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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
12 Results for "
maleimide moiety
" in MedChemExpress (MCE) Product Catalog:
Products (12)
12 Results for "maleimide moiety" in MCE Product Catalog:
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TCO-PEG3-maleimide (TCO-PEG3-NEM) is a click chemistry reagent. TCO-PEG3-maleimide efficiently binds TCO (trans-cyclooctene) moiety to thiol-containing molecules (such as antibodies, cysteine-containing peptides) .
Cat. No.: HY-W440719
Cholesterol-PEG2000-MAL is a PEG derivative and can be used to prepare liposome or nanoparticle due to its ability to self-assemble in water. The maleimide moiety is reactive with thiol molecule to form a covalent thioether bond.
Cat. No.: HY-P1801
CAS No.: 583836-55-9
Synonyms: Cys-[HIV-Tat (47-57)]
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Cat. No.: HY-D0152
CAS No.: 174568-68-4
Cat. No.: HY-W591479
CAS No.: 1895916-22-9
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MC-Val-Ala-NHS ester is a cleavable ADC linker with a malimide group and an NHS ester group. The Val-Ala linkers can be cleaved by Cathepsin B. Maleimide group is reactive toward thiol groups. MC is reactive with thiol moieties. The NHS ester is able to react specifically and efficiently with amines (e.g. the side chain of lysine residues or aminosilane-coated surfaces) at neutral or slightly basic condition to form a covalent bond.
Cat. No.: HY-W800817
CAS No.: 2748945-56-2
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TCO-PEG4-maleimide is a click chemistry building block containing a TCO moiety and a maleimide group. The maleimide group will react with a thiol group to form a covalent bond. TCO moiety is very reactive with tetrazine (3rd generation click chemistry).
Cat. No.: HY-W800679
CAS No.: 2639395-45-0
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Mal-Cyclohexyl-PEG3-Biotin is a PEG linker containing a maleimide moiety and a biotin group. Maleimides react specifically with sulfhydryl groups to form a stable thioether linkage when the pH is between 6.5 and 7.5. The biotinylation can react with amine molecules in the presence of activator EDC or HATU. PEG attached to the biotin gives an extended spacer arm that permits the biotin to reach into the binding pocket of the protein. The PEG moiety also increases solubility of Biotin-PEG conjugates considerably.
Cat. No.: HY-W440722
Cholesterol-PEG1000-Thiol is a PEGylated lipid that forms micelles in water and can be used to prepare liposomes or nanoparticles as drug delivery systems. The thiol moiety reacts with maleimide to form a stable thioether bond .
Cat. No.: HY-W440724
Cholesterol-PEG3400-Thiol is an amphiphatic PEG derivative which forms micelles in water and can be used to prepare liposomes or nanoparticles for drug delivery system. The thiol moiety is reactive with maleimide to form a stable thioether bond.
Cat. No.: HY-D3576
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AF532 C5 Maleimide is a Fluorescent dye used for protein labeling. AF532 C5 Maleimide covalently binds to thiol groups via its maleimide moiety. AF532 C5 Maleimide can label VASP to support visualization studies in phase separation and focused actin polymerization experiments .
Cat. No.: HY-181777
Mal-Pip-ValCit-PAB-AZ7550 is a prodrug of EGFR inhibitor. Mal-Pip-ValCit-PAB-AZ7550 selectively binds covalently to albumin via its maleimide moiety. Mal-Pip-ValCit-PAB-AZ7550 exhibits potent in vivo anticancer activity in non-small cell lung cancer xenograft models. Mal-Pip-ValCit-PAB-AZ7550 can be used in research related to non-small cell lung cancer .
Cat. No.: HY-D3095
CAS No.: 2244914-41-6
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TPEP-6-NH-MA is a Fluorescent probe that selectively detects cysteine (Cys) and homocysteine (Hcy) without interference from glutathione (GSH) and other amino acids, and can also be used for bioimaging of biothiols in living cells. Its detection mechanism relies on terminating the photoinduced electron transfer (PET) effect via a Michael addition reaction between the maleimide recognition moiety and the thiol group of Cys or Hcy. The excitation wavelength of TPEP-6-NH-MA is Ex = 361 nm .
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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
