TCO Phosphoramidite
TCO Phosphoramidite is a nucleic acid phosphoramidite modifier containing a trans-cyclooctene (TCO) reactive group. TCO Phosphoramidite enables nucleic acid fragment ligation via the inverse electron demand Diels-Alder (IEDDA) bioorthogonal reaction between TCO and tetrazine (Tz), and it can be used for research on oligonucleotide and RNA modification and assembly.
For research use only. We do not sell to patients.
- Formula: C24H44N3O4P
- Molecular Weight:469.60
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
All DNA/RNA Synthesis Isoforms
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Biological Activity
TCO Phosphoramidite supports the synthesis of an oligonucleotide with an unnatural neutral backbone when attached to solid support and used for sequential ligation of bis-Tz and bis-TCO monomers[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 469.60
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Formula C24H44N3O4P
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SMILES
CC(C)N(C(C)C)P(OCCC#N)OCCCCCCNC(OC1CC/C=C/CCC1)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)