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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
7 Results for "
homeobox genes
" in MedChemExpress (MCE) Product Catalog:
Products (7)
7 Results for "homeobox genes" in MCE Product Catalog:
Research Areas:
MI-389 is a potent menin-MLL interaction inhibitor (IC50=25 nM) and a CRBN-recruiting, GSPT1-targeted PROTAC degrader. MI-389 upregulates myeloid differentiation-related genes that are lowly expressed in primitive hematopoietic progenitor cells, thereby inducing myeloid differentiation phenotypic changes in MLL-rearranged leukemia cells. MI-389 competitively blocks the MG-H1-RAGE interaction to interfere with the AGEs-RAGE pathway, thus alleviating AGEs-induced HUVEC injury . MI-389 can be used in studies related to MLL-rearranged acute leukemia .
Cat. No.: HY-177971
Research Areas:
Braxlosiran is a component of the AOC reagent Delpacibart braxlosiran (HY-177566), consisting of an siRNA targeting DUX4 (double homeobox protein) and SMCC linker (HY-42360). Delpacibart braxlosiran binds to TfR1. Aberrant expression of the DUX4 protein causes changes in gene expression in muscle cells, which are associated with muscle function loss in facioscapulohumeral muscular dystrophy (FSHD) .
Cat. No.: HY-174544
Human POU class 5 homeobox 1 (POU5F1) mRNA encodes a transcription factor containing a POU homeodomain that plays a key role in embryonic development and stem cell pluripotency. Aberrant expression of this gene in adult tissues is associated with tumorigenesis.
Cat. No.: HY-174669
Human HNF1A mRNA encodes the human HNF1 homeobox A (HNF1A) protein, a transcription factor that required for the expression of several liver-specific genes. HNF1A functions as a homodimer and binds to the inverted palindrome 5''-GTTAATNATTAAC-3''.
Cat. No.: HY-174547
Target:
Research Areas:
Human PDX1 mRNA encodes the human pancreatic and duodenal homeobox 1 (PDX1) protein, a transcriptional activator of several genes, including insulin, somatostatin, glucokinase, islet amyloid polypeptide, and glucose transporter type 2. PDX1 may be involved in the early development of the pancreas. It also plays a major role in glucose-dependent regulation of insulin gene expression.
Cat. No.: HY-174545
Target:
Research Areas:
Human POU3F2 mRNA encodes the human POU class 3 homeobox 2 (POU3F2) protein, a member of the POU-III class of neural transcription factors. POU3F2 is involved in neuronal differentiation and enhances the activation of corticotropin-releasing hormone regulated genes.
Cat. No.: HY-174589
Target:
Research Areas:
Human LMX1A mRNA encodes the human LIM homeobox transcription factor 1 alpha (LMX1A) protein, a homeodomain and LIM-domain containing protein. LMX1A is a transcription factor that acts as a positive regulator of insulin gene transcription. It also plays a role in the development of dopamine producing neurons during embryogenesis.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
