2. Metabolic Enzyme/Protease Cell Cycle/DNA Damage
  3. Mitosis Proteasome
  4. FiVe1

FiVe1 is a vimentin (VIM) inhibitor. FiVe1 binds to the rod domain of VIM, causing metaphase VIM disassembly and hyperphosphorylation at Ser56, ultimately leading to mitotic catastrophe, multinucleation, and loss of stemness. FiVe1 has anticancer activity against soft tissue sarcomas. FiVe1 increases the sensitivity of ovarian cancer to Cisplatin (HY-17394). FiVe1 can be used for researches of mesenchymal cancers (including breast cancer and soft tissue sarcoma) and ovarian cancers.

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FiVe1

FiVe1 構造式

CAS 番号 : 932359-76-7

容量 価格（税別） 在庫状況 数量
5 mg $333 在庫あり
10 mg $533 在庫あり
25 mg $1066 在庫あり
50 mg $1600 在庫あり
100 mg $2400 在庫あり
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500 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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Based on 1 publication(s) in Google Scholar

FiVe1 関連抗体

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  • 生物活性

  • 純度とドキュメンテーション

  • 参考文献

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製品説明

FiVe1 is a vimentin (VIM) inhibitor. FiVe1 binds to the rod domain of VIM, causing metaphase VIM disassembly and hyperphosphorylation at Ser56, ultimately leading to mitotic catastrophe, multinucleation, and loss of stemness. FiVe1 has anticancer activity against soft tissue sarcomas. FiVe1 increases the sensitivity of ovarian cancer to Cisplatin (HY-17394). FiVe1 can be used for researches of mesenchymal cancers (including breast cancer and soft tissue sarcoma) and ovarian cancers[1][2][3].

IC50 & Target

IC50: VIM[1]
Cellular Effect
Cell Line Type Value Description References
GCT IC50
1686 nM
Compound: FiVe1
Antiproliferative activity against human GCT cells assessed as inhibition of cell growth measured after 72 hrs by Celltiter-glo proliferation assay
Antiproliferative activity against human GCT cells assessed as inhibition of cell growth measured after 72 hrs by Celltiter-glo proliferation assay
[PMID: 36001933]
HT-1080 IC50
1564 nM
Compound: FiVe1
Antiproliferative activity against human HT-1080 cells assessed as inhibition of cell growth measured after 72 hrs by Celltiter-glo proliferation assay
Antiproliferative activity against human HT-1080 cells assessed as inhibition of cell growth measured after 72 hrs by Celltiter-glo proliferation assay
[PMID: 36001933]
MCF7 IC50
>20000 nM
Compound: FiVe1
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth measured after 72 hrs by Celltiter-glo proliferation assay
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth measured after 72 hrs by Celltiter-glo proliferation assay
[PMID: 36001933]
MCF7 IC50
>20 μM
Compound: FiVe1
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth measured after 72 hrs by Celltiter-glo proliferation assay
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth measured after 72 hrs by Celltiter-glo proliferation assay
[PMID: 36001933]
RD IC50
3095 nM
Compound: FiVe1
Antiproliferative activity against human RD cells assessed as inhibition of cell growth measured after 72 hrs by Celltiter-glo proliferation assay
Antiproliferative activity against human RD cells assessed as inhibition of cell growth measured after 72 hrs by Celltiter-glo proliferation assay
[PMID: 36001933]
体外実験

FiVe1 (2 μM; 72 h) selectively inhibits the growth of FOXC2-HMLER cells while showing little toxicity to HMLER cells[1].
FiVe1 (250 nM) results in a collapsed VIM filamentous structure in FOXC2-HMLER cells[1].
FiVe1 (1 μM for multinucleation test; 24 h for multinucleation test) inhibits the growth of multiple soft tissue sarcoma (STS) cell lines (HT1080, SW684, RD, GCT, SW872, SW982) and promotes multinucleation in these cell lines, respectively[1].
FiVe1 (72 h) inhibits the growth of HUVECs and human lung fibroblasts (HLFs), with IC50 values of 1.70 μM and 2.32 μM, respectively[1].
FiVe1 inhibits the growth of HT-1080 fibrosarcoma cells, with an IC50 of 1.6 μM[2].
FiVe1 (0.2 μM; 72 h) significantly sensitizes both A2780 and A2780cis cells towards Cisplatin (HY-17394)[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

FiVe1 関連抗体
分子量

359.25

分子式

C18H16Cl2N4
CAS 番号
Appearance

Solid

Color

Light yellow to brown

SMILES

ClC1=CC(N2CCN(C3=C4C=CC=C(Cl)C4=NN=C3)CC2)=CC=C1
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : 3.6 mg/mL (10.02 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7836 mL 13.9179 mL 27.8358 mL
5 mM 0.5567 mL 2.7836 mL 5.5672 mL
10 mM 0.2784 mL 1.3918 mL 2.7836 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
純度とドキュメンテーション
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7836 mL 13.9179 mL 27.8358 mL 69.5894 mL
5 mM 0.5567 mL 2.7836 mL 5.5672 mL 13.9179 mL
10 mM 0.2784 mL 1.3918 mL 2.7836 mL 6.9589 mL
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FiVe1 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FiVe1932359-76-7FiVe 1FiVe-1MitosisProteasomevimentinEMTcancer stem cellmitosisdrug discoveryA2780A2780cisHUVECInhibitorinhibitorinhibit

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製品名:
FiVe1
製品番号:
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