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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
30 Results for "
multidrug transporter
" in MedChemExpress (MCE) Product Catalog:
Products (30)
30 Results for "multidrug transporter" in MCE Product Catalog:
1
1 Cited Publications
Category:
Target:
1
1 Cited Publications
Cat. No.: HY-P81118
Synonyms: ABC30 antibody;
abcC2 antibody;
ATP binding cassette sub family C (CFTR/MRP) member 2 antibody;
ATP binding cassette subfamily C member 2 antibody;
ATP-binding cassette sub-family C member 2 antibody;
Canalicular multidrug resistance protein antibody;
Canalicular multispecific organic anion transporter 1 antibody;
CMOAT antibody;
CMOAT1 antibody;
cMRP antibody;
DJS antibody;
KIAA1010 antibody;
MRP 2 antibody;
MRP2_HUMAN antibody;
multidrug resistance associated protein 2 antibody;
multidrug resistance-associated protein 2 antibody;
1
1 Cited Publications
Cat. No.: HY-P703175
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: ABCB1; P-170; Prev. PGY1; ATP-Dependent Translocase ABCB1; Prev. MDR1; Phospholipid transporter ABCB1; Prev. CLCS; Colchicin Sensitivity; multidrug Resistance Protein 1; ATP-Binding Cassette Sub-Family B Member 1; ATP-Binding Cassette, Sub-Family B (MDR/T
Species:
Human
Source:
HEK293
Cat. No.: HY-B0396
CAS No.: 161715-24-8
Synonyms: L084
Target:
Research Areas:
Tebipenem pivoxil (L084 hydrobromide) is an orally active carbapenem Antibiotic. Tebipenem pivoxil acts as a substrate of OATP1A2 with high affinity for this transporter (Km = 41.1 μM) . Tebipenem pivoxil achieves intestinal absorption via carrier-mediated uptake and simple diffusion. Tebipenem pivoxil inhibits the growth of Gram-positive bacteria, Gram-negative bacteria, multidrug-resistant bacteria, and pathogens producing extended-spectrum β-lactamases. Tebipenem pivoxil eliminates intestinal infection pathogens and reduces mortality in septic mice. Tebipenem pivoxil can be used in research related to bacterial pneumonia, severe gastrointestinal infections, bacterial sepsis, complicated urinary tract infections, and acute pyelonephritis .
Cat. No.: HY-D0180
CAS No.: 17455-13-9
Synonyms: 18C6; 1,4,7,10,13,16-Hexaoxacyclooctadecane
Category:
Alkaloids Leguminosae Other Diseases Plants Disease Research Fields Indigofera Indole Alkaloids
Target:
Target:
Research Areas:
Ceefourin 1 is a potent and highly selective multidrug resistance protein 4 (MRP4) inhibitor. Ceefourin 1 inhibits transport of a broad range of MRP4 substrates, yet is highly selective for MRP4 over other ABC transporters. Ceefourin 1 is a benzothiazol and primarily as a chemosensitizer for high-risk neuroblastoma .
Cat. No.: HY-132189
CAS No.: 197509-46-9
Target:
Research Areas:
Laniquidar is a non-competitive P-gp inhibitor with an IC50 of 0.51 μM. Laniquidar binds to the P-gp transporter with high affinity and exhibits low activity as a substrate. Laniquidar is applicable to epilepsy-related research .
Cat. No.: HY-W014118
CAS No.: 101-86-0
Target:
Cat. No.: HY-162753
CAS No.: 2351940-23-1
Target:
Research Areas:
ZW-1226 is a dual Tyrosyl DNA phosphodiesterase 2 (TDP2) and Multidrug resistance-associated protein 1 (MRP1) inhibitor with IC50 values of 0.2 and 0.5 μM, respectively. ZW-1226 exhibits selectivity over other ABC transporters. ZW-1226 elevates intracellular GSH levels, and reverses MRP1-mediated drug resistance. ZW-1226 can be used for the research of leukemia, non-small-cell lung cancer, and multidrug resistant small-cell lung cancer .
Cat. No.: HY-N0406
CAS No.: 861691-37-4
Category:
other families Flavonoids Plants Disease Research Fields Inflammation/Immunology Isoflavones
Target:
Research Areas:
MCT1-IN-3 is a monocarboxylate transporter 1 (MCT1) inhibitor with an IC50 value of 81.0 nM. MCT1-IN-3 has also significant inhibitivity against the multidrug transporter ABCB1. MCT1-IN-3 can be used for the research of cancer .
Cat. No.: HY-B0396A
CAS No.: 211558-19-9
Synonyms: L084 hydrochloride
Target:
Research Areas:
Tebipenem pivoxil hydrochloride (L084 hydrochloride) is an orally active carbapenem Antibiotic. Tebipenem pivoxil hydrochloride acts as a substrate of OATP1A2 with high affinity for this transporter (Km = 41.1 μM) . Tebipenem pivoxil hydrochloride achieves intestinal absorption via carrier-mediated uptake and simple diffusion. Tebipenem pivoxil hydrochloride inhibits the growth of Gram-positive bacteria, Gram-negative bacteria, multidrug-resistant bacteria, and pathogens producing extended-spectrum β-lactamases. Tebipenem pivoxil hydrochloride eliminates intestinal infection pathogens and reduces mortality in septic mice. Tebipenem pivoxil hydrochloride can be used in research related to bacterial pneumonia, severe gastrointestinal infections, bacterial sepsis, complicated urinary tract infections, and acute pyelonephritis .
Cat. No.: HY-120950
CAS No.: 125741-64-2
Target:
Research Areas:
S-Farnesyl-L-cysteine methyl ester is a multidrug resistance transporter activator. S-Farnesyl-L-cysteine methyl ester acts by stimulating the multidrug resistance transporter ATPase activity and competing for drug binding .
Cat. No.: HY-155152
CAS No.: 3052839-42-3
Target:
Research Areas:
P-gp/BCRP-IN-2 (compound 15) is an oxadiazole derivative and a dual inhibitor of the ABC transporter P-glycoprotein (IC50: 1.6 nM) and BCRP (IC50: 600 nM). P-gp/BCRP-IN-2 also enhances the anti-proliferative effects of Doxorubicin (HY-15142A) in drug-resistant human adenocarcinoma colon cancer cell lines HT29/DX and MDCK-MDR1 cells .
Cat. No.: HY-130004
CAS No.: 2909443-13-4
Target:
Research Areas:
MsbA-IN-6 is a potent inhibitor of MsbA. MsbA-IN-6 is an antibiotic. Gram-negative ATP-binding cassette (ABC) transporter MsbA, an essential inner membrane protein, transports lipopolysaccharide from the inner leaflet to the periplasmic face of the inner membrane. MsbA-IN-6 kills Escherichia coli through inhibition of its ATPase and transport activity, with no loss of activity against clinical multidrug-resistant strains .
Cat. No.: HY-N0406R
CAS No.: 861691-37-4
Category:
Target:
Cat. No.: HY-144393
CAS No.: 2764596-06-5
P-gp/BCRP-IN-1 (compound 19) is a potential, relatively safe, orally active and efficient efflux transporter (P-gp and BCRP) inhibitor. P-gp/BCRP-IN-1 exerts resistance reversal by inhibiting the efflux function of P-gp and BCRP. P-gp/BCRP-IN-1 can overcome the resistance and improve the oral bioavailability of PTX (Paclitaxel) .
Cat. No.: HY-W014118R
CAS No.: 101-86-0
Cat. No.: HY-B0396R
CAS No.: 161715-24-8
Synonyms: L084 (Standard)
Target:
Research Areas:
Tebipenem pivoxil (Standard) (L084 (Standard)) is the analytical standard of Tebipenem pivoxil (HY-B0396). This product is intended for research and analytical applications. Tebipenem pivoxil (L084 hydrobromide) is an orally active carbapenem Antibiotic. Tebipenem pivoxil acts as a substrate of OATP1A2 with high affinity for this transporter (Km = 41.1 μM) . Tebipenem pivoxil achieves intestinal absorption via carrier-mediated uptake and simple diffusion. Tebipenem pivoxil inhibits the growth of Gram-positive bacteria, Gram-negative bacteria, multidrug-resistant bacteria, and pathogens producing extended-spectrum β-lactamases. Tebipenem pivoxil eliminates intestinal infection pathogens and reduces mortality in septic mice. Tebipenem pivoxil can be used in research related to bacterial pneumonia, severe gastrointestinal infections, bacterial sepsis, complicated urinary tract infections, and acute pyelonephritis .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
