4 Results for "

inhibition of IL-1β release

" in MedChemExpress (MCE) Product Catalog:
Products (4)

4 Results for "inhibition of IL-1β release" in MCE Product Catalog:

7
(2Z)-2-Methyl-2-butenedioic acid
(2Z)-2-Methyl-2-butenedioic acid
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7 Cited Publications
Cat. No.: HY-113298
CAS No.: 498-23-7
Purity:  98.73%
Synonyms: Methylmaleic acid; Citraconate
Category:  

Microorganisms Ketones, Aldehydes, Acids Other Diseases Endogenous metabolite Disease Research Fields

Target:  

NOD-like Receptor (NLR) Keap1-Nrf2 Reactive Oxygen Species (ROS)

Citraconic acid (Methylmaleic acid) is an orally active inhibitor targeting the NLRP3 inflammasome and Keap1-Nrf2 pathway. Citraconic acid reduces reactive oxygen species (ROS) generation by inhibiting succinate dehydrogenase (SDH) activity. Citraconic acid also modifies the conformation of Keap1 protein, relieves its inhibition of Nrf2, promotes antioxidant gene expression, and inhibits NLRP3 activation and the release of pro-inflammatory factors such as IL-1β and IL-18. Citraconic acid has anti-inflammatory and antioxidant activities, can reduce oxidative stress and cell pyroptosis, improve tissue damage, and can be used for the research of inflammation-related diseases such as acute renal ischemia-reperfusion injury. Citraconic acid is an isomer of Itaconic acid (HY-Y052) .
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Citraconic acid (Standard)
Citraconic acid (Standard)
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Cat. No.: HY-113298R
CAS No.: 498-23-7
Synonyms: Methylmaleic acid (Standard); Citraconate (Standard)
Category:  

Microorganisms Ketones, Aldehydes, Acids Endogenous metabolite

Target:  

Reference Standards NOD-like Receptor (NLR) Keap1-Nrf2 Reactive Oxygen Species (ROS)

Citraconic acid (Methylmaleic acid) (Standard) is the analytical standard of Citraconic acid (HY-113298). This product is intended for research and analytical applications. Citraconic acid is an orally active inhibitor targeting the NLRP3 inflammasome and Keap1-Nrf2 pathway. Citraconic acid reduces reactive oxygen species (ROS) generation by inhibiting succinate dehydrogenase (SDH) activity. Citraconic acid also modifies the conformation of Keap1 protein, relieves its inhibition of Nrf2, promotes antioxidant gene expression, and inhibits NLRP3 activation and the release of pro-inflammatory factors such as IL-1β and IL-18. Citraconic acid has anti-inflammatory and antioxidant activities, can reduce oxidative stress and cell pyroptosis, improve tissue damage, and can be used for the research of inflammation-related diseases such as acute renal ischemia-reperfusion injury. Citraconic acid is an isomer of Itaconic acid (HY-Y052) .
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DPTIP-prodrug 18
DPTIP-prodrug 18
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Cat. No.: HY-149025
CAS No.: 2881068-33-1
Synonyms: P18
Target:  

Phospholipase

Research Areas:  

Inflammation/Immunology Cancer

DPTIP-proagent 18 (P18) is a orally active and brain-penetrable proagent of DPTIP (HY-131002). DPTIP-proagent 18 is a potent nSMase2 inhibitor. DPTIP-proagent 18 significantly inhibits IL-1β-induced EV (extracellular vesicle) release by inhibition of nSMase2 (neutral sphingomyelinase-2) activity. DPTIP-proagent 18 can be used for brain injury research .
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NT-0527
NT-0527
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Cat. No.: HY-186072
CAS No.: 2771019-10-2
Target:  

NOD-like Receptor (NLR) Interleukin Related Cytochrome P450

Research Areas:  

Neurological Disease Metabolic Disease Inflammation/Immunology

NT-0527 is a selective, orally active, and brain-permeable NLRP3 inflammasome inhibitor. NT-0527 can specifically block the formation of the NLRP3 inflammasome, resulting in the reduction in the maturation and release of IL-1β, exhibit inhibition on CYP2C19. NT-0527 displays anti-inflammatory activity in the mouse LPS (HY-D1056) /ATP (HY-B2176)-induced peritonitis model. NT-0527 can be used for the research of neuroinflammatory disorders (Parkinson's disease, Alzheimer's disease, amyotrophic lateral sclerosis) and peripheral inflammatory disorders (type II diabetes, atherosclerosis, gout, etc.) associated with NLRP3 inflammasome .
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