji domain containing 1B antibody; Jumonji domain containing protein 1B antibody; Jumonji domain-containing protein 1B antibody; KDM3B antibody; 5qNCA antibody; C5orf7 antibody; JHDM2B antibody; JmjC domain containing histone demethylation protein 2B antibody; JmjC domain-containing histone demethylation protein 2B antibody; jmjd1b antibody; Jumonji domain containing 1B antibody; Jumonji domain containing protein 1B antibody; Jumonji domain-containing protein 1B antibody; KDM3B antibody; KDM3B_HUMAN antibody; KIAA1082 antibody; Lysine (K) specific demethylase 3B antibody; Lysine-specific demethylase 3B antibody; NET22 antibody; Nuclear protein 5qNCA antibody;
Cat. No.: HY-P703619
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: KDM4C; Jumonji Domain-Containing Protein 2C; Prev. JMJD2C; Lysine-Specific Demethylase 4C; GASC1; Tudor Domain Containing 14C; KIAA0780; JHDM3C; TDRD14C; [histone H3]-Trimethyl-L-Lysine(9) Demethylase; JmjC Domain-Containing histone demethylation Protein
Species:
Human
Source:
E. coli
Cat. No.: HY-P702951
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: KDM4C; Jumonji Domain-Containing Protein 2C; Prev. JMJD2C; Lysine-Specific Demethylase 4C; GASC1; Tudor Domain Containing 14C; KIAA0780; JHDM3C; TDRD14C; [histone H3]-Trimethyl-L-Lysine(9) Demethylase; JmjC Domain-Containing histone demethylation Protein
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-126207
CAS No.: 726201-10-1
Target:
Research Areas:
CBN209350 is a selective KDM4 inhibitor with an IC50 of 4 μM. CBN209350 exerts antiproliferative effects on prostate cancer cells. CBN209350 can be used for the research of prostate cancer .
Cat. No.: HY-P83586A
Synonyms: KDM4A; JHDM3A; JMJD2; JMJD2A; KIAA0677; Lysine-specific demethylase 4A; JmjC domain-containing histone demethylation protein 3A; Jumonji domain-containing protein 2A
Cat. No.: HY-P71585
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: KDM3B; Lysine (K)-Specific Demethylase 3B; Prev. C5orf7; Jumonji Domain Containing 1B; Prev. JMJD1B; Nuclear Protein 5qNCA; KIAA1082; Chromosome 5 Open Reading Frame 7; NET22; JHDM2B; JmjC Domain-Containing histone demethylation Protein 2B; 5qNCA; [Histon
Species:
Human
Source:
E. coli
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
