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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
410 Results for "
mu
" in MedChemExpress (MCE) Product Catalog:
Products (410)
410 Results for "mu" in MCE Product Catalog:
74
Target:
Research Areas:
4μ8C (IRE1 Inhibitor III) is a small-molecule inhibitor of IRE1α.
22
22 Cited Publications
Synonyms: PFTμ; 2-Phenylethynesulfonamide
Research Areas:
Pifithrin-μ is an inhibitor of p53 and HSP70, with antitumor and neuroprotective activity.
19
Category:
Neurological Disease Sinomenium acutum(Thunb．)Rehd．Et Wils． Plants Menispermaceae Alkaloids Piperidine Alkaloids Monophenols Phenols Disease Research Fields Inflammation/Immunology
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19
19 Cited Publications
Synonyms: Cucoline hydrochloride
Category:
Neurological Disease Sinomenium acutum(Thunb．)Rehd．Et Wils． Plants Menispermaceae Alkaloids Piperidine Alkaloids Monophenols Phenols Disease Research Fields Inflammation/Immunology
Target:
17
17 Cited Publications
Cat. No.: HY-P81140
Synonyms: 8-hydroxy-2'-deoxyguanosine; 2'-Deoxy-8-oxoguanosine; 7,8-Dihydro-8-oxo-2'-deoxyguanosine; 8-Oxo-7,8-dihydro-2'-deoxyguanosine; 8-Oxo-7,8-dihydrodeoxyguanosine; 2'-Deoxy-8-oxo-D-guanosine; 8-Oxo-7,8-dihydro-2μ-deoxyguanosine,8-Oxo-dG; 2'-Deoxy-8-hydroxyguanosine;
15
15 Cited Publications
Cat. No.: HY-P0210
CAS No.: 78123-71-4
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Research Areas:
15
15 Cited Publications
Cat. No.: HY-P0210B
CAS No.: 950492-85-0
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14
14 Cited Publications
Target:
Research Areas:
PD 150606 is a selective, cell-permeable non-peptide calpain inhibitor with Ki values of 0.21 μM and 0.37 μM for μ- and m-calpains respectively, which is neuroprotective .
13
Target:
Research Areas:
Loperamide (ADL 2-1294) is selective and orally active μ opioid receptor agonist with Ki valuess of 3, 48 and 1156 nM against μ, δ and κ opioid receptor, respectively. Loperamide produces antinociception and antihyperalgesia. Loperamide exhibits peripheral selectivity, enhancing fluid, electrolyte, and glucose absorption, reversing PGE2 (HY-101952)- and Cholera toxin (HY-P1446)-induced intestinal secretion, and reducing intestinal motility. Loperamide can be used for the researches of inflammatory pain and protracted diarrhoea .
9
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Ritlecitinib (PF-06651600) is a highly selective, orally active, irreversible covalent JAK3 inhibitor (IC50=33 nM) without inhibitory activity towards JAK1, JAK2, and TYK2 (IC50 >10 μ M). Ritlecitinib rapidly inactivates the JAK3 kinase, and blocks signaling and downstream STAT phosphorylation mediated by common gamma chain cytokines such as IL-2 and IL-15. Ritlecitinib can inhibit Th1/Th17 cell differentiation and function, and effectively suppress preclinical animal models such as alopecia areata, adjuvant-induced arthritis (AIA), and experimental autoimmune encephalomyelitis (EAE) .
9
9 Cited Publications
Synonyms: PF-06651600 tosylate
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Research Areas:
Ritlecitinib (PF-06651600) tosylate is a highly selective, orally active, irreversible covalent JAK3 inhibitor (IC50=33 nM) without inhibitory activity towards JAK1, JAK2, and TYK2 (IC50 >10 μ M). Ritlecitinib tosylate rapidly inactivates the JAK3 kinase, and blocks signaling and downstream STAT phosphorylation mediated by common gamma chain cytokines such as IL-2 and IL-15. Ritlecitinib tosylate can inhibit Th1/Th17 cell differentiation and function, and effectively suppress preclinical animal models such as alopecia areata, adjuvant-induced arthritis (AIA), and experimental autoimmune encephalomyelitis (EAE) .
8
Category:
Cardiovascular Disease Polygonaceae Reynoutria japonica Houtt. Coumarins Plants Microorganisms Monophenols Phenols Phenylpropanoids Disease Research Fields
Target:
8
8 Cited Publications
Synonyms: Hymecromone sodium salt; 4-mu sodium salt
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Research Areas:
4-Methylumbelliferone (sodium salt) is a coumarin derivative. 4-Methylumbelliferone (sodium salt) can be used as a standard to quantify the free 4-methylumbelliferone released as a result of enzyme-substrate action. 4-Methylumbelliferone (sodium salt) inhibits hyaluronan production in vitro. 4-Methylumbelliferone (sodium salt) can be studied in ovarian cancer research .
7
7 Cited Publications
Cat. No.: HY-N6771
CAS No.: 18172-33-3
7
7 Cited Publications
Cat. No.: HY-19749
CAS No.: 181765-30-0
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Research Areas:
PD 151746 is a selective calpain-1 inhibitor with an IC50 of 260 nM. PD 151746 binds μ-calpain Ca 2+-binding sites, and shows selectivity over cathepsin B, papain, trypsin, thermolysin, and basal calcineurin. PD 151746 reduces Oxidized low-density lipoprotein (oxLDL)-induced cytotoxicity, apoptotic DNA fragmentation, and blocks IL-1α maturation. PD 151746 can be used for the research of atherosclerosis and psoriasis .
5
5 Cited Publications
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PZM21 is a potent and selective μ opioid receptor agonist with an EC50 of 1.8 nM .
5
3
3 Cited Publications
Cat. No.: HY-P0185
CAS No.: 189388-22-5
Category:
Natural Products Monophenols Pyrrole Alkaloids Neurological Disease Phenols Endogenous metabolite Disease Research Fields Indole Alkaloids
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3
3 Cited Publications
Cat. No.: HY-P0185A
CAS No.: 1276123-71-7
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3
3 Cited Publications
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Research Areas:
Naltriben mesylate is a potent δ2-opioid receptor antagonist and a TRPM7 activator. Naltriben mesylate shows Ki values of 0.013 nM, 19 nM and 152 nM for δ, μ and κ receptors, respectively. Naltriben mesylate enhances glioblastoma cell migration and invasion. Naltriben mesylate can be used in research into neurological diseases and cancer .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
