Search Result

Results for "

isoflavone

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (2) Akt (5) Aldehyde Dehydrogenase (ALDH) (4) AMPK (1) Amyloid-β (1) Apoptosis (18) Aurora Kinase (1) Autophagy (4) Bacterial (5) Bcl-2 Family (3) Biochemical Assay Reagents (1) Carboxylesterase (CES) (1) Casein Kinase (1) Caspase (4) CDK (2) Chloride Channel (1) Cytochrome P450 (3) Dengue Virus (1) Drug Derivative (4) Drug Metabolite (3) EGFR (6) Endogenous Metabolite (13) ERK (3) Estrogen Receptor/ERR (7) Flavivirus (1) Fungal (2) Glycosidase (2) HCV (1) Heme Oxygenase (HO) (1) HSP (1) IFNAR (1) Influenza Virus (2) Interleukin Related (1) Isotope-Labeled Compounds (2) JAK (2) JNK (2) Microtubule/Tubulin (2) Mitochondrial Metabolism (3) mTOR (1) NF-κB (3) NO Synthase (6) p38 MAPK (2) PARP (2) PERK (1) PI3K (4) PPAR (6) Pyruvate Kinase (2) Quinone Reductase (1) Reactive Oxygen Species (ROS) (13) Reference Standards (19) Reverse Transcriptase (2) RIG-I-like receptor (RLR) (1) SARS-CoV (1) Sirtuin (1) Sodium Channel (1) STAT (2) Taste Receptor (1) TNF Receptor (1) Tyrosinase (3) VEGFR (1)
By Research Areas:	Cancer (56) Cardiovascular Disease (11) Endocrinology (9) Infection (10) Inflammation/Immunology (25) Metabolic Disease (24) Neurological Disease (12)

By Targets:

5-HT Receptor (2)

Akt (5)

Aldehyde Dehydrogenase (ALDH) (4)

AMPK (1)

Amyloid-β (1)

Apoptosis (18)

Aurora Kinase (1)

Autophagy (4)

Bacterial (5)

Bcl-2 Family (3)

Biochemical Assay Reagents (1)

Carboxylesterase (CES) (1)

Casein Kinase (1)

Caspase (4)

CDK (2)

Chloride Channel (1)

Cytochrome P450 (3)

Dengue Virus (1)

Drug Derivative (4)

Drug Metabolite (3)

EGFR (6)

Endogenous Metabolite (13)

ERK (3)

Estrogen Receptor/ERR (7)

Flavivirus (1)

Fungal (2)

Glycosidase (2)

HCV (1)

Heme Oxygenase (HO) (1)

HSP (1)

IFNAR (1)

Influenza Virus (2)

Interleukin Related (1)

Isotope-Labeled Compounds (2)

JAK (2)

JNK (2)

Microtubule/Tubulin (2)

Mitochondrial Metabolism (3)

mTOR (1)

NF-κB (3)

NO Synthase (6)

p38 MAPK (2)

PARP (2)

PERK (1)

PI3K (4)

PPAR (6)

Pyruvate Kinase (2)

Quinone Reductase (1)

Reactive Oxygen Species (ROS) (13)

Reference Standards (19)

Reverse Transcriptase (2)

RIG-I-like receptor (RLR) (1)

SARS-CoV (1)

Sirtuin (1)

Sodium Channel (1)

STAT (2)

Taste Receptor (1)

TNF Receptor (1)

Tyrosinase (3)

VEGFR (1)

By Research Areas:

Cancer (56)

Cardiovascular Disease (11)

Endocrinology (9)

Infection (10)

Inflammation/Immunology (25)

Metabolic Disease (24)

Neurological Disease (12)

125

Inhibitors & Agonists

104

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-14596

Genistein Maximum Cited Publications 88 Publications Verification NPI 031L	EGFR Autophagy Apoptosis Endogenous Metabolite	Cancer
Genistein, a soy isoflavone, is a multiple tyrosine kinases (e.g., EGFR) inhibitor which acts as a chemotherapeutic agent against different types of cancer, mainly by altering apoptosis, the cell cycle, and angiogenesis and inhibiting metastasis.

HY-N0019

Daidzein 20+ Cited Publications	PPAR Endogenous Metabolite	Cardiovascular Disease Endocrinology Cancer
Daidzein is a soy isoflavone, which acts as a PPAR activator.

HY-N0018

Daidzin 10+ Cited Publications Daidzoside; NPI-031D; Daidzein 7-O-glucoside	Mitochondrial Metabolism Reverse Transcriptase Aldehyde Dehydrogenase (ALDH)	Cardiovascular Disease Others Cancer
Daidzin is an isoflavone with antioxidant, anticancer, and antiatherosclerotic activities. Daidzin is a potent and selective inhibitor of mitochondrial ALDH-2. Daidzin reduces ethanol consumption .

HY-N0016

Glycitein 5 Publications Verification Glycetein	Apoptosis Autophagy	Endocrinology Cancer
Glycitein is a soy isoflavone used to study apoptosis and antioxidant .

HY-N0520

Calycosin-7-O-β-D-glucoside 5 Publications Verification Calycosin-7-glucoside	Reactive Oxygen Species (ROS)	Others
Calycosin-7-O-β-D-glucoside is an isoflavone isolated from Astragali Radix. Calycosin-7-O-β-D-glucoside has variety of biological activities, such as neuroprotective, cardioprotection, anti-inflammation, and antioxidative stress effects .

HY-100583A

(±)-Equol	Estrogen Receptor/ERR Drug Metabolite	Cardiovascular Disease Neurological Disease Cancer
(±)-Equol is the racemate of equol. (±)-equol exhibits EC₅₀s of 200 and 74 nM for human ERα and ERβ, respectively. Equol is a metabolite of the soy isoflavones, daidzin and daidzein.

HY-N0595

Genistin 5+ Cited Publications Genistine; Genistoside; Genistein 7-O-β-D-glucopyranoside	Estrogen Receptor/ERR Apoptosis	Metabolic Disease Cancer
Genistin (Genistine), an isoflavone belonging to the phytoestrogen family, is a potent anti-adipogenic and anti-lipogenic agent. Genistin attenuates cellular growth and promotes apoptotic cell death breast cancer cells through modulation of ERalpha signaling pathway .

HY-N0423

Sophoricoside 4 Publications Verification	Others	Inflammation/Immunology Cancer
Sophoricoside is an isoflavone glycoside isolated from Sophora japonica and has anti-inflammatory, anti-cancer and immunosuppressive effects.

HY-W006405

*Isoflavone*	Estrogen Receptor/ERR	Cardiovascular Disease Cancer
Isoflavone is an orally available bioactive component of soy phytoestrogen with lipid-lowering and antioxidant activities. Isoflavone prevents a variety of chronic diseases by regulating fatty acid oxidation in the liver and gene expression in adipose tissue. In addition, isoflavone has important value in the research of cancer and cardiovascular diseases .

HY-N0012

Glycitin 5+ Cited Publications Glycitein 7-O-β-glucoside	Bacterial	Infection Cancer
Glycitin (Glycitein 7-O-β-glucoside) is a natural isoflavone with antibacterial, antiviral, anticancer, anti-inflammation, anti-aging and estrogenic effects. Glycitin may regulate osteoblasts through TGF-β or AKT signaling pathways in bone marrow stem cells (BMSCs) .

HY-N2597

Prunetin 3 Publications Verification	Aldehyde Dehydrogenase (ALDH)	Inflammation/Immunology
Prunetin, an O-methylated isoflavone, possesses anti-inflammatory activity. Prunetin is a potent human aldehyde dehydrogenases inhibitor .

HY-N1993

5-Methyl-7-methoxyisoflavone 3 Publications Verification	Cytochrome P450 NF-κB	Metabolic Disease Cancer
5-Methyl-7-methoxyisoflavone is an orally active anti-oxidant with remyelinating activity. 5-Methyl-7-methoxyisoflavone inhibits the enzyme aromatase, interfering with the normal metabolic pathways of testosterone. 5-Methyl-7-methoxyisoflavone is a non-steroidal anabolic isoflavone, used as a anabolic agent. 5-Methyl-7-methoxyisoflavone shows better potency increasing muscle mass and endurance than Ipriflavone (HY-N0094). 5-Methyl-7-methoxyisoflavone can be used for fat loss besides the maintenance of low cholesterol level and strengthen bones. 5-Methyl-7-methoxyisoflavone is the inhibitor for NF-κB .

HY-14596S

Genistein-d4 NPI 031L-d₄	EGFR Autophagy Apoptosis Endogenous Metabolite	Cancer
Genistein-d₄ is the deuterium labeled Genistein. Genistein, a soy isoflavone, is a multiple tyrosine kinases (e.g., EGFR) inhibitor which acts as a chemotherapeutic agent against different types of cancer, mainly by altering apoptosis, the cell cycle, and angiogenesis and inhibiting metastasis .

HY-N2693

6,8-Diprenylorobol	Apoptosis Reactive Oxygen Species (ROS) Caspase Akt ERK JNK p38 MAPK Bcl-2 Family	Cancer
6,8-Diprenylorobol, a prenylated isoflavone, is a nature product that could be isolated from the leaves of Cudrania tricuspidata. 6,8-Diprenylorobol antiproliferative effect and induces apoptosis through activation of p53 and generation of ROS .

HY-N3127

Orobol	Casein Kinase PI3K VEGFR	Metabolic Disease
Orobol is one of the major soy isoflavones and has various pharmacological activities, including anti-skin-aging and anti-obesity effects. Orobol inhibits CK1ε, VEGFR2, MAP4K5, MNK1, MUSK, TOPK, and TNIK (IC₅₀=1.24-4.45 μM). Orobol also inhibits PI3K isoforms (IC₅₀=3.46-5.27 μM for PI3K α/β/γ/K/δ) .

HY-N0094

Ipriflavone 2 Publications Verification	Cytochrome P450	Metabolic Disease Cancer
Ipriflavone is a synthetic isoflavone derivative used to suppress bone resorption.

HY-N0268

Irisflorentin 4 Publications Verification	NO Synthase	Inflammation/Immunology
Irisflorentin, a naturally occurring isoflavone, is an abundant active constituent in Belamcanda chinensis. Irisflorentin markedly reduces the transcriptional and translational levels of inducible nitric oxide synthase (iNOS) as well as the production of NO. Anti-inflammatory activity .

HY-N0917

6''-O-Malonylgenistin 1 Publications Verification Malonylgenistin; Genistin malonate	Drug Metabolite Taste Receptor	Others
6''-O-Malonylgenistin (Malonylgenistin) is a glycosylated isoflavone and metabolite of Genistin (HY-N0595). 6''-O-Malonylgenistin activates hTAS2R39. 6''-O-Malonylgenistin can be used in the research of bitter taste .

HY-N4073

6"-O-Malonyldaidzin 1 Publications Verification	Others	Inflammation/Immunology
6"-O-Malonyldaidzin is a malonylated isoflavone isolated from soybean seeds. 6"-O-Malonyldaidzin may has protective effect on eye .

HY-N1135

Toxicarol isoflavone	Endogenous Metabolite	Others
Toxicarol isoflavone is a natural isoflavone compound found in the leaves of Millettia brandisiana, and it belongs to flavonoid secondary metabolites .

HY-N3354

Lupiwighteone 8-prenylgenistein	Apoptosis	Cancer
Lupiwighteone is an isoflavone present widely in wild-growing plants, with antioxidant, antimicrobial and anticancer effects. Lupiwighteone induces caspase-dependent and -independent apoptosis on human breast cancer cells via inhibiting PI3K/Akt/mTOR pathway .

HY-N0019S

Daidzein-d4	PPAR Endogenous Metabolite	Endocrinology Cancer
Daidzein-d₄ is the deuterium labeled Daidzein. Daidzein is a soy isoflavone, which acts as a PPAR activator.

HY-N0019R

Daidzein (Standard) 20+ Cited Publications	Reference Standards PPAR Endogenous Metabolite	Endocrinology Cancer
Daidzein (Standard) is the analytical standard of Daidzein. This product is intended for research and analytical applications. Daidzein is a soy isoflavone, which acts as a PPAR activator.

HY-N4244

Kakkalide 1 Publications Verification	Reactive Oxygen Species (ROS)	Inflammation/Immunology
Kakkalide is an isoflavone derived from the flowers of Pueraria lobata. Kakkalide ameliorates endothelial insulin resistance by suppressing reactive oxygen species (ROS)-associated inflammation .

HY-N0791

Tectoridin 1 Publications Verification	Estrogen Receptor/ERR	Cancer
Tectoridin is a isoflavone isolated from Maackia amurensis. Tectoridin is a phytoestrogen and activates estrogen and thyroid hormone receptors. Tectoridin exerts the estrogenic effects via ER-dependent genomic pathway and GPR30-dependent nongenomic pathway .

HY-N3389

Licoisoflavone A 2 Publications Verification	SARS-CoV Sirtuin CDK Apoptosis	Infection Metabolic Disease Cancer
Licoisoflavone A is an orally active isoflavone. Licoisoflavone A inhibits proliferation, induces apoptosis, and causes G1/S phase arrest in colorectal cancer (CRC) cells. Licoisoflavone A inhibits the CDK2-Cyclin E1 axis. Licoisoflavone A inhibits lipid peroxidation with an IC₅₀ of 7.2 μM. Licoisoflavone A shows a dose-dependent inhibition effect on SARS-CoV-2 infection. Licoisoflavone A exhibits significant anti-tumor efficacy in mice bearing CT26 cell subcutaneous xenografts. Licoisoflavone A can be used for the study of colorectal cancer and SARS-CoV-2 infection .

HY-126113

KIN101	Flavivirus Dengue Virus RIG-I-like receptor (RLR) Influenza Virus HCV	Infection
KIN101 is a potent RNA viral inhibitor with IC₅₀s of 2 μM, >5 μM for influenza virus and Dengue virus (DNV), respectively. KIN101, an isoflavone agonist of IRF-3 dependent signaling, induces IRF-3 nuclear translocation. KIN101 has broad-spectrum activity against RNA viruses .

HY-N4072

6''-O-Acetylglycitin 4 Publications Verification	Others	Metabolic Disease
6''-O-Acetylglycitin, a acetyl glucoside, is one of the isoflavone isomer in soybeans, shows various extents of content reduction dependent on storage temperature, packaging condition, and its isoflavone isomer kind .

HY-N6631

7-Methoxyisoflavone 4 Publications Verification	AMPK	Metabolic Disease Cancer
7-Methoxyisoflavone is an isoflavone derivative and also an activator of adenosine monophosphate-activated protein kinase (AMPK).

HY-N6819

Iristectorin B	Others	Cancer
Iristectorin B is an isoflavone from Iris tectorum, has anti-cancer activities in breast cancer .

HY-N3125

Osajin CID 95168; NSC 21565	Apoptosis	Cardiovascular Disease Metabolic Disease Inflammation/Immunology Cancer
Osajin is the major bioactive isoflavone present in the fruit of Maclura pomifera with antitumor, antioxidant and anti-inflammatory activities.

HY-N4075

O-Desmethylangolensin	Endogenous Metabolite	Metabolic Disease Cancer
O-Desmethylangolensin is a metabolite of soy isoflavone, daidzein metabolized by gut microbiota. O-Desmethylangolensin possesses antioxidant activity .

HY-N0145R

Puerarin (Standard)	Reference Standards 5-HT Receptor	Inflammation/Immunology Cancer
Puerarin (Standard) is the analytical standard of Puerarin. This product is intended for research and analytical applications. Puerarin, an isoflavone extracted from Radix puerariae, is a 5-HT2C receptor antagonist.

HY-N1980

3'-Hydroxypuerarin	Reactive Oxygen Species (ROS)	Inflammation/Immunology
3'-Hydroxypuerarin is an isoflavone isolated from the roots of Pueraria lobata (Willd.) Ohwi. 3'-Hydroxypuerarin is a antioxidant, which shows marked ONOO(-), NO•, total ROS scavenging activities .

HY-N7335

Dehydroglyasperin C	Quinone Reductase Others	Neurological Disease Inflammation/Immunology Cancer
Dehydroglyasperin C, a isoflavone, is a potent NAD(P)H:oxidoquinone reductase (NQO1) and phase 2 enzyme inducer. Dehydroglyasperin C has antioxidant, neuroprotective, cancer chemopreventive, and anti-inflammatory activities .

HY-N3353

Luteone	Bacterial Fungal	Infection
Luteone is a natural isoflavone, with antioxidant, antibacterial and antifung activities .

HY-N4070

6"-O-Acetylgenistin	Others	Others
6"-O-Acetylgenistin is an isoflavone glycoside isolated from soybeans. 6"-O-Acetylgenistin significantly inhibits lipid peroxidation in rat liver microsome with an IC₅₀ of 10.6 μM .

HY-N4071

6"-O-Acetyldaidzin	Others	Others
6"-O-Acetyldaidzin is an isoflavone glycoside isolated from soybeans. 6"-O-Acetyldaidzin significantly inhibits lipid peroxidation in rat liver microsome with an IC₅₀ of 8.2 μM .

HY-N0018R

Daidzin (Standard) Daidzoside (Standard); NPI-031D (Standard); Daidzein 7-O-glucoside (Standard)	Reference Standards Mitochondrial Metabolism Reverse Transcriptase Aldehyde Dehydrogenase (ALDH)	Others
Daidzin (Standard) is the analytical standard of Daidzin. This product is intended for research and analytical applications. Daidzin is an isoflavone with antioxidant, anticancer, and antiatherosclerotic activities. Daidzin is a potent and selective inhibitor of mitochondrial ALDH-2. Daidzin reduces ethanol consumption .

HY-W031126

7-Hydroxyisoflavone	Drug Derivative	Others
7-Hydroxyisoflavone (compound 3) is a natural isoflavone compound .

HY-N4172

Tectorigenin 7-O-Xylosyl Glucoside	Others	Others
Tectorigenin 7-O-Xylosyl Glucoside is a glycosidic isoflavone isolated from Pueraria thomsonii flower .

HY-N2505

Iristectorigenin A	Others	Inflammation/Immunology
Iristectorigenin A is a natural isoflavone isolated from B. chinensis rhizomes. Iristectorigenin A shows antioxidant activity .

HY-N1978

3'-Methoxypuerarin 2 Publications Verification	Others	Neurological Disease
3'-Methoxypuerarin (3'-MOP) is an isoflavone extracted from radix puerariae that shows neuron protection activity.

HY-N2412

Irisolidone 1 Publications Verification	Chloride Channel	Neurological Disease Cancer
Irisolidone is a major isoflavone found in Pueraria lobata flowers. Irisolidone exhibits potent hepatoprotective activity. Irisolidone shows the high efficacy for volume-regulated anion channels (VRAC) blockade (IC₅₀=9.8 μM) .

HY-N11985

Ophiopogonone C	Others	Others
Ophiopogonone C (compound 3) is an isoflavone compound isolated from the ethanol extract of Ophiopogon japonicus tubers .

HY-N2134

Mirificin Puerarin apioside	Tyrosinase	Endocrinology
Mirificin (Puerarin apioside) is a isoflavone in Puerariae Lobatae Radix. Mirificin inhibits tyrosinase (TYR) with an IC₅₀ of 12.66 μM .

HY-N6984

Glycyroside	Others	Metabolic Disease
Glycyroside is a isoflavone diglycoside isolated from Glycyrrhiza eurycarpa P. C. Li .

HY-142099

Hispaglabridin A	Reactive Oxygen Species (ROS)	Others
Hispaglabridin A is an isoflavone derivative extracted from licorice roots. Hispaglabridin A is an antioxidant that is effective at inhibiting lipid peroxidation .

HY-129899

(±)-Equol 4'-sulfate sodium (R,S)-Equol 4'-sulfate sodium	Endogenous Metabolite	Cardiovascular Disease Neurological Disease Cancer
(±)-Equol 4'-sulfate sodium is a metabolite of the isoflavonoid phytoestrogen (±)-Equol (HY-100583A) .

HY-N0019S1

Daidzein-d6	Isotope-Labeled Compounds PPAR Endogenous Metabolite	Endocrinology
Daidzein-d₆ is a deuterium labeled Daidzein (HY-N0019). Daidzein is a soy isoflavone, which acts as a PPAR activator.

Cat. No.	Product Name	Category	Target	Chemical Structure