10 Results for "

human M2 macrophages

" in MedChemExpress (MCE) Product Catalog:
Products (10)

10 Results for "human M2 macrophages" in MCE Product Catalog:

1
Medrysone
Medrysone
0 Images
1 Cited Publications
Cat. No.: HY-B1076
CAS No.: 2668-66-8
Synonyms: HMS; 6α-Methyl-11β-hydroxyprogesterone
Target:  

VEGFR CCR STAT

Research Areas:  

Neurological Disease

Medrysone (HMS; 6α-Methyl-11β-hydroxyprogesterone) is a STAT6 modulator and M2 macrophage polarization inducer. Medrysone enhances IL-4-triggered STAT6 activation, upregulates the expression of M2 markers, and promotes the secretion of VEGF and CCL2. Medrysone also enhances the pro-migratory activity of M2-like macrophages toward endothelial cells. By regulating macrophage polarization and related repair pathways, Medrysone significantly promotes corneal wound repair in a rat mechanical injury model. Medrysone can be used for research related to corneal injury .
loading...
    loading...
View All Sizes
Zovostotug
Zovostotug
0 Images
Cat. No.: HY-P990087
CAS No.: 2756228-84-7
Synonyms: OR-2805

Target:  

Scavenger Receptor Class B type I (SR-BI）

Research Areas:  

Inflammation/Immunology Cancer

Zovostotug (OR-2805) is a fully human IgG1 antibody that binds to CD163. Zovostotug binds to CD163 expressed on TAMs and M2-like macrophages. Zovostotug does not bind to other hematopoietic cells nor to a panel of human primary non-immune cells. Zovostotug canbe used for the study of lung cancer .
loading...
    loading...
View All Sizes
Peptide R
Peptide R
0 Images
Cat. No.: HY-P4111
CAS No.: 1318232-11-9
Target:  

CXCR

Research Areas:  

Inflammation/Immunology Cancer

Peptide R is a cyclic peptide and a specific CXCR4 antagonist. Peptide R exhibits excellent ability to effectively remodel tumor stroma. Peptide R has potential for use in tumor research .
loading...
    loading...
View All Sizes
Resolvin D5
Resolvin D5
0 Images
Cat. No.: HY-145491
CAS No.: 578008-43-2
Category:  

Ketones, Aldehydes, Acids Endogenous metabolite

Target:  

ERK NF-κB CCR

Resolvin D5 is an anti-inflammatory and analgesic agent produced in M2 macrophages. Resolvin D5 alleviates Paclitaxel (HY-B0015)-induced mechanical allodynia and inflammatory pain by activating the GPR32 receptor, with gender specificity (effective only in male mice) and independence from TRPV1 or TRPA1 channels. Resolvin D5 attenuates LPS-induced ERK phosphorylation and NF-κB nuclear translocation, downregulates proinflammatory mediators such as IL-6 and CCL5, inhibits Th17 cell differentiation and osteoclastogenesis, promotes regulatory T cell differentiation, and shows no cytotoxicity to human monocytes. The level of Resolvin D5 is elevated in arthritic SKG mice, but Resolvin D5 has no effect on dendritic cell differentiation or M1 macrophage polarization, nor does it prevent ZyA-induced arthritis progression. Resolvin D5 is suitable for research related to chemotherapy-induced peripheral neuropathy, inflammatory pain and rheumatoid arthritis .
loading...
    loading...
View All Sizes
Polzastobart
Polzastobart
0 Images
Cat. No.: HY-P990061
CAS No.: 2640981-19-5
Synonyms: JTX 8064

Target:  

Transmembrane Glycoprotein LILRB

Research Areas:  

Inflammation/Immunology Cancer

Polzastobart (JTX-8064) is a humanized IgG4 monoclonal antibody and LILRB2 (ILT4) antagonist. Polzastobart specifically binds to and antagonizes LILRB2, relieves ILT4-mediated myeloid immunosuppression, and promotes the polarization of macrophages from an M2-like phenotype to an M1-like phenotype. Polzastobart induces macrophage polarization, IFNγ signaling, and T cell inflammation-related pharmacodynamic responses in ex vivo human renal cancer, lung cancer, and head and neck cancer tissues. Polzastobart can be used in studies related to tumor-associated macrophages and tumor immunity. For the isotype control of Polzastobart, refer to: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003) .
loading...
    loading...
View All Sizes
Dazdotuftide
Dazdotuftide
0 Images
Cat. No.: HY-P3449
CAS No.: 2522933-44-2
Synonyms: TRS01
Target:  

Toll-like Receptor (TLR) Complement System

Research Areas:  

Inflammation/Immunology

Dazdotuftide (TRS01) is a multi-target immunomodulator composed of tuftsin and phosphorylcholine-related groups. Dazdotuftide regulates TLR4/NF-κB and NRP1/VEGF165 related signaling pathways and inhibits the production of pro-inflammatory cytokines. Dazdotuftide can be used in studies related to inflammation and immunoregulation .
loading...
    loading...
View All Sizes
CT-1119
CT-1119
0 Images
Cat. No.: HY-P992338

Target:  

Mesothelin Constitutive Androstane Receptor

Research Areas:  

Inflammation/Immunology Cancer

CT-1119 is an autologous human anti-Mesothelin chimeric antigen receptor macrophage (CAR-M). CT-1119 mediates CAR-dependent, antigen-dependent functional activities. CT-1119 acts as a phagocytosis inducer, tumor cell killer, pro-inflammatory cytokine inducer, and M1 macrophage polarizer. CT-1119 exhibits stronger resistance to M2 repolarization and reduces tumor burden in a mouse lung cancer xenograft model. CT-1119 can be used for the research of mesothelin-expressing solid tumors .
loading...
    loading...
View All Sizes
Dazdotuftide TFA
Dazdotuftide TFA
0 Images
Cat. No.: HY-P3449A
CAS No.: 2522933-45-3
Synonyms: TRS01 TFA
Target:  

Toll-like Receptor (TLR) Complement System

Research Areas:  

Inflammation/Immunology

Dazdotuftide TFA (TRS01 TFA) is a multi-target immunomodulator composed of tuftsin and phosphorylcholine-related groups. Dazdotuftide TFA regulates TLR4/NF-κB and NRP1/VEGF165 related signaling pathways and inhibits the production of pro-inflammatory cytokines. Dazdotuftide TFA can be used in studies related to inflammation and immunoregulation .
loading...
    loading...
View All Sizes
BODIPY−DOX
BODIPY−DOX
0 Images
Cat. No.: HY-D3190
CAS No.: 2173116-67-9
BODIPY-DOX is a conjugate composed of BODIPY and Doxorubicin (HY-15142A), as well as a pH-activated fluorescent probe for M1 macrophages and an apoptosis inducer. BODIPY-DOX undergoes pH-induced hydrazone bond cleavage in acidic M1 macrophage phagosomes, thereby releasing cytotoxic Doxorubicin (Dox) and inhibiting the function of pro-inflammatory M1 macrophages. BODIPY-DOX highly selectively inhibits the production of relevant pro-inflammatory cytokines by mouse and human monocyte-derived M1 macrophages, while exerting minimal effects on M2 or unactivated macrophages. Therefore, BODIPY-DOX enables simultaneous fluorescent tracing, differentiation and elimination of specific macrophage subsets, and exhibits the potential to regulate tissue regeneration in zebrafish models .
loading...
    loading...
View All Sizes
CDr17
CDr17
0 Images
Cat. No.: HY-D3410
CAS No.: 2991899-29-5
CDr17 is a GLUT1 substrate and selective fluorescent dye staining M1 microphages. CDr17 utilizes the Gating-Oriented Live-cell Distinction (GOLD) mechanism to enter M1 macrophages (Ex/Em = 646/662 nm) .
loading...
    loading...
View All Sizes
Assay Types