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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
6 Results for "
homogentisate 1
" in MedChemExpress (MCE) Product Catalog:
Products (6)
6 Results for "homogentisate 1" in MCE Product Catalog:
1
Cyclopyrimorate, a highly effective bleaching herbicide for weed control in rice fields, targets homogentisate solanesyltransferase (HST). HST is a downstream enzyme of 4-hydroxyphenylpyruvate dioxygenase in the plastoquinone (PQ) biosynthesis pathway [1] .
Cat. No.: HY-E71849
Target:
Research Areas:
4-Hydroxyphenylacetate 1-monooxygenase (EC 1.14.13.18) is an oxidoreductase that can catalyze multiple reactions, including reaction 1: convert 4-hydroxyphenylacetate, NADPH, O2 and H + into homogentisate, NADP + and H2O; reaction 2: convert 4-hydroxyphenylacetate, NADH, O2 and H + into homogentisate, NAD + and H2O.
Cat. No.: HY-E71855
Target:
Research Areas:
4-Hydroxyphenylpyruvate dioxygenase (EC 1.13.11.27) is an oxidoreductase that can convert 3-(4-hydroxyphenyl)pyruvate and O2 into homogentisate and CO2.
Cat. No.: HY-E71698
Target:
Research Areas:
3-Hydroxy-2-methylquinolin-4-one 2,4-dioxygenase (EC 1.13.11.48) is an oxidoreductase that catalyzes a key step in the tyrosine degradation pathway, converting 4-hydroxyphenylpyruvate into homogentisate.
Cat. No.: HY-108046
CAS No.: 869743-37-3
Synonyms: UP302
Target:
Tyrosinase PI3K Akt Bcl-2 Family Caspase PINK1/Parkin Atg8/LC3 Mitophagy Apoptosis Reactive Oxygen Species (ROS)
Research Areas:
Nivitol (UP302) is a natural phenolic compound discovered from Dianella ensifolia and also acts as a Tyrosinase inhibitor. Nivitol competitively and reversibly inhibits tyrosinase, suppressing melanin production. Nivitol inhibits homogentisate 1,2-dioxygenase (HGD). In human leukemia cells, Nivitol inhibits PI3K/AKT pathway phosphorylation, increases ROS, decreases mitochondrial membrane potential, and induces G2/M cell cycle arrest, apoptosis, and PINK1/Parkin-mediated mitophagy. Nivitol exhibits inhibition of tumor growth in the MV411 xenograft mouse model. Nivitol is used for research on exogenous ochronosis, hyperpigmentation, and leukemia [1] .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
