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inositol pyrophosphates

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Amyloid-β (4) Autophagy (4) Endogenous Metabolite (5) IPK Superfamily (3) MOFs (1)
By Research Areas:	Cancer (4) Cardiovascular Disease (5) Endocrinology (1) Metabolic Disease (5) Neurological Disease (5)

Inhibitors & Agonists

Natural
Products

Targets Recommended: IRE1

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N2581

Phytic acid sodium salt 1 Publications Verification myo-inositol, hexakisdihydrogen phosphate sodium salt; inositol hexaphosphate sodium salt	MOFs Endogenous Metabolite Amyloid-β Autophagy	Cardiovascular Disease Neurological Disease Metabolic Disease Cancer
Phytic acid (myo-Inositol; hexakis dihydrogen phosphate; Inositol hexaphosphate) sodium salt is an orally active compound. Phytic acid sodium salt can be derived from the seeds of legumes. Phytic acid sodium salt is a [PO4] ³- storage depot and precursor for other **inositol phosphates and pyrophosphates. Phytic acid sodium salt attenuates Aβ oligomers and upregulates autophagy** protein. Phytic acid sodium salt can be used in cardiovascular disease, metabolic disease, nervous system disease and cancer research .

HY-N0814

Phytic acid (50% w/w in water) 1 Publications Verification inositol hexaphosphate; SNF472 free acid	Endogenous Metabolite Amyloid-β Autophagy	Cardiovascular Disease Neurological Disease Metabolic Disease Cancer
Phytic acid (myo-Inositol; hexakis dihydrogen phosphate; Inositol hexaphosphate) is an orally active compound. Phytic acid can be derived from the seeds of legumes. Phytic acid is a [PO4] ³- storage depot and precursor for other **inositol phosphates and pyrophosphates. Phytic acid attenuates Aβ oligomers and upregulates autophagy** protein. Phytic acid can be used in cardiovascular disease, metabolic disease, nervous system disease and cancer research .

HY-171099

SC-919 LI-2124	IPK Superfamily	Cardiovascular Disease Endocrinology
SC-919 is an orally active IP6K inhibitor, with an IC₅₀ of < 5.2 nM against IP6K1, < 3.8 nM against IP6K2, and 0.65 nM against IP6K3. By inhibiting the activity of IP6K, SC-919 reduces intracellular IP7 levels, thereby suppressing XPR1-mediated cellular phosphate efflux. SC-919 increases intracellular phosphate and ATP levels while reducing phosphate entry into the bloodstream, thus decreasing plasma phosphate levels. SC-919 can be used in research related to chronic kidney disease and hyperphosphatemia .

HY-150607

UNC7467	IPK Superfamily	Others
UNC7467 is a potent IP6K inhibitor with values of 4.9, 8.9 and 1320 nM for IP6K2, IP6K1 and IP6K6, respectively. UNC7467 reduces levels of inositol pyrophosphates. UNC7467 can be used for obesity research .

HY-N2580

Zinc Phytate 1 Publications Verification	Endogenous Metabolite Amyloid-β Autophagy	Cardiovascular Disease Neurological Disease Metabolic Disease Cancer
Zinc Phytate (myo-Inositol; hexakis dihydrogen phosphate; Inositol hexaphosphate) is an orally active compound. Zinc Phytate can be derived from the seeds of legumes. Zinc Phytate is a [PO4] ³- storage depot and precursor for other **inositol phosphates and pyrophosphates. Zinc Phytate attenuates Aβ oligomers and upregulates autophagy** protein. Zinc Phytate can be used in cardiovascular disease, metabolic disease, nervous system disease and cancer research .

HY-153530

LI-2242	IPK Superfamily	Neurological Disease Metabolic Disease
LI-2242 is an inositol hexakisphosphate kinase (IP6K) inhibitor. LI-2242 has inhibition effect for IP6K1, IP6K2, IP6K3 and IPMK with IC₅₀ values of 31 nM, 42 nM, 8.7 nM and 1944 nM, respectively. LI-2242 can be used for thew research of type II diabetes, obesity, metabolic complications, venous thrombosis, and psychiatric disorders .

HY-N16070

1-PP-myo-InsP5	Endogenous Metabolite	Others
1-PP-myo-InsP5 is an inositol pyrophosphate. 1-PP-myo-InsP5, as a signaling molecule in mammals, can transmit signals by binding to specific receptors or through non-enzymatic transphosphorylation. 1-PP-myo-InsP5 can be involved in various biological processes such as insulin signaling and telomere length regulation .

HY-181448

Phytic acid hexalithium inositol hexaphosphate hexalithium; SNF472 hexalithium	Endogenous Metabolite Amyloid-β Autophagy	Cardiovascular Disease Neurological Disease Metabolic Disease Cancer
Phytic acid (Inositol hexaphosphate hexalithium) hexalithium is an orally active compound. Phytic acid hexalithium can be derived from the seeds of legumes. Phytic acid is a [PO4] ³- storage depot and precursor for other **inositol phosphates and pyrophosphates. Phytic acid hexalithium attenuates Aβ oligomers and upregulates Autophagy** protein. Phytic acid hexalithium can be used in cardiovascular disease, metabolic disease, nervous system disease and cancer research .

Phytic acid sodium salt 1 Publications Verification myo-inositol, hexakisdihydrogen phosphate sodium salt; inositol hexaphosphate sodium salt	Structural Classification Natural Products Zea mays L. Classification of Application Fields Gramineae Other Diseases Plants Disease Research Fields Source Classification	MOFs Endogenous Metabolite Amyloid-β Autophagy
Phytic acid (myo-Inositol; hexakis dihydrogen phosphate; Inositol hexaphosphate) sodium salt is an orally active compound. Phytic acid sodium salt can be derived from the seeds of legumes. Phytic acid sodium salt is a [PO4] ³- storage depot and precursor for other **inositol phosphates and pyrophosphates. Phytic acid sodium salt attenuates Aβ oligomers and upregulates autophagy** protein. Phytic acid sodium salt can be used in cardiovascular disease, metabolic disease, nervous system disease and cancer research .

Phytic acid (50% w/w in water) 1 Publications Verification inositol hexaphosphate; SNF472 free acid	Structural Classification other families Neurological Disease Classification of Application Fields Food Preservation Research Ketones, Aldehydes, Acids Plants Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification Agricultural Research	Endogenous Metabolite Amyloid-β Autophagy
Phytic acid (myo-Inositol; hexakis dihydrogen phosphate; Inositol hexaphosphate) is an orally active compound. Phytic acid can be derived from the seeds of legumes. Phytic acid is a [PO4] ³- storage depot and precursor for other **inositol phosphates and pyrophosphates. Phytic acid attenuates Aβ oligomers and upregulates autophagy** protein. Phytic acid can be used in cardiovascular disease, metabolic disease, nervous system disease and cancer research .

Zinc Phytate 1 Publications Verification	Natural Products other families Classification of Application Fields Other Diseases Plants Disease Research Fields Source Classification	Endogenous Metabolite Amyloid-β Autophagy
Zinc Phytate (myo-Inositol; hexakis dihydrogen phosphate; Inositol hexaphosphate) is an orally active compound. Zinc Phytate can be derived from the seeds of legumes. Zinc Phytate is a [PO4] ³- storage depot and precursor for other **inositol phosphates and pyrophosphates. Zinc Phytate attenuates Aβ oligomers and upregulates autophagy** protein. Zinc Phytate can be used in cardiovascular disease, metabolic disease, nervous system disease and cancer research .

1-PP-myo-InsP5	Natural Products Endogenous metabolite Source Classification	Endogenous Metabolite
1-PP-myo-InsP5 is an inositol pyrophosphate. 1-PP-myo-InsP5, as a signaling molecule in mammals, can transmit signals by binding to specific receptors or through non-enzymatic transphosphorylation. 1-PP-myo-InsP5 can be involved in various biological processes such as insulin signaling and telomere length regulation .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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inositol pyrophosphates

Inhibitors & Agonists

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