2909443-13-4
Chemical Structure
MsbA-IN-6
- CAS No.: 2909443-13-4
- Formula:C24H20Cl2N4O
- Molecular Weight:451.35
IUPAC Name: (S,E)-5-(2-(1-cyclopropyl-7-(1-(2,6-dichlorophenyl)ethoxy)naphthalen-2-yl)vinyl)-2H-tetrazole
InChIKey: BRIRTHDHCSCYFI-WONIAPNHSA-N
SMILES: C[C@H](OC1=CC2=C(C(/C=C/C3=NNN=N3)=CC=C2C=C1)C4CC4)C5=C(C=CC=C5Cl)Cl
Biological Activity: MsbA-IN-6 is a potent inhibitor of MsbA. MsbA-IN-6 is an antibiotic. Gram-negative ATP-binding cassette (ABC) transporter MsbA, an essential inner membrane protein, transports lipopolysaccharide from the inner leaflet to the periplasmic face of the inner membrane. MsbA-IN-6 kills Escherichia coli through inhibition of its ATPase and transport activity, with no loss of activity against clinical multidrug-resistant strains[1][2].
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MsbA-IN-6 | MsbA-IN-6 is a potent inhibitor of MsbA. MsbA-IN-6 is an antibiotic. Gram-negative ATP-binding cassette (ABC) transporter MsbA, an essential inner membrane protein, transports lipopolysaccharide from the inner leaflet to the periplasmic face of the inner membrane. MsbA-IN-6 kills Escherichia coli through inhibition of its ATPase and transport activity, with no loss of activity against clinical multidrug-resistant strains. | |||||||||||||||||||||
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