446-72-0
446-72-0
Chemical Structure
Genistein
Synonym(s): NPI 031L
- CAS No.: 446-72-0
- Formula:C15H10O5
- Molecular Weight:270.24
IUPAC Name: 5,7-dihydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one
InChIKey: TZBJGXHYKVUXJN-UHFFFAOYSA-N
SMILES: OC1=C2C(OC=C(C3=CC=C(O)C=C3)C2=O)=CC(O)=C1
Biological Activity: Genistein, a soy isoflavone, is a multiple tyrosine kinases (e.g., EGFR) inhibitor which acts as a chemotherapeutic agent against different types of cancer, mainly by altering apoptosis, the cell cycle, and angiogenesis and inhibiting metastasis.
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Genistein | 99.82% | Genistein, a soy isoflavone, is a multiple tyrosine kinases (e.g., EGFR) inhibitor which acts as a chemotherapeutic agent against different types of cancer, mainly by altering apoptosis, the cell cycle, and angiogenesis and inhibiting metastasis. | ||||||||||||||||||||
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Genistein (Standard) | 98.70% | Genistein (Standard) is the analytical standard of Genistein. This product is intended for research and analytical applications. Genistein, a soy isoflavone, is a multiple tyrosine kinases (e.g., EGFR) inhibitor which acts as a chemotherapeutic agent against different types of cancer, mainly by altering apoptosis, the cell cycle, and angiogenesis and inhibiting metastasis. | ||||||||||||||||||||
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Genistein-d4 | 98.81% | Genistein-d4 is the deuterium labeled Genistein. Genistein, a soy isoflavone, is a multiple tyrosine kinases (e.g., EGFR) inhibitor which acts as a chemotherapeutic agent against different types of cancer, mainly by altering apoptosis, the cell cycle, and angiogenesis and inhibiting metastasis. | ||||||||||||||||||||
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Biochanin A (Standard) | 98.74% | Biochanin A (Standard) is the analytical standard of Biochanin A. This product is intended for research and analytical applications. Biochanin A is a naturally occurring fatty acid amide hydrolase (FAAH) inhibitor, which inhibits FAAH with IC50s of 1.8, 1.4 and 2.4 μM for mouse, rat, and human FAAH, respectively. | ||||||||||||||||||||
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Quercetin-d3 | 98.73% | Quercetin-d3 is the deuterium labeled Quercetin. Quercetin, a natural flavonoid, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC50 of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively. | ||||||||||||||||||||
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Daidzein (Standard) | 98.65% | Daidzein (Standard) is the analytical standard of Daidzein. This product is intended for research and analytical applications. Daidzein is a soy isoflavone, which acts as a PPAR activator. | ||||||||||||||||||||
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Daidzein-d4 | 99.18% | Daidzein-d4 is the deuterium labeled Daidzein. Daidzein is a soy isoflavone, which acts as a PPAR activator. | ||||||||||||||||||||
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Daidzein-d6 | Daidzein-d6 is a deuterium labeled Daidzein (HY-N0019). Daidzein is a soy isoflavone, which acts as a PPAR activator. | |||||||||||||||||||||
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Tectorigenin | 99.89% | Tectorigenin is a plant isoflavonoid originally isolated from the dried flower of Pueraria lobate Benth. | ||||||||||||||||||||
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2′-Hydroxygenistein | 99.58% | 2′-Hydroxygenistein is a natural product that can be isolated from Crotalaria pallida and C. assamica. 2′-Hydroxygenistein shows anti-inflammatory activity. 2′-Hydroxygenistein shows significant concentration-dependent inhibitory effects on the release of β-glucuronidase and lysozyme from rat neutrophils, with IC50 values of 5.9 ± 1.4 and 9.7 ± 3.5 μM, respectively. | ||||||||||||||||||||
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3'-O-Methylorobol | 3'-O-Methylorobol, an antioxidant flavonoid, exhibits moderate antioxidant activity in the 2,2-diphenyl-1-picrylhydrazyl free radical scavenging assay. | |||||||||||||||||||||
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Prunetin (Standard) | ≥98% | Prunetin, an O-methylated isoflavone, possesses anti-inflammatory activity. Prunetin is a potent human aldehyde dehydrogenases inhibitor. | ||||||||||||||||||||
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Orobol | 98.66% | Orobol is one of the major soy isoflavones and has various pharmacological activities, including anti-skin-aging and anti-obesity effects. Orobol inhibits CK1ε, VEGFR2, MAP4K5, MNK1, MUSK, TOPK, and TNIK (IC50=1.24-4.45 μM). Orobol also inhibits PI3K isoforms (IC50=3.46-5.27 μM for PI3K α/β/γ/K/δ). | ||||||||||||||||||||
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Desmethylglycitein | 99.99% | Desmethylglycitein (4',6,7-Trihydroxyisoflavone), a metabolite of daidzein, sourced from Glycine max with antioxidant, and anti-cancer activities. Desmethylglycitein binds directly to CDK1 and CDK2 in vivo, resulting in the suppresses CDK1 and CDK2 activity. Desmethylglycitein is a direct inhibitor of protein kinase C (PKC)α, against solar UV (sUV)-induced matrix matrix metalloproteinase 1 (MMP1). Desmethylglycitein binds to PI3K in an ATP competitive manner in the cytosol, where it inhibits the activity of PI3K and downstream signaling cascades, leading to the suppression of adipogenesis in 3T3-L1 preadipocytes. | ||||||||||||||||||||
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Pratensein | 99.92% | Pratensein, a flavonoid, ameliorates β-amyloid-induced cognitive impairment in rats via reducing oxidative damage and restoring synapse and BDNF levels. | ||||||||||||||||||||
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6-Methylgenistein | 6-Methylgenistein is a Flavonoids product that can be isolated from the roots of Sophora dunnii.. | |||||||||||||||||||||
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5-O-Methylgenistein | 99.03% | 5-O-Methylgenistein (Isoprunetin) is an isoflavone that can be isolated from M. amurensis wood. 5-O-Methylgenistein inhibits β-gal activityy induced by 17β-Estradiol (HY-B0141) in yeast. | ||||||||||||||||||||
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Daidzein-3',5',8-d3 | Daidzein-3',5',8-d3 is the deuterium labeled Daidzein (HY-N0019). Daidzein is a soy isoflavone, which acts as a PPAR activator. | |||||||||||||||||||||
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6-Hydroxygenistein | 6-Hydroxygenistein is an isoflavonoid compound that can be found in Baptisia hirsuta and serves as a key precursor for the synthesis of various methylated isoflavonoids. | |||||||||||||||||||||
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