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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
2 Results for "
hyperosmotic shock
" in MedChemExpress (MCE) Product Catalog:
Products (2)
2 Results for "hyperosmotic shock" in MCE Product Catalog:
Cat. No.: HY-D3092
CAS No.: 2757682-01-0
Target:
Research Areas:
NRERf is an endoplasmic reticulum (ER)-targeted solvatochromic fluorescent probe based on Nile Red (HY-D0718). It possesses ER-targeting capability and can sense changes in local polarity and lipid order of biological membranes. NRERf undergoes excited-state charge transfer, with its emission color changing according to local polarity: the tightly packed, low-polarity liquid-ordered phase (Lo) induces a blue-shifted emission, while the high-polarity liquid-disordered phase (Ld) induces a red-shifted emission. The emission wavelength of NRERf varies with the environment. NRERf can be used to detect changes in lipid order and polarity induced in the ER by cholesterol extraction/enrichment, oxidative stress, and hyperosmotic shock .
Cat. No.: HY-D3110
CAS No.: 2757682-03-2
Research Areas:
NRGolgi is a Nile Red-based solvatochromic fluorescent probe targeted to the Golgi apparatus. NRGolgi localizes selectively to the Golgi membrane via its myristic acid group, and leverages the property of its emission wavelength undergoing blue/red shift with local polarity to quantitatively detect the lipid order of the Golgi membrane in living cells using dual-emission ratiometric imaging (550-600 nm / 600-650 nm). NRGolgi is suitable for real-time monitoring of Golgi lipid order under conditions of oxidative stress, mechanical stress, and altered cholesterol metabolism .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
