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mitochondrial energy production

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By Targets:	Mitochondrial Metabolism (4) AMPK (1) Drug Metabolite (2) Endogenous Metabolite (2) Insulin Receptor (1) Oxidative Phosphorylation (2) Reactive Oxygen Species (ROS) (2) Reference Standards (1)
By Research Areas:	Cancer (1) Metabolic Disease (5)

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Targets Recommended: Mitochondrial Metabolism Mitophagy

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P2776A

Hexokinase, Yeast	Endogenous Metabolite	Others
Hexokinase, Yeast catalyzes the phosphorylation of glucose, and is involved in glycolysis. Hexokinase, Yeast participates is also related to energy production, protection of mitochondrial integrity, and cell survival .

HY-113285

Ureidopropionic acid 3-Ureidopropionic acid	Oxidative Phosphorylation Reactive Oxygen Species (ROS)	Metabolic Disease
Ureidopropionic acid (3-Ureidopropionic acid) is a selective mitochondrial respiratory chain complex V inhibitor. Ureidopropionic acid induces the production of reactive oxygen species, delayed elevation of intracellular calcium concentration, secondary energy-dependent excitotoxicity and neurodegeneration in neurons. Ureidopropionic acid promotes neuropathological changes by impairing mitochondrial energy metabolism, oxidative stress and excitotoxicity pathways. Ureidopropionic acid can be used in studies related to 3-ureidopropionase deficiency and severe propionic aciduria .

HY-121006

Biguanide	Mitochondrial Metabolism AMPK Insulin Receptor	Metabolic Disease Cancer
Biguanide is an orally active antihyperglycemic agent. Biguanide inhibits mitochondrial ATP production, activates the LKB1-AMPK signaling pathway, and damages the energy homeostasis. Biguanide enhances insulin-receptor activation and downstream signaling. Biguanide exhibits potential in ameliorating the type 2 diabetes and the insulin-associated cancers.

HY-P2776B

Hexokinase, Bacillus sp.	Endogenous Metabolite	Others
Hexokinase, Bacillus sp. catalyzes the phosphorylation of glucose, and is involved in glycolysis. Hexokinase, Bacillus sp. participates is also related to energy production, protection of mitochondrial integrity, and cell survival .

HY-113285R

Ureidopropionic acid (Standard) 3-Ureidopropionic acid (Standard)	Reference Standards Oxidative Phosphorylation Reactive Oxygen Species (ROS)	Others
Ureidopropionic acid (Standard) is the analytical standard of Ureidopropionic acid. This product is intended for research and analytical applications. Ureidopropionic acid (3-Ureidopropionic acid) is a selective mitochondrial respiratory chain complex V inhibitor. Ureidopropionic acid induces the production of reactive oxygen species, delayed elevation of intracellular calcium concentration, secondary energy-dependent excitotoxicity and neurodegeneration in neurons. Ureidopropionic acid promotes neuropathological changes by impairing mitochondrial energy metabolism, oxidative stress and excitotoxicity pathways. Ureidopropionic acid can be used in studies related to 3-ureidopropionase deficiency and severe propionic aciduria .

HY-153995A

D-Ribonic acid	Drug Metabolite Mitochondrial Metabolism	Metabolic Disease
D-Ribonic acid is a metabolite of D-Ribose (HY-113375). Ribonic acid is associated with genetic variations in ENOSF1 and NUBPL. Ribonic acid may participate in the mitochondrial energy production process .

HY-114886

IGP-5	Mitochondrial Metabolism	Metabolic Disease
IGP-5 is a mitochondrial sn-Glycerol 3-phosphate Dehydrogenase (mGPDH) inhibitor with the IC₅₀ of 0.7 μM aganist mGPDH H2O2 production . IGP-5 can be used for study of energy metabolism .

HY-153995B

D-Ribonic acid ammonium	Mitochondrial Metabolism Drug Metabolite	Metabolic Disease
D-Ribonic acid ammonium is a metabolite of D-Ribose (HY-113375). Ribonic acid ammonium is associated with genetic variations in ENOSF1 and NUBPL. Ribonic acid ammonium may participate in the mitochondrial energy production process .

Cat. No.	Product Name

HY-L089

Mitochondria-Targeted Compound Library	1,122 compounds
Mitochondria plays an important role in many vital processes in cells, including energy production, fatty-acid oxidation and the Tricarboxylic Acid (TCA) cycle, calcium signaling, permeability transition, apoptosis and heat production. At present, it is recognized that many diseases are associated with impaired mitochondrial function, such as increased accumulation of ROS and decreased OXPHOS and ATP production. Mitochondria are recognized as one of the most important targets for new drug design in cancer, cardiovascular, and neurological diseases, etc. Some small molecule drugs or biologics can act on mitochondria through various pathways, including ETC inhibition, OXPHOS uncoupling, mitochondrial Ca²⁺ modulation, and control of oxidative stress via decrease or increase of mitochondrial ROS accumulation. MCE supplies a unique collection of 1,122 mitochondria-targeted compound that mainly targeting Mitochondrial Metabolism, ATP Synthase, Mitophagy, Reactive Oxygen Species, etc. MCE Mitochondria-Targeted Compound Library is a useful tool for mitochondria-targeted drug discovery and related research.

Mitochondria-Targeted Compound Library

1,122 compounds

Mitochondria plays an important role in many vital processes in cells, including energy production, fatty-acid oxidation and the Tricarboxylic Acid (TCA) cycle, calcium signaling, permeability transition, apoptosis and heat production. At present, it is recognized that many diseases are associated with impaired mitochondrial function, such as increased accumulation of ROS and decreased OXPHOS and ATP production. Mitochondria are recognized as one of the most important targets for new drug design in cancer, cardiovascular, and neurological diseases, etc. Some small molecule drugs or biologics can act on mitochondria through various pathways, including ETC inhibition, OXPHOS uncoupling, mitochondrial Ca²⁺ modulation, and control of oxidative stress via decrease or increase of mitochondrial ROS accumulation.

MCE supplies a unique collection of 1,122 mitochondria-targeted compound that mainly targeting Mitochondrial Metabolism, ATP Synthase, Mitophagy, Reactive Oxygen Species, etc. MCE Mitochondria-Targeted Compound Library is a useful tool for mitochondria-targeted drug discovery and related research.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-113285

Ureidopropionic acid 3-Ureidopropionic acid	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Other Diseases Endogenous metabolite Disease Research Fields	Oxidative Phosphorylation Reactive Oxygen Species (ROS)
Ureidopropionic acid (3-Ureidopropionic acid) is a selective mitochondrial respiratory chain complex V inhibitor. Ureidopropionic acid induces the production of reactive oxygen species, delayed elevation of intracellular calcium concentration, secondary energy-dependent excitotoxicity and neurodegeneration in neurons. Ureidopropionic acid promotes neuropathological changes by impairing mitochondrial energy metabolism, oxidative stress and excitotoxicity pathways. Ureidopropionic acid can be used in studies related to 3-ureidopropionase deficiency and severe propionic aciduria .

HY-113285R

Ureidopropionic acid (Standard) 3-Ureidopropionic acid (Standard)	Structural Classification Ketones, Aldehydes, Acids Endogenous metabolite	Reference Standards Oxidative Phosphorylation Reactive Oxygen Species (ROS)
Ureidopropionic acid (Standard) is the analytical standard of Ureidopropionic acid. This product is intended for research and analytical applications. Ureidopropionic acid (3-Ureidopropionic acid) is a selective mitochondrial respiratory chain complex V inhibitor. Ureidopropionic acid induces the production of reactive oxygen species, delayed elevation of intracellular calcium concentration, secondary energy-dependent excitotoxicity and neurodegeneration in neurons. Ureidopropionic acid promotes neuropathological changes by impairing mitochondrial energy metabolism, oxidative stress and excitotoxicity pathways. Ureidopropionic acid can be used in studies related to 3-ureidopropionase deficiency and severe propionic aciduria .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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mitochondrial energy production

Inhibitors & Agonists

Screening Libraries

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Natural
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