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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
16 Results for "
human glucose-dependent insulinotropic polypeptide receptor
" in MedChemExpress (MCE) Product Catalog:
Products (16)
16 Results for "human glucose-dependent insulinotropic polypeptide receptor" in MCE Product Catalog:
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Research Areas:
Cardiovascular Disease Neurological Disease Metabolic Disease Cancer
Tirzepatide sodium (LY3298176 sodium) is a dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist. Tirzepatide sodium exerts anti-apoptotic and pro-differentiation effects via the pAkt/CREB/BDNF cascade and miRNA in neurons; in the heart, it promotes BCAA catabolism and inhibits the mTOR pathway by mediating the dephosphorylation of BCKDHA; meanwhile, it effectively reduces insulin and leptin levels and suppresses inflammatory responses at the systemic level. Tirzepatide sodium can be used for research on myocardial infarction, colon cancer, diabetes, diabetic cognitive impairment, neurodegeneration, diabetes-related neuropathy, and obesity .
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Cat. No.: HY-164535
CAS No.: 2887445-76-1
Synonyms: AMG 133
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Maridebart cafraglutide (AMG 133) is a long-acting peptide-antibody conjugate that combines GLP-1 receptor agonist with glucose-dependent insulinotropic polypeptide (GIP) receptor antagonism. Maridebart cafraglutide shows antagonist activity against human, cynomolgus monkey and rat GIPR with IC50 values of 46.4 nM, 26.5 nM, 822.3 nM, respectively. Maridebart cafraglutide shows agonist activity against human, cynomolgus monkey, rat and mouse GLP-1R with EC50 values of 24.4 pM, 5.7 pM, 2.4 pM and 123 pM, respectively. Maridebart cafraglutide can be used for the study of obesity and type 2 diabetes .
Cat. No.: HY-P2542
CAS No.: 1802086-25-4
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Cat. No.: HY-P3506CP
CAS No.: 2381089-83-2
Synonyms: LY3437943 (crude)
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Cat. No.: HY-P1731CP
CAS No.: 2023788-19-2
Target:
Research Areas:
Cardiovascular Disease Neurological Disease Metabolic Disease Cancer
Tirzepatide (LY3298176) (crude) is the crude form of Tirzepatide (HY-P1731).Tirzepatide (LY3298176) is a dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist. Tirzepatide exerts anti-apoptotic and pro-differentiation effects via the pAkt/CREB/BDNF cascade and miRNA in neurons; in the heart, it promotes BCAA catabolism and inhibits the mTOR pathway by mediating the dephosphorylation of BCKDHA; meanwhile, it effectively reduces insulin and leptin levels and suppresses inflammatory responses at the systemic level. Tirzepatide can be used for research on myocardial infarction, colon cancer, diabetes, diabetic cognitive impairment, neurodegeneration, diabetes-related neuropathy, and obesity .
Cat. No.: HY-P702285
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: GIPR; GIP-R; Gastric Inhibitory polypeptide receptor; PGQTL2; glucose-dependent insulinotropic polypeptide receptor
Species:
Human
Source:
E. coli Cell-free
Cat. No.: HY-P702800
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: GIPR; GIP-R; Gastric Inhibitory polypeptide receptor; PGQTL2; glucose-dependent insulinotropic polypeptide receptor
Species:
Human
Source:
HEK293
Cat. No.: HY-P703990
Purity: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: GIPR; GIP-R; Gastric Inhibitory polypeptide receptor; PGQTL2; glucose-dependent insulinotropic polypeptide receptor
Species:
Human
Source:
HEK293
Cat. No.: HY-P703982
Purity: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: GIPR; GIP-R; Gastric Inhibitory polypeptide receptor; PGQTL2; glucose-dependent insulinotropic polypeptide receptor
Species:
Human
Source:
HEK293
Cat. No.: HY-P0276F
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Cat. No.: HY-P3506S
Synonyms: LY3437943, Pro40(13C5,15N) TFA
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Retatrutide, Pro40( 13C5, 15N) (LY3437943, Pro40( 13C5, 15N) TFA) is the 13C, 15N-labeled Retatrutide (HY-P3506). Retatrutide (LY3437943) is a triple agonist peptide of the glucagon receptor (GCGR), glucosedependent insulinotropic polypeptide receptor (GIPR), and glucagon-like peptide-1 receptor (GLP-1R). Retatrutide binds human GCGR, GIPR, and GLP-1R with EC50 values of 5.79, 0.0643 and 0.775 nM, respectively. Retatrutide can be used for the research of obesity .
Cat. No.: HY-P3506S1
Synonyms: LY3437943, Phe22(13C9,15N) TFA
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Retatrutide, Phe22( 13C9, 15N) (LY3437943, Phe22( 13C9, 15N) TFA is the 13C, 15N-labeled Retatrutide (HY-P3506). Retatrutide (LY3437943) is a triple agonist peptide of the glucagon receptor (GCGR), glucosedependent insulinotropic polypeptide receptor (GIPR), and glucagon-like peptide-1 receptor (GLP-1R). Retatrutide binds human GCGR, GIPR, and GLP-1R with EC50 values of 5.79, 0.0643 and 0.775 nM, respectively. Retatrutide can be used for the research of obesity .
Cat. No.: HY-171302
CAS No.: 2766799-78-2
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GLP-1R/GIPR agonist-2 is a GIPR agonist. GLP-1R/GIPR agonist-2 potentiates GIP(1-42)-induced intracellular cAMP production in cells expressing human GIPR. GLP-1R/GIPR agonist-2 can be used for the research of type II diabetes mellitus .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
