315702-40-0
315702-40-0
Chemical Structure
Ceefourin 1
- CAS No.: 315702-40-0
- Formula:C11H10N4S3
- Molecular Weight:294.42
IUPAC Name: 5-((benzo[d]thiazol-2-ylthio)methyl)-4-methyl-2,4-dihydro-3H-1,2,4-triazole-3-thione
InChIKey: KVNBVHCJAUXKPJ-UHFFFAOYSA-N
SMILES: S=C1NN=C(CSC2=NC3=CC=CC=C3S2)N1C
Biological Activity: Ceefourin 1 is a potent and highly selective multidrug resistance protein 4 (MRP4) inhibitor. Ceefourin 1 inhibits transport of a broad range of MRP4 substrates, yet is highly selective for MRP4 over other ABC transporters. Ceefourin 1 is a benzothiazol and primarily as a chemosensitizer for high-risk neuroblastoma[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Ceefourin 1 | 99.72% | Ceefourin 1 is a potent and highly selective multidrug resistance protein 4 (MRP4) inhibitor. Ceefourin 1 inhibits transport of a broad range of MRP4 substrates, yet is highly selective for MRP4 over other ABC transporters. Ceefourin 1 is a benzothiazol and primarily as a chemosensitizer for high-risk neuroblastoma. | ||||||||||||||||||||
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Ceefourin 1 (Standard) | ≥98% | Ceefourin 1 (Standard) is the analytical standard of Ceefourin 1 (HY-101453). This product is intended for research and analytical applications. Ceefourin 1 is a potent and highly selective multidrug resistance protein 4 (MRP4) inhibitor. Ceefourin 1 inhibits transport of a broad range of MRP4 substrates, yet is highly selective for MRP4 over other ABC transporters. Ceefourin 1 is a benzothiazol and primarily as a chemosensitizer for high-risk neuroblastoma. | ||||||||||||||||||||
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References
- [1]. Leanna Cheung, et al. High-throughput screening identifies Ceefourin 1 and Ceefourin 2 as highly selective inhibitors of multidrug resistance protein 4 (MRP4). Biochem Pharmacol. 2014 Sep 1;91(1):97-108. [Content Brief]
- [2]. Tony Huynh, et al. CCI52 sensitizes tumors to 6-mercaptopurine and inhibits MYCN-amplified tumor growth. Biochem Pharmacol. 2020 Feb;172:113770. [Content Brief]
