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inverse electron-demand Diels-Alder ligation

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-134599
    (2E)-TCO-PNB ester

    		Biochemical Assay Reagents Cancer
    (2E)-TCO-PNB ester is an active reaction substrate with the properties of trans-cyclooctene derivatives. The core chemical property of (2E)-TCO-PNB ester is its ability to undergo efficient inverse electron-demand Diels-Alder (IEDDA) cycloaddition with tetrazine groups. (2E)-TCO-PNB ester can be used in ligation reactions to verify the integrity of tetrazine groups, and also serves as a key synthetic raw material for the preparation of the prodrug TCO-DOX. (2E)-TCO-PNB ester is applied in research related to drug synthesis and bioorthogonal chemistry .
    (2E)-TCO-PNB ester
  • HY-W422109
    4-(6-Methyl-1,2,4,5-tetrazin-3-yl)benzoic acid

    		Drug Derivative Others
    4-(6-Methyl-1,2,4,5-tetrazin-3-yl) benzoic acid is an asymmetric tetrazine derivative and a bioorthogonal reaction partner. 4-(6-Methyl-1,2,4,5-tetrazin-3-yl) benzoic acid can be conjugated with Bevacizumab (HY-P9906) via EDC/NHS activation while retaining the VEGF-binding affinity of the antibody, thus constructing a targeting agent for pretargeted immuno-PET/NIRF imaging .
    4-(6-Methyl-1,2,4,5-tetrazin-3-yl)benzoic acid

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