1 Result for "

kras+g13d+inhibitor

" in MedChemExpress (MCE) Product Catalog:
Products (1)

1 Results for "kras+g13d+inhibitor" in MCE Product Catalog:

Cat. No.: HY-179452
Research Areas:  

Cancer

KRAS G13D-IN-2 (compound 8B) is a potent orally active KRAS G13D inhibitor with IC50 values of 1.95 μM (HCT-116 G13D) and 2.16 μM (HCT-15 G13D). KRAS G13D-IN-2 induces G1-phase arrest and mitochondrial membrane depolarization. KRAS G13D-IN-2 induces senescence through CDK6/TWIST1 inhibition. KRAS G13D-IN-2 inhibits tumor growth in murine models. KRAS G13D-IN-2 can be used for KRAS G13D-mutant colorectal cancer research .
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