41 Results for "

humanized IgG4-κ antibody

" in MedChemExpress (MCE) Product Catalog:
Products (41)

41 Results for "humanized IgG4-κ antibody" in MCE Product Catalog:

1
1 Cited Publications
Cat. No.: HY-P99264
CAS No.: 1660159-36-3
Synonyms: humanized Anti-CD22 Recombinant antibody
Research Areas:  

Cancer

Inotuzumab (Humanized Anti-CD22 Recombinant Antibody) is a humanized IgG4κ antibody that targets human CD22. Inotuzumab can be linked to a toxic agent Ozogamicin as an antibody-drug conjugate (ADC), Inotuzumab ozogamicin (HY-P9959). Inotuzumab can be used for the research of acute lymphoblastic leukemia and non-Hodgkin lymphoma .
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Cat. No.: HY-P990070
CAS No.: 2642175-46-8
Synonyms: BION-1301

Target:  

TNF Receptor

Research Areas:  

Inflammation/Immunology Cancer

Zigakibart (BION-1301) is an IgG4-kappa, humanized monoclonal antibody against TNFSF13 (tumor necrosis factor (TNF) superfamily member 13, APRIL, CD256). Zigakibart exhibits anti-inflammatory activity .
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Cat. No.: HY-P990540
Synonyms: CSL346; Reflocibart

Target:  

VEGFR

Research Areas:  

Metabolic Disease

Anti-VEGFB Antibody (CSL346; Reflocibart) is a humanized IgG4κ monoclonal antibody targeting VEGF-B, which binds to VEGF-B with high affinity to reduce its activity. Anti-VEGFB Antibody (CSL346) inhibits ectopic lipid deposition in the kidney, improves the histological manifestations of glomerular injury, and reduces proteinuria in animal models. Anti-VEGFB Antibody (CSL346) can be used in studies related to diabetic nephropathy .
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Cat. No.: HY-P99573
CAS No.: 2245725-04-4
Synonyms: MGD-013

Target:  

LAG-3

Research Areas:  

Inflammation/Immunology Cancer

Tebotelimab (MGD-013) is a humanized IgG4κ bispecific PD-1/LAG-3 dual-affinity re-targeting (DART) antibody. Tebotelimab binds cell-surface expressed PD-1 and LAG-3 with EC50s of 1.65 nM and 0.41 nM in NS0 cells, respectively. Tebotelimab blocks PD-1/PD-L1, PD-1/PD-L2 and LAG-3/HLA (MHC-II) interactions and PD-1 signaling. Tebotelimab restores exhausted T-cell responses and and enhances antitumour immunity .
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Cat. No.: HY-P991201

Target:  

Interleukin Related

Research Areas:  

Inflammation/Immunology

REGN-7257 is a humanized monoclonal antibody targeting IL2RG. REGN-7257 blocks the signal transduction induced by common gamma chain (γc) cytokines via the IL2RG chain of the γc cytokine receptor complex. REGN-7257 is applicable for research on immune-mediated diseases and T cell-mediated diseases . Its corresponding isotype control is Human IgG4 kappa, Isotype Control (HY-P99003).
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Cat. No.: HY-P990669
CAS No.: 2241728-76-5

Target:  

Interleukin Related

Research Areas:  

Inflammation/Immunology

Torudokimab is a humanized antibody expressed in CHO, targeting IL-33. Torudokimab has a huIgG4SP type heavy chain and a huκ type light chain, with a predicted molecular weight (MW) of 145.22 kDa. The isotype control for Torudokimab can refer to Human IgG4 kappa, Isotype Control (HY-P99003).
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Cat. No.: HY-P99264A
CAS No.: 1660159-36-3
Synonyms: humanized Anti-CD22 Recombinant antibody (powder)

Research Areas:  

Cancer

Inotuzumab (Humanized Anti-CD22 Recombinant Antibody) (powder) is a humanized IgG4κ antibody that targets human CD22. Inotuzumab (powder) can be linked to a toxic agent Ozogamicin as an antibody-drug conjugate (ADC), Inotuzumab ozogamicin (HY-P9959). Inotuzumab (powder) can be used for the research of acute lymphoblastic leukemia and non-Hodgkin lymphoma .
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Cat. No.: HY-P990631
CAS No.: 2305770-44-7

Research Areas:  

Inflammation/Immunology

Mibavademab is a CHO-expressed humanized antibody that targets LEPR/CD295. Mibavademab is equipped with a huIgG4SP heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 145.58 kDa. The isotype control for Mibavademab can be referenced as Human IgG4 kappa, Isotype Control (HY-P99003).
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Cat. No.: HY-P990670
CAS No.: 2935496-38-9
Synonyms: Eltivutabart

Target:  

Inhibitory Antibodies

Research Areas:  

Inflammation/Immunology

TTX-030 is a humanized antibody expressed in CHO cells, targeting ENTPD1/CD39. TTX-030 contains huIgG4SP heavy chain and huκ light chain, with a predicted molecular weight (MW) of 150 kDa. The isotype control for TTX-030 can refer to Human IgG4 kappa, Isotype Control (HY-P99003).
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Cat. No.: HY-P990555
Synonyms: OSE-172

Target:  

CD47

Research Areas:  

Inflammation/Immunology

BI-765063 (OSE-172) is a humanized antibody expressed in CHO that targets SIRPa/CD172a. BI-765063 contains an IgG4-type heavy chain and a huκ-type light chain, with a predicted molecular weight (MW) of 146.3 kDa. The isotype control for BI-765063 can be referenced as Human IgG4 kappa, Isotype Control (HY-P99003).
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Cat. No.: HY-P991698
CAS No.: 2785392-78-9
Synonyms: BAT-1308

Target:  

PD-1/PD-L1

Research Areas:  

Cancer

Liscastobart is a humanized IgG4κ antibody targeting PDCD1/PD-1/CD279. The corresponding isotype control is: Human IgG4 kappa, Isotype Control (HY-P99003) .
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Cat. No.: HY-P991705
CAS No.: 2911556-99-3
Synonyms: JJP-1212

Target:  

Fc Receptor (FcR)

Research Areas:  

Inflammation/Immunology

Nebaprubart (JJP-1212) is a humanized IgG4κ antibody against FCAR/CD89, and its corresponding isotype control is Human IgG4 kappa, Isotype Control (HY-P99003). Nebaprubart works by blocking a key receptor involved in inflammation .
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Cat. No.: HY-P991038
CAS No.: 2904575-77-3

Target:  

CD28

Research Areas:  

Inflammation/Immunology

HY-P991038 is an BTLA-targeting IgG4κ type humanized antibody, the recommed isotype control is Human IgG4 (S228P) kappa, Isotype Control (HY-P99003) .
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Cat. No.: HY-P99106
CAS No.: 2506324-29-2

Target:  

PD-1/PD-L1

Research Areas:  

Cancer

Acrixolimab a humanized IgG4-κ antibody, targeting to PD-1 .
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Cat. No.: HY-P990426

Target:  

TGF-beta/Smad

Research Areas:  

Inflammation/Immunology

The Anti-GREM1/Gremlin Antibody is a humanized antibody expressed in CHO that targets GREM1/Gremlin. The Anti-GREM1/Gremlin Antibody has a huIgG4SP heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 150 kDa. The isotype control for the Anti-GREM1/Gremlin Antibody can refer to Human IgG4 kappa, Isotype Control (HY-P99003).
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Cat. No.: HY-P991710
CAS No.: 3035680-82-8

Target:  

Interleukin Related

Research Areas:  

Inflammation/Immunology

Ponumkibart is a humanized IgG4κ antibody targeting IL-17RB. The corresponding isotype control is: Human IgG4 kappa, Isotype Control (HY-P99003) .
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Cat. No.: HY-P991721
CAS No.: 3033317-31-3

Target:  

PCSK9

Research Areas:  

Cardiovascular Disease

Ticalicibart is a humanized IgG4κ monoclonal antibody inhibitor targeting PCSK9. Ticalicibart has anti-hyperlipidaemic activity. Ticalicibart can be used for cardiovascular disease like hypercholesterolaemia research .
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Cat. No.: HY-P991708
CAS No.: 3034664-43-9
Synonyms: REGN-4336

Target:  

PSMA CD3

Research Areas:  

Cancer

Olsutamig is a bivalent humanized IgG4κ monoclonal antibody inhibitor targeting FOLH1/PSMA and CD3E. Olsutamig simultaneously binds to PSMA on the tumor cell surface and CD3E on the T cell surface, markedly activating T cells and thereby specifically killing prostate cancer cells .
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Cat. No.: HY-P990515
Synonyms: NKTT320

Target:  

Inhibitory Antibodies

Research Areas:  

Inflammation/Immunology

Anti-TCR Antibody (NKTT320) is a humanized antibody expressed in CHO, targeting TCR. Anti-TCR Antibody (NKTT320) features huIgG4 heavy chain and huκ light chain, with a predicted molecular weight (MW) of 150 kDa. The isotype control for Anti-TCR Antibody (NKTT320) can refer to Human IgG4 kappa, Isotype Control (HY-P99003).
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Cat. No.: HY-P991688
CAS No.: 3037526-90-9

Target:  

Interleukin Related

Research Areas:  

Inflammation/Immunology

Gimvekibart is a humanized IgG4κ monoclonal antibody inhibitor targeting IL-4Ra/CD124. Gimvekibart can be used for inflammatory diseases like idiopathic pulmonary fibrosis (IPF) research .
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