4 Results for "

isrib inhibitor

" in MedChemExpress (MCE) Product Catalog:
Products (4)

4 Results for "isrib inhibitor" in MCE Product Catalog:

50
50 Cited Publications
Cat. No.: HY-12495
CAS No.: 1597403-47-8
Purity:  99.49%
Target:  

PERK Autophagy Apoptosis

Research Areas:  

Neurological Disease

ISRIB (trans-isomer) is a potent inhibitor of PERK with an IC50 of 5 nM. ISRIB potently reverses the effects of eIF2α phosphorylation (IC50=5 nM).
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37
37 Cited Publications
Cat. No.: HY-12495A
CAS No.: 548470-11-7
Purity:  98.58%
ISRIB is a brain-penetrant inhibitor of integrated stress response (ISR). Persistent activation of the ISR has been linked to the development of several neurological disorders as ISR represses translation through inhibiting eIF2B. ISRIB inhibits the ISR by promoting the nucleotide exchange activity of eIF2B and recovering the translation, and thus can be used for neurological disorders research .
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Cat. No.: HY-179109
Research Areas:  

Others

EIF2B-IN-1 (Compound A) is an eIF2B inhibitor. EIF2B-IN-1 binds eIF2B. EIF2B-IN-1 stabilises the eIF2B decamer and favours inhibitory eIF2B:eIF2(αP) complex formation. EIF2B-IN-1 exhibits weak displacement of ISRIB. EIF2B-IN-1 can be used in the research of integrated stress responses .
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Cat. No.: HY-12495R
CAS No.: 1597403-47-8
ISRIB (trans-isomer) (Standard) is the analytical standard of ISRIB (trans-isomer) (HY-12495). This product is intended for research and analytical applications. ISRIB (trans-isomer) is a potent inhibitor of PERK with an IC50 of 5 nM. ISRIB potently reverses the effects of eIF2α phosphorylation (IC50=5 nM).
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