Monascorubramine
Based on 1 Customer Validation
Monascorubramine is a metabolite derived from Monascus with antibacterial, cytotoxic and antimitotic activities. Monascorubramine interferes with mitotic spindle tubulin, triggers metaphase mitotic arrest, induces abnormal c‑mitosis division, and exerts antimitotic effects. Monascorubramine exhibits antibacterial activity and inhibits both Gram-positive and Gram-negative bacteria. Monascorubramine can be used in studies related to bacterial infections.
For research use only. We do not sell to patients.
- Purity: 99.15%
- CAS No.: 3627-51-8
- Formula: C23H27NO4
- Molecular Weight:381.46
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Endogenous Metabolite Isoforms
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Biological Activity
Monascorubramine (compound 5) (0.1-200 μM; 24 h) reduces the viability of immortalized human kidney epithelial (IHKE) cells, with an EC50 value of 20.1-31.1 μM after 24 h of incubation. Its interfering effect on cellular metabolism is stronger than its effect on cell membrane integrity[1].
Monascorubramine (25-100 μM; 24 h) induces metaphase mitotic arrest in immortalized human kidney epithelial (IHKE) cells, triggers complete metaphase arrest, and induces c-mitosis by interfering with mitotic spindle tubulin[1].
Monascorubramine potently binds to Staphylococcus aureus DHFR (with a Kd of 0.266 μM), Escherichia coli DHFR (with a Kd of 0.552 μM), and Candida albicans DHFR (with a Kd of 1.493 μM), exhibiting the highest selectivity for Staphylococcus aureus DHFR[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:immortalized human kidney epithelial (IHKE) cells
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Concentration:1 μM; 10 μM; 25 μM
25 μM -
Incubation Time:12 h; 24 h
12h -
Result:Did not induce changes in caspase 3 activity in IHKE cells at any tested concentration or incubation time.
Did not induce formation of apoptotic bodies in IHKE cells at any tested concentration or incubation time.
Chemical Information
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CAS No. 3627-51-8
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Appearance Solid
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Molecular Weight 381.46
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Formula C23H27NO4
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Color Brown to black
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SMILES
C/C=C/C(NC=C1C2=O)=CC1=CC([C@]23C)=C(C(O3)=O)C(CCCCCCC)=O
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Structure Classification
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Initial Source
Talaromyces amestolkiae
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 7.6 mg/mL (19.92 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.6215 mL | 13.1075 mL | 26.2151 mL | 65.5377 mL |
| 5 mM | 0.5243 mL | 2.6215 mL | 5.2430 mL | 13.1075 mL | |
| 10 mM | 0.2622 mL | 1.3108 mL | 2.6215 mL | 6.5538 mL | |
| 15 mM | 0.1748 mL | 0.8738 mL | 1.7477 mL | 4.3692 mL |
Monascorubramine Related Classifications
HY-N11071 Related Classifications
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- Monascorubramine
- 3627-51-8
- Endogenous Metabolite
- Bacterial
- Microtubule/Tubulin
- Monascus ruber
- Escherichia coli DHFR
- Monascus purpureus
- Staphylococcus aureus DHFR
- CYP enzymes
- mitotic spindle tubulin
- immortalized human kidney epithelial (IHKE) cells
- Candida albicans DHFR
- Gram-negative bacteria
- Gram-positive bacteria
- Inhibitor
- inhibitor
- inhibit