486-62-4
486-62-4
Chemical Structure
Ononin
Synonym(s): Ononoside; Formononetin 7-O-β-D-glucopyranoside
- CAS No.: 486-62-4
- Formula:C22H22O9
- Molecular Weight:430.40
IUPAC Name: 3-(4-methoxyphenyl)-7-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-4H-chromen-4-one
InChIKey: MGJLSBDCWOSMHL-MIUGBVLSSA-N
SMILES: O[C@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)[C@@H]1OC2=CC=C(C(C(C3=CC=C(OC)C=C3)=CO4)=O)C4=C2
Biological Activity: Ononin is an orally active isoflavone. Ononin inhibits the ERK/JNK/p38 and PI3K/Akt/mTOR pathways. Ononin regulates Apoptosis. Ononin has anti-tumor effects on laryngeal cancer and lung cancer. Ononin has neuroprotective effects. Ononin alleviates endoplasmic reticulum stress and diabetic nephropathy[1][2][3][4][5][6].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Ononin | 99.97% | Ononin is an orally active isoflavone. Ononin inhibits the ERK/JNK/p38 and PI3K/Akt/mTOR pathways. Ononin regulates Apoptosis. Ononin has anti-tumor effects on laryngeal cancer and lung cancer. Ononin has neuroprotective effects. Ononin alleviates endoplasmic reticulum stress and diabetic nephropathy. | ||||||||||||||||||||
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Ononin (Standard) | ≥98% | Ononin (Standard) is the analytical standard of Ononin. Ononin is an orally active isoflavone. Ononin inhibits the ERK/JNK/p38 and PI3K/Akt/mTOR pathways. Ononin regulates Apoptosis. Ononin has anti-tumor effects on laryngeal cancer and lung cancer. Ononin has neuroprotective effects. Ononin alleviates endoplasmic reticulum stress and diabetic nephropathy. | ||||||||||||||||||||
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Formononetin 7-O-β-D-glucuronide | Formononetin 7-O-β-D-glucuronide is a metabolite of Formononetin (HY-N0183) and can be absorbed and metabolized through the intestine. | |||||||||||||||||||||
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Daidzin | 99.65% | Daidzin is an isoflavone with antioxidant, anticancer, and antiatherosclerotic activities. Daidzin is a potent and selective inhibitor of mitochondrial ALDH-2. Daidzin reduces ethanol consumption. | ||||||||||||||||||||
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Calycosin-7-O-β-D-glucoside | 99.63% | Calycosin-7-O-β-D-glucoside is an isoflavone isolated from Astragali Radix. Calycosin-7-O-β-D-glucoside has variety of biological activities, such as neuroprotective, cardioprotection, anti-inflammation, and antioxidative stress effects. | ||||||||||||||||||||
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Sissotrin | 98.46% | Sissotrin (Biochanin A 7-glucoside; Sissonin) is an orally active isoflavone glycoside natural product found in Leguminosae plants, with weak antibacterial activity. Sissotrin exacerbates the increase in blood glucose after glucose loading. Sissotrin is used in studies related to glucose metabolism. | ||||||||||||||||||||
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6"-O-Acetyldaidzin | 99.89% | 6"-O-Acetyldaidzin is an isoflavone glycoside isolated from soybeans. 6"-O-Acetyldaidzin significantly inhibits lipid peroxidation in rat liver microsome with an IC50 of 8.2 μM. | ||||||||||||||||||||
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4''-methyloxy-Daidzin | 98.88% | 4''-methyloxy-Daidzin (Daidzein 7-O-Β-D-glucoside 4''-O-methylate), an isoflavone methyl-glycoside, is isolated from Cordyceps militaris grown on germinated soybeans. Isoflavones possess immunomodulating and antiallergic activities. | ||||||||||||||||||||
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Prunetrin | 98.88% | Prunetrin (Trifoside) is a flavonoid identified as a potential anti-prostate cancer agent in in silico screening. | ||||||||||||||||||||
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Daidzein-4'-glucoside | 99.31% | Daidzein-4'-glucoside is a Flavonoids product that can be isolated from the fruits of Sophora japonica L.. | ||||||||||||||||||||
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3′-Methoxydaidzin | 3′-Methoxydaidzin is a flavonoid compound isolated from the leaves of Ilex cornuta Lindl ex Paxt. | |||||||||||||||||||||
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Wistin | 97.63% | Wistin, isolated from Caragana sinica roots, is a PPARα and PPARγ agonist. | ||||||||||||||||||||
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References
- [1]. Ye B, et al. Ononin Shows Anticancer Activity Against Laryngeal Cancer via the Inhibition of ERK/JNK/p38 Signaling Pathway. Front Oncol. 2022 Jul 14;12:939646. [Content Brief]
- [2]. Chen L, et al. Prediction of anti-tumor chemical probes of a traditional Chinese medicine formula by HPLC fingerprinting combined with molecular docking. Eur J Med Chem. 2014 Aug 18;83:294-306. [Content Brief]
- [3]. Gong G, et al. Antitumor Effects of Ononin by Modulation of Apoptosis in Non-Small-Cell Lung Cancer through Inhibiting PI3K/Akt/mTOR Pathway. Oxid Med Cell Longev. 2022 Dec 27;2022:5122448. [Content Brief]
- [4]. Chen X, et al. Neuroprotective effects of ononin against the aluminium chloride-induced Alzheimer's disease in rats. Saudi J Biol Sci. 2021 Aug;28(8):4232-4239. [Content Brief]
- [5]. Dong L, et al. Ononin mitigates streptozotocin-induced diabetic nephropathy in rats via alleviating oxidative stress and inflammatory markers. Journal of King Saud University-Science, 2022, 34(6): 102029.
- [6]. Zhang H, et al. Ononin alleviates endoplasmic reticulum stress in doxorubicin-induced cardiotoxicity by activating SIRT3. Toxicol Appl Pharmacol. 2022 Oct 1;452:116179. [Content Brief]
