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Results for "

kelch-like

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Caspase (1) CDK (1) Keap1-Nrf2 (1)
By Research Areas:	Cancer (1) Infection (1) Inflammation/Immunology (1) Metabolic Disease (1)

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Natural
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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N0260

Epmedin C 5+ Cited Publications Epimedin-C; Baohuoside-VI	Keap1-Nrf2 CDK Caspase	Infection Metabolic Disease Inflammation/Immunology Cancer
Epmedin C (Epimedin-C; Baohuoside-VI) is an orally active anti-inflammatory agent and immunomodulator that binds to multiple key proteins including UCP1, Caspase-1, CDK2 and Keap1. Epmedin C inhibits epithelial cell proliferation by disrupting the complex function of CDK2/Cyclin E. Epmedin C also upregulates Nrf2 expression, reduces ROS levels and inhibits pro-inflammatory cytokine secretion, thereby effectively restoring antibody production and alleviating tissue damage. Epmedin C has good safety with no hepatotoxicity or skin sensitization, and it has been used in studies on diseases such as obesity, Deoxynivalenol (HY-N6684)-induced immunotoxicity and mammary hyperplasia .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0260

Epmedin C 5+ Cited Publications Epimedin-C; Baohuoside-VI	Flavonols Structural Classification Monophenols Flavonoids Classification of Application Fields Phenols Epimedium brevicornu Maxim. Plants Berberidaceae Inflammation/Immunology Disease Research Fields Source Classification	Keap1-Nrf2 CDK Caspase
Epmedin C (Epimedin-C; Baohuoside-VI) is an orally active anti-inflammatory agent and immunomodulator that binds to multiple key proteins including UCP1, Caspase-1, CDK2 and Keap1. Epmedin C inhibits epithelial cell proliferation by disrupting the complex function of CDK2/Cyclin E. Epmedin C also upregulates Nrf2 expression, reduces ROS levels and inhibits pro-inflammatory cytokine secretion, thereby effectively restoring antibody production and alleviating tissue damage. Epmedin C has good safety with no hepatotoxicity or skin sensitization, and it has been used in studies on diseases such as obesity, Deoxynivalenol (HY-N6684)-induced immunotoxicity and mammary hyperplasia .

Species:	Human (16) Mouse (1)
Tag:	SUMO (1) His (10) Strep (5) Tag Free (7) GST (1)
Source:	HEK293 (2) Sf9 insect cells (13) E. coli (2)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P701583

	KLHL21 Protein, Human (sf9) KLHL21; kelch-like protein 21	Human	Sf9 insect cells
	KLHL21 acts as a substrate-specific linker in the BCR E3 ubiquitin ligase complex to ensure efficient chromosome alignment and cytokinesis. The BCR(KLHL21) complex coordinates chromosomal passenger complex (CPC) dynamics, directing its transition from chromosomes to the spindle midzone during anaphase. KLHL21 Protein, Human (sf9) is the recombinant human-derived KLHL21 protein, expressed by sf9 insect cells , with tag free.

HY-P701585

	KLHL3 Protein, Human (sf9) KLHL3; kelch-like protein 3	Human	Sf9 insect cells
	KLHL3 serves as a substrate-specific linker in the BCR E3 ubiquitin ligase complex and is critical for ion transport in the distal nephron. The BCR(KLHL3) complex coordinates the degradation of WNK1, WNK4, WNK3, and CLDN8, fine-tunes NaCl reabsorption, and maintains electrolyte balance. KLHL3 Protein, Human (sf9) is the recombinant human-derived KLHL3 protein, expressed by sf9 insect cells , with tag free.

HY-P76470

	KLHL2 Protein, Human (His) kelch-like protein 2; Actin-binding protein Mayven; KLHL2	Human	E. coli
	KLHL2 is a substrate-specific linker in the BCR E3 ubiquitin ligase complex that directs ubiquitination and proteasomal degradation of targets such as NPTXR, WNK1, WNK3, and WNK4. KLHL2 is critical for cellular homeostasis and catalyzes NPTXR ubiquitination, emphasizing its role in targeted protein turnover. KLHL2 Protein, Human (His) is the recombinant human-derived KLHL2 protein, expressed by E. coli , with N-6*His labeled tag.

HY-P701584

	KLHL21 Protein, Human (sf9, His, StrepⅡ) KLHL21; kelch-like protein 21	Human	Sf9 insect cells
	KLHL21 acts as a substrate-specific linker in the BCR E3 ubiquitin ligase complex to ensure efficient chromosome alignment and cytokinesis. The BCR(KLHL21) complex coordinates chromosomal passenger complex (CPC) dynamics, directing its transition from chromosomes to the spindle midzone during anaphase. KLHL21 Protein, Human (sf9, His, Strep) is the recombinant human-derived KLHL21 protein, expressed by sf9 insect cells , with N-Strep, N-8*His labeled tag.

HY-P701586

	KLHL3 Protein, Human (sf9, His, StrepⅡ) KLHL3; kelch-like protein 3	Human	Sf9 insect cells
	KLHL3 serves as a substrate-specific linker in the BCR E3 ubiquitin ligase complex and is critical for ion transport in the distal nephron. The BCR(KLHL3) complex coordinates the degradation of WNK1, WNK4, WNK3, and CLDN8, fine-tunes NaCl reabsorption, and maintains electrolyte balance. KLHL3 Protein, Human (sf9, His, Strep) is the recombinant human-derived KLHL3 protein, expressed by sf9 insect cells , with N-Strep, N-8*His labeled tag.

HY-P701570

	IPP Protein, Human (sf9) IPP; Actin-binding protein IPP; Intracisternal A particle-promoted polypeptide; IPP; kelch-like protein 27	Human	Sf9 insect cells
	IPP may organize the actin cytoskeleton, affecting the structural arrangement and dynamics of the cell's cytoskeletal network. It contributes to the organization of actin filaments, which is critical for cell morphology, movement and signaling. IPP Protein, Human (sf9) is the recombinant human-derived IPP protein, expressed by sf9 insect cells , with tag free.

HY-P75897

	KEAP1 Protein, Human (sf9) 3 Publications Verification kelch-like ECH-associated protein 1; Cytosolic inhibitor of Nrf2; KEAP1; KEAP1	Human	Sf9 insect cells
	KEAP1 in the BCR E3 ubiquitin ligase complex complex regulates cellular responses to oxidative stress by ubiquitinating NFE2L2/NRF2. As an oxidative stress sensor, KEAP1 normally promotes NFE2L2/NRF2 degradation. KEAP1 Protein, Human (sf9) is the recombinant human-derived KEAP1 protein, expressed by Sf9 insect cells , with tag free.

HY-P702829

	KEAP1 Protein, Mouse (His, SUMO) 2 Publications Verification kelch-like ECH-associated protein 1; Cytosolic inhibitor of Nrf2; KEAP1; KEAP1	Mouse	E. coli
	KEAP1 in the BCR E3 ubiquitin ligase complex complex regulates cellular responses to oxidative stress by ubiquitinating NFE2L2/NRF2. As an oxidative stress sensor, KEAP1 normally promotes NFE2L2/NRF2 degradation. KEAP1 Protein, Mouse (His, SUMO) is the recombinant human-derived KEAP1 protein, expressed by E. coli , with N-6*His, N-SUMO.

HY-P75897Y

	KEAP1 Protein, Human (sf9, solution) kelch-like ECH-associated protein 1; Cytosolic inhibitor of Nrf2; KEAP1; KEAP1	Human	Sf9 insect cells
	KEAP1 in the BCR E3 ubiquitin ligase complex complex regulates cellular responses to oxidative stress by ubiquitinating NFE2L2/NRF2. As an oxidative stress sensor, KEAP1 normally promotes NFE2L2/NRF2 degradation. KEAP1 Protein, Human (sf9) is the recombinant human-derived KEAP1 protein, expressed by Sf9 insect cells , with tag free.

HY-P75899

	KEAP1 Protein, Human (sf9, His-GST) kelch-like ECH-associated protein 1; Cytosolic inhibitor of Nrf2; KEAP1; KEAP1	Human	Sf9 insect cells
	KEAP1 in the BCR E3 ubiquitin ligase complex complex regulates cellular responses to oxidative stress by ubiquitinating NFE2L2/NRF2. As an oxidative stress sensor, KEAP1 normally promotes NFE2L2/NRF2 degradation. KEAP1 Protein, Human (sf9, His-GST) is the recombinant human-derived KEAP1 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.

HY-P701571

	IPP Protein, Human (sf9, His, StrepⅡ) IPP; Actin-binding protein IPP; Intracisternal A particle-promoted polypeptide; IPP; kelch-like protein 27	Human	Sf9 insect cells
	IPP may organize the actin cytoskeleton, affecting the structural arrangement and dynamics of the cell's cytoskeletal network. It contributes to the organization of actin filaments, which is critical for cell morphology, movement and signaling. IPP Protein, Human (sf9, His, Strep) is the recombinant human-derived IPP protein, expressed by sf9 insect cells , with N-Strep, N-8*His labeled tag.

HY-P701587

	KLHL42 Protein, Human (sf9) KLHL42; kelch-like protein 42; Cullin-3-binding protein 9; Ctb9; kelch domain-containing protein 5	Human	Sf9 insect cells
	KLHL42 serves as a substrate-specific linker in the BCR E3 ubiquitin ligase complex and plays a critical role in mitotic progression and cytokinesis. The BCR(KLHL42) complex actively ubiquitinates and degrades KATNA1, contributing to the regulation of microtubule dynamics during mitosis. KLHL42 Protein, Human (sf9) is the recombinant human-derived KLHL42 protein, expressed by sf9 insect cells , with tag free.

HY-P701588

	KLHL42 Protein, Human (sf9, His, StrepⅡ) KLHL42; kelch-like protein 42; Cullin-3-binding protein 9; Ctb9; kelch domain-containing protein 5	Human	Sf9 insect cells
	KLHL42 serves as a substrate-specific linker in the BCR E3 ubiquitin ligase complex and plays a critical role in mitotic progression and cytokinesis. The BCR(KLHL42) complex actively ubiquitinates and degrades KATNA1, contributing to the regulation of microtubule dynamics during mitosis. KLHL42 Protein, Human (sf9, His, Strep) is the recombinant human-derived KLHL42 protein, expressed by sf9 insect cells , with N-Strep, N-8*His labeled tag.

HY-P701572

	IVNS1ABP Protein, Human (sf9) IVNS1ABP; Influenza virus NS1A-binding protein; NS1-BP; NS1-binding protein; Aryl hydrocarbon receptor-associated protein 3; kelch-like protein 39	Human	Sf9 insect cells
	The IVNS1ABP protein is intricately involved in multiple cellular functions, including pre-mRNA splicing, aryl hydrocarbon receptor (AHR) pathway, F-actin organization, and protein ubiquitination. It binds to F-actin through Kelch repeats, thereby stabilizing actin filaments and thereby protecting cells from actin instability-induced cell death. IVNS1ABP Protein, Human (sf9) is the recombinant human-derived IVNS1ABP protein, expressed by sf9 insect cells , with tag free.

HY-P701573

	IVNS1ABP Protein, Human (sf9, His, StrepⅡ) IVNS1ABP; Influenza virus NS1A-binding protein; NS1-BP; NS1-binding protein; Aryl hydrocarbon receptor-associated protein 3; kelch-like protein 39	Human	Sf9 insect cells
	The IVNS1ABP protein is intricately involved in multiple cellular functions, including pre-mRNA splicing, aryl hydrocarbon receptor (AHR) pathway, F-actin organization, and protein ubiquitination. It binds to F-actin through Kelch repeats, thereby stabilizing actin filaments and thereby protecting cells from actin instability-induced cell death. IVNS1ABP Protein, Human (sf9, His, Strep) is the recombinant human-derived IVNS1ABP protein, expressed by sf9 insect cells , with N-Strep, N-8*His labeled tag.

HY-P70324

	*KEL/Kelch-like* protein 41 Protein, Human (HEK293, His, solution)** rHuKell blood group glycoprotein/KEL, His; Kell blood group glycoprotein; CD238; KEL	Human	HEK293
	KEL/Kelch-like protein 41 acts as a zinc endopeptidase with a distinct endothelin-3-converting enzyme function. It selectively cleaves endothelin-1 (EDN1), endothelin-2 (EDN2), and endothelin-3 (EDN3), displaying a preference for EDN3. KEL's endopeptidase activity plays a pivotal role in processing endothelin peptides, emphasizing its involvement in the modulation of endothelin signaling pathways. KEL/Kelch-like protein 41 Protein, Human (HEK293, His, solution) is the recombinant human-derived KEL/Kelch-like protein 41 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P70324A

	*KEL/Kelch-like* protein 41 Protein, Human (HEK293, C-His)** rHuKell blood group glycoprotein/KEL, His; Kell blood group glycoprotein; CD238; KEL	Human	HEK293
	KEL/Kelch-like protein 41 acts as a zinc endopeptidase with a distinct endothelin-3-converting enzyme function. It selectively cleaves endothelin-1 (EDN1), endothelin-2 (EDN2), and endothelin-3 (EDN3), displaying a preference for EDN3. KEL's endopeptidase activity plays a pivotal role in processing endothelin peptides, emphasizing its involvement in the modulation of endothelin signaling pathways. KEL/Kelch-like protein 41 Protein, Human (HEK293, C-His) is the recombinant human-derived KEL/Kelch-like protein 41 protein, expressed by HEK293 , with C-6*His labeled tag.

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Host:	Mouse (7) Rabbit (2)
Reactivity:	Human (9) Rat (2) Mouse (2) Dog (1)
Application:	IHC-P (4) ICC/IF (6) IP (2) WB (5) ELISA (7)
Isotype:	IgG (2) IgG1 (6)
Conjugation:	Non-conjugated (9)
Clonality:	Monoclonal (7)
Modification:	Unmodified (7)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P85866

	Keap1 Antibody (YA5558) kelch-like ECH-associated protein 1; Cytosolic inhibitor of Nrf2; INrf2; kelch-like protein 19;	WB, ICC/IF, ELISA	Human, Mouse, Rat, Dog
	Keap1 Antibody (YA5558) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Keap1.

HY-P86405

	Keap1 Antibody (YA6097) kelch-like ECH-associated protein 1 (Cytosolic inhibitor of Nrf2) (INrf2) (kelch-like protein 19)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	Keap1 Antibody (YA6097) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Keap1.

HY-P85241

	KLHL11 Antibody (YA4933) KLHL11; kelch-like protein 11	WB, IHC-P, ICC/IF	Human
	KLHL11 Antibody (YA4933) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to KLHL11.

HY-P86282

	KLHL6 Antibody (YA5974) KLHL6; kelch-like protein 6;	WB, ICC/IF, IP	Human
	KLHL6 Antibody (YA5974) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to KLHL6.

HY-P85240

	KLHL1 Antibody (YA4932) KLHL1; KIAA1490; kelch-like protein 1	ICC/IF, ELISA	Human
	KLHL1 Antibody (YA4932) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to KLHL1.

HY-P85244

	KLHL21 Antibody (YA4936) KLHL21; KIAA0469; kelch-like protein 21	IHC-P, ELISA	Human
	KLHL21 Antibody (YA4936) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to KLHL21.

HY-P85240A

	KLHL1 Antibody (YA4932)(PBS only) KLHL1; KIAA1490; kelch-like protein 1	ICC/IF, ELISA	Human
	KLHL1 Antibody (YA4932) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to KLHL1.

HY-P85244A

	KLHL21 Antibody (YA4936)(PBS only) KLHL21; KIAA0469; kelch-like protein 21	IHC-P, ELISA	Human
	KLHL21 Antibody (YA4936) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to KLHL21.

HY-P85246

	KLHL25 Antibody (YA4938) KLHL25; ENC2; Ectoderm-neural cortex protein 2; ENC-2; kelch-like protein 25	WB, ELISA	Human
	KLHL25 Antibody (YA4938) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to KLHL25.

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Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

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kelch-like

Inhibitors & Agonists

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Recombinant Proteins

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