Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
3 Results for "
inverse electron-demand Diels-Alder ligation
" in MedChemExpress (MCE) Product Catalog:
Products (3)
3 Results for "inverse electron-demand Diels-Alder ligation" in MCE Product Catalog:
Cat. No.: HY-134599
CAS No.: 1580501-97-8
Target:
Research Areas:
(2E)-TCO-PNB ester is an active reaction substrate with the properties of trans-cyclooctene derivatives. The core chemical property of (2E)-TCO-PNB ester is its ability to undergo efficient inverse electron-demand Diels-Alder (IEDDA) cycloaddition with tetrazine groups. (2E)-TCO-PNB ester can be used in ligation reactions to verify the integrity of tetrazine groups, and also serves as a key synthetic raw material for the preparation of the prodrug TCO-DOX. (2E)-TCO-PNB ester is applied in research related to drug synthesis and bioorthogonal chemistry .
Cat. No.: HY-185797
Target:
Research Areas:
TCO Phosphoramidite is a nucleic acid phosphoramidite modifier containing a trans-cyclooctene (TCO) reactive group. TCO Phosphoramidite enables nucleic acid fragment ligation via the inverse electron demand Diels-Alder (IEDDA) bioorthogonal reaction between TCO and tetrazine (Tz), and it can be used for research on oligonucleotide and RNA modification and assembly .
Cat. No.: HY-W422109
CAS No.: 1345866-66-1
Target:
Research Areas:
4-(6-Methyl-1,2,4,5-tetrazin-3-yl) benzoic acid is an asymmetric tetrazine derivative and a bioorthogonal reaction partner. 4-(6-Methyl-1,2,4,5-tetrazin-3-yl) benzoic acid can be conjugated with Bevacizumab (HY-P9906) via EDC/NHS activation while retaining the VEGF-binding affinity of the antibody, thus constructing a targeting agent for pretargeted immuno-PET/NIRF imaging .
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
