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lactate dehydrogenase C

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By Targets:	Lactate Dehydrogenase (6) Apoptosis (3) Bacterial (4) Biochemical Assay Reagents (1) Cytochrome P450 (1) DNA/RNA Synthesis (1) Endogenous Metabolite (1) Environmental Pollutants (1) Fungal (1) Keap1-Nrf2 (1) Na+/H+ Exchanger (NHE) (1) Reactive Oxygen Species (ROS) (3)
By Research Areas:	Cancer (4) Cardiovascular Disease (3) Endocrinology (1) Infection (5) Inflammation/Immunology (2) Metabolic Disease (2)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-100742A

(R)-GNE-140 15+ Cited Publications	Lactate Dehydrogenase Bacterial	Cardiovascular Disease Infection Inflammation/Immunology Cancer
(R)-GNE-140 is a potent inhibitor of lactate dehydrogenase (LDH) A, B and C, with IC₅₀ values of 3, 5 and 5 nM against LDHA, LDHB, LDHC, respectively. (R)-GNE-140 blocks the conversion of pyruvate to lactate, reduces lactate production and histone lysine lactylation, and inhibits glycolysis. (R)-GNE-140 attenuates cardiac hypertrophy, alleviates PM_2.5-induced pulmonary inflammation and fibrosis, blocks MRSA-induced Arg1 expression. (R)-GNE-140 is applicable to research related to pathological cardiac hypertrophy, pulmonary fibrosis, MRSA infection and pancreatic cancer .

HY-B0854

Mancozeb	Environmental Pollutants Lactate Dehydrogenase Apoptosis Fungal Cytochrome P450 Keap1-Nrf2	Infection Metabolic Disease Cancer
Mancozeb is a widely used fungicide that is effective against fungal diseases in most cereals, vegetables, fruits and ornamental plants. In addition, Mancozeb can cause liver damage in mice by activating the Keap1/Nrf2 signaling pathway. Mancozeb upregulates **lactate dehydrogenase and cytochrome c** to alter cell metabolism and induce cell death. Mancozeb has reproductive toxicity and can induce apoptosis in ovarian cells .

HY-113383

2-Hydroxyvaleric acid	Endogenous Metabolite Lactate Dehydrogenase Biochemical Assay Reagents	Metabolic Disease Endocrinology
2-Hydroxyvaleric acid is a medium chain α-hydroxy fatty acid. 2-Hydroxyvaleric acid is an activator in fat metabolism of palmitic acid-1-C ¹⁴. 2-hydroxyvaleric acid is also used as a staining agent for measuring tissue-specific **Lactate dehydrogenase** activity and elevated levels of 2-hydroxyvaleric acid induces lactic acidosis .

HY-123659

KR-33028	Na+/H+ Exchanger (NHE) Apoptosis	Cardiovascular Disease Cancer
KR-33028 is a selective NHE1 inhibitor. KR-33028 reduces hypoxia-induced necrosis and apoptosis in H9c2 cells. KR-33028 inhibits hypoxia-induced increases in cytoplasmic and mitochondrial Ca ²⁺ levels and cytochrome c release. KR-33028 improves cardiac contractility, reduces lactate dehydrogenase release, and increases tissue ATP, creatine phosphate, and glycogen levels. KR-33028 can be used in research on cancers such as cardioblastoma and cardiovascular diseases such as ischemic stroke .

HY-161279

Antibiofilm agent-5	Bacterial Lactate Dehydrogenase Reactive Oxygen Species (ROS)	Infection
Antibiofilm agent-5 (compound 6c) is a multitargeting antibacterial agent with potent antibiofilm activity. Antibiofilm agent-5 could induce metabolic dysfunction by deactivating **lactate dehydrogenase and promote the accumulation of reactive oxygen species** to decrease the reduced glutathione and ultimately cause oxidative damage in bacteria. Antibiofilm agent-5 can be used for the research of refractory biofilm-intensified bacterial infections .

HY-118241

GNE-140	Lactate Dehydrogenase Bacterial Apoptosis Reactive Oxygen Species (ROS)	Cardiovascular Disease Infection Inflammation/Immunology Cancer
GNE-140 is an orally active and selective inhibitor of lactate dehydrogenase (LDH) A, B and C, with IC₅₀ values of 3, 5 and 5 nM against LDHA, LDHB, LDHC, respectively. GNE-140 blocks the conversion of pyruvate to lactate, reduces lactate production and histone lysine lactylation, and inhibits glycolysis. GNE-140 attenuates cardiac hypertrophy, alleviates PM_2.5-induced pulmonary inflammation and fibrosis, blocks MRSA-induced Arg1 expression, regulates metabolites of glycolysis and the pentose phosphate pathway, reduces glucose uptake, increases ROS, and induces cancer cell apoptosis. GNE-140 is applicable to research related to pathological cardiac hypertrophy, pulmonary fibrosis, MRSA infection and pancreatic cancer .

HY-180151

Antibacterial agent 306	Lactate Dehydrogenase Bacterial DNA/RNA Synthesis Reactive Oxygen Species (ROS)	Infection
Antibacterial agent 306 (Compound 8c), a **lactate dehydrogenase** inhibitor, is a highly effective antibacterial agent, especially effective against Gram-positive bacteria. Antibacterial agent 306 exhibits MIC against Staphylococcus aureus of as low as 1 μg/mL. Antibacterial agent 306 can not only damage membrane integrity and block the replication of DNA by intercalation, but also make reactive oxygen species (ROS) burst. Antibacterial agent 306 can be used for research on anti-multi-drug resistant bacteria .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-113383

2-Hydroxyvaleric acid	Source Classification	Endogenous Metabolite Lactate Dehydrogenase Biochemical Assay Reagents
2-Hydroxyvaleric acid is a medium chain α-hydroxy fatty acid. 2-Hydroxyvaleric acid is an activator in fat metabolism of palmitic acid-1-C ¹⁴. 2-hydroxyvaleric acid is also used as a staining agent for measuring tissue-specific **Lactate dehydrogenase** activity and elevated levels of 2-hydroxyvaleric acid induces lactic acidosis .

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P702855

	LDHC Protein, Human (sf9, His) L-lactate dehydrogenase C chain; EC:1.1.1.27; Cancer/testis antigen 32; CT32; LDH testis subunit; LDH-X; LDH3; LDHX	Human	Sf9 insect cells
	LDHC Protein, Human (sf9, His) is the recombinant human-derived LDHC, expressed by Sf9 insect cells , with N-6*His labeled tag. ,

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Host:	Rabbit (4)
Reactivity:	Human (4) Rat (1) Mouse (2)
Application:	IHC-P (2) ICC/IF (1) IP (1) WB (4) ELISA (1)
Isotype:	IgG (4)
Conjugation:	Non-conjugated (4)
Clonality:	polyclonal (1) Monoclonal (2) Recombinant (1)
Modification:	Unmodified (3)

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HY-P80739

	Lactate Dehydrogenase C Antibody (YA315) CT32; LDH3; LDHX	WB	Human
	Lactate Dehydrogenase C Antibody (YA315) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Lactate Dehydrogenase C.

HY-P810486

	Lactate Dehydrogenase C Antibody CT32, LDH3, LDHX, Cell proliferation-inducing gene 19 protein, GSD11, L lactate dehydrogenase B chain,	WB, IHC-P	Human, Mouse
	Lactate Dehydrogenase C Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to Lactate Dehydrogenase C.

HY-P80739A

	Lactate Dehydrogenase C Antibody (YA315)(PBS only) CT32; LDH3; LDHX	WB	Human
	Lactate Dehydrogenase C Antibody (YA315) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Lactate Dehydrogenase C.

HY-P86602

	Lactate Dehydrogenase Antibody (YA6294) LDHA; PIG19; LDHB; LDHC; LDH3; LDHX; L-lactate dehydrogenase A chain; LDH-A; Cell proliferation-inducing gene 19 protein; LDH muscle subunit; LDH-M; Renal carcinoma antigen NY-REN-59; L-lactate dehydrogenase B chain; LDH-B; LDH heart subunit; LDH-H; Renal carcinoma antigen NY-REN-46; L-lactate dehydrogenase C chain; LDH-C; Cancer/testis antigen 32; CT32; LDH testis subunit; LDH-X;	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	Lactate Dehydrogenase Antibody (YA6294) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Lactate Dehydrogenase.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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