metaphase

By Targets:	ADC Antibody (1) Antibody-Drug Conjugates (ADCs) (1) APC (1) Apoptosis (2) Autophagy (1) CDK (1) DNA Stain (3) Endogenous Metabolite (1) Fluorescent Dye (2) Microtubule/Tubulin (3) Mitosis (1) Nucleoside Antimetabolite/Analog (1) Proteasome (1) Reverse Transcriptase (1) TNF Receptor (1) Transmembrane Glycoprotein (2)
By Research Areas:	Cancer (9) Endocrinology (1) Infection (1) Metabolic Disease (1) Neurological Disease (2)
Click Chemistry:	Labeling and Fluorescence Imaging (2)
Oligonucleotides:	Nucleotide Analogs (1) Nucleoside Analogs (1)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-124955

proTAME Maximum Cited Publications 6 Publications Verification	APC	Cancer
proTAME, a cell-permeable proagent form of TAME, is an anaphase promoting complex/cyclosome (APC/C) inhibitor. proTAME causes cell cycle arrest in metaphase .

HY-D1725

Cy3-dCTP	Fluorescent Dye DNA Stain	Others
Cy3-dCTP is a directly fluorescently labeled deoxyribonucleotide, in which Cy3 is a cyanine fluorescent dye. Cy3-dCTP is used for direct enzymatic labeling of DNA and cDNA: with the aid of DNA polymerases, this modified nucleotide is incorporated into the extending DNA strand during processes such as reverse transcription, PCR, nick translation or random primer labeling .

HY-13033

CDK-IN-2 1 Publications Verification CDK inhibitor II	CDK	Endocrinology
CDK-IN-2 is a specific CDK9 inhibitor with an IC₅₀ of less than 8 nM. CDK-IN-2 reduces the phosphorylation level of H3S10. CDK-IN-2 decreases the transition rate of spermatocytes from prophase to metaphase I .

HY-124757

FiVe1 1 Publications Verification	Proteasome Mitosis	Cancer
FiVe1 is a vimentin (VIM) inhibitor. FiVe1 binds to the rod domain of VIM, causing metaphase VIM disassembly and hyperphosphorylation at Ser56, ultimately leading to mitotic catastrophe, multinucleation, and loss of stemness. FiVe1 has anticancer activity against soft tissue sarcomas. FiVe1 increases the sensitivity of ovarian cancer to Cisplatin (HY-17394). FiVe1 can be used for researches of mesenchymal cancers (including breast cancer and soft tissue sarcoma) and ovarian cancers .

HY-D1668

Biotin-11-dCTP	DNA Stain Reverse Transcriptase	Infection Neurological Disease Cancer
Biotin-11-dCTP is a biotinylated deoxynucleoside triphosphate and an important DNA labeling reagent. In random primer DNA labeling reactions, Biotin-11-dCTP incorporates into newly synthesized DNA strands to generate labeled DNA probes suitable for hybridization applications. In addition, Biotin-11-dCTP can serve as a substrate for terminal deoxynucleotidyl transferase to end-label oligonucleotides for telomere sequence detection, or to label the cut ends of linearized DNA molecules, thereby supporting streptavidin-based electron microscopy analysis. For example, Biotin-11-dCTP can label the cut ends of linearized DNA molecules under the action of dGTP and avian myeloblastosis virus reverse transcriptase .

HY-119357

TN-16	Microtubule/Tubulin Apoptosis Autophagy	Neurological Disease Cancer
TN-16 is a Microtubule polymerization inhibitor. TN-16 induces G₂/M cell cycle arrest, metaphase mitotic arrest and Apoptotic cell death in cells, and blocks late Autophagic flux by inhibiting autophagosome-lysosome fusion. TN-16 suppresses tumor growth in syngeneic mouse breast cancer models. TN-16 can be used in research related to neuroblastoma, cervical cancer, breast cancer and other tumors .

HY-136248

Cyanine 3 Tyramide 1 Publications Verification Tyramide-Cy3	DNA Stain Fluorescent Dye	Others
Cyanine 3 Tyramide (Tyramide-Cy3) is an orange fluorescent dye used as a reporter fluorescent substrate for horseradish peroxidase (HRP)-catalyzed deposition, which serves as a signal amplification technique in immunoassays and in situ nucleic acid hybridization .

HY-N7710

FF-MAS	Others	Metabolic Disease
FF-MAS is a potent meiotic maturation agonist. FF-MAS promotes meiotic maturation and preimplantation development of mouse oocytes maturing in vitro. FF-MAS promotes the completion of meiotic maturation to metaphase II (MII) and improves competence to complete the 2-cell stage to blastocyst transition .

HY-P991661

AMG-172 Antibody	ADC Antibody TNF Receptor Transmembrane Glycoprotein	Cancer
AMG-172 Antibody is an anti-CD27L antibody. AMG-172 Antibody can be used for synthesis of ADC AMG-172 (HY-185483) .

HY-101741

A-259745 A-289099	Microtubule/Tubulin Apoptosis	Cancer
A-259745 is an orally active antimitotic agent that binds to the colchicine-binding site of tubulin. A-259745 exhibits potent in vitro cytotoxic activity against both multi-drug-resistant and non-multi-drug-resistant cancer cell lines, with ED₅₀ values of 0.018 μM against HCT-15 and 0.028 μM against NCI-H460 cell lines. A-259745 inhibits tubulin polymerization, disrupts the dynamic equilibrium of the mitotic spindle, arrests dividing cells in metaphase, and subsequently induces apoptosis. A-259745 shows dose-dependent antitumor efficacy in murine tumor models. A-259745 can be used for the study of cancer .

HY-185483

AMG-172	Antibody-Drug Conjugates (ADCs) Transmembrane Glycoprotein Microtubule/Tubulin	Cancer
AMG-172 is an antibody-drug conjugate (ADC) composed of a fully human IgG1 monoclonal anti-CD27L antibody conjugated to DM1 (HY-19792) via the non-cleavable linker MCC. AMG-172 releases the intracellular active component Lysine-MCC-DM through catabolism. Lysine-MCC-DM inhibits the assembly and disassembly dynamics of Microtubule and induces cell arrest at metaphase. AMG-172 can be used for research on relapsed/refractory clear cell renal cell carcinoma .

HY-119200

LY-195448 hydrochloride	Endogenous Metabolite	Cancer
LY-195448 hydrochloride is a phenethanolamine that exhibits anti-tumour activity across various murine tumour models. LY-195448 hydrochloride acts by blocking cells at metaphase. LY-195448 hydrochloride has demonstrated a lack of "standard" side effects commonly associated with cancer treatments, such as myelosuppression and gastrointestinal toxicity. LY-195448 hydrochloride was evaluated in a phase I trial, where it showed only mild and reversible side effects like hypotension, tachycardia, and tremor.

HY-178588

Fluorescein-12-dUTP	Nucleoside Antimetabolite/Analog	Cancer
Fluorescein-12-dUTP is a fluorescent labeling and detection reagent that can be used for nucleic acid synthesis. Fluorescein-12-dUTP can be used to synthesize labeled DNA probes for in situ hybridization, microarray or western blot analysis .

Cat. No.	Product Name	Type

HY-D1725

Cy3-dCTP	Fluorescent Dyes
Cy3-dCTP is a directly fluorescently labeled deoxyribonucleotide, in which Cy3 is a cyanine fluorescent dye. Cy3-dCTP is used for direct enzymatic labeling of DNA and cDNA: with the aid of DNA polymerases, this modified nucleotide is incorporated into the extending DNA strand during processes such as reverse transcription, PCR, nick translation or random primer labeling .

HY-D1668

Biotin-11-dCTP	Fluorescent Dyes
Biotin-11-dCTP is a biotinylated deoxynucleoside triphosphate and an important DNA labeling reagent. In random primer DNA labeling reactions, Biotin-11-dCTP incorporates into newly synthesized DNA strands to generate labeled DNA probes suitable for hybridization applications. In addition, Biotin-11-dCTP can serve as a substrate for terminal deoxynucleotidyl transferase to end-label oligonucleotides for telomere sequence detection, or to label the cut ends of linearized DNA molecules, thereby supporting streptavidin-based electron microscopy analysis. For example, Biotin-11-dCTP can label the cut ends of linearized DNA molecules under the action of dGTP and avian myeloblastosis virus reverse transcriptase .

Biotin-11-dCTP

Fluorescent Dyes

Biotin-11-dCTP is a biotinylated deoxynucleoside triphosphate and an important DNA labeling reagent. In random primer DNA labeling reactions, Biotin-11-dCTP incorporates into newly synthesized DNA strands to generate labeled DNA probes suitable for hybridization applications. In addition, Biotin-11-dCTP can serve as a substrate for terminal deoxynucleotidyl transferase to end-label oligonucleotides for telomere sequence detection, or to label the cut ends of linearized DNA molecules, thereby supporting streptavidin-based electron microscopy analysis. For example, Biotin-11-dCTP can label the cut ends of linearized DNA molecules under the action of dGTP and avian myeloblastosis virus reverse transcriptase .

HY-136248

Cyanine 3 Tyramide 1 Publications Verification Tyramide-Cy3	Fluorescent Dyes
Cyanine 3 Tyramide (Tyramide-Cy3) is an orange fluorescent dye used as a reporter fluorescent substrate for horseradish peroxidase (HRP)-catalyzed deposition, which serves as a signal amplification technique in immunoassays and in situ nucleic acid hybridization .

Cat. No.	Product Name	Target	Research Area	Image

HY-P991661

AMG-172 Antibody	ADC Antibody TNF Receptor Transmembrane Glycoprotein	Cancer
AMG-172 Antibody is an anti-CD27L antibody. AMG-172 Antibody can be used for synthesis of ADC AMG-172 (HY-185483) .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N7710

FF-MAS	Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Animals Metabolic Disease Endogenous metabolite Disease Research Fields Steroids Source Classification	Others
FF-MAS is a potent meiotic maturation agonist. FF-MAS promotes meiotic maturation and preimplantation development of mouse oocytes maturing in vitro. FF-MAS promotes the completion of meiotic maturation to metaphase II (MII) and improves competence to complete the 2-cell stage to blastocyst transition .

Cat. No.	Product Name		Classification

HY-D1725

Cy3-dCTP		Labeling and Fluorescence Imaging
Cy3-dCTP is a directly fluorescently labeled deoxyribonucleotide, in which Cy3 is a cyanine fluorescent dye. Cy3-dCTP is used for direct enzymatic labeling of DNA and cDNA: with the aid of DNA polymerases, this modified nucleotide is incorporated into the extending DNA strand during processes such as reverse transcription, PCR, nick translation or random primer labeling .

HY-D1668

Biotin-11-dCTP		Labeling and Fluorescence Imaging
Biotin-11-dCTP is a biotinylated deoxynucleoside triphosphate and an important DNA labeling reagent. In random primer DNA labeling reactions, Biotin-11-dCTP incorporates into newly synthesized DNA strands to generate labeled DNA probes suitable for hybridization applications. In addition, Biotin-11-dCTP can serve as a substrate for terminal deoxynucleotidyl transferase to end-label oligonucleotides for telomere sequence detection, or to label the cut ends of linearized DNA molecules, thereby supporting streptavidin-based electron microscopy analysis. For example, Biotin-11-dCTP can label the cut ends of linearized DNA molecules under the action of dGTP and avian myeloblastosis virus reverse transcriptase .

Cat. No.	Product Name		Classification

HY-178588

Fluorescein-12-dUTP		Nucleoside Analogs Nucleotide Analogs
Fluorescein-12-dUTP is a fluorescent labeling and detection reagent that can be used for nucleic acid synthesis. Fluorescein-12-dUTP can be used to synthesize labeled DNA probes for in situ hybridization, microarray or western blot analysis .

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metaphase

Inhibitors & Agonists

Fluorescent Dyes

Inhibitory Antibodies

NaturalProducts

Click Chemistry

Oligonucleotides

Natural
Products