2. GPCR/G Protein Neuronal Signaling
  3. Opioid Receptor
  4. DAMGO TFA

DAMGO TFA is a μ-opioid receptor (μ-OPR ) selective agonist with a Kd of 3.46 nM for native μ-OPR.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

CAS No. : 950492-85-0

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
 In-stock
Solution
10 mM * 1 mL in Water In-stock
Solid
5 mg In-stock
10 mg In-stock
25 mg In-stock
50 mg   Get quote  
100 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 12 publication(s) in Google Scholar

Other Forms of DAMGO TFA:

DAMGO TFA Related Antibodies

Top Publications Citing Use of Products

    DAMGO TFA purchased from MedChemExpress. Usage Cited in: Aquaculture. 2025 Apr 15.

    Transcript levels of agrp, drd1 and drd2 in glucose and DAMGO stimulation (20 μM; 24 h). DAMGO treatment eliminated the increased expression of drd2 induced by glucose stimulation.

    DAMGO TFA purchased from MedChemExpress. Usage Cited in: Aquaculture. 2025 Apr 15.

    Fluorescence levels of AgRP and c-Fos in glucose and DAMGO (20 μM) or SCK-39394 stimulation for 24 h. DAMGO treatment rescued the decreased immunoreactivity of Agrp and c-Fos proteins suppressed by glucose.

    DAMGO TFA purchased from MedChemExpress. Usage Cited in: bioRxiv. 2024 Jul 26:2024.07.26.605282.  [Abstract]

    Representative kinetics of cAMP accumulation in response to agonist stimulation of indicated GPCRs using DAMGO (1 μM; 25 min). Application of DAMGO revealed a robust accumulation of intracellular cAMP as measured using a split-luciferase GloSensor.

    DAMGO TFA purchased from MedChemExpress. Usage Cited in: Seoul National University. 2024 Feb.

    The effect of DAMGO (0.1-1000 nM) on forskolin (3 μM)-induced cAMP production was measured using a GloSensor cAMP assay. DAMGO induced μOR activation and effectively inhibited forskolininduced cAMP production.

    View All Opioid Receptor Isoform Specific Products:

    View All Isoforms
    μ Opioid Receptor/MOR κ Opioid Receptor/KOR δ Opioid Receptor/DOR NOP Receptor/ORL1

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    DAMGO TFA is a μ-opioid receptor (μ-OPR ) selective agonist with a Kd of 3.46 nM for native μ-OPR[1].

    IC50 & Target

    μ Opioid Receptor/MOR

     

    In Vitro

    DAMGO (1-10 μM) TFA significantly reduces the activation of neuronal Akt and ERK1/2 by CXCL12 and inhibits CXCL12-promoted neuronal survival, but does not down-regulate CXCR4 protein expression[2].
    DAMGO (1 μM) TFA effectively inhibits the prostaglandin E 2 (PGE 2) induced increase in a tetrodotoxin-resistant voltage-gated Na+ current (TTX-R I Na), i.e. PGE 2 (1 μM) can increase the TTX-R I Na peak by 103 % compared to 24.9 % with the addition of DAMGO[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    DAMGO TFA Related Antibodies
    In Vivo

    DAMGO (i.v., 0.5-2 mg/kg) TFA can produce significant anti-injury effects on injured paws of male Sprague-Dawley rats weighing 200-225 g in a dose-dependent manner, producing an effective and long-lasting analgesic effect[4].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    Molecular Weight

    627.61

    Formula

    C28H36F3N5O8
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    Sequence

    Tyr-{d-Ala}-Gly-{Me-Phe}-Gly-ol
    Sequence Shortening

    Y-{d-Ala}-G-{Me-Phe}-G-ol
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Sealed storage, away from moisture

    Powder -80°C 2 years
    -20°C 1 year

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    Solvent & Solubility
    In Vitro: 

    H2O : ≥ 100 mg/mL (159.33 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.5933 mL 7.9667 mL 15.9335 mL
    5 mM 0.3187 mL 1.5933 mL 3.1867 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
    =
    Concentration
    ×
    Volume
    ×
    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

    ×
    Volume (start)

    V1

    =
    Concentration (final)

    C2

    ×
    Volume (final)

    V2

    In Vivo:

    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  PBS

      Solubility: 100 mg/mL (159.33 mM); Clear solution; Need ultrasonic

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Purity & Documentation
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O 1 mM 1.5933 mL 7.9667 mL 15.9335 mL 39.8337 mL
    5 mM 0.3187 mL 1.5933 mL 3.1867 mL 7.9667 mL
    10 mM 0.1593 mL 0.7967 mL 1.5933 mL 3.9834 mL
    15 mM 0.1062 mL 0.5311 mL 1.0622 mL 2.6556 mL
    20 mM 0.0797 mL 0.3983 mL 0.7967 mL 1.9917 mL
    25 mM 0.0637 mL 0.3187 mL 0.6373 mL 1.5933 mL
    30 mM 0.0531 mL 0.2656 mL 0.5311 mL 1.3278 mL
    40 mM 0.0398 mL 0.1992 mL 0.3983 mL 0.9958 mL
    50 mM 0.0319 mL 0.1593 mL 0.3187 mL 0.7967 mL
    60 mM 0.0266 mL 0.1328 mL 0.2656 mL 0.6639 mL
    80 mM 0.0199 mL 0.0996 mL 0.1992 mL 0.4979 mL
    100 mM 0.0159 mL 0.0797 mL 0.1593 mL 0.3983 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • No file chosen (Maximum size is: 1024 Kb)
    • If you have published this work, please enter the PubMed ID.
    • Your name will appear on the site.

    DAMGO TFA Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    DAMGO950492-85-0Opioid Receptorμ-opioid receptorμ-OPRanalgesic effectInhibitorinhibitorinhibit

    Your Recently Viewed Products:

    Inquiry Online

    Your information is safe with us. * Required Fields.

    Product Name

    		  

    Requested Quantity *

    Applicant Name *

    		 

    Salutation

    Email Address *

    		 

    Phone Number *

    Department

    		 

    Organization Name *

    City

    State

    Country or Region *

    		      

    Remarks

    Bulk Inquiry

    Inquiry Information

    Product Name:
    DAMGO TFA
    Cat. No.:
    HY-P0210B
    Quantity:
    MCE Japan Authorized Agent:

    Customer Review

    Thank You for Your Feedback!

    Request for HNMR Report

    Please fill out this form to request the QC report. We will send it to your Email address shortly.

    Your information is safe with us. * Required Fields.

    Product Name

    		  

    Lot #

    Applicant Name *

    		 

    Email Address *

    Phone Number

    		 

    Department *

    Organization Name *

    		 

    Country or Region *

    Remarks

    SAFETY DATA SHEET (SDS)

    English - EN (252 KB) Français - FR (252 KB) Deutsch - DE (252 KB) Norwegian - NO (252 KB) Español - ES (252 KB) Swedish - SV (252 KB) Italian - IT (252 KB) Korean - KR (252 KB) Portuguese - PT (252 KB)

    Request for HNMR Report

    We have received your request and will respond to you as soon as possible.